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    Method of detecting the presence of a liquid in a mix
    2.
    发明授权
    Method of detecting the presence of a liquid in a mix 有权
    检测混合物中液体的存在的方法

    公开(公告)号：US06952259B2

    公开(公告)日：2005-10-04

    申请号：US10296970

    申请日：2001-05-28

    申请人： Olivier Pible ,  Emmanuel Bois

    发明人： Olivier Pible ,  Emmanuel Bois

    IPC分类号： G01N21/64 ,  G01N33/542 ,  G01N35/00 ,  G01N35/02 ,  G01N35/10 ,  G01J3/30

    CPC分类号： G01N21/6428 ,  G01N33/542 ,  G01N35/00603 ,  G01N35/1009 ,  G01N2021/6439 ,  G01N2021/6443 ,  G01N2458/40

    摘要： The invention relates to a method of detecting the presence of a liquid introduced into a mix of constituents. The method comprises the following steps: excitation of the mix by a light signal in the absence of the liquid to be detected; measurement of a fluorescence signal over a time Δt characteristic of the liquid to be detected, so as to produce a reference quantity Ro; introduction of an amount of liquid to be detected in the mix; excitation of the mix by a light signal; measurement of a fluorescence signal over a time Δt so as to produce a quantity R; comparison of the quantity R with a quantity k×Ro. The invention applies to the detection of serum pipetting errors within the context of bioassays, especially immunological tests.

    摘要翻译： 本发明涉及检测引入到组分混合物中的液体的存在的方法。 该方法包括以下步骤：在不存在待检测液体的情况下通过光信号激发混合物; 在一段时间内测量荧光信号要检测的液体的特征，以产生参考量Ro; 在混合物中引入待检测的液体量; 通过光信号激发混合物; 在一段时间内测量荧光信号Deltat以产生数量R; 数量R与数量kxRo的比较。 本发明适用于在生物测定的上下文中检测血液移液误差，特别是免疫学测试。

    Fluorometric titrator
    3.
    发明授权
    Fluorometric titrator 失效
    荧光滴定仪

    公开(公告)号：US4476095A

    公开(公告)日：1984-10-09

    申请号：US460297

    申请日：1974-04-12

    申请人： Robert L. Scott ,  Samuel Nejame, Jr. ,  Charles S. Jacobs, Jr. ,  Charles A. Bell

    发明人： Robert L. Scott ,  Samuel Nejame, Jr. ,  Charles S. Jacobs, Jr. ,  Charles A. Bell

    IPC分类号： G01N1/00 ,  G01N21/79 ,  G01N31/16

    CPC分类号： G01N21/79 ,  G01N2021/6432 ,  G01N2021/6443 ,  G01N35/1095 ,  Y10T436/116664

    摘要： A fluorometric titrator has means to transfer a pipette between first and second positions and a buret for a chelating agent has a reversible drive powered either by a pulse generator or an oscillator. Valve controlled means are operable to place the buret in communication with the pipette or a reservoir. In the first position of the pipette, a precise sample volume is aspirated into it by the buret, then driven by the oscillator and in its second position and with the buret drive reversed but still powered by the oscillator, the sample volume is discharged from the pipette into a cuvette in the fluorometer. On the resulting fluorescence the fluorometer output drives the pulse generator to dispense chelating agent and to operate a counter until a selected end point is reached. The pipette is then returned to its second position with the buret drive again operated by the oscillator and during the return, the buret is refilled. Both before the sample volume is aspirated, and before that volume is discharged, backlash is removed from the buret drive. The effect of hysteresis on the photocell of the fluorometer is minimized by light control also enabling the response time of the titrator to be accelerated.

    摘要翻译： 荧光滴定仪具有在第一和第二位置之间转移移液管的手段，并且用于螯合剂的滴定管具有由脉冲发生器或振荡器供电的可逆驱动。 阀控制装置可操作以将滴定管与移液管或储液器连通。 在移液器的第一位置，通过滴定管将精确的样品体积吸入其中，然后由振荡器驱动并处于其第二位置，并且滴定管驱动器反转但仍由振荡器供电，样品体积从 移液到荧光计中的比色杯中。 在产生的荧光上，荧光计输出驱动脉冲发生器分配螯合剂并操作计数器，直到达到选定的终点。 然后，移液管返回到第二位置，滴定管驱动器再次由振荡器操作，并且在返回期间，滴定管被再填充。 在吸取样品体积之前，在排出该体积之前，从滴定管驱动器移除齿隙。 通过光控制使滞后对荧光计的光电池的影响最小化，使得能够加速滴定器的响应时间。

    Device for dispensing and observing the luminescence of individual specimens in multi-specimen arrangements
    6.
    发明授权
    Device for dispensing and observing the luminescence of individual specimens in multi-specimen arrangements 失效
    用于分配和观察多标本布置中各个样本的发光的装置

    公开(公告)号：US07371347B2

    公开(公告)日：2008-05-13

    申请号：US10630199

    申请日：2003-07-30

    申请人： Juergen Wulf ,  Werner Pongratz ,  Andreas Fina ,  Michael Heil ,  Michael Jurtz

    发明人： Juergen Wulf ,  Werner Pongratz ,  Andreas Fina ,  Michael Heil ,  Michael Jurtz

    IPC分类号： B01L3/02

    CPC分类号： G01N35/109 ,  G01N21/6428 ,  G01N21/6452 ,  G01N35/1011 ,  G01N35/1065 ,  G01N2021/6443 ,  G01N2021/6482 ,  G01N2035/0422

    摘要： The invention is directed to a device for dispensing and observing the luminescence of individual specimens in multi-specimen arrangements, particularly for the examination of biological, chemical or cytobiological assays with high specimen throughput. It is the object of the invention to find a novel possibility for dispensing in multi-specimen arrangements (microplates) and for observing the luminescence of the individual specimens, particularly for examining biological assays with high specimen throughput, which permits an immediate observation of the course of luminescence while dispensing proceeds at the same time without being limited to a determined type of microplate. This object is met, according to the invention, in that the dispensing unit has at least one linear dispensing comb containing an even number of dispensing nozzles representing an integral divisor of the number of wells along one dimension of the microplate, the dispensing combs are arranged so as to be displaceable orthogonal to their longitudinal dimension, every dispensing comb is connected to a controllable pump for metering the amount of liquid to be dispensed without immersion in the wells of the microplate, and the CCD camera is oriented by a fast optical system to a large-area rectangular region of the underside of the microplate across from the dispensing unit, the surface being adapted to the dimension of the dispensing comb and to the area of the microplate covered by the dispensing comb, so that the elapsed time for the luminescence is measurable simultaneously while dispensing continues.

    摘要翻译： 本发明涉及一种用于分配和观察多个样品装置中的各个样品的发光的装置，特别是用于以高样品生产量检查生物，化学或细胞生物学测定。 本发明的目的是找到一种新型的多样品布置（微孔板）分配和用于观察单个样品的发光的可能性，特别是用于检查具有高样品通量的生物测定法，其允许立即观察该过程 的发光，同时分配在同一时间进行，而不限于确定类型的微孔板。 根据本发明，符合本发明的目的在于，分配单元具有至少一个线性分配梳，其包含偶数个分配喷嘴，分配喷嘴表示沿着微孔板的一个维度的孔数的积分因子，分配梳被布置 为了能够与其纵向尺寸正交地移动，每个分配梳都连接到可控制的泵，用于计量待分配的液体量而不浸没在微板的孔中，并且CCD相机通过快速光学系统定向 微孔板下面的从分配单元的大面积矩形区域，该表面适于分配梳的尺寸和由分配梳覆盖的微板的面积，使得发光的经过时间 可同时测量，同时分配持续。