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360 条记录 (耗时 0.046 秒)

    Method for controlling beetles
    1.
    发明申请
    Method for controlling beetles 审中-公开
    甲虫防治方法

    公开(公告)号：US20040248824A1

    公开(公告)日：2004-12-09

    申请号：US10490587

    申请日：2004-03-25

    发明人： Daniel Earl Snyder

    IPC分类号： A01N043/04

    CPC分类号： A01N43/22 ,  A01N25/34 ,  A01N25/08 ,  A01N2300/00 ,  A01N25/00

    摘要： The invention provides a method for controlling darkling, hide or related beetle species in a poultry facility, comprising delivering to a locus of infestation or locus to be protected, an amount of a spinosyn that is effective to control the beetles.

    摘要翻译： 本发明提供了一种用于在家禽设施中控制黑暗，隐藏或相关甲虫物种的方法，其包括递送至受保护的感染位点或受保护位点，一定量的有效控制甲虫的多杀菌素。

    Topical anthelmintic veterinary formulations
    3.
    发明申请
    Topical anthelmintic veterinary formulations 有权
    主题驱虫剂兽药配方

    公开(公告)号：US20040198676A1

    公开(公告)日：2004-10-07

    申请号：US10818313

    申请日：2004-04-05

    发明人： Mark D. Soll ,  Krishan Kumar ,  Robert P. Waranis ,  Natalya Shub

    IPC分类号： A01N043/04

    CPC分类号： A61K9/0017 ,  A61K31/365 ,  A61K31/495 ,  A61K31/506 ,  A61K2300/00

    摘要： This invention provides for inter alia, topical anthelmintic formulations which comprise a pharmaceutically active combination consisting of at least one macrocyclic compound and at least one compound selected from the group consisting of praziquantel, morantel and pyrantel, which are dissolved in a non-aqueous solvent or solvent mixture and optionally a thickening agent.

    摘要翻译： 本发明尤其提供了包含由至少一种大环化合物和至少一种选自吡喹酮，芒硝和吡哆醇的化合物组成的药物活性组合的局部驱肠制剂，它们溶于非水溶剂或 溶剂混合物和任选的增稠剂。

    Model of autoimmune disease and methods for identifying agents against autoimmune disease
    4.
    发明申请
    Model of autoimmune disease and methods for identifying agents against autoimmune disease 审中-公开
    自身免疫疾病模型和鉴定抗自身免疫疾病药物的方法

    公开(公告)号：US20040191756A1

    公开(公告)日：2004-09-30

    申请号：US10487116

    申请日：2004-04-06

    发明人： Patrick Daniel Matthias ,  Jian Sun

    IPC分类号： A61K031/70 ,  A01N043/04 ,  A01N037/18 ,  A61K038/00 ,  C12Q001/00 ,  C12Q001/68

    CPC分类号： G01N33/564 ,  A01K2217/075 ,  A01K2227/105 ,  A01K2267/0325 ,  A61K38/1709 ,  C12N15/8509 ,  C12Q1/6897 ,  G01N33/5008 ,  G01N33/5023 ,  G01N33/5052 ,  G01N2800/104 ,  G01N2800/24

    摘要： Homozygouse knock-out mice lacking the Aiolos gene are shown to exhibit multiple phenotypes in common with humans suffering from the autoimmune disease Systemic Lupus Erythematosus (SLE). When Aiolos null/null mice are crossed with homozygous knock out mice lacking the OBF-1 transcription factor gene, resultant double knock out mice lack all signs of SLE. Methods of screening for agents active against autoimmune diseases, for example SLE are provided. In vitro methods include screening for antagonists of OBF-1, screening for agents which inhibit binding of OBF-1 to oct-1 or oct-2, screening for agonists or antagonists of Aiolos protein and screening for agents which upregulate expression of Aiolos or downregulate expression of OBF-1. Also disclosed are methods of screening using knock-out mice and B cells from knock-out mice.

    摘要翻译： 缺乏Aiolos基因的纯合子敲除小鼠显示与患有自身免疫疾病系统性狼疮红斑狼疮（SLE）的人共同表现出多种表型。 当Aiolos - / - 小鼠与缺乏OBF-1转录因子基因的纯合敲除小鼠杂交时，双重敲除小鼠缺乏SLE的所有迹象。 提供了对自身免疫性疾病活性物质（例如SLE）进行筛选的方法。 体外方法包括筛选OBF-1的拮抗剂，筛选抑制OBF-1与oct-1或oct-2结合的试剂，筛选Aiolos蛋白的激动剂或拮抗剂并筛选上调Aiolos或下调的药物 OBF-1的表达。 还公开了使用敲除小鼠和敲除小鼠的B细胞进行筛选的方法。

    Method of controlling animal pests and disinfecting inanimate surfaces
    5.
    发明申请
    Method of controlling animal pests and disinfecting inanimate surfaces 失效
    控制动物害虫和消毒无生命表面的方法

    公开(公告)号：US20040138144A1

    公开(公告)日：2004-07-15

    申请号：US10705688

    申请日：2003-11-10

    发明人： Will H. Hartfeldt

    IPC分类号： A01N043/04

    CPC分类号： A01N61/00 ,  A01N33/22 ,  Y10S514/97 ,  Y10S514/973 ,  A01N2300/00 ,  A01N25/30 ,  A01N37/02 ,  A01N59/20

    摘要： A method of treating plant and animal systems and inanimate surfaces for the purposes of controlling plant pests, introducing pesticides and nutrients into plants, mitigating frost damage to plants, increasing crop yields, controlling certain plant diseases, controlling arthropod, bacterial, fungal, mycoplasma, rickettsia, and viral pests of animals and humans, and disinfecting inanimate surfaces. The method utilizes the unique multi-directional dispersion property of the tannate complex of picro ammonium formate and the tannate complex of picro cupric ammonium formate, in aqueous solution, combined with a minor amount of a surfactant sufficient to prevent formation of ammonium picrate, to penetrate plant and animal systems and inanimate surfaces and travelling multidirectionally therein. The method is carried out by introducing a small but effective amount of the tannate complex to the plant or animal system or inanimate surface.

    摘要翻译： 一种处理植物和动物系统和无生命表面的方法，用于控制植物害虫，将农药和营养物质引入植物中，减轻对植物的霜冻损害，增加作物产量，控制某些植物病害，控制节肢动物，细菌，真菌，支原体， 立克次体和动物和人类的病毒性害虫，以及消毒无生命的表面。 该方法利用了独特的多氨基甲酸铵复合物的多向分散性质，并且在水溶液中与微量甲酸铵形成的鞣酸复合物与少量足以防止形成苦味酸铵的表面活性剂结合，渗透 植物和动物系统和无生命的表面，并在其中多向行进。 该方法通过将少量但有效量的鞣酸复合物引入植物或动物系统或无生命的表面来进行。

    Method for determining pharmaceutically active substances
    6.
    发明申请
    Method for determining pharmaceutically active substances 审中-公开
    确定药物活性物质的方法

    公开(公告)号：US20040093170A1

    公开(公告)日：2004-05-13

    申请号：US10468375

    申请日：2003-08-19

    发明人： Soheila Anzali ,  Gerhard Barnickel ,  Bertram Cezanne ,  Michael Krug ,  Joachim Marz

    IPC分类号： G06F019/00 ,  C12Q001/00 ,  C12Q001/68 ,  A01N037/18 ,  A01N043/04

    CPC分类号： G01N33/50

    摘要： The present invention relates to a method for determining pharmaceutically active substances with the aid of test series, in which the action of a large number of different substances on one or more biological targets is tested and a hit list of those substances which actually or apparently have shown a pharmaceutical action on at least one biological target is prepared, whereupon a selection is made from the hits for more detailed investigations of pharmaceutical activity and/or applicability. In order to provide a method of the type stated at the outset, by means of which the success rate can be significantly increased, the following features are proposed: a) Determination of the chemical structure of the substances in the hit list, b) splitting of the structure of the substances into individual components or fragments, c) classification of the substances into groups having in each case identical and/or virtually identical or similar fragments, d) evaluation of the pharmacological activity of the various groups, e) comparison of the pharmacological activity of the various groups and f) selection of substances from those groups which, on the basis of the evaluation and of the comparison according to steps d and e, have the highest activity.

    摘要翻译： 本发明涉及一种借助于试验系列确定药物活性物质的方法，其中测试了大量不同物质对一种或多种生物靶标的作用，以及实际上或显然具有 显示了对至少一种生物靶标的药物作用，因此从命中进行了对药物活性和/或适用性的更详细研究的选择。 为了提供一开始所述类型的方法，通过该方法可以显着提高成功率，提出以下特征：a）确定命中列表中物质的化学结构，b）分裂 的物质结构分成单独的组分或片段，c）将物质分类为在每种情况下具有相同和/或实质上相同或相似的片段的组，d）评估各组的药理活性，e）比较 各组的药理活性，f）从根据步骤d和e的评价和比较的基础中选出具有最高活性的那些组的物质。