公开(公告)号：US07615234B2

公开(公告)日：2009-11-10

申请号：US10238415

申请日：2002-09-10

Applicant: David Stuart Potter ,  Charles David Ogilvy Potter

Inventor： David Stuart Potter ,  Charles David Ogilvy Potter

IPC: A61K2/02

CPC classification number: A61M37/0069 ,  A61K9/0024 ,  A61M5/2033 ,  A61M5/30 ,  A61M5/3015 ,  A61M2005/005 ,  A61M2005/2013 ,  F42B12/54

Abstract: The invention relates to a novel drug delivery technology. More particularly the invention relates to a method of delivering at least one therapeutic compound or a formulation comprising the at least one therapeutic compound to a patient; to a throwaway or reusable device for delivering at least one therapeutic compound or a formulation comprising the at least one therapeutic compound to a patient in a manner as set out by the method; to a pioneer projectile for use in said method; to formulations for use in said method and to an injectate comprising a pioneer projectile and formulation. It also relates to a disposable component containing either a pioneer projectile or an injectate. The invention also relates to a throwaway or reusable device for delivering at least one therapeutic compound, or a formulation comprising the at least one therapeutic compound (hereafter drug) to a patient, and a method for administering a drug to a patient using said device. It also relates to a packaged drug for use with said device.

Abstract translation: 本发明涉及一种新的药物递送技术。 更具体地，本发明涉及将至少一种治疗化合物或包含至少一种治疗化合物的制剂递送至患者的方法; 涉及一种一次性或可重复使用的装置，用于以所述方法所述的方式将至少一种治疗化合物或包含所述至少一种治疗化合物的制剂递送至患者; 用于所述方法的先驱射弹; 用于所述方法的制剂和包含先驱射弹和制剂的注射剂。 它还涉及包含先驱射弹或注射剂的一次性部件。 本发明还涉及用于将至少一种治疗化合物或包含至少一种治疗化合物（以下称为药物）的制剂递送至患者的一次性或可重复使用的装置，以及使用所述装置向患者施用药物的方法。 它还涉及与所述装置一起使用的包装药物。

公开(公告)号：US6004547A

公开(公告)日：1999-12-21

申请号：US944035

申请日：1997-09-29

Applicant: Stephen C. Rowe ,  Jeffrey A. Hubbell ,  Stephen J. Herman ,  Vae Sun ,  Michael F. Lang ,  George E. Selecman ,  Frederick F. Ahari

Inventor： Stephen C. Rowe ,  Jeffrey A. Hubbell ,  Stephen J. Herman ,  Vae Sun ,  Michael F. Lang ,  George E. Selecman ,  Frederick F. Ahari

IPC: A61B1/00 ,  A61B17/00 ,  A61B19/00 ,  A61C13/15 ,  A61M37/00 ,  B05C17/01 ,  A61K31/74 ,  A61N1/30 ,  A61K2/02

CPC classification number: A61B1/00165 ,  A61B17/00491 ,  A61C19/004 ,  A61M37/00 ,  B05C17/01 ,  A61B2017/005 ,  A61B2090/0816

Abstract: An apparatus is provided for applying to a surface of mammalian tissue including soft, living tissue an initially fluent material and then activating the material by exposure to an energy source. The material may be a liquid capable of polymerization to a non-fluent state by exposure to actinic light. The device, and methods that may be practised in association with the device, enable a wide range of medical conditions to be treated including, for example, the application of a barrier to soft tissue to prevent post-surgical adhesions.

Abstract translation: 提供了一种装置，用于向哺乳动物组织的表面施加包括软的活体组织的初始流畅的材料，然后通过暴露于能量源来激活材料。 该材料可以是能够通过暴露于光化光聚合成非流动状态的液体。 可以与装置相关联地实施的装置和方法使得能够治疗的广泛的医疗状况包括例如对软组织的屏障的应用以防止手术后粘连。

公开(公告)号：US06913764B2

公开(公告)日：2005-07-05

申请号：US10100839

申请日：2002-03-19

Applicant: Sebastian Vogt ,  Matthias Schnabelrauch ,  Klaus-Dieter Kühn

Inventor： Sebastian Vogt ,  Matthias Schnabelrauch ,  Klaus-Dieter Kühn

IPC: A61K9/00 ,  A61K9/10 ,  A61K9/14 ,  A61K9/20 ,  A61K9/22 ,  A61K9/70 ,  A61K31/00 ,  A61K31/70 ,  A61K31/7036 ,  A61K31/726 ,  A61K45/06 ,  A61K45/08 ,  A61K47/02 ,  A61K47/14 ,  A61K47/16 ,  A61K47/20 ,  A61K47/24 ,  A61L27/54 ,  A61L31/16 ,  A61K2/02

CPC classification number: A61K31/7036 ,  A61K9/0024 ,  A61K9/2013 ,  A61K31/00 ,  A61L27/54 ,  A61L2300/406 ,  A61L2300/602 ,  A61L2300/802

Abstract: The present invention concerns an antibiotic/antibiotics preparation for resorbable and non-resorbable implants for human and veterinary medicine, for the treatment of local microbial infections in hard and soft tissue. The invented antibiotic/antibiotics preparation is a mixture consisting of at least one amphiphilic component of a representative of the alkyl sulfates, aryl sulfates, alkylaryl sulfates, cycloalkyl sulfates, alkylcycloalkyl sulfates, alkyl sulfamates, cycloalkyl sulfamates, alkylcycloalkyl sulfamates, aryl sulfamates, alkylaryl sulfamates, alkyl sulfonates, fatty acid-2-sulfonates, aryl sulfonates, alkylaryl sulfonates, cycloalkyl sulfonates, alkylcycloalkyl sulfonates, alkyl disulfates, cycloalkyl disulfates, alkyl disulfonates, cycloalkyl disulfonates, aryl disulfonates, alkylaryl disulfonates, aryl trisulfonates and alkylaryl trisulfonates as well as at least one antibiotic component from the group of aminoglycoside antibiotics, lincosamide antibiotics, 4-quinolone antibiotics and tetracycline antibiotics, and if need be at least one anhydrous organic auxiliary component and if need be at least one inorganic auxiliary component and if need be at least one biologically active component. The antibiotic/antibiotics preparation of the invention has a retarding active ingredient release.

Abstract translation: 本发明涉及用于人和兽医药物的可再吸收和不可吸收植入物的抗生素/抗生素制剂，用于治疗硬组织和软组织中的局部微生物感染。 本发明的抗生素/抗生素制剂是由至少一种代表烷基硫酸盐，芳基硫酸盐，烷基芳基硫酸盐，环烷基硫酸盐，烷基环烷基硫酸盐，氨基磺酸烷基酯，环烷基磺酸盐，烷基环烷基氨基磺酸盐，芳基亚磺酸盐，烷基芳基亚磺酸盐 烷基磺酸盐，脂肪酸-2-磺酸盐，芳基磺酸盐，烷基芳基磺酸盐，环烷基磺酸盐，烷基环烷基磺酸盐，烷基二硫酸盐，环烷基二硫酸盐，烷基二磺酸盐，环烷基二磺酸盐，芳基二磺酸盐，烷基芳基二磺酸盐，芳基三磺酸盐和烷基芳基三磺酸盐以及 至少一种来自氨基糖苷类抗生素的抗生素成分，林可素类抗生素，4-喹诺酮类抗生素和四环素抗生素，如果需要至少一种无机有机辅助成分，如果需要至少一种无机辅助成分，如果需要至少一种 生物活性成分 ent。 本发明的抗生素/抗生素制剂具有缓释活性成分释放。

公开(公告)号：US06852330B2

公开(公告)日：2005-02-08

申请号：US09747488

申请日：2000-12-21

Applicant: Steven M. Bowman ,  Izi Bruker ,  Alireza Rezania

Inventor： Steven M. Bowman ,  Izi Bruker ,  Alireza Rezania

IPC: A61L27/44 ,  A61L27/48 ,  A61L27/56 ,  A61K2/02 ,  A61K9/14 ,  B32B3/12

CPC classification number: A61L27/48 ,  A61L27/44 ,  A61L27/56 ,  Y10T428/24149

Abstract: A biocompatible tissue repair stimulating implant or “scaffold” device, and methods for making and using such a device, are provided. The implant includes one or more layers of a bioabsorbable polymeric foam having pores with an open cell pore structure. A reinforcement component is also present within the implant to contribute enhanced mechanical and handling properties. The implant houses a biological component that may be released to tissue adjacent the location in which the implant is implanted to faciliate and/or expedite the healing of tissue. This biological component resides primarily within the foam component of the implant, being incorporated within pores formed within the foam.

Abstract translation: 提供了生物相容性组织修复刺激植入物或“支架”装置，以及制造和使用这种装置的方法。 植入物包括一层或多层具有开孔细孔结构的孔的生物可吸收聚合物泡沫。 植入物内还存在增强组分，以增强机械和操作性能。 植入物容纳可以被释放到植入物植入位置附近的组织以促进和/或加速组织愈合的生物成分。 该生物成分主要存在于植入物的泡沫组分内，并被结合在泡沫内形成的孔中。

公开(公告)号：US07750041B2

公开(公告)日：2010-07-06

申请号：US10472844

申请日：2001-12-20

Applicant: Ulrich Speck ,  Brunn Scheller

Inventor： Ulrich Speck ,  Brunn Scheller

IPC: A61K31/337 ,  A61K31/517 ,  A61K2/02 ,  A61K31/00

CPC classification number: A61L29/08 ,  A61K9/0019 ,  A61K9/5094 ,  A61K31/095 ,  A61K31/165 ,  A61K31/337 ,  A61K45/06 ,  A61K49/0433 ,  A61K49/0438 ,  A61K49/0447 ,  A61K49/0452 ,  A61K49/105 ,  A61K49/106 ,  A61K49/18 ,  A61L29/16 ,  A61L29/18 ,  A61L31/16 ,  A61L2300/416 ,  A61K2300/00

Abstract: The invention relates to a preparation for restenosis prevention. The preparations for restenosis prevention known as yet do not reach sufficient active agent concentrations in the affected sections of the vascular walls as higher doses cause undesirable side effects. The present invention is a preparation to which at least one antihyperplastic agent is added that has a distribution ratio between butanol and water ≧0.5. The lipophilic active agent is absorbed by the vascular wall fast and in sufficient quantity. The preparation may be a liquid that can pass through capillaries and may contain a contrast agent so that the active agent is transferred into the vascular wall without any additional effort while the usually required contrast radiograms are taken. The preparation may also be applied to a catheter.

Abstract translation: 本发明涉及预防再狭窄的制剂。 已知的再狭窄预防制剂在血管壁的受影响部分中不能达到足够的活性剂浓度，因为较高剂量引起不期望的副作用。 本发明是一种具有至少一种抗高血压剂的制剂，其具有丁醇和水之间的分配比≥0.5。 亲脂性活性剂被血管壁快速且足够的量吸收。 该制剂可以是可以通过毛细血管并且可以含有造影剂的液体，使得活性剂在没有任何额外的努力的同时转移到血管壁中，而通常需要的对比度放射照相。 该制剂也可以应用于导管。

公开(公告)号：US07625580B1

公开(公告)日：2009-12-01

申请号：US09724382

申请日：2000-11-28

Applicant: Robert S. Langer ,  Jennifer Elisseeff ,  Kristi Anseth ,  Derek Sims

Inventor： Robert S. Langer ,  Jennifer Elisseeff ,  Kristi Anseth ,  Derek Sims

IPC: A61K2/02

CPC classification number: A61L27/50 ,  A61L27/38 ,  A61L27/3817 ,  A61L27/3852 ,  A61L27/52 ,  A61L2400/06 ,  A61L2430/06

Abstract: Compositions for tissue engineering and drug delivery have been developed based on solutions of two or more polymers which form semi-interpenetrating or interpenetrating polymer networks upon exposure to active species following injection at a site in a patient in need thereof. The polymers crosslink to themselves but not to each other; semi-interpenetrating networks are formed when only one of the polymers crosslink. The resulting viscous solutions retain the biologically active molecules or cells at the site of injection until release or tissue formation, respectfully, occurs.As a result of studies conducted with polymer-cell suspensions forming interpenetrating polymer networks, it has been determined that polymer solutions can be formulated wherein the active species is provided by exposure of the polymer solution to an exogenous source of active species, typically electromagnetic radiation, preferably light. Studies demonstrate that light will penetrate through skin, body fluids (such as synovial fluid) and membranes and polymerize the polymer solutions. The polymer solutions can be crosslinked ionically or covalently, to form a hydrogel, semi-interpenetrating polymer network or an interpenetrating polymer network.

Abstract translation: 已经开发了用于组织工程和药物递送的组合物，其基于在需要其的患者的部位注射后暴露于活性物质时形成半互穿或互穿聚合物网络的两种或更多种聚合物的溶液。 聚合物自身交联而不是彼此交联; 当只有一种聚合物交联时，形成半互穿网络。 所得粘稠溶液将生物活性分子或细胞保留在注射部位，直到发生释放或组织形成。 作为通过形成互穿聚合物网络的聚合物 - 细胞悬浮液进行的研究的结果，已经确定可以配制聚合物溶液，其中通过将聚合物溶液暴露于外源性活性物质（通常是电磁辐射）来提供活性物质， 最好是光。 研究表明，光将穿透皮肤，体液（如滑液）和膜，并聚合聚合物溶液。 聚合物溶液可以离子交换或共价交联，以形成水凝胶，半互穿聚合物网络或互穿聚合物网络。

公开(公告)号：US07618647B2

公开(公告)日：2009-11-17

申请号：US10677834

申请日：2003-10-03

Applicant: Jan Weber ,  Tom Holman ,  Tracee Eidenschink ,  John Jianhua Chen

Inventor： Jan Weber ,  Tom Holman ,  Tracee Eidenschink ,  John Jianhua Chen

IPC: A61K2/02

CPC classification number: A61K31/01 ,  A61F2/0077 ,  A61F2/02 ,  A61F2/04 ,  A61F2/06 ,  A61F2/07 ,  A61F2/82 ,  A61F2250/0067 ,  A61K9/00 ,  A61K45/06 ,  A61L27/303 ,  A61L31/084

Abstract: Methods, systems, and uses of bucky paper are provided in the present invention. These embodiments include covering medical implants with single or multiple layers of bucky paper, treating bucky paper with various therapeutics to be released through the bucky paper to a target site, shaping bucky paper into non-conventional configurations for improved therapeutic deliver, and using bucky paper alone or in conjunction with other materials to treat a target site.

Abstract translation: 本发明提供了巴克纸的方法，系统和用途。 这些实施方案包括用单层或多层巴克纸覆盖医疗植入物，用各种治疗剂处理巴克纸以通过巴克纸释放到目标部位，将巴克纸成形为非常规构型以改善治疗递送，并使用巴克纸 单独或与其他材料结合来治疗目标部位。

公开(公告)号：US07101565B2

公开(公告)日：2006-09-05

申请号：US10068750

申请日：2002-02-05

Applicant: Woodrow C. Monte

Inventor： Woodrow C. Monte

IPC: A61K2/02 ,  A61K9/48 ,  A61K9/20 ,  A61F13/02

CPC classification number: A61K35/745 ,  A61K35/747 ,  A61K2300/00

Abstract: A prebiotic, composition comprising a probiotic and prebiotic, and method of delivering a probiotic, prebiotic or composition directly into the intestinal tract of a mammal are disclosed. The probiotic is any beneficial bacteria and the prebiotic is a substance beneficial to a probiotic. Most preferably, the prebiotic includes a mucopolysaccharide. The method preferably involves delivering the prebiotic, probiotic or composition via a delivery tube, such as an enteral feeding tube, directly to a position downstream of the stomach, most preferably to the jejunum.

Abstract translation: 公开了包含益生菌和益生元的益生元组合物，以及将益生菌，益生元或组合物直接递送到哺乳动物的肠道中的方法。 益生菌是任何有益的细菌，益生元是有益于益生菌的物质。 最优选地，益生元包括粘多糖。 该方法优选地包括通过输送管（例如肠内喂养管）将益生元，益生菌或组合物直接递送到胃下游的位置，最优选地向空肠递送。

公开(公告)号：US07294144B1

公开(公告)日：2007-11-13

申请号：US09307956

申请日：1999-05-10

Applicant: James R. Schneider

Inventor： James R. Schneider

IPC: A61F2/00 ,  A61F2/04 ,  A61L17/00 ,  A61K2/02

CPC classification number: A61F2/06 ,  A61L27/3625 ,  A61L27/3687

Abstract: A preserved vessel isolated from a human umbilical cord or placenta and lyophilized for use as an allograft which improves blood supply to human tissue without antigenicity.

Abstract translation: 从人脐带或胎盘分离的保存的血管，并冻干以用作同种异体移植物，其改善对人体组织的血液供应而不具有抗原性。

公开(公告)号：US06936270B2

公开(公告)日：2005-08-30

申请号：US10139143

申请日：2002-05-02

Applicant: David A. Watson ,  Thomas J. Smith ,  Richard Laporte ,  Jianbing Chen ,  Paul Ashton

Inventor： David A. Watson ,  Thomas J. Smith ,  Richard Laporte ,  Jianbing Chen ,  Paul Ashton

IPC: A61B17/56 ,  A61B17/00 ,  A61B17/064 ,  A61B17/16 ,  A61B17/80 ,  A61B17/82 ,  A61B17/86 ,  A61B17/88 ,  A61F2/30 ,  A61K9/00 ,  A61K31/58 ,  A61K38/00 ,  A61L31/16 ,  A61M31/00 ,  A61P19/02 ,  A61K2/02

CPC classification number: A61K9/0024 ,  A61B17/0642 ,  A61B17/1615 ,  A61B17/80 ,  A61B17/82 ,  A61B17/8615 ,  A61B17/8877 ,  A61B17/8886 ,  A61B2017/00004 ,  A61B2017/00429 ,  A61B2017/00955 ,  A61B2017/0647 ,  A61B2017/0648 ,  A61F2/30744 ,  A61F2002/30673 ,  A61F2002/30677 ,  A61L31/16 ,  A61L2300/222 ,  A61L2300/416 ,  A61L2300/602 ,  A61M31/002 ,  A61M2210/02

Abstract: A therapeutically effective compound is locally administered by associating the compound with a piece of orthopedic hardware that is implanted at an appropriate site within a body. The compound is adapted, such as through a sustained release device, to administer an effective dosage continuously over an extended period of time. The compound may be administered, for example, to a joint of a mammal by intraarticularly implanting a sustained release device to deliver the therapeutically effective compound within a synovial capsule of the joint, such that synovial fluid concentration of the compound is greater than plasma concentration of the compound. A wide range of orthopedic hardware, such as bone screws and staples, may be adapted to use in the systems described herein to provide treatment for a variety of medical conditions.

Abstract translation: 通过将化合物与植入体内适当部位的整形外科硬件相结合来局部施用治疗有效的化合物。 化合物例如通过持续释放装置适于在长时间内连续施用有效剂量。 该化合物可以例如通过关节内植入持续释放装置来将哺乳动物的关节施用于在关节的滑膜内递送治疗有效化合物，使得该化合物的滑液浓度大于 化合物。 诸如骨螺钉和钉钉的各种矫形硬件可适于在本文所述的系统中使用以提供针对各种医疗状况的治疗。