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    NON-HIGH DENSITY LIPOPROTEIN DERIVED CVD MARKERS
    3.
    发明申请
    NON-HIGH DENSITY LIPOPROTEIN DERIVED CVD MARKERS 审中-公开
    非高密度脂蛋白衍生化CVD标记

    公开(公告)号：US20160018423A1

    公开(公告)日：2016-01-21

    申请号：US14773095

    申请日：2014-03-07

    Applicant: ZORA BIOSCIENCES OY

    Inventor： Reijo Laaksonen

    IPC: G01N33/92

    CPC classification number: G01N33/92 ,  A61K31/00 ,  A61K38/1709 ,  G01N2333/775 ,  G01N2405/02 ,  G01N2405/04 ,  G01N2405/08 ,  G01N2570/00 ,  G01N2800/32 ,  G01N2800/323 ,  G01N2800/324 ,  G01N2800/50 ,  G01N2800/52

    Abstract: The present invention inter alia relates to methods and uses involving the determination of lipid/lipid concentration ratios in order to diagnose, predict, prevent and/or treat atherosclerosis or cardiovascular disease (CVD) and its complications including, e.g., acute myocardial infarction. The methods include analyzing lipid concentrations and resulting lipid/lipid concentration ratios of a non-high density lipoprotein samples from patients and comparing them to a control.

    Abstract translation: 本发明尤其涉及涉及确定脂质/脂质浓度比以便诊断，预测，预防和/或治疗动脉粥样硬化或心血管疾病（CVD）及其并发症（包括例如急性心肌梗死）的方法和用途。 方法包括分析来自患者的非高密度脂蛋白样品的脂质浓度和所得脂质/脂质浓度比，并将其与对照进行比较。

    Method for the High-Speed Detection and/or Measurement of a Lipase or Phospholipase Activity
    4.
    发明申请
    Method for the High-Speed Detection and/or Measurement of a Lipase or Phospholipase Activity 失效
    高速检测和/或测量脂肪酶或磷脂酶活性的方法

    公开(公告)号：US20080193958A1

    公开(公告)日：2008-08-14

    申请号：US11884139

    申请日：2006-02-10

    Applicant: Robert Verger ,  Carole Serveau-Avesque ,  Henri Chahinian

    Inventor： Robert Verger ,  Carole Serveau-Avesque ,  Henri Chahinian

    IPC: C12Q1/00 ,  C12M3/00 ,  C12M1/34

    CPC classification number: C12Q1/34 ,  B01J2219/00315 ,  B01J2219/00603 ,  B01J2219/00659 ,  B01J2219/00734 ,  B01L3/5085 ,  B01L2200/16 ,  B01L2300/0829 ,  B01L2300/16 ,  G01N2333/918 ,  G01N2405/02

    Abstract: The invention relates to a method for the detection and/or measurement in vitro of a lipase or phospholipase activity, characterized in that it comprises: the addition of a sample likely to contain said lipase or phospholipase into the wells of microtitration plates coated with a layer of a lipid substrate which is able to be hydrolyzed by said lipase or phospholipase by releasing α-eleostearic acid, the detection and/or the measurement of the lipase or phospholipase activity by UV spectrophotometry of the α-eleostearic acid released during the previous stage. The invention also relates to the application of the above-mentioned method to the in vitro diagnosis of pathologies linked to an increase in the plasma lipase level.

    Abstract translation: 本发明涉及用于体外检测和/或测量脂肪酶或磷脂酶活性的方法，其特征在于其包括：将可能含有所述脂肪酶或磷脂酶的样品加入涂覆有层的微量滴定板的孔中 的脂质底物，其能够通过释放α-桐酸被所述脂肪酶或磷脂酶水解，通过前一阶段释放的α-桐酸的紫外分光光度法检测和/或测量脂肪酶或磷脂酶活性。 本发明还涉及上述方法用于与血浆脂肪酶水平增加相关的病理学的体外诊断的应用。

    LIPID BIOMARKERS OF HEALTHY AGEING
    8.
    发明申请
    LIPID BIOMARKERS OF HEALTHY AGEING 审中-公开
    健康老化的脂肪生物标志物

    公开(公告)号：US20160245786A1

    公开(公告)日：2016-08-25

    申请号：US15028244

    申请日：2014-11-05

    Applicant: NESTEC S.A.

    Inventor： Sebastiano Collino ,  Ivan Montoliu Roura ,  Françios-Pierre Martin ,  Fiona Camille Beguelin ,  Serge André Dominique Rezzi

    IPC: G01N33/487

    CPC classification number: G01N33/487 ,  G01N33/6893 ,  G01N33/92 ,  G01N2405/00 ,  G01N2405/02 ,  G01N2405/04 ,  G01N2405/08 ,  G01N2560/00 ,  G01N2570/00 ,  G01N2800/50 ,  G01N2800/52

    Abstract: In one aspect there is provided a method for predicting a risk of unhealthy ageing in a subject, comprising: (a) determining a level of two or more lipid biomarkers in a sample from the subject, wherein the biomarkers are selected from two or more of the following groups: (i) a triacylglycerol (TAG) from TAG (46:5) to TAG (54:3); (ii) an ether phosphatidylcholine (PC-O) from PC-O(28:0) to PC-O(38:6); (iii) a sphingomyelin (SM) from SM (33:1) to SM(50:1); (iv) a phosphatidylcholine (PC) from PC (32:1) to PC (40:5); (v) a phosphatidylinositol (PI) from PI (36:1) to PI (38:3); (vi) a phosphatidylethanolamine (PE) from PE (36:2) to PE (38:4); and (b) comparing the levels of the biomarkers in the sample to reference values; wherein the levels of the biomarkers in the sample compared to the reference values are indicative of the risk of unhealthy ageing in the subject.

    Abstract translation: 一方面，提供了一种用于预测受试者中不健康衰老风险的方法，其包括：（a）测定来自所述受试者的样品中两种或更多种脂质生物标志物的水平，其中所述生物标志物选自 以下组：（i）TAG（46:5）至TAG（54:3）的三酰基甘油（TAG）; （ii）从PC-O（28:0）到PC-O（38:6）的醚磷脂酰胆碱（PC-O）; （iii）SM（33：1）至SM（50：1）的鞘磷脂（SM）; （iv）从PC（32:1）到PC（40:5）的磷脂酰胆碱（PC）; （v）PI（36：1）至PI（38：3）的磷脂酰肌醇（PI）; （vi）从PE（36:2）到PE（38:4）的磷脂酰乙醇胺（PE）; 和（b）将样品中生物标志物的水平与参考值进行比较; 其中与参考值相比，样品中的生物标志物的水平表明受试者中不健康老化的风险。

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