公开(公告)号：US20240142475A1

公开(公告)日：2024-05-02

申请号：US18278740

申请日：2022-02-24

Applicant: Washington University

Inventor： Jennifer Philips ,  Pallavi Chandra ,  Heloise Coullon

IPC: G01N33/92

CPC classification number: G01N33/92 ,  G01N2405/02 ,  G01N2800/52

Abstract: Methods for diagnosis of bacterial infections (e.g., tuberculosis) are disclosed. In particular, the disclosure relates to the use of a panel of biomarkers for aiding diagnosis, prognosis, and treatment of bacterial infections such as tuberculosis. The identified biomarkers can be used to detect active infection as well as bacterial burden, and for monitoring responses to treatment.

公开(公告)号：US20210000821A1

公开(公告)日：2021-01-07

申请号：US16979443

申请日：2019-03-15

Applicant: Washington University in St. Louis ,  New York University

Inventor： Jennifer A. Philips ,  Kathryn Moore ,  Pallavi Chandra ,  Mireille Ouimet

IPC: A61K31/495 ,  A61K31/336

Abstract: Methods of using small molecule inhibitors of fatty acid oxidation (FAO) as antimicrobials against intracellular Mycobacteria are disclosed. FAO inhibitors including etomoxir, trimetazidine, oxfenicine perhexeline and/or can be used alone, or in combination with known as antimycobacterial agents against intracellular Mycobacteria.

公开(公告)号：US20240000774A1

公开(公告)日：2024-01-04

申请号：US18338717

申请日：2023-06-21

Applicant: Washington University in St. Louis ,  New York University

Inventor： Jennifer A. Philips ,  Kathryn Moore ,  Pallavi Chandra ,  Mireille Ouimet

IPC: A61K31/495 ,  A61K31/336 ,  A61K31/198 ,  A61K31/352 ,  A61K31/365 ,  A61K31/4453

CPC classification number: A61K31/495 ,  A61K31/336 ,  A61K31/198 ,  A61K31/352 ,  A61K31/365 ,  A61K31/4453 ,  A61K45/06

Abstract: Methods of using small molecule inhibitors of fatty acid oxidation (FAO) as antimicrobials against intracellular Mycobacteria are disclosed. FAO inhibitors including etomoxir, trimetazidine, oxfenicine perhexeline and/or can be used alone, or in combination with known as antimycobacterial agents against intracellular Mycobacteria.

公开(公告)号：US11717519B2

公开(公告)日：2023-08-08

申请号：US16979443

申请日：2019-03-15

Applicant: Washington University in St. Louis ,  New York University

Inventor： Jennifer A. Philips ,  Kathryn Moore ,  Pallavi Chandra ,  Mireille Ouimet

IPC: A61K31/495 ,  A61K31/336 ,  A61K45/06 ,  A61K31/198 ,  A61K31/352 ,  A61K31/365 ,  A61K31/4453 ,  A61K31/155

CPC classification number: A61K31/495 ,  A61K31/198 ,  A61K31/336 ,  A61K31/352 ,  A61K31/365 ,  A61K31/4453 ,  A61K31/155 ,  A61K45/06

Abstract: Methods of using small molecule inhibitors of fatty acid oxidation (FAO) as antimicrobials against intracellular Mycobacteria are disclosed. FAO inhibitors including etomoxir, trimetazidine, oxfenicine perhexeline and/or can be used alone, or in combination with known as antimycobacterial agents against intracellular Mycobacteria.