公开(公告)号：US20130233544A1

公开(公告)日：2013-09-12

申请号：US13870734

申请日：2013-04-25

Applicant: H R D CORPORATION

Inventor： Abbas HASSAN ,  Ebrahim Bagherzadeh ,  Rayford G. Anthony ,  Gregory G. Borsinger ,  Aziz Hassan

IPC: C09K8/54 ,  E21B41/02

CPC classification number: C09K8/54 ,  B01F7/00766 ,  B01F13/1027 ,  B01F2215/0481 ,  E21B41/02 ,  Y10S516/923 ,  Y10S516/929

Abstract: A method for introducing inhibitor into a fluid to be treated by forming a dispersion comprising droplets, particles, or gas bubbles of inhibitor dispersed in a continuous phase of a carrier, wherein forming the dispersion comprises subjecting a mixture of the inhibitor and the carrier to a shear rate of greater than about 20,000 s−1 in a high shear device comprising at least one generator comprising a rotor and a complementarily-shaped stator, wherein the rotor and the stator each comprise grooves, and wherein the grooves of the stator and the grooves of the rotor of each generator are disposed in alternating directions, and using at least a portion of the dispersion to inhibit corrosion.

Abstract translation: 通过形成包含分散在载体的连续相中的抑制剂的液滴，颗粒或气泡的分散体将抑制剂引入待处理的流体的方法，其中形成所述分散体包括将所述抑制剂和载体的混合物 在包括至少一个包括转子和互补形状的定子的发电机的高剪切装置中，剪切速率大于约20,000s -1，其中转子和定子各自包括凹槽，并且其中定子和凹槽 每个发电机的转子设置在交替的方向上，并且使用至少一部分分散体来抑制腐蚀。

公开(公告)号：US20100068366A1

公开(公告)日：2010-03-18

申请号：US12623780

申请日：2009-11-23

Applicant: Anna Lee Tonkovich ,  Laura J. Silva ,  David John Hesse ,  Michael Alan Marchiando ,  Micheal Jay Lamont ,  Dongming Qiu ,  Terrence Andrew Dritz ,  Kristina M. Pagnotto ,  Richard Stevenson ,  Steven T. Perry ,  Maddalena Fanelli ,  Ravi Arora ,  Bin Yang ,  Sean Patrick Fitzgerald ,  Timothy J. Sullivan ,  Kai Tod Paul Jarosch ,  Thomas Yuschak

Inventor： Anna Lee Tonkovich ,  Laura J. Silva ,  David John Hesse ,  Michael Alan Marchiando ,  Micheal Jay Lamont ,  Dongming Qiu ,  Terrence Andrew Dritz ,  Kristina M. Pagnotto ,  Richard Stevenson ,  Steven T. Perry ,  Maddalena Fanelli ,  Ravi Arora ,  Bin Yang ,  Sean Patrick Fitzgerald ,  Timothy J. Sullivan ,  Kai Tod Paul Jarosch ,  Thomas Yuschak

IPC: C11B5/00 ,  B01F17/00 ,  B01F3/04 ,  D21C9/147 ,  C01B15/01

CPC classification number: B01F3/0446 ,  B01F3/0807 ,  B01F5/0475 ,  B01F5/0476 ,  B01F5/0483 ,  B01F13/0059 ,  B01F15/065 ,  B01F2003/0838 ,  B01F2003/0842 ,  B01F2215/0431 ,  B01F2215/045 ,  B01F2215/0472 ,  B01J19/0093 ,  B01J2219/00783 ,  B01J2219/00788 ,  B01J2219/00822 ,  B01J2219/00826 ,  B01J2219/00828 ,  B01J2219/00831 ,  B01J2219/00833 ,  B01J2219/00835 ,  B01J2219/0086 ,  B01J2219/00873 ,  B01J2219/00889 ,  F28D2021/0052 ,  F28F3/12 ,  F28F2260/02 ,  Y10S516/928 ,  Y10S516/929 ,  Y10T436/2575

Abstract: The disclosed invention relates to a process for making a multiphase mixture, comprising: flowing a first fluid stream through a process microchannel, the first fluid stream comprising at least one liquid and/or at least one gas, the process microchannel having an apertured section; flowing a second fluid stream through the apertured section into the process microchannel in contact with the first fluid stream to form the multiphase mixture, the second fluid stream comprising at least one gas and/or at least one microbody-forming material, the first fluid stream forming a continuous phase in the multiphase mixture, the second fluid stream forming a discontinuous phase dispersed in the continuous phase.

Abstract translation: 所公开的本发明涉及一种制备多相混合物的方法，包括：使第一流体流通过工艺微通道，所述第一流体流包含至少一种液体和/或至少一种气体，所述工艺微通道具有带孔部分; 将第二流体流流过有孔部分进入与第一流体流接触的工艺微通道以形成多相混合物，第二流体流包含至少一种气体和/或至少一种微生物形成材料，第一流体流 在多相混合物中形成连续相，第二流体流形成分散在连续相中的不连续相。

公开(公告)号：US5538667A

公开(公告)日：1996-07-23

申请号：US144778

申请日：1993-10-28

Applicant: Ira D. Hill ,  Dale G. Brown

Inventor： Ira D. Hill ,  Dale G. Brown

IPC: A61K8/55 ,  A61K8/04 ,  A61K8/06 ,  A61K8/58 ,  A61K8/86 ,  A61K8/89 ,  A61K8/891 ,  A61K8/90 ,  A61Q11/00 ,  B01F17/00 ,  B01J13/00 ,  C08J3/03 ,  C08L83/04 ,  C11D1/722 ,  C11D1/76 ,  C11D3/37 ,  C11D17/00 ,  C11D17/08 ,  C11D1/82

CPC classification number: C08J3/03 ,  A61K8/06 ,  A61K8/891 ,  A61K8/90 ,  A61Q11/00 ,  B01F17/00 ,  C08L83/04 ,  C11D1/76 ,  C11D17/0017 ,  C11D3/3707 ,  C11D3/373 ,  C08G77/04 ,  C08J2383/04 ,  Y10S516/929

Abstract: The present invention relates to water-free, co-solvent free, stable, dispersions of certain polydimethylsiloxanes in certain nonionic, poloxamer surfactants; wherein:a. the dispersed polydimethylsiloxanes, which are insoluble in said surfactant, are oriented by the surfactant such that when dispersed in water they are particularly adept at forming oriented, monolayer coatings on various substrates, andb. the particle size of the dispersed polydimethylsiloxane is from between about 0.5 and about 10 microns, with a particle size distribution such that from between about 80 and 95% of the dispersed polydimethylsiloxane is within this particle size range. These stable dispersions are described as ultramulsions, which, together with their physical properties, distinguishes them from emulsions, microemulsions and solutions.

Abstract translation: 本发明涉及某些聚二甲基硅氧烷在某些非离子，泊洛沙姆表面活性剂中的无水，无溶剂，稳定的分散体; 其中：a。 不溶于所述表面活性剂的分散的聚二甲基硅氧烷通过表面活性剂取向，使得当分散在水中时，它们特别适用于在各种基材上形成定向的单层涂层，以及b。 分散的聚二甲基硅氧烷的粒度为约0.5至约10微米，其粒度分布使得分散的聚二甲基硅氧烷的约80至95％在该粒度范围内。 这些稳定的分散体被描述为超临界，其与物理性质一起将其与乳液，微乳液和溶液区分开。

公开(公告)号：US5154854A

公开(公告)日：1992-10-13

申请号：US664786

申请日：1991-03-05

Applicant: Arlette Zabotto ,  Jacqueline Griat ,  Rose-Marie J. Handjani ,  Guy G. Vanlerberghe ,  Alain J. Ribier

Inventor： Arlette Zabotto ,  Jacqueline Griat ,  Rose-Marie J. Handjani ,  Guy G. Vanlerberghe ,  Alain J. Ribier

IPC: A61K9/127 ,  A61K45/08 ,  B01D19/04 ,  B01F17/00 ,  C11D17/00

CPC classification number: C11D3/0084 ,  A61K9/1272 ,  A61K9/1277 ,  B01D19/04 ,  B01D19/0404 ,  B01F17/00 ,  C11D17/0026 ,  D06M7/00 ,  C10M2201/02 ,  C10M2203/02 ,  C10M2203/022 ,  C10M2203/024 ,  C10M2203/04 ,  C10M2215/04 ,  C10M2215/26 ,  C10M2223/10 ,  C10N2240/62 ,  D06M2200/40 ,  Y10S516/923 ,  Y10S516/929

Abstract: A process for the preparation of a stable emulsion of at least one water-immiscible liquid phase L in an aqueous phase D is described which comprises mixing the liquid phase or phases L with a dispersion of spheres in an aqueous phase D, the spheres having an average diameter of 0.025 to 5 microns and consisting of substantially concentric lipid laminae encapsulating an aqueous phase E between them, the lipid or lipids constituting the laminae being ionic or nonionic amphiphilic substances capable of forming a lamellar phase in water, and subjecting the whole to mechanical agitation so as to disperse the phase (or phases) L in the phase D in the form of droplets having an average diameter of 0.1 micron to a few microns.

Abstract translation: 描述了在水相D中制备至少一种与水不混溶的液相L的稳定乳液的方法，其包括将液相或相L与水相D中的球体分散体混合，所述球体具有 平均直径为0.025至5微米并且由它们之间包封水相E的基本上同心的脂质层构成，构成层的脂质或脂质是能够在水中形成层状相的离子或非离子两亲物质，并使整个机械 搅拌以将相D中的相（或相）L以平均直径为0.1微米的液滴的形式分散至几微米。

公开(公告)号：US1460718A

公开(公告)日：1923-07-03

申请号：US46649621

申请日：1921-05-03

Applicant: LAVAL SEPARATOR CO DE

Inventor： HOWARD HAPGOOD CYRUS

IPC: B04B1/00

CPC classification number: B04B1/00 ,  Y10S494/901 ,  Y10S516/929

公开(公告)号：US20110171269A1

公开(公告)日：2011-07-14

申请号：US12990540

申请日：2009-04-30

Applicant: Bong Hyun Chung ,  Yong Taik Lim ,  Jung Hyun Han

Inventor： Bong Hyun Chung ,  Yong Taik Lim ,  Jung Hyun Han

IPC: A61K9/00 ,  A61K31/235 ,  A61P1/16 ,  B82Y40/00 ,  B82Y5/00

CPC classification number: A61K9/1652 ,  A61K9/5153 ,  A61K31/235 ,  A61K31/343 ,  A61K31/513 ,  A61K31/519 ,  A61K31/5415 ,  A61K31/573 ,  A61K31/585 ,  A61K31/704 ,  A61K31/7048 ,  B01D65/00 ,  C08J3/03 ,  Y10S516/929

Abstract: The present invention relates to a method for manufacturing uniform size polymeric nanoparticles containing poorly soluble drugs, and more particularly, to a method for manufacturing uniform size polymeric nanoparticles containing poorly soluble drugs, including a first step of dissolving a biodegradable polymer in a non-volatile polar organic solvent, a second step of adding poorly soluble drugs to water and the biodegradable polymer solution to produce a dispersion, and a third step of adding the dispersion to emulsifier solutions in a batch under the condition of low mechanical energy level stirring. The polymeric nanoparticles of the present invention is capable of manufacturing nano-sized small and uniform polymeric nanoparticles through a simple method of employing a non-volatile polar solvent, especially a solvent having a polarity similar to that of water, as a solvent for a mixture solution of biodegradable polymer and poorly soluble materials, and using a low mechanical energy condition and batch-adding of dispersion in an emulsifying process. The polymeric nanoparticles of the present invention are advantageous in that the dissolution rate of the poorly soluble drugs contained in polymeric particles is dramatically improved, and the poorly soluble drugs are gradually and steadily released and maintained at a constant density over a long period of time.

Abstract translation: 本发明涉及一种制备均匀尺寸的含有难溶性药物的聚合物纳米颗粒的方法，更具体地说，涉及一种制备均匀尺寸的含有难溶性药物的聚合物纳米颗粒的方法，包括将可生物降解聚合物溶解在非挥发性物质中的第一步骤 极性有机溶剂，向水中添加难溶性药物和生物降解性聚合物溶液以产生分散体的第二步骤，以及在低机械能级搅拌的条件下将分散体分批加入到乳化剂溶液中的第三步骤。 本发明的聚合物纳米颗粒能够通过使用非挥发性极性溶剂，特别是极性类似于水的溶剂的简单方法作为混合物的溶剂来制造纳米尺寸的小而均匀的聚合物纳米颗粒 可生物降解聚合物和难溶性物质的溶液，并且使用低机械能条件和在乳化过程中分批添加分散体。 本发明的聚合物纳米颗粒的优点在于，包含在聚合物颗粒中的难溶性药物的溶解速度显着提高，并且难溶性药物在长时间内逐渐且稳定地释放并保持在恒定的密度。

公开(公告)号：US07446130B2

公开(公告)日：2008-11-04

申请号：US10424672

申请日：2003-04-27

Applicant: Garry R. Maskaly ,  Yet-Ming Chiang ,  W. Craig Carter ,  R. Edwin Garcia

Inventor： Garry R. Maskaly ,  Yet-Ming Chiang ,  W. Craig Carter ,  R. Edwin Garcia

IPC: B01F3/12 ,  F21V9/14

CPC classification number: C30B5/00 ,  C30B29/60 ,  Y10S516/924 ,  Y10S516/929

Abstract: Ionic colloidal crystals (ordered multicomponent colloids formed by attractive electrostatic interactions) may be produced by controlling the surface potential and relative size of multiple populations of colloidal particles in suspension. Such suspensions are dried or otherwise caused to precipitate out the particles in ordered arrays. The crystal structure of the arrays may be controlled by appropriate choices of particle materials, sizes, and charge ratios.

Abstract translation: 离子胶体晶体（有吸引力的静电相互作用形成的有序多组分胶体）可以通过控制悬浮液中多个胶体颗粒群的表面电位和相对大小来产生。 这种悬浮液被干燥或以其它方式引起以有序排列的颗粒沉淀出来。 阵列的晶体结构可以通过适当选择粒子材料，尺寸和电荷比来控制。

公开(公告)号：US07351749B2

公开(公告)日：2008-04-01

申请号：US10320029

申请日：2002-12-16

Applicant: Peter Anthony Divone ,  Walter Anthony Biercevicz ,  Joseph James Regan ,  Christy Ann Bridges ,  Kimberly Ann Priest ,  Matthew Jungblut

Inventor： Peter Anthony Divone ,  Walter Anthony Biercevicz ,  Joseph James Regan ,  Christy Ann Bridges ,  Kimberly Ann Priest ,  Matthew Jungblut

IPC: B01F3/08

CPC classification number: B01F3/0819 ,  B01F3/088 ,  B01F5/10 ,  B01F15/0416 ,  B01F2215/0031 ,  B01F2215/0431 ,  B01F2215/045 ,  B01F2215/0468 ,  B01F2215/0472 ,  B01F2215/0477 ,  B01F2215/0495 ,  Y10S516/929

Abstract: A process which may be continuous is provided for manufacture of personal care product compositions. The process involves feeding a first water phase which is a concentrate containing most if not all water soluble ingredients of the composition into a blending tube. A second phase which can be oily or aqueous and a third water phase, the latter being essentially pure water, are also fed into the blending tube. All of the phases are transported through the tube at a flow rate of about 5 to about 5,000 lbs./minute and at a pressure of about 10 to about 5,000 psi. Preferably the tube leads into a homogenizer such as a sonolator.

Abstract translation: 提供可以是连续的方法用于制造个人护理产品组合物。 该方法包括将第一水相进料，该第一水相是将包含组合物的大多数（如果不是全部）水溶性成分的浓缩物加入到共混管中。 可以是油性或水性的第二相以及后者基本上是纯水的第三水相也被加入到共混管中。 所有相以约5至约5,000磅/分钟的流速和约10至约5,000psi的压力通过管输送。 优选地，管引入均化器，例如声音抛光器。

公开(公告)号：US07214717B1

公开(公告)日：2007-05-08

申请号：US10088651

申请日：2000-09-04

Applicant: Jérôme Michel Jaques Bibette ,  Fernando Leal Calderon ,  Philippe Gorria

Inventor： Jérôme Michel Jaques Bibette ,  Fernando Leal Calderon ,  Philippe Gorria

IPC: B01F3/00 ,  B01F17/00

CPC classification number: B01F17/0021 ,  B01F17/0028 ,  Y10S516/929 ,  Y10S516/93

Abstract: A fractionable polydisperse stable double oil-in-water emulsion, having 50 to 95 wt. % relative to the total weight of the double emulsion, droplets of an invert monodisperse emulsion Ei dispersed in a continuous aqueous phase. The continuous aqueous phase includes a polysaccharide thickening agent in a proportion of 1 to 10 wt. % relative to the total weight of the continuous aqueous phase, a water-soluble ethylene oxide and propylene oxide block copolymer as surfactant, and an osmotic pressure balancing agent. The emulsion Ei has a viscosity not higher than the viscosity of the continuous aqueous phase and has 50 to 95 wt. %, relative to the total weight of Ei, droplets of an internal aqueous phase dispersed in an oily phase. The internal aqueous phase includes an active hydrophilic substance and the oily phase includes poly glycerol polyricinoleate as surfactant.

Abstract translation: 一种可分散的多分散稳定的双重水包油乳液，其具有50至95wt。 相对于双重乳液的总重量的％，分散在连续水相中的反转单分散乳液Ei的液滴。 连续水相包含1〜10重量％的多糖增稠剂。 相对于连续水相的总重量，作为表面活性剂的水溶性环氧乙烷和环氧丙烷嵌段共聚物以及渗透压平衡剂。 乳液Ei具有不高于连续水相粘度的粘度，并且具有50至95wt。 相对于Ei的总重量，分散在油相中的内部水相的液滴为％。 内部水相包含活性亲水物质，油相包括作为表面活性剂的聚甘油聚蓖麻油酸酯。

公开(公告)号：US20040014821A1

公开(公告)日：2004-01-22

申请号：US10422388

申请日：2003-04-23

Inventor： Ramesh Varadaraj

IPC: C09K003/00

CPC classification number: C10L1/328 ,  C09K8/58 ,  C10M173/00 ,  C10M2203/1006 ,  C10M2203/1085 ,  C10M2207/126 ,  C10M2207/141 ,  C10M2207/146 ,  C10M2207/401 ,  C10M2219/044 ,  C10M2223/02 ,  C10M2227/025 ,  C10N2210/01 ,  C10N2210/02 ,  C10N2250/02 ,  C10N2250/021 ,  C10N2250/022 ,  Y10S516/929

Abstract: An oil-in-water-in-oil emulsion (O/W/O) comprising a first oil-in-water emulsion dispersed in a second oil, and a method of preparing the same. The O/W/O emulsion can be used as a drive fluid in an enhanced oil recovery process. The O/W/O emulsion of this invention may also be used as a lubricant, and has the beneficial property of being resistant to shear forces.

Abstract translation: 包含分散在第二种油中的第一种水包油乳液的油包水包油乳液（O / W / O）及其制备方法。 O / W / O乳液可用作增强采油过程中的驱动流体。 本发明的O / W / O乳液也可以用作润滑剂，并具有耐剪切力的有益特性。