公开(公告)号：US20210000821A1

公开(公告)日：2021-01-07

申请号：US16979443

申请日：2019-03-15

Applicant: Washington University in St. Louis ,  New York University

Inventor： Jennifer A. Philips ,  Kathryn Moore ,  Pallavi Chandra ,  Mireille Ouimet

IPC: A61K31/495 ,  A61K31/336

Abstract: Methods of using small molecule inhibitors of fatty acid oxidation (FAO) as antimicrobials against intracellular Mycobacteria are disclosed. FAO inhibitors including etomoxir, trimetazidine, oxfenicine perhexeline and/or can be used alone, or in combination with known as antimycobacterial agents against intracellular Mycobacteria.

公开(公告)号：US20240000774A1

公开(公告)日：2024-01-04

申请号：US18338717

申请日：2023-06-21

Applicant: Washington University in St. Louis ,  New York University

Inventor： Jennifer A. Philips ,  Kathryn Moore ,  Pallavi Chandra ,  Mireille Ouimet

IPC: A61K31/495 ,  A61K31/336 ,  A61K31/198 ,  A61K31/352 ,  A61K31/365 ,  A61K31/4453

CPC classification number: A61K31/495 ,  A61K31/336 ,  A61K31/198 ,  A61K31/352 ,  A61K31/365 ,  A61K31/4453 ,  A61K45/06

Abstract: Methods of using small molecule inhibitors of fatty acid oxidation (FAO) as antimicrobials against intracellular Mycobacteria are disclosed. FAO inhibitors including etomoxir, trimetazidine, oxfenicine perhexeline and/or can be used alone, or in combination with known as antimycobacterial agents against intracellular Mycobacteria.

公开(公告)号：US11717519B2

公开(公告)日：2023-08-08

申请号：US16979443

申请日：2019-03-15

Applicant: Washington University in St. Louis ,  New York University

Inventor： Jennifer A. Philips ,  Kathryn Moore ,  Pallavi Chandra ,  Mireille Ouimet

IPC: A61K31/495 ,  A61K31/336 ,  A61K45/06 ,  A61K31/198 ,  A61K31/352 ,  A61K31/365 ,  A61K31/4453 ,  A61K31/155

CPC classification number: A61K31/495 ,  A61K31/198 ,  A61K31/336 ,  A61K31/352 ,  A61K31/365 ,  A61K31/4453 ,  A61K31/155 ,  A61K45/06

Abstract: Methods of using small molecule inhibitors of fatty acid oxidation (FAO) as antimicrobials against intracellular Mycobacteria are disclosed. FAO inhibitors including etomoxir, trimetazidine, oxfenicine perhexeline and/or can be used alone, or in combination with known as antimycobacterial agents against intracellular Mycobacteria.