知搜-全球专利检索

  1. 登录
  2. 注册

搜索结果

15 条记录 (耗时 0.016 秒)

    FLOW ADAPTER FOR DRUG DELIVERY DEVICE
    2.
    发明申请
    FLOW ADAPTER FOR DRUG DELIVERY DEVICE 审中-公开

    公开(公告)号：US20200297927A1

    公开(公告)日：2020-09-24

    申请号：US16649412

    申请日：2018-09-26

    申请人： AMGEN INC.

    发明人： Carl Conrath ,  Ali Nekouzadeh ,  Basel Hasan Taha

    IPC分类号： A61M5/168 ,  A61M5/142 ,  A61M39/22

    摘要： A drug delivery device includes a housing defining a shell, a container, a drive mechanism, a needle assembly having first and second ends, a fluid flow connection, and a flow adapter, each of which is at least partially disposed within the housing. The container has first and second ends and an inner volume to contain a medicament to be administered to a user. The drive mechanism is adapted to exert a force to urge the medicament out the second end of the container. The fluid flow connection is coupled to the second end of the container and the first end of the needle assembly and is adapted to allow the medicament to flow from the container to the needle assembly. The flow adapter includes at least one protrusion for generating a minor head loss to the medicament flowing within the fluid flow connection and helps to reduce variations of injection rates due to variations in drug product viscosities.

    DRUG DELIVERY DEVICE
    3.
    发明公开
    DRUG DELIVERY DEVICE 审中-公开

    公开(公告)号：US20240082502A1

    公开(公告)日：2024-03-14

    申请号：US17767463

    申请日：2020-10-07

    申请人： AMGEN INC.

    发明人： Ali Nekouzadeh ,  Carl Conrath ,  Kimberly Sepulveda ,  Jimmie L. Ward

    IPC分类号： A61M5/315 ,  A61M5/20

    CPC分类号： A61M5/31578 ,  A61M5/2033

    摘要： A drug delivery device may include a housing having an opening, a drug storage container, a plunger rod, and a drive mechanism. The drug storage container may have an inner surface at least partially defining a drug storage chamber and an outer surface defining an outer diameter. The drug storage container may further include a plunger stopper and a delivery member having an insertion end configured to extend at least partially through the opening during a delivery state. The drive mechanism may be activatable to drive the plunger stopper in a distal direction to expel a drug from the drug storage container through the delivery member. The drive mechanism may have an inner surface with an inner diameter greater than the outer diameter of the outer surface of the drug storage container.

    SEALING ARRANGEMENT FOR DRUG DELIVERY DEVICE
    4.
    发明申请
    SEALING ARRANGEMENT FOR DRUG DELIVERY DEVICE 有权

    公开(公告)号：US20220249778A1

    公开(公告)日：2022-08-11

    申请号：US17627008

    申请日：2020-07-16

    申请人： AMGEN INC.

    发明人： Mehran Mojarrad ,  Ali Nekouzadeh ,  Sheldon B. Moberg ,  Scott R. Gibson ,  Paul Daniel Faucher

    IPC分类号： A61M5/31 ,  A61M5/145 ,  A61M5/162 ,  A61M5/20 ,  A61M5/24

    摘要： A drug delivery device includes a housing releasably coupled with a patient, a container disposed in the housing, a plunger disposed in the container, an activation mechanism, and a seal member. The container includes a wall with an interior surface. The plunger includes an interior surface and is moveably disposed in the container. The interior surfaces of the wall and the plunger define a reservoir adapted to contain a drug. The activation mechanism is adapted to release a drive fluid for moving the plunger through the container to expel the drug therefrom. The seal member is moveably disposed in the container and is adapted to inhibit ingress of the drive fluid into the reservoir.

    PRESSURE RELIEF VALVE FOR DRUG DELIVERY DEVICE
    5.
    发明申请
    PRESSURE RELIEF VALVE FOR DRUG DELIVERY DEVICE 有权

    公开(公告)号：US20220288305A1

    公开(公告)日：2022-09-15

    申请号：US17626667

    申请日：2020-07-16

    申请人： AMGEN INC.

    发明人： Mehran Mojarrad ,  Ali Nekouzadeh ,  Scott R. Gibson ,  Sheldon Moberg ,  Paul Daniel Faucher

    IPC分类号： A61M5/145 ,  A61M5/142

    摘要： A drug delivery device includes a housing releasably coupled with a patient, a pressure chamber disposed in the housing and including a vent, a container at least partially disposed in the pressure chamber for storing a drug connectable in fluid communication with a fluid conduit, an activation mechanism, and a relief mechanism. The activation mechanism releases a pressurized drive fluid into the pressure chamber for expelling the drug from the container into the fluid conduit. The relief mechanism is operably coupled to the fluid conduit and is adapted to open the vent to release the drive fluid from the pressure chamber in response to a predetermined condition.

    DRUG DELIVERY DEVICES WITH PARTIAL DRUG DELIVERY MEMBER RETRACTION
    6.
    发明申请
    DRUG DELIVERY DEVICES WITH PARTIAL DRUG DELIVERY MEMBER RETRACTION 有权

    公开(公告)号：US20220031939A1

    公开(公告)日：2022-02-03

    申请号：US17277599

    申请日：2019-10-14

    申请人： AMGEN INC.

    发明人： Ali Nekouzadeh ,  Carl Conrath ,  Scott Robert Gibson ,  Basel Hasan Taha

    IPC分类号： A61M5/145 ,  A61M5/158

    摘要： Methods, devices, and components are provided to reduce tissue resistive pressure during a subcutaneous drug delivery operation by increasing the size of the injection cavity by partially retracting the drug delivery member after inserting the drug delivery member to a subcutaneous position. The drug delivery devices described herein include a motor operably coupled to a drug delivery member. The motor can be selectively activated by a controller to retract the drug delivery member a predetermined distance to relieve pressure in an injection cavity in a patient. A force sensor can provide the controller with a drug delivery member insertion force. The controller can then estimate a tissue resistive pressure based on the drug delivery member insertion force and determine the predetermined distance for the partial drug delivery member retraction based on the tissue resistive pressure.

    Flow adapter for drug delivery device
    9.
    发明授权
    Flow adapter for drug delivery device 有权

    公开(公告)号：US11759565B2

    公开(公告)日：2023-09-19

    申请号：US16649412

    申请日：2018-09-26

    申请人： AMGEN INC.

    发明人： Carl Conrath ,  Ali Nekouzadeh ,  Basel Hasan Taha

    IPC分类号： A61M5/168 ,  A61M5/142 ,  A61M39/22

    CPC分类号： A61M5/16813 ,  A61M5/14248 ,  A61M39/22 ,  A61M2005/14252

    摘要： A drug delivery device includes a housing defining a shell, a container, a drive mechanism, a needle assembly having first and second ends, a fluid flow connection, and a flow adapter, each of which is at least partially disposed within the housing. The container has first and second ends and an inner volume to contain a medicament to be administered to a user. The drive mechanism is adapted to exert a force to urge the medicament out the second end of the container. The fluid flow connection is coupled to the second end of the container and the first end of the needle assembly and is adapted to allow the medicament to flow from the container to the needle assembly. The flow adapter includes at least one protrusion for generating a minor head loss to the medicament flowing within the fluid flow connection and helps to reduce variations of injection rates due to variations in drug product viscosities.

    Drug delivery devices with partial drug delivery member retraction
    10.
    发明授权
    Drug delivery devices with partial drug delivery member retraction 有权

    公开(公告)号：US11213620B2

    公开(公告)日：2022-01-04

    申请号：US17278618

    申请日：2019-10-07

    申请人： AMGEN INC.

    发明人： Ali Nekouzadeh ,  Carl Conrath ,  Scott Robert Gibson ,  Basel Hasan Taha

    IPC分类号： A61M5/20 ,  A61M5/172 ,  A61M5/145 ,  A61M5/142

    摘要： Methods, devices, and components are provided to reduce tissue resistive pressure during a subcutaneous drug delivery operation by increasing the size of the injection cavity by partially retracting the drug delivery member after inserting the drug delivery member to a subcutaneous position. The drug delivery devices described herein include a magnetic actuator operably coupled to a primary container assembly including a drug delivery member. Power can be selectively provided to the magnetic actuator by a controller to retract the drug delivery member a predetermined distance to relieve pressure in an injection cavity in a patient. A force sensor can provide the controller with a drug delivery member insertion force. The controller can then estimate a tissue resistive pressure based on the drug delivery member insertion force and determine the predetermined distance for the drug delivery member retraction based on the tissue resistive pressure.