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公开(公告)号：US12053618B2
公开(公告)日：2024-08-06
申请号：US16761149
申请日：2018-11-06
Applicant: AMGEN INC.
Inventor： Justin Harris , Matthew Wayne Janke , Wael Mismar , Jerome Olivas , Thomas Clark Pearson , Sudeshna Dutta Ray , Ryan M. Agard , Alexis Dechelette , Michael Gammelager , Mads Hansen , Valerio Mazzon , Owen Ryan , Clive Smith
CPC classification number: A61M5/28 , A61M5/1782 , A61M5/24 , A61M5/3134 , A61M2005/2488 , A61M2005/3115
Abstract: Fill-finish assemblies facilitating the manufacture of a drug delivery device are disclosed. The fill-finish assembly may include a container, an insertion mechanism, a fluid pathway connection assembly disposed between the container and the insertion mechanism, and a carrier. The insertion mechanism may include a delivery member and an insertion mechanism housing. The insertion mechanism may be configured to move the delivery member from a retracted position inside the insertion mechanism housing to a deployed position outside the insertion mechanism housing. The fluid pathway connection assembly may be selectively activatable to establish fluid communication between the container and the delivery member. The carrier may have a hollow interior containing at least a portion of each of the container, the insertion mechanism, and the fluid pathway connection assembly. The carrier may be configured to hold the container, the insertion mechanism, and the fluid pathway connection assembly in alignment with each other.
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公开(公告)号：US12178991B2
公开(公告)日：2024-12-31
申请号：US17359825
申请日：2021-06-28
Applicant: AMGEN INC.
Inventor： Ali Nekouzadeh , Jerome Olivas , Joshua Merilos , Matthew Wayne Janke , Justin Harris , Marc Orloff , Edward Stapleford Nielsen , Chitra Nadig , Yasaman Damestani , Guojie Song , Bryton De Guia
Abstract: An adhesive patch for a drug delivery device with a bacteria impermeable sterility margin surrounding an edge surface of the adhesive patch is disclosed, as well as a drug delivery device fixed to such an adhesive patch and a method of assembling a drug delivery device with such an adhesive patch. In some arrangements, the sterility margin is attached to or integral with a lower liner on a lower surface of the adhesive patch. In other arrangements, the sterility margin is attached to or integral with an upper liner on an upper surface of the adhesive patch.
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公开(公告)号：US20190247579A1
公开(公告)日：2019-08-15
申请号：US16151720
申请日：2018-10-04
Applicant: AMGEN INC.
Inventor： Yasaman Damestani , Bryton De Guia , Martin Hering , Matthew Wayne Janke , Jerome Olivas , David Plescia , Brendan Smyth , Guojie Song
CPC classification number: A61M5/20 , A61M5/3129 , A61M2005/3142 , B29L2031/7544
Abstract: A testing assembly for a drug delivery device is disclosed. The testing assembly can include a pressure vessel having a sealed pressure chamber that is configured to be pressurized to a predetermined pressure. The pressure vessel further defines an injection opening extending from an exterior thereof to the pressure chamber. A pierceable barrier extends over and seals the injection opening. The testing assembly further includes a measurement device disposed within the pressure chamber and a container aligned with the injection opening, such that the container is configured to collect a dose of a drug delivered via a drug delivery device through the pierceable barrier and the measurement device is configured to measure the dose of the drug.
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公开(公告)号：US20210228797A1
公开(公告)日：2021-07-29
申请号：US17256240
申请日：2019-07-12
Applicant: AMGEN INC.
Inventor： Matthew Wayne Janke , Sudeshna Dutta Ray , Scott R. Gibson , Daniel Eduardo Groszmann , Wael Mismar , Mehran Mojarrad , Robert Allen Dees , Paul Daniel Faucher
Abstract: Fluid path assemblies for drug delivery devices and methods of establishing a fluid flow path for drug delivery devices are described that include a needle shield valve member that couples to a reservoir having a needle mounted thereto. The needle shield valve member includes an internal barrier that protects the needle and/or contains a drug within the reservoir until activation of the drug delivery device. Upon activation, there is relative movement between the reservoir and needle shield valve member until the needle pierces the barrier to establish a fluid flow path from the reservoir through the needle shield valve member.
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公开(公告)号：US20200254172A1
公开(公告)日：2020-08-13
申请号：US16753711
申请日：2018-10-01
Applicant: AMGEN INC.
Inventor： Ronald Forster , Gregory Gordon , Martin Hering , Matthew Wayne Janke , Andrew N. King , Wael Mismar
Abstract: Drug delivery devices and related methods of assembly are disclosed. The drug delivery device may include a housing, a container, a trigger member, and an interlock assembly. The trigger member may be selectively moveable relative to the housing to activate operation of at least one activatable element of the drug delivery device. The interlock assembly may include a lever mounted rotatably relative to the housing, a proximity sensor moveable between a first position extending beyond an exterior surface of the housing and a second position retracted toward the housing, and a rotational biasing member operably connected to the proximity sensor via the lever. When the proximity sensor is in the first position, the interlock assembly may limit movement of the trigger member relative to the housing. The rotational biasing member may be configured to exert a torque biasing the proximity sensor toward the first sensor position.
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Patent Agency Ranking
公开(公告)号：US11813426B2
公开(公告)日：2023-11-14
申请号：US16753711
申请日：2018-10-01
Applicant: AMGEN INC.
Inventor： Ronald Forster , Gregory Gordon , Martin Hering , Matthew Wayne Janke , Andrew N. King , Wael Mismar
CPC classification number: A61M5/14248 , A61M5/1456 , A61M5/31571 , A61M2005/14256 , A61M2005/14506 , A61M2005/1585 , A61M2005/3154 , A61M2205/583
Abstract: Drug delivery devices and related methods of assembly are disclosed. The drug delivery device may include a housing, a container, a trigger member, and an interlock assembly. The trigger member may be selectively moveable relative to the housing to activate operation of at least one activatable element of the drug delivery device. The interlock assembly may include a lever mounted rotatably relative to the housing, a proximity sensor moveable between a first position extending beyond an exterior surface of the housing and a second position retracted toward the housing, and a rotational biasing member operably connected to the proximity sensor via the lever. When the proximity sensor is in the first position, the interlock assembly may limit movement of the trigger member relative to the housing. The rotational biasing member may be configured to exert a torque biasing the proximity sensor toward the first sensor position.
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公开(公告)号：US20230043679A1
公开(公告)日：2023-02-09
申请号：US17960906
申请日：2022-10-06
Applicant: AMGEN INC.
Inventor： Sheldon Moberg , Matthew Wayne Janke , Wael Mismar , Alexis Dechelette
Abstract: Drug delivery devices and related methods of assembly are disclosed. The drug delivery device may include a container including a wall with an interior surface and a seal member with an end surface. The interior surface of the wall and the end surface of the seal member may define a reservoir filled with a drug. A fluid pathway assembly may be connected to the container and include an overmold member that covers a length of a container access needle and which defines an enclosed space with the seal member. The overmold member may be moveable relative to the seal member to carry the container access needle between a storage position, where a point of the container access needle is disposed exterior to the reservoir, and a delivery position, where the point extends through the end surface of the seal member into the reservoir.
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公开(公告)号：US11484648B2
公开(公告)日：2022-11-01
申请号：US16625208
申请日：2018-07-11
Applicant: AMGEN INC.
Inventor： Sheldon Moberg , Matthew Wayne Janke , Wael Mismar , Alexis Dechelette
Abstract: Drug delivery devices and related methods of assembly are disclosed. The drug delivery device may include a container including a wall with an interior surface and a seal member with an end surface. The interior surface of the wall and the end surface of the seal member may define a reservoir filled with a drug. A fluid pathway assembly may be connected to the container and include an overmold member that covers a length of a container access needle and which defines an enclosed space with the seal member. The overmold member may be moveable relative to the seal member to carry the container access needle between a storage position, where a point of the container access needle is disposed exterior to the reservoir, and a delivery position, where the point extends through the end surface of the seal member into the reservoir.
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公开(公告)号：US11385140B2
公开(公告)日：2022-07-12
申请号：US16151720
申请日：2018-10-04
Applicant: AMGEN INC.
Inventor： Yasaman Damestani , Bryton De Guia , Martin Hering , Matthew Wayne Janke , Jerome Olivas , David Plescia , Brendan Smyth , Guojie Song
IPC: G01M99/00 , G01F25/00 , F04B51/00 , A61M5/00 , G01L25/00 , A61M5/20 , B29L31/00 , A61M5/31 , A61M5/142
Abstract: A testing assembly for a drug delivery device is disclosed. The testing assembly can include a pressure vessel having a sealed pressure chamber that is configured to be pressurized to a predetermined pressure. The pressure vessel further defines an injection opening extending from an exterior thereof to the pressure chamber. A pierceable barrier extends over and seals the injection opening. The testing assembly further includes a measurement device disposed within the pressure chamber and a container aligned with the injection opening, such that the container is configured to collect a dose of a drug delivered via a drug delivery device through the pierceable barrier and the measurement device is configured to measure the dose of the drug.
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公开(公告)号：US20190083702A1
公开(公告)日：2019-03-21
申请号：US16049850
申请日：2018-07-31
Applicant: AMGEN INC.
Inventor： Ali Nekouzadeh , Jerome Olivas , Joshua Merilos , Matthew Wayne Janke , Justin Harris , Marc Orloff , Edward Stapleford Nielsen , Chitra Nadig , Yasaman Damestani , Guojie Song , Bryton De Guia
Abstract: An adhesive patch for a drug delivery device with a bacteria impermeable sterility margin surrounding an edge surface of the adhesive patch is disclosed, as well as a drug delivery device fixed to such an adhesive patch and a method of assembling a drug delivery device with such an adhesive patch. In some arrangements, the sterility margin is attached to or integral with a lower liner on a lower surface of the adhesive patch. In other arrangements, the sterility margin is attached to or integral with an upper liner on an upper surface of the adhesive patch.
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