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公开(公告)号：US10093686B2
公开(公告)日：2018-10-09
申请号：US15680842
申请日：2017-08-18
Applicant: Tetra Discovery Partners, LLC
Inventor： Mark E. Gurney , Timothy J. Hagen , Xuesheng Mo , A. Samuel Vellekoop , Donna L. Romero , Robert F. Campbell , Joel R. Walker , Lei Zhu
IPC: A61K31/505 , C07F5/02 , C07D213/72 , C07D403/12 , C07D413/14 , C07D213/74 , C07D221/04 , C07D409/04 , C07D409/14 , C07D413/12 , C07D495/04 , C07D213/56 , A61K45/06 , A61K31/435 , A61K31/4418 , A61K31/517 , A61K31/53 , A61K31/69 , C07D239/26 , C07D239/70 , C07D251/22 , C07D401/12 , C07D405/04 , A61K31/44 , A61K31/496 , A61K31/506 , A61K31/519 , A61K31/5377 , C07D251/30 , C07D251/42 , C07D401/04
Abstract: The present invention relates to compounds and methods useful as inhibitors of phosphodiesterase 4 (PDE4) for the treatment or prevention of inflammatory diseases and other diseases involving elevated levels of cytokines and proinflammatory mediators.
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公开(公告)号：US20150119362A1
公开(公告)日：2015-04-30
申请号：US14349688
申请日：2013-10-24
Applicant: Tetra Discovery Partners, LLC
Inventor： Mark E. Gurney , Timothy J. Hagen , Joel R. Walker , Xuesheng Mo , A. Samuel Vellekoop , Robert Campbell , Lei Zhu , Donna L. Romero
IPC: C07F5/02 , A61K31/435 , C07D213/74 , A61K31/4418 , C07D409/04 , A61K31/517 , C07D239/70 , A61K31/53 , C07D405/04 , C07D251/22 , C07D401/12 , C07D239/26 , A61K31/505 , A61K31/69 , A61K45/06 , C07D221/04
CPC classification number: C07F5/027 , A61K31/435 , A61K31/44 , A61K31/4418 , A61K31/496 , A61K31/505 , A61K31/506 , A61K31/517 , A61K31/519 , A61K31/53 , A61K31/5377 , A61K31/69 , A61K45/06 , C07D213/56 , C07D213/72 , C07D213/74 , C07D221/04 , C07D239/26 , C07D239/70 , C07D251/22 , C07D251/30 , C07D251/42 , C07D401/04 , C07D401/12 , C07D403/12 , C07D405/04 , C07D409/04 , C07D409/14 , C07D413/12 , C07D413/14 , C07D495/04 , C07F5/025
Abstract: The present invention relates to compounds and methods useful as inhibitors of phosphodiesterase 4 (PDE4) for the treatment or prevention of disease.
Abstract translation: 本发明涉及用作治疗或预防疾病的磷酸二酯酶4（PDE4）抑制剂的化合物和方法。
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Patent Agency Ranking
公开(公告)号：US20160137672A1
公开(公告)日：2016-05-19
申请号：US14938544
申请日：2015-11-11
Applicant: Tetra Discovery Partners, LLC
Inventor： Mark E. Gurney , Timothy J. Hagen , Xuesheng Mo , A. Samuel Vellekoop , Donna L. Romero , Robert F. Campbell , Joel R. Walker , Lei Zhu
IPC: C07F5/02 , A61K31/435 , C07D213/74 , A61K31/44 , C07D409/04 , A61K31/517 , C07D239/70 , A61K31/53 , C07D251/42 , C07D251/30 , C07D401/12 , C07D405/04 , C07D403/12 , C07D239/26 , A61K31/505 , A61K31/69 , C07D409/14 , A61K31/506 , C07D401/04 , C07D413/12 , A61K31/496 , A61K31/5377 , C07D495/04 , A61K31/519 , A61K45/06 , C07D221/04
CPC classification number: C07F5/027 , A61K31/435 , A61K31/44 , A61K31/4418 , A61K31/496 , A61K31/505 , A61K31/506 , A61K31/517 , A61K31/519 , A61K31/53 , A61K31/5377 , A61K31/69 , A61K45/06 , C07D213/56 , C07D213/72 , C07D213/74 , C07D221/04 , C07D239/26 , C07D239/70 , C07D251/22 , C07D251/30 , C07D251/42 , C07D401/04 , C07D401/12 , C07D403/12 , C07D405/04 , C07D409/04 , C07D409/14 , C07D413/12 , C07D413/14 , C07D495/04 , C07F5/025
Abstract: The present invention relates to compounds and methods useful as inhibitors of phosphodiesterase 4 (PDE4) for the treatment or prevention of disease.
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公开(公告)号：US09777024B2
公开(公告)日：2017-10-03
申请号：US14938544
申请日：2015-11-11
Applicant: Tetra Discovery Partners, LLC
Inventor： Mark E. Gurney , Timothy J. Hagen , Xuesheng Mo , A. Samuel Vellekoop , Donna L. Romero , Robert F. Campbell , Joel R. Walker , Lei Zhu
IPC: C07D213/24 , A61K31/505 , C07F5/02 , C07D213/72 , C07D403/12 , C07D413/14 , C07D213/74 , C07D221/04 , C07D409/04 , C07D409/14 , C07D413/12 , C07D495/04 , C07D213/56 , A61K45/06 , A61K31/435 , A61K31/4418 , A61K31/517 , A61K31/53 , A61K31/69 , C07D239/26 , C07D239/70 , C07D251/22 , C07D401/12 , C07D405/04 , A61K31/44 , A61K31/496 , A61K31/506 , A61K31/519 , A61K31/5377 , C07D251/30 , C07D251/42 , C07D401/04
CPC classification number: C07F5/027 , A61K31/435 , A61K31/44 , A61K31/4418 , A61K31/496 , A61K31/505 , A61K31/506 , A61K31/517 , A61K31/519 , A61K31/53 , A61K31/5377 , A61K31/69 , A61K45/06 , C07D213/56 , C07D213/72 , C07D213/74 , C07D221/04 , C07D239/26 , C07D239/70 , C07D251/22 , C07D251/30 , C07D251/42 , C07D401/04 , C07D401/12 , C07D403/12 , C07D405/04 , C07D409/04 , C07D409/14 , C07D413/12 , C07D413/14 , C07D495/04 , C07F5/025
Abstract: The present invention relates to compounds and methods useful as inhibitors of phosphodiesterase 4 (PDE4) for the treatment or prevention of disease.
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公开(公告)号：US11767334B2
公开(公告)日：2023-09-26
申请号：US17808439
申请日：2022-06-23
Applicant: Tetra Discovery Partners, LLC
Inventor： Mark E. Gurney , Timothy J. Hagen , Xuesheng Mo , A. Samuel Vellekoop , Donna L. Romero , Robert Campbell , Joel R. Walker , Lei Zhu
IPC: A61K31/4418 , C07F5/02 , C07D213/72 , C07D403/12 , C07D413/14 , C07D213/74 , C07D221/04 , C07D409/04 , C07D409/14 , C07D413/12 , C07D495/04 , C07D213/56 , A61K45/06 , A61K31/435 , A61K31/505 , A61K31/517 , A61K31/53 , A61K31/69 , C07D239/26 , C07D239/70 , C07D251/22 , C07D401/12 , C07D405/04 , A61K31/44 , A61K31/496 , A61K31/506 , A61K31/519 , A61K31/5377 , C07D251/30 , C07D251/42 , C07D401/04
CPC classification number: C07F5/027 , A61K31/435 , A61K31/44 , A61K31/4418 , A61K31/496 , A61K31/505 , A61K31/506 , A61K31/517 , A61K31/519 , A61K31/53 , A61K31/5377 , A61K31/69 , A61K45/06 , C07D213/56 , C07D213/72 , C07D213/74 , C07D221/04 , C07D239/26 , C07D239/70 , C07D251/22 , C07D251/30 , C07D251/42 , C07D401/04 , C07D401/12 , C07D403/12 , C07D405/04 , C07D409/04 , C07D409/14 , C07D413/12 , C07D413/14 , C07D495/04 , C07F5/025
Abstract: The present invention relates to compounds and methods useful as inhibitors of phosphodiesterase 4 (PDE4) for the treatment or prevention of inflammatory diseases and other diseases involving elevated levels of cytokines and proinflammatory mediators.
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公开(公告)号：US10364258B2
公开(公告)日：2019-07-30
申请号：US16111700
申请日：2018-08-24
Applicant: Tetra Discovery Partners, LLC
Inventor： Mark E. Gurney , Timothy J. Hagen , Xuesheng Mo , A. Samuel Vellekoop , Donna L. Romero , Robert F. Campbell , Joel R. Walker , Lei Zhu
IPC: A61K31/505 , C07F5/02 , C07D213/72 , C07D403/12 , C07D413/14 , C07D213/74 , C07D221/04 , C07D409/04 , C07D409/14 , C07D413/12 , C07D495/04 , C07D213/56 , A61K45/06 , A61K31/435 , A61K31/4418 , A61K31/517 , A61K31/53 , A61K31/69 , C07D239/26 , C07D239/70 , C07D251/22 , C07D401/12 , C07D405/04 , A61K31/44 , A61K31/496 , A61K31/506 , A61K31/519 , A61K31/5377 , C07D251/30 , C07D251/42 , C07D401/04
Abstract: The present invention relates to compounds and methods useful as inhibitors of phosphodiesterase 4 (PDE4) for the treatment or prevention of inflammatory diseases and other diseases involving elevated levels of cytokines and proinflammatory mediators.
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公开(公告)号：US09221843B2
公开(公告)日：2015-12-29
申请号：US14349688
申请日：2013-10-24
Applicant: Tetra Discovery Partners, LLC
Inventor： Mark E. Gurney , Timothy J. Hagen , Xuesheng Mo , A. Samuel Vellekoop , Donna L. Romero , Robert F. Campbell , Joel R. Walker , Lei Zhu
IPC: C07D213/24 , C07D239/26 , A61K31/4418 , C07F5/02 , C07D213/72 , C07D403/12 , C07D413/14 , C07D213/74 , C07D221/04 , C07D409/04 , C07D409/14 , C07D413/12 , C07D495/04 , C07D213/56 , A61K45/06 , A61K31/435 , A61K31/505 , A61K31/517 , A61K31/53 , A61K31/69 , C07D239/70 , C07D251/22 , C07D401/12 , C07D405/04
CPC classification number: C07F5/027 , A61K31/435 , A61K31/44 , A61K31/4418 , A61K31/496 , A61K31/505 , A61K31/506 , A61K31/517 , A61K31/519 , A61K31/53 , A61K31/5377 , A61K31/69 , A61K45/06 , C07D213/56 , C07D213/72 , C07D213/74 , C07D221/04 , C07D239/26 , C07D239/70 , C07D251/22 , C07D251/30 , C07D251/42 , C07D401/04 , C07D401/12 , C07D403/12 , C07D405/04 , C07D409/04 , C07D409/14 , C07D413/12 , C07D413/14 , C07D495/04 , C07F5/025
Abstract: The present invention relates to compounds and methods useful as inhibitors of phosphodiesterase 4 (PDE4) for the treatment or prevention of disease.
Abstract translation: 本发明涉及用作治疗或预防疾病的磷酸二酯酶4（PDE4）抑制剂的化合物和方法。
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