-
公开(公告)号：US12208238B2
公开(公告)日：2025-01-28
申请号：US17360140
申请日：2021-06-28
Applicant: AMGEN INC.
Inventor： Scott Robert Gibson , Sudeshna Dutta Ray , Daniel Eduardo Groszmann , Mehran Mojarrad , Nathan Thomas Balcom , Alejandro Campillo-Agusti , Alan D. Payne , Lawrence Scott Ring
Abstract: Modular fluid path assemblies are provided that include conduit, coupling, and needle portions of a fluid path fluidly coupled to an outlet of a container. The modular fluid path assemblies further include a needle shield having a tip of the needle embedded therein. So configured, in embodiments, the modular fluid path assemblies can be sterilized, a medicament can be filled in the container, and a stopper inserted in the container so that the pre-sterilized and pre-filled modular fluid path assemblies can have a closed container integrity (CCI) seal.
-
公开(公告)号：US12042642B2
公开(公告)日：2024-07-23
申请号：US17264157
申请日：2019-09-17
Applicant: AMGEN INC.
Inventor： Sudeshna Dutta Ray , Scott Robert Gibson , Daniel Eduardo Groszmann , Mehran Mojarrad , Andrew James Carlson , Lee Gordon Macklem , Mikhail Tikh
CPC classification number: A61M5/31576 , A61M5/14248 , A61M5/1452 , A61M2005/1585 , A61M2005/31588 , A61M2205/52
Abstract: Drug delivery devices are described that include an escapement activation assembly. The escapement activation assembly includes a slide having a plurality of pallet engagement portions and a switch engagement portion and a pallet having a plurality of slide engagement portions. A drive is coupled to the pallet to cause the pallet to move relative to the slide to move the plurality of slide engagement portions into and out of engagement with the plurality of pallet engagement portions to allow the slide to move along a path within the drug delivery device. Movement of the slide can cause the switch engagement portion to move out of engagement with an activation trigger of a mechanism of the drug delivery device.
-
公开(公告)号：US11534547B2
公开(公告)日：2022-12-27
申请号：US16725069
申请日：2019-12-23
Applicant: AMGEN INC.
Inventor： Daniel Eduardo Groszmann , Scott Robert Gibson
Abstract: Systems and methods for drug delivery with pressure sensitive control are disclosed. A drug delivery system may include a reservoir filled or fillable with a drug, a drug delivery device coupled to the reservoir to deliver the drug from the reservoir to a patient, a pressure sensor, an output device, and a controller. The controller may be configured to determine if the drug delivery device has completed delivering a dose of the drug to the patient, and if delivery of the dose of the drug is complete, to measure tissue back pressure using the pressure sensor. Subsequently, the controller may be configured to determine if the tissue back pressure is below a first predetermined value, and if so, control the output device at least once and/or control a mechanism to retract an administration member from the patient.
-
公开(公告)号：US11660391B2
公开(公告)日：2023-05-30
申请号：US16745693
申请日：2020-01-17
Applicant: AMGEN INC.
Inventor： Daniel Eduardo Groszmann , Scott Robert Gibson
CPC classification number: A61M5/16836 , A61M5/14212 , A61M5/2033 , A61M5/2459 , A61M5/3157 , A61M2205/18 , A61M2205/3344
Abstract: Systems and methods for injecting a drug and detecting tissue induced back pressure are disclosed. A drug delivery system may include a reservoir filled or fillable with a drug, an administration member connected or connectable in fluid communication with the reservoir, a drive assembly, and a pressure sensor. The administration member may be configured for insertion into and subsequently retraction from a patient. The drive assembly may be configured to urge the drug from the reservoir to deliver a dose of the drug to the patient via the administration member. The pressure sensor may be configured to detect tissue back pressure during use of the drug delivery system, including after dose completion and prior to retraction of the administration member. The drug delivery system may be controlled in a manner that accounts for the tissue back pressure measurement.
-
公开(公告)号：US20210228797A1
公开(公告)日：2021-07-29
申请号：US17256240
申请日：2019-07-12
Applicant: AMGEN INC.
Inventor： Matthew Wayne Janke , Sudeshna Dutta Ray , Scott R. Gibson , Daniel Eduardo Groszmann , Wael Mismar , Mehran Mojarrad , Robert Allen Dees , Paul Daniel Faucher
Abstract: Fluid path assemblies for drug delivery devices and methods of establishing a fluid flow path for drug delivery devices are described that include a needle shield valve member that couples to a reservoir having a needle mounted thereto. The needle shield valve member includes an internal barrier that protects the needle and/or contains a drug within the reservoir until activation of the drug delivery device. Upon activation, there is relative movement between the reservoir and needle shield valve member until the needle pierces the barrier to establish a fluid flow path from the reservoir through the needle shield valve member.
-
Patent Agency Ranking
公开(公告)号：US20200238005A1
公开(公告)日：2020-07-30
申请号：US16725069
申请日：2019-12-23
Applicant: AMGEN INC.
Inventor： Daniel Eduardo Groszmann , Scott Robert Gibson
Abstract: Systems and methods for drug delivery with pressure sensitive control are disclosed. A drug delivery system may include a reservoir filled or fillable with a drug, a drug delivery device coupled to the reservoir to deliver the drug from the reservoir to a patient, a pressure sensor, an output device, and a controller. The controller may be configured to determine if the drug delivery device has completed delivering a dose of the drug to the patient, and if delivery of the dose of the drug is complete, to measure tissue back pressure using the pressure sensor. Subsequently, the controller may be configured to determine if the tissue back pressure is below a first predetermined value, and if so, control the output device at least once and/or control a mechanism to retract an administration member from the patient.
-
公开(公告)号：US11890450B2
公开(公告)日：2024-02-06
申请号：US16297408
申请日：2019-03-08
Applicant: AMGEN INC.
Inventor： Lawrence Scott Ring , Tohid Pirbodaghi , Samin Akbari , Daniel Eduardo Groszmann , Mehran Mojarrad , Mark Gordon , Mikhail Tikh , Jimmie L. Ward , Scott R. Gibson , Sheldon B. Moberg , Joshua Tamsky , Paul Faucher , Jeff Lind
CPC classification number: A61M5/16813 , A61M5/1413 , A61M5/14248 , A61M5/158 , A61M5/16822 , A61M39/24 , A61M5/14526 , A61M5/155 , A61M2005/1403 , A61M2005/1406 , A61M2005/14252 , A61M2039/244 , A61M2039/2406 , A61M2039/248 , A61M2039/2426 , A61M2205/3561 , A61M2205/505 , A61M2205/7527 , A61M2205/7536 , A61M2209/045
Abstract: A drug delivery device includes a housing defining a shell and an inner volume, a container, a drive mechanism, a needle assembly, a fluid flow connection, and a backflow prevention mechanism. The container has an inner volume to contain a medicament to be administered to a user. The drive mechanism is at least partially disposed within the housing and exerts a force to urge the medicament out the container. The fluid flow connection is coupled to the container and the needle assembly and allows the medicament to flow from the container to the needle assembly to be administered. The backflow prevention mechanism is associated with at least one of the container, the fluid flow connection, or the needle assembly and includes at least one flow restrictor to restrict a fluid from flowing from the needle assembly to the container.
-
公开(公告)号：US11766519B2
公开(公告)日：2023-09-26
申请号：US16961762
申请日：2019-01-17
Applicant: AMGEN INC.
Inventor： Sudeshna Dutta Ray , Scott R. Gibson , Daniel Eduardo Groszmann , Mehran Mojarrad , Robert Allen Dees , Jonathan Dean Johnson , Antonio S. Murcia
CPC classification number: A61M5/31511 , A61M5/2033 , A61M5/31583
Abstract: A flexible plunger rod, drug delivery mechanism, drug delivery device, and methods are described that utilize the flexible plunger rod perform drug delivery operations. In embodiments, the flexible plunger rod can be stored in a curved configuration to thereby reduce a footprint of the drug delivery mechanism and device.
-
公开(公告)号：US20210228811A1
公开(公告)日：2021-07-29
申请号：US17264157
申请日：2019-09-17
Applicant: AMGEN INC.
Inventor： Sudeshna Dutta Ray , Scott Robert Gibson , Daniel Eduardo Groszmann , Mehran Mojarrad , Andrew James Carlson , Lee Gordon Macklem , Mikhail Tikh
Abstract: Drug delivery devices are described that include an escapement activation assembly. The escapement activation assembly includes a slide having a plurality of pallet engagement portions and a switch engagement portion and a pallet having a plurality of slide engagement portions. A drive is coupled to the pallet to cause the pallet to move relative to the slide to move the plurality of slide engagement portions into and out of engagement with the plurality of pallet engagement portions to allow the slide to move along a path within the drug delivery device. Movement of the slide can cause the switch engagement portion to move out of engagement with an activation trigger of a mechanism of the drug delivery device.
-
公开(公告)号：US20200261648A1
公开(公告)日：2020-08-20
申请号：US16761521
申请日：2018-10-04
Applicant: AMGEN INC.
Inventor： Daniel Eduardo Groszmann , Scott Robert Gibson
IPC: A61M5/172
Abstract: A drug delivery device is provided that includes an on-board controller to determine when proper placement on the patient's body has occurred as well as an amount of drug delivered to the patient. The controller can also be used to determine if and when the proper placement has been disturbed during drug delivery and/or if less than a full dose of the drug has been dispensed.
-
-
-
-
-
-
-
-
-
Search Results
17
records
(took 0.015 seconds)
