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    Phosphate suspensions
    2.
    发明申请
    Phosphate suspensions 审中-公开
    磷酸盐悬浮液

    公开(公告)号：US20040242496A1

    公开(公告)日：2004-12-02

    申请号：US10483926

    申请日：2004-07-01

    发明人： John Hawkins

    IPC分类号： A61K031/70

    CPC分类号： C11D17/0026 ,  C11D3/06 ,  C11D3/221 ,  C11D7/16 ,  C11D7/268

    摘要： A stable suspension of phosphate in water, which may be used as a basis for dishwashing formulations, comprises a phosphate, such as sodium tripolyphosphate, a carbohydrate, such as sucrose and water in about equal proportions, together optionally with minor proportion, e.g. up to 10% each, of surfactants, stain removers, alkalis and/or other conventional ingredients of automatic dishwashing formulations

    摘要翻译： 磷酸盐在水中的稳定悬浮液可用作餐具洗涤制剂的基础，包括磷酸盐，例如三聚磷酸钠，碳水化合物，例如大约相等比例的蔗糖和水，一起可选地以较小的比例，例如。 多达10％的表面活性剂，去污剂，碱和/或其他常规成分的自动洗碗剂制剂

    Skin-protective compositions effective against vesicants & percutaneous chemical agents
    3.
    发明申请
    Skin-protective compositions effective against vesicants & percutaneous chemical agents 失效
    有效对抗囊泡和经皮化学药剂的皮肤保护组合物

    公开(公告)号：US20040235756A1

    公开(公告)日：2004-11-25

    申请号：US10475878

    申请日：2004-04-05

    发明人： Itzhak Barness ,  Tamar Kadar ,  Eliezer Fishbine

    IPC分类号： A61K031/70 ,  A61K031/715 ,  A61K031/7012

    CPC分类号： A61Q17/00 ,  A61K8/19 ,  A61K8/20 ,  A61K8/22 ,  A61K8/345 ,  A61K8/36 ,  A61K8/362 ,  A61K8/365 ,  A61K8/368 ,  A61K8/38 ,  A61K8/44 ,  A61K8/46 ,  A61K8/55 ,  A61K8/60 ,  A61K8/676 ,  A61K8/73 ,  A61K8/732 ,  A61K8/86 ,  A61K2800/75 ,  Y10T442/2516

    摘要： A protective agent suitable to protect the human skin against lesions caused by vesicants or other percutaneous chemical agents, particularly against sulfur mustard gas injury and VX intoxication, which comprises a protective-effective amount of a hydrophilic water-based cream, alone or together with one or more additives selected from among the group consisting essentially of polyols, mono-, oligo- or polysaccharides, and salts of organic or inorganic acids. The additive polyol may be glycol, propylene glycol, polyglygcerol, glycerin, sorbitol, dulcitol, tritol, sorbitol or mannitol. The additive monosaccharide may be ribose, xylose, glucose, fructose, galactose or mannose. The additive oligosaccharide may be sucrose, maltose, lactose, raffinose or cellobiose.

    摘要翻译： 一种保护剂，适用于保护人体皮肤免受由呕吐物或其他经皮化学药剂引起的损伤，特别是针对硫芥子气体损伤和VX中毒，其包含单独或一起与保护有效量的亲水性水性霜剂 或更多选自基本上由多元醇，单糖，寡糖或多糖，以及有机或无机酸的盐组成的组中的添加剂。 添加剂多元醇可以是二醇，丙二醇，聚甘油，甘油，山梨糖醇，曲醇醇，三羟甲基纤维素，山梨糖醇或甘露糖醇。 添加单糖可以是核糖，木糖，葡萄糖，果糖，半乳糖或甘露糖。 添加剂寡糖可以是蔗糖，麦芽糖，乳糖，棉子糖或纤维二糖。

    Model of autoimmune disease and methods for identifying agents against autoimmune disease
    7.
    发明申请
    Model of autoimmune disease and methods for identifying agents against autoimmune disease 审中-公开
    自身免疫疾病模型和鉴定抗自身免疫疾病药物的方法

    公开(公告)号：US20040191756A1

    公开(公告)日：2004-09-30

    申请号：US10487116

    申请日：2004-04-06

    发明人： Patrick Daniel Matthias ,  Jian Sun

    IPC分类号： A61K031/70 ,  A01N043/04 ,  A01N037/18 ,  A61K038/00 ,  C12Q001/00 ,  C12Q001/68

    CPC分类号： G01N33/564 ,  A01K2217/075 ,  A01K2227/105 ,  A01K2267/0325 ,  A61K38/1709 ,  C12N15/8509 ,  C12Q1/6897 ,  G01N33/5008 ,  G01N33/5023 ,  G01N33/5052 ,  G01N2800/104 ,  G01N2800/24

    摘要： Homozygouse knock-out mice lacking the Aiolos gene are shown to exhibit multiple phenotypes in common with humans suffering from the autoimmune disease Systemic Lupus Erythematosus (SLE). When Aiolos null/null mice are crossed with homozygous knock out mice lacking the OBF-1 transcription factor gene, resultant double knock out mice lack all signs of SLE. Methods of screening for agents active against autoimmune diseases, for example SLE are provided. In vitro methods include screening for antagonists of OBF-1, screening for agents which inhibit binding of OBF-1 to oct-1 or oct-2, screening for agonists or antagonists of Aiolos protein and screening for agents which upregulate expression of Aiolos or downregulate expression of OBF-1. Also disclosed are methods of screening using knock-out mice and B cells from knock-out mice.

    摘要翻译： 缺乏Aiolos基因的纯合子敲除小鼠显示与患有自身免疫疾病系统性狼疮红斑狼疮（SLE）的人共同表现出多种表型。 当Aiolos - / - 小鼠与缺乏OBF-1转录因子基因的纯合敲除小鼠杂交时，双重敲除小鼠缺乏SLE的所有迹象。 提供了对自身免疫性疾病活性物质（例如SLE）进行筛选的方法。 体外方法包括筛选OBF-1的拮抗剂，筛选抑制OBF-1与oct-1或oct-2结合的试剂，筛选Aiolos蛋白的激动剂或拮抗剂并筛选上调Aiolos或下调的药物 OBF-1的表达。 还公开了使用敲除小鼠和敲除小鼠的B细胞进行筛选的方法。

    Treatment of rumen acidosis with alpha-amylase inhibitors
    8.
    发明申请
    Treatment of rumen acidosis with alpha-amylase inhibitors 失效
    用α-淀粉酶抑制剂治疗瘤胃酸中毒

    公开(公告)号：US20040167082A1

    公开(公告)日：2004-08-26

    申请号：US10774139

    申请日：2004-02-06

    申请人： Pfizer Inc

    发明人： Bernard Joseph Banks ,  Mark Andrew Haxell ,  Graham Lunn ,  Michael Stephen Pacey ,  Lee Richard Roberts

    IPC分类号： A61K031/70

    CPC分类号： A61K31/715 ,  A23K10/12 ,  A23K20/163 ,  A23K50/10 ,  A61K31/7016 ,  A61K31/702

    摘要： The invention described herein relates to: the use of an effective inhibitor of a bacterial null-amylase and/or null-glucosidase in the manufacture of a composition for the treatment of acidosis; a method of treatment of rumen acidosis which comprises administration of an effective amount of an effective inhibitor of a bacterial null-amylase and/or null-glucosidase to a ruminant; a formulation suitable for the treatment of acidosis in an animal which comprises an effective inhibitor of a bacterial null-amylase and/or null-glucosidase in admixture with a suitable excipient, diluent or carrier selected with regard to the intended route of administration and standard pharmaceutical/veterinary/farming practice; screening methods useful in the identification of a suitable inhibitor of a bacterial null-amylase and/or null-glucosidase for the treatment of acidosis in a ruminant; a process for improving ruminant milk quality and/or quantity which comprises treatment of a ruminant with an effective amount of an inhibitor of bacterial null-amylase and/or null-glucosidase; a compound of the formula I: 1 or veterinarily acceptable salt, solvate (including hydrate) or prodrug thereof; and processes to make an effective inhibitor of a bacterial null-amylase and/or null-glucosidase useful for the treatment of acidosis in a ruminant.

    摘要翻译： 本文描述的发明涉及：在制备用于治疗酸中毒的组合物中使用细菌α-淀粉酶和/或α-葡糖苷酶的有效抑制剂; 一种治疗瘤胃酸中毒的方法，包括向反刍动物施用有效量的有效的细菌α-淀粉酶和/或α-葡糖苷酶抑制剂; 适用于治疗动物中的酸中毒的制剂，其包含与适当的赋形剂，稀释剂或载体混合的有效抑制细菌α-淀粉酶和/或α-葡萄糖苷酶的方法，所述适合的赋形剂，稀释剂或载体相对于预期给药途径和标准药物 /兽医/农业实践; 用于鉴定用于治疗反刍动物酸中毒的细菌α-淀粉酶和/或α-葡糖苷酶的合适抑制剂的筛选方法; 一种改善反刍动物奶质量和/或量的方法，其包括用有效量的细菌α-淀粉酶和/或α-葡糖苷酶抑制剂处理反刍动物; 式I化合物或兽医学上可接受的盐，溶剂合物（包括水合物）或其前药; 并且制备用于治疗反刍动物酸中毒的细菌α-淀粉酶和/或α-葡糖苷酶的有效抑制剂的方法。

    Method and composition for maintaining urinary tract health in the face of infections
    9.
    发明申请
    Method and composition for maintaining urinary tract health in the face of infections 审中-公开
    面对感染时维持尿道健康的方法和组成

    公开(公告)号：US20040147459A1

    公开(公告)日：2004-07-29

    申请号：US10691423

    申请日：2003-10-22

    发明人： Joseph Oneal ,  Gary White

    IPC分类号： A61K031/70 ,  A61K035/78

    CPC分类号： A61K31/7004 ,  A61K31/70 ,  A61K36/00 ,  A61K36/185 ,  A61K36/76 ,  A61K45/06 ,  Y02A50/473 ,  A61K2300/00

    摘要： The sugar mannose has been used to maintain urinary tract health in the face of E. coli infections. An optimal dose is disclosed to be of one teaspoon (two grams) three times a day for one to two weeks or until symptoms subside. The maintenance dosage for prophalaxis is one-half teaspoon (1 gram) 1 to two times per day. Children's dosages are cut in half. For women who experience UTIs after sexual relations, one teaspoon is taken an hour prior to intimate relations and an additional one teaspoon immediately afterwards. It is further disclosed to use any of an extract of Crataeva nurvala, white willow bark, and pollen extract in conjunction with the mannose to provide further effect.

    摘要翻译： 面对大肠杆菌感染，糖甘露糖已被用于维持尿道健康。 公开了最佳剂量为1茶匙（2克），每天3次，持续1至2周或直至症状消退。 头痛的维持剂量是每天1至2次的半茶匙（1克）。 儿童用量减半。 对于经历性关系之后的UTI的女性，在一个小时之前，一个茶匙在亲密关系之前和另外一茶匙紧随其后。 进一步公开使用与甘露糖结合的任何Crataeva nurvala，白柳树皮和花粉提取物的提取物以提供进一步的效果。