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1.发明申请COMPOSITION DERIVED FROM STEM CELL RELEASED MOLECULES & METHODS FOR FORMULATION THEREOF 审中-公开从干细胞释放的分子衍生的组合物及其制备方法公开(公告)号：US20170000724A1
公开(公告)日：2017-01-05
申请号：US15266951
申请日：2016-09-15
发明人： Greg Maguire
CPC分类号： A61K8/981 , A61K35/12 , A61K35/28 , A61K35/33 , A61K2800/74 , A61Q7/00 , C12N5/0628 , C12N5/0656 , C12N5/0667
摘要： Compositions for use in treatment of a variety of tissue diseases include stem cells and stem cell released molecules (SRM's) suspended in an aqueous solution with a cellulosic material or other thickening agent. The stem cells and SRM's can be derived from one or more distinct cell lines. The SRM's can further include one or more mucins, cytokines, or growth factors. Exemplary formulations include stem cells and SRMs derived from epithelial stem cells, corneal limbal stem cells, and fibroblasts. Other compositions and methods for formulation thereof are described.
摘要翻译： 用于治疗各种组织疾病的组合物包括用纤维素材料或其它增稠剂悬浮在水溶液中的干细胞和干细胞释放分子（SRM）。 干细胞和SRM可以衍生自一个或多个不同的细胞系。 SRM可以进一步包括一种或多种粘蛋白，细胞因子或生长因子。 示例性制剂包括源自上皮干细胞，角膜缘干细胞和成纤维细胞的干细胞和SRM。 其他组合物及其配制方法进行了描述。
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2.发明授权Compositions derived from stem cell released molecules and methods for formulation thereof 有权衍生自干细胞释放分子的组合物及其制备方法公开(公告)号：US09446075B2
公开(公告)日：2016-09-20
申请号：US14218926
申请日：2014-03-18
发明人： Greg Maguire
CPC分类号： A61K8/981 , A61K35/12 , A61K35/28 , A61K35/33 , A61K2800/74 , A61Q7/00 , C12N5/0628 , C12N5/0656 , C12N5/0667
摘要： Compositions for use in treatment of a variety of tissue diseases include stem cells and stem cell released molecules (SRM's) suspended in an aqueous solution with a cellulosic material or other thickening agent. The stem cells and SRM's can be derived from one or more distinct cell lines. The SRM's can further include one or more mucins, cytokines, or growth factors. Exemplary formulations include stem cells and SRMs derived from epithelial stem cells, corneal limbal stem cells, and fibroblasts. Other compositions and methods for formulation thereof are described.
摘要翻译： 用于治疗各种组织疾病的组合物包括用纤维素材料或其它增稠剂悬浮在水溶液中的干细胞和干细胞释放分子（SRM）。 干细胞和SRM可以衍生自一个或多个不同的细胞系。 SRM可以进一步包括一种或多种粘蛋白，细胞因子或生长因子。 示例性制剂包括源自上皮干细胞，角膜缘干细胞和成纤维细胞的干细胞和SRM。 其他组合物及其配制方法进行了描述。
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公开(公告)号：US20150071877A1
公开(公告)日：2015-03-12
申请号：US14539910
申请日：2014-11-12
发明人： Greg Maguire , Peter Friedman
IPC分类号： A61K38/39 , A61Q7/00 , A61K38/17 , A61K8/65 , A61K38/19 , A61K38/18 , A61K38/30 , A61K8/64 , A61K38/20 , A61K31/728
CPC分类号： A61K8/985 , A61K8/64 , A61K8/65 , A61K8/981 , A61K31/728 , A61K35/12 , A61K35/28 , A61K35/33 , A61K2800/59 , A61K2800/70 , A61K2800/86 , A61Q7/00 , C12N5/0667 , C12N2502/09 , C12N2502/092 , C12N2502/1323 , C12N2502/1382
摘要： A method for preparing a bioactive composition containing conditioned cell culture medium is disclosed. The method comprises culturing cells of two or more eukaryotic cell line to form conditioned culture media, separating the cultured cells from the conditioned culture media, and combining conditioned culture media to form a bioactive composition. Novel bioactive compositions, formulations and their use in treating of a variety of diseases and health conditions are also disclosed.
摘要翻译： 公开了一种制备含有条件细胞培养基的生物活性组合物的方法。 该方法包括培养两个或多个真核生物细胞系的细胞以形成条件培养基，将培养的细胞与条件培养基分离，并将条件培养基合并形成生物活性组合物。 还公开了新的生物活性组合物，制剂及其在治疗各种疾病和健康状况中的用途。
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公开(公告)号：US20170095416A1
公开(公告)日：2017-04-06
申请号：US15382463
申请日：2016-12-16
发明人： Greg Maguire
CPC分类号： A61K8/985 , A61K8/64 , A61K8/65 , A61K8/981 , A61K31/728 , A61K35/12 , A61K35/28 , A61K35/33 , A61K2800/59 , A61K2800/70 , A61K2800/86 , A61Q7/00 , C12N5/0667 , C12N2502/09 , C12N2502/092 , C12N2502/1323 , C12N2502/1382
摘要： A method for preparing a bioactive composition containing conditioned cell culture medium is disclosed. The method comprises culturing cells of two or more eukaryotic cell line to form conditioned culture media, separating the cultured cells from the conditioned culture media, and combining conditioned culture media to form a bioactive composition. Novel bioactive compositions, formulations and their use in treating of a variety of diseases and health conditions are also disclosed.
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公开(公告)号：US09545370B2
公开(公告)日：2017-01-17
申请号：US14539910
申请日：2014-11-12
发明人： Greg Maguire
IPC分类号： A61K35/33 , A61K35/28 , A61K8/64 , C12N5/0775 , A61K8/65 , A61Q7/00 , A61K31/728 , A61K35/12
CPC分类号： A61K8/985 , A61K8/64 , A61K8/65 , A61K8/981 , A61K31/728 , A61K35/12 , A61K35/28 , A61K35/33 , A61K2800/59 , A61K2800/70 , A61K2800/86 , A61Q7/00 , C12N5/0667 , C12N2502/09 , C12N2502/092 , C12N2502/1323 , C12N2502/1382
摘要： A method for preparing a bioactive composition containing conditioned cell culture medium is disclosed. The method comprises culturing cells of two or more eukaryotic cell line to form conditioned culture media, separating the cultured cells from the conditioned culture media, and combining conditioned culture media to form a bioactive composition. Novel bioactive compositions, formulations and their use in treating of a variety of diseases and health conditions are also disclosed.
摘要翻译： 公开了一种制备含有条件细胞培养基的生物活性组合物的方法。 该方法包括培养两个或多个真核生物细胞系的细胞以形成条件培养基，将培养的细胞与条件培养基分离，并将条件培养基合并形成生物活性组合物。 还公开了新的生物活性组合物，制剂及其在治疗各种疾病和健康状况中的用途。
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