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公开(公告)号：US20190010463A1
公开(公告)日：2019-01-10
申请号：US16044413
申请日：2018-07-24
IPC分类号： C12N5/071 , C12M3/04 , C12N5/077 , C12N5/0775 , C12N5/0781 , C12N5/00 , C12N5/0783 , C12N5/0784
CPC分类号： C12N5/0671 , C07K16/00 , C07K16/1081 , C07K2317/21 , C07K2317/76 , C12M3/04 , C12N5/0018 , C12N5/0062 , C12N5/0635 , C12N5/0637 , C12N5/0638 , C12N5/064 , C12N5/0667 , C12N5/0669 , C12N5/0691 , C12N5/0697 , C12N5/0698 , C12N2502/09 , C12N2502/094 , C12N2502/1114 , C12N2502/1121 , C12N2502/1323 , C12N2502/45 , C12N2506/1384 , C12N2506/28 , C12N2510/02 , C12N2513/00 , C12N2527/00 , C12N2533/30 , C12N2533/54 , C12N2533/74 , C12N2533/76 , C12N2533/80 , C12N2539/10
摘要： Provided herein are methods and systems for bio-printing of three-dimensional organs and organoids. Also provided herein are bio-printed three-dimensional organs and organoids for use in the generation and/or the assessment of immunological products and/or immune responses. Also provided herein are methods and system for bio-printing three-dimensional matrices.
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2.发明授权公开(公告)号：US09074182B2
公开(公告)日：2015-07-07
申请号：US13679663
申请日：2012-11-16
IPC分类号： C12N5/074 , C12N5/0797
CPC分类号： C12N5/0622 , C12N5/0081 , C12N5/0607 , C12N5/0623 , C12N2502/09 , C12N2502/23 , C12N2506/02
摘要： The invention provides methods for depleting extraneous phenotypes from a mixed population of cells comprising the in vitro differentiated progeny of primate pluripotent stem cells. The invention also provides mixed cell populations enriched for a target cell phenotype where the mixed cell population comprises the differentiated in vitro progeny of primate embryonic stem cells.
摘要翻译： 本发明提供从包含灵长类动物多能干细胞的体外分化后代的混合细胞群体中消耗外来表型的方法。 本发明还提供了富集靶细胞表型的混合细胞群，其中混合细胞群体包含灵长类动物胚胎干细胞分化的体外后代。
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3.发明申请公开(公告)号：US20100330670A1
公开(公告)日：2010-12-30
申请号：US12823739
申请日：2010-06-25
IPC分类号： C12N5/00
CPC分类号： C12N5/0622 , C12N5/0081 , C12N5/0607 , C12N5/0623 , C12N2502/09 , C12N2502/23 , C12N2506/02
摘要： The invention provides methods for depleting extraneous phenotypes from a mixed population of cells comprising the in vitro differentiated progeny of primate pluripotent stem cells. The invention also provides mixed cell populations enriched for a target cell phenotype where the mixed cell population comprises the differentiated in vitro progeny of primate embryonic stem cells.
摘要翻译： 本发明提供从包含灵长类动物多能干细胞的体外分化后代的混合细胞群体中消耗外来表型的方法。 本发明还提供了富集靶细胞表型的混合细胞群，其中混合细胞群体包含灵长类动物胚胎干细胞分化的体外后代。
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4.发明申请公开(公告)号：US20170281528A1
公开(公告)日：2017-10-05
申请号：US15625541
申请日：2017-06-16
申请人： Jordan Fabrikant
发明人： Jordan Fabrikant
IPC分类号： A61K8/98 , A61L27/38 , A61L27/54 , B33Y70/00 , B29C67/00 , B33Y10/00 , B33Y80/00 , A61Q7/00 , C12N5/071
CPC分类号： A61K8/985 , A61K35/36 , A61L27/3804 , A61L27/3813 , A61L27/3834 , A61L27/3891 , A61L27/54 , A61Q7/00 , B29K2089/00 , B29K2995/0056 , B33Y70/00 , B33Y80/00 , C12N5/0062 , C12N5/0627 , C12N2501/10 , C12N2502/09 , C12N2506/094
摘要： The present invention recognizes that there exists a long felt need for reliable hair growth methods and compositions that do not suffer from side effects and limitations of current technologies, such as surgery using a subject's own hair and pharmaceutical compositions. A first aspect of the present invention is a method of making at least one three dimensional collection of cells capable of forming a functional hair follicle. A second aspect of the present invention is a product produced by the method of making at least one three dimensional collection of cells capable of forming a functional hair follicle of the present invention. A third aspect of the present invention is a method of making at least one functional hair follicle. A fourth aspect of the present invention is a product produced by the method of making at least one functional hair follicle of the present invention. A fifth aspect of the present invention is a method of hair growth in a subject using at least one three dimensional collection of cells capable of forming a functional hair follicle of the present invention. A sixth aspect of the present invention is a method of hair growth in a subject using at least one functional hair follicle of the present invention.
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5.发明申请PREPARATION AND USE OF FISH SKIN FERMENTATION LIQUID OBTAINED BY FERMENTING FISH SKIN WITH ASPERGILLUS 有权通过用ASPERGILLUS发酵鱼皮来获得的鱼皮发酵液的制备和使用公开(公告)号：US20160263165A1
公开(公告)日：2016-09-15
申请号：US15163005
申请日：2016-05-24
发明人： SHU-CHEN HUANG , PEI-JOU LIU , CHIAO-MING LIAO , HING-YUEN CHAN
CPC分类号： A61K35/60 , A23L17/00 , A23L17/65 , C12N9/0071 , C12N2502/09 , C12P1/02 , C12Y114/18001
摘要： The present invention relates to a method for fermenting fish skin by using Aspergillus. Also provided is a use of the fermentation liquid obtained by fermenting fish skin with Aspergillus obtained from the method in inhibiting the activity of tyrosinase, inhibiting the activity of angiotensin-converting enzyme and/or improving the survival of fibroblasts.
摘要翻译： 本发明涉及使用曲霉菌发酵鱼皮的方法。 还提供了通过从抑制酪氨酸酶的活性，抑制血管紧张素转化酶的活性和/或改善成纤维细胞的存活的方法获得的用曲霉发酵鱼皮获得的发酵液的用途。
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公开(公告)号：US20150071877A1
公开(公告)日：2015-03-12
申请号：US14539910
申请日：2014-11-12
发明人： Greg Maguire , Peter Friedman
IPC分类号： A61K38/39 , A61Q7/00 , A61K38/17 , A61K8/65 , A61K38/19 , A61K38/18 , A61K38/30 , A61K8/64 , A61K38/20 , A61K31/728
CPC分类号： A61K8/985 , A61K8/64 , A61K8/65 , A61K8/981 , A61K31/728 , A61K35/12 , A61K35/28 , A61K35/33 , A61K2800/59 , A61K2800/70 , A61K2800/86 , A61Q7/00 , C12N5/0667 , C12N2502/09 , C12N2502/092 , C12N2502/1323 , C12N2502/1382
摘要： A method for preparing a bioactive composition containing conditioned cell culture medium is disclosed. The method comprises culturing cells of two or more eukaryotic cell line to form conditioned culture media, separating the cultured cells from the conditioned culture media, and combining conditioned culture media to form a bioactive composition. Novel bioactive compositions, formulations and their use in treating of a variety of diseases and health conditions are also disclosed.
摘要翻译： 公开了一种制备含有条件细胞培养基的生物活性组合物的方法。 该方法包括培养两个或多个真核生物细胞系的细胞以形成条件培养基，将培养的细胞与条件培养基分离，并将条件培养基合并形成生物活性组合物。 还公开了新的生物活性组合物，制剂及其在治疗各种疾病和健康状况中的用途。
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公开(公告)号：US09782444B2
公开(公告)日：2017-10-10
申请号：US15163005
申请日：2016-05-24
发明人： Shu-Chen Huang , Pei-Jou Liu , Chiao-Ming Liao , Hing-Yuen Chan
CPC分类号： A61K35/60 , A23L17/00 , A23L17/65 , C12N9/0071 , C12N2502/09 , C12P1/02 , C12Y114/18001
摘要： The present invention relates to a method for fermenting fish skin by using Aspergillus. Also provided is a use of the fermentation liquid obtained by fermenting fish skin with Aspergillus obtained from the method in inhibiting the activity of tyrosinase, inhibiting the activity of angiotensin-converting enzyme and/or improving the survival of fibroblasts.
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公开(公告)号：US20170095416A1
公开(公告)日：2017-04-06
申请号：US15382463
申请日：2016-12-16
发明人： Greg Maguire
CPC分类号： A61K8/985 , A61K8/64 , A61K8/65 , A61K8/981 , A61K31/728 , A61K35/12 , A61K35/28 , A61K35/33 , A61K2800/59 , A61K2800/70 , A61K2800/86 , A61Q7/00 , C12N5/0667 , C12N2502/09 , C12N2502/092 , C12N2502/1323 , C12N2502/1382
摘要： A method for preparing a bioactive composition containing conditioned cell culture medium is disclosed. The method comprises culturing cells of two or more eukaryotic cell line to form conditioned culture media, separating the cultured cells from the conditioned culture media, and combining conditioned culture media to form a bioactive composition. Novel bioactive compositions, formulations and their use in treating of a variety of diseases and health conditions are also disclosed.
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公开(公告)号：US20170058264A1
公开(公告)日：2017-03-02
申请号：US14787648
申请日：2015-05-19
IPC分类号： C12N5/09
CPC分类号： C12N5/0693 , C12N2502/09 , C12N2502/095 , C12N2502/1323 , C12N2502/1358 , C12N2503/02 , C12N2513/00
摘要： Described herein are compositions and methods of forming multi-cellular tumoroids. Also described herein are methods of using the multi-cellular tumoroids.
摘要翻译： 本文描述了形成多细胞肿瘤样物质的组合物和方法。 本文还描述了使用多细胞肿瘤样物质的方法。
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公开(公告)号：US09545370B2
公开(公告)日：2017-01-17
申请号：US14539910
申请日：2014-11-12
发明人： Greg Maguire
IPC分类号： A61K35/33 , A61K35/28 , A61K8/64 , C12N5/0775 , A61K8/65 , A61Q7/00 , A61K31/728 , A61K35/12
CPC分类号： A61K8/985 , A61K8/64 , A61K8/65 , A61K8/981 , A61K31/728 , A61K35/12 , A61K35/28 , A61K35/33 , A61K2800/59 , A61K2800/70 , A61K2800/86 , A61Q7/00 , C12N5/0667 , C12N2502/09 , C12N2502/092 , C12N2502/1323 , C12N2502/1382
摘要： A method for preparing a bioactive composition containing conditioned cell culture medium is disclosed. The method comprises culturing cells of two or more eukaryotic cell line to form conditioned culture media, separating the cultured cells from the conditioned culture media, and combining conditioned culture media to form a bioactive composition. Novel bioactive compositions, formulations and their use in treating of a variety of diseases and health conditions are also disclosed.
摘要翻译： 公开了一种制备含有条件细胞培养基的生物活性组合物的方法。 该方法包括培养两个或多个真核生物细胞系的细胞以形成条件培养基，将培养的细胞与条件培养基分离，并将条件培养基合并形成生物活性组合物。 还公开了新的生物活性组合物，制剂及其在治疗各种疾病和健康状况中的用途。
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