公开(公告)号：US12097027B2

公开(公告)日：2024-09-24

申请号：US15818173

申请日：2017-11-20

申请人： Magnolia Medical Technologies, Inc.

发明人： Gregory J. Bullington ,  Richard G. Patton ,  Shan E. Gaw ,  Jay M. Miazga ,  Jed McCann ,  Paul Goldenbaum

IPC分类号： A61B5/15 ,  A61B5/153 ,  A61B5/154 ,  A61B5/155 ,  A61M5/162 ,  A61M5/178 ,  A61M5/48 ,  A61M39/02 ,  A61M39/22 ,  B01L3/00 ,  A61M5/32 ,  A61M25/00 ,  A61M25/06

CPC分类号： A61B5/150206 ,  A61B5/15003 ,  A61B5/150099 ,  A61B5/150221 ,  A61B5/150236 ,  A61B5/150244 ,  A61B5/150251 ,  A61B5/150351 ,  A61B5/150396 ,  A61B5/150519 ,  A61B5/150572 ,  A61B5/150732 ,  A61B5/15074 ,  A61B5/150946 ,  A61B5/153 ,  A61B5/154 ,  A61B5/155 ,  A61M5/162 ,  A61M5/178 ,  A61M5/48 ,  A61M39/0208 ,  A61M39/22 ,  B01L3/50825 ,  B01L3/563 ,  A61B5/150389 ,  A61M5/3286 ,  A61M25/005 ,  A61M25/065 ,  B01L2200/0689 ,  B01L2300/042 ,  B01L2300/044 ,  B01L2300/069 ,  B01L2300/0854 ,  B01L2400/0457 ,  B01L2400/0478 ,  B01L2400/049 ,  B01L2400/0616 ,  B01L2400/084

摘要： A collection system configured to maintain the integrity of a bodily fluid sample has a proximal end portion, a distal end portion, and an inner surface defining a fluid flow path therethrough. The distal end portion is configured to be placed in fluid communication with a patient. The proximal end portion is configured to be placed in fluid communication with a fluid reservoir. The fluid flow path defined by the inner surface is associated with at least one flow characteristic configured to limit a stress within the flow of the bodily fluid between the distal end portion and the proximal end portion.

公开(公告)号：US11957886B2

公开(公告)日：2024-04-16

申请号：US17959194

申请日：2022-10-03

申请人： 410 Medical, Inc.

发明人： Mark D. Piehl ,  Galen C. Robertson ,  John Tyler Willis Hagler ,  Robert W. Titkemeyer ,  Frederic C. Feiler, Jr.

IPC分类号： A61M5/142 ,  A61M5/00 ,  A61M5/14 ,  A61M5/145 ,  A61M5/178 ,  A61M5/19 ,  A61M5/20 ,  A61M5/31 ,  A61M5/315 ,  A61M5/48 ,  A61M39/10 ,  A61M39/24 ,  A61M39/28

CPC分类号： A61M5/31581 ,  A61M5/002 ,  A61M5/007 ,  A61M5/1413 ,  A61M5/14244 ,  A61M5/1456 ,  A61M5/1782 ,  A61M5/19 ,  A61M5/2033 ,  A61M5/3146 ,  A61M5/3158 ,  A61M5/31586 ,  A61M5/486 ,  A61M5/488 ,  A61M39/10 ,  A61M39/105 ,  A61M39/24 ,  A61M39/28 ,  A61M2005/202 ,  A61M2005/2026 ,  A61M2005/2073 ,  A61M2005/3128 ,  A61M2005/31588 ,  A61M2039/2493 ,  A61M2205/332 ,  A61M2205/3331 ,  A61M2205/3379 ,  A61M2205/3584 ,  A61M2205/50

摘要： A system includes a tubing set and a drive assembly. The tubing set includes inlet tubing couplable to a source of fluid, a valve coupled to the inlet tubing, a syringe coupled to the inlet tubing via the valve, and outlet tubing coupled to the valve. The valve is configured to allow fluid to be drawn from the source of fluid via the inlet tubing into a syringe body of the syringe and to be expelled from the syringe body and through the outlet tubing, and to prevent fluid from being drawn from the outlet tubing into the syringe body and to prevent fluid expelled from the syringe body from flowing through the inlet tubing. The drive assembly is configured to reversibly receive the tubing set such that a drive mechanism is engaged with a plunger of the syringe to reciprocally translate the plunger relative to the syringe body.

公开(公告)号：US11883637B2

公开(公告)日：2024-01-30

申请号：US17064298

申请日：2020-10-06

申请人： Ypsomed AG

发明人： Patrick Hostettler ,  Markus Tschirren

IPC分类号： A61M5/31 ,  A61M5/315 ,  A61M5/20 ,  A61M5/32 ,  A61M5/145 ,  A61M5/46 ,  A61M5/48

CPC分类号： A61M5/31581 ,  A61M5/1454 ,  A61M5/20 ,  A61M5/2033 ,  A61M5/3157 ,  A61M5/3159 ,  A61M5/31583 ,  A61M5/31585 ,  A61M5/31586 ,  A61M5/3204 ,  A61M5/326 ,  A61M5/46 ,  A61M5/484 ,  A61M2005/202 ,  A61M2005/2013 ,  A61M2005/2086 ,  A61M2005/3143 ,  A61M2005/3152 ,  A61M2005/3247 ,  A61M2005/3267 ,  A61M2205/3341 ,  A61M2205/581 ,  A61M2205/582 ,  A61M2207/00

摘要： An autoinjector for dispensing a liquid product, in particular a highly viscous medication, includes: a housing, a product container, which is arranged in the housing and has a slidable piston, wherein the piston can be slid in a dispensing direction in order to dispense the product contained in the product container, a forward drive element, which acts on the piston as the product is being dispensed, a first spring, which is preloaded such that the product can be dispensed from the product container by the sliding of the forward drive element and the piston, and a rotation element, which is operatively coupled to the forward drive element, wherein the first spring acts on the rotation element in such a way that the rotation element is set into rotation in order to dispense the product, wherein the rotation element or the forward drive element has a thread having a variable pitch.

公开(公告)号：US20230347075A1

公开(公告)日：2023-11-02

申请号：US17780596

申请日：2020-11-17

申请人： AMGEN INC.

发明人： Ali Nekouzadeh ,  Mehran Mojarrad ,  Joshua Tamsky ,  Paul Daniel Faucher ,  Scott R. Gibson ,  Kimberly Sepulveda ,  Sheldon B. Moberg

IPC分类号： A61M5/48 ,  A61M5/158 ,  A61M5/315

CPC分类号： A61M5/482 ,  A61M5/158 ,  A61M5/31576

摘要： A drug delivery device includes a housing, a container disposed in the housing, a drive mechanism, a needle assembly, a fluid flow path, and a vortex flow adapter. The container contains a medicament which is urged out of the container by the drive mechanism. The needle assembly has a needle and/or a cannula to deliver the medicament from the container. The fluid flow path fluidically connects the container and the needle assembly. The vortex flow adapter is disposed within or defines at least a portion of the fluid flow path, and is adapted to urge the medicament to flow in a vortex pattern.

公开(公告)号：US11607490B2

公开(公告)日：2023-03-21

申请号：US16346427

申请日：2017-10-30

申请人： Sanofi-Aventis Deutschland GmbH

发明人： Rene Richter ,  Robert Witt ,  Richard Guenther ,  Thomas Nagel

IPC分类号： A61M5/168 ,  A61M5/315 ,  A61M5/48 ,  G01F22/02 ,  A61M5/14 ,  A61M5/142 ,  A61M5/145 ,  A61M5/20 ,  G01F17/00 ,  G01F22/00

摘要： The present disclosure relates in one aspect to a measuring arrangement for measuring a volume occupied by a liquid medium inside a liquid reservoir, the measuring arrangement including a container having an interior volume containing a gas reservoir filled with a gaseous medium and containing a liquid reservoir filled with a liquid medium, wherein the gas reservoir and the liquid reservoir are hermetically separated by an impenetrable separation wall, a volume modulator to induce a volume change of the gas reservoir, a pressure sensor arranged inside the gas reservoir to measure a pressure change of the gaseous medium in response to the volume change of the gas reservoir, and a controller connectable to the pressure sensor, wherein the controller is configured to calculate the volume of the liquid reservoir on the basis of the pressure change and the volume change.

公开(公告)号：US20230063936A1

公开(公告)日：2023-03-02

申请号：US17982477

申请日：2022-11-07

申请人： CELLULAR VEHICLES INC.

发明人： Nikhil Joshi ,  Marcus Foley ,  Avnesh Thakor

IPC分类号： A61M5/48 ,  G16H20/17 ,  A61M5/315 ,  A61M5/168 ,  A61M5/145

摘要： Cellular therapy infusion devices for the delivery of media including cellular therapies to a patient's tissue, cells, and/or blood include a barrel, a plunger that fits within the barrel, a syringe shaft, and a pressure relief system configured to achieve and/or maintain a desired level of pressure and/or force within the device so that cellular behavior and/or viability is not adversely impacted by the mechanical forces exerted thereon via depressing the plunger into the barrel so the cellular therapy media may be pushed from the barrel into a patient delivery device for administration to the patient. The cellular therapy infusion devices may cooperate with and/or fit into cellular therapy infusion systems designed to create and/or maintain preferred conditions for the cellular therapy media stored in the barrel and automatically administer the cellular therapy media from the cellular therapy infusion device to the patient in a steady, regulated, and/or preferred manner.

公开(公告)号：US11559428B2

公开(公告)日：2023-01-24

申请号：US16510238

申请日：2019-07-12

申请人： CLEARSIDE BIOMEDICAL, INC.

发明人： Rafael Victor Andino ,  Vladimir Zarnitsyn ,  Jesse Yoo ,  Christopher John Brooks ,  Trent John Kahute ,  Justin William Arsenault ,  David Jackson Trettin ,  Andrew Kent Bauer ,  Stephanie Elaine Lewis

IPC分类号： A61F9/00 ,  A61M5/20 ,  A61M5/48 ,  A61J1/20 ,  A61M5/46 ,  A61M37/00 ,  A61M5/31 ,  A61M5/34 ,  A61M5/32 ,  A61M5/315

摘要： An apparatus includes a housing coupled to a medicament container, which is coupled to a needle. An injection assembly is disposed within the housing and includes an energy storage member and an actuation rod. A distal end portion of the actuation rod is disposed within the medicament container. The energy storage member can produce a force on a proximal end portion of the actuation rod sufficient to move the distal end portion of the actuation rod within the medicament container. This can convey at least a portion of a substance from the medicament container via the needle when a distal tip of the needle is disposed within a first region of a target location. The force is insufficient to move the distal end portion of the actuation rod within the medicament container when the distal tip of the needle is disposed within a second region of the target location.

公开(公告)号：US20220379032A1

公开(公告)日：2022-12-01

申请号：US17886137

申请日：2022-08-11

申请人： Antares Pharma, Inc.

发明人： Paul R. Lesch

IPC分类号： A61M5/20 ,  A61M5/28 ,  A61M5/30 ,  A61M5/178 ,  A61M5/48 ,  A61M5/32 ,  A61M5/46

摘要： A jet injector that includes a prefilled syringe. The syringe includes a fluid chamber that contains a medicament. The syringe also has an injection-assisting needle, and a plunger is movable within the fluid chamber. A housing is configured for allowing insertion of the needle to a penetration depth. An energy source is configured for biasing the plunger to produce an injecting pressure in the medicament in the fluid chamber of between about 80 and 1000 p.s.i. to jet inject the medicament from the fluid chamber through the needle to an injection site.

公开(公告)号：US11413398B2

公开(公告)日：2022-08-16

申请号：US16100014

申请日：2018-08-09

申请人： HASELMEIER AG

发明人： Frederic Gabriel ,  Sascha Pohl

IPC分类号： A61M5/14 ,  A61M5/315 ,  A61M5/20 ,  A61M5/48 ,  A61M5/142 ,  A61M5/24

摘要： An example injector includes a rotary knob for selecting a function and setting a dosing quantity for an injection, a button located on an end of the rotary knob for initiating the injection, an electric motor, an encoder for evaluating output rotary motion of the motor, and a processor that converts the dosing quantity into a number of encoder pulses and controls operation of the motor based on the number of encoder pulses when dosage is triggered. The injector also includes a transmission coupled to the electric motor to convert a speed of the motor, a threaded spindle coupled to the transmission that moves linearly based on the output rotary motion of the motor at the speed as converted by the transmission, and a punch connected to an end of the threaded spindle. The linear movement of the spindle causes the punch to release medicament.

公开(公告)号：US11331434B2

公开(公告)日：2022-05-17

申请号：US16311728

申请日：2017-06-20

申请人： Merz Pharma GmbH & Co. KGAA

发明人： Markus Vogt

IPC分类号： A61M5/31 ,  A61M5/315 ,  A61M5/48 ,  A61M5/178 ,  A61K38/48 ,  A61M5/32 ,  A61M5/00

摘要： The present invention relates a botulinum toxin prefilled syringe system with desirable injection force characteristics, in particular low gliding force and low break loose force, comprising a syringe barrel of glass containing a liquid botulinum toxin composition, a plunger stopper and a closure device such as a tip cap or a needle shield. In addition, the present invention relates to a kit comprising the botulinum toxin prefilled syringe system, and optionally instructions for use, and to the use of the botulinum toxin prefilled syringe system in therapeutic and cosmetic applications.