公开(公告)号：US20160245786A1

公开(公告)日：2016-08-25

申请号：US15028244

申请日：2014-11-05

Applicant: NESTEC S.A.

Inventor： Sebastiano Collino ,  Ivan Montoliu Roura ,  Françios-Pierre Martin ,  Fiona Camille Beguelin ,  Serge André Dominique Rezzi

IPC: G01N33/487

CPC classification number: G01N33/487 ,  G01N33/6893 ,  G01N33/92 ,  G01N2405/00 ,  G01N2405/02 ,  G01N2405/04 ,  G01N2405/08 ,  G01N2560/00 ,  G01N2570/00 ,  G01N2800/50 ,  G01N2800/52

Abstract: In one aspect there is provided a method for predicting a risk of unhealthy ageing in a subject, comprising: (a) determining a level of two or more lipid biomarkers in a sample from the subject, wherein the biomarkers are selected from two or more of the following groups: (i) a triacylglycerol (TAG) from TAG (46:5) to TAG (54:3); (ii) an ether phosphatidylcholine (PC-O) from PC-O(28:0) to PC-O(38:6); (iii) a sphingomyelin (SM) from SM (33:1) to SM(50:1); (iv) a phosphatidylcholine (PC) from PC (32:1) to PC (40:5); (v) a phosphatidylinositol (PI) from PI (36:1) to PI (38:3); (vi) a phosphatidylethanolamine (PE) from PE (36:2) to PE (38:4); and (b) comparing the levels of the biomarkers in the sample to reference values; wherein the levels of the biomarkers in the sample compared to the reference values are indicative of the risk of unhealthy ageing in the subject.

Abstract translation: 一方面，提供了一种用于预测受试者中不健康衰老风险的方法，其包括：（a）测定来自所述受试者的样品中两种或更多种脂质生物标志物的水平，其中所述生物标志物选自 以下组：（i）TAG（46:5）至TAG（54:3）的三酰基甘油（TAG）; （ii）从PC-O（28:0）到PC-O（38:6）的醚磷脂酰胆碱（PC-O）; （iii）SM（33：1）至SM（50：1）的鞘磷脂（SM）; （iv）从PC（32:1）到PC（40:5）的磷脂酰胆碱（PC）; （v）PI（36：1）至PI（38：3）的磷脂酰肌醇（PI）; （vi）从PE（36:2）到PE（38:4）的磷脂酰乙醇胺（PE）; 和（b）将样品中生物标志物的水平与参考值进行比较; 其中与参考值相比，样品中的生物标志物的水平表明受试者中不健康老化的风险。