公开(公告)号：US20240277803A1

公开(公告)日：2024-08-22

申请号：US18439331

申请日：2024-02-12

申请人： Minerva Biotechnologies Corporation

发明人： Cynthia Bamdad ,  Benoit Smagghe

IPC分类号： A61K38/17 ,  A01K67/0271 ,  A61K38/45 ,  A61K39/395 ,  A61K49/00 ,  A61P35/00 ,  C07K14/47 ,  C07K16/18 ,  C07K16/30 ,  C07K16/40 ,  C12N9/12 ,  G01N33/50 ,  G01N33/574

CPC分类号： A61K38/1735 ,  A61P35/00 ,  A01K67/0271 ,  A01K2267/0331 ,  A61K38/45 ,  A61K39/3955 ,  A61K49/0008 ,  C07K14/4727 ,  C07K16/18 ,  C07K16/3092 ,  C07K16/40 ,  C12N9/1229 ,  C12Y207/04006 ,  G01N33/5073 ,  G01N33/574 ,  G01N2333/71 ,  G01N2500/10 ,  G01N2800/56

摘要： The present application discloses inhibitors of NME family of proteins.

公开(公告)号：US11806366B2

公开(公告)日：2023-11-07

申请号：US17245031

申请日：2021-04-30

申请人： Immatics Biotechnologies GmbH

发明人： Heiko Schuster ,  Janet Peper ,  Philipp Wagner ,  Hans-Georg Rammensee

IPC分类号： A61K39/00 ,  A61K35/17 ,  C07K14/47 ,  C07K7/06 ,  C07K7/08 ,  C07K14/725 ,  C07K16/30 ,  C12N15/115 ,  C12P21/02 ,  C12Q1/6881 ,  C12Q1/6886 ,  G01N33/574

CPC分类号： A61K35/17 ,  A61K39/0011 ,  C07K7/06 ,  C07K7/08 ,  C07K14/4727 ,  C07K14/4748 ,  C07K14/7051 ,  C07K16/30 ,  C12N15/115 ,  C12P21/02 ,  C12Q1/6881 ,  C12Q1/6886 ,  G01N33/57484 ,  A61K2039/5158 ,  C12N2310/16 ,  C12Q2600/136 ,  C12Q2600/156 ,  C12Q2600/158 ,  G01N2333/70539 ,  G01N2500/04

摘要： The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.

公开(公告)号：US11732017B2

公开(公告)日：2023-08-22

申请号：US17240260

申请日：2021-04-26

申请人： The USA, as represented by the Secretary, Dept. of Health and Human Services

发明人： Jeffrey Schlom ,  Kwong-Yok Tsang

IPC分类号： C07K14/47 ,  C07K14/82 ,  A61K38/19 ,  A61K38/20 ,  A61K38/21 ,  A61K38/22 ,  A61K31/00 ,  A61K45/06 ,  A61K39/00 ,  A61K39/39 ,  C12N7/00 ,  A61K38/00

CPC分类号： C07K14/4727 ,  A61K31/00 ,  A61K38/191 ,  A61K38/193 ,  A61K38/195 ,  A61K38/20 ,  A61K38/217 ,  A61K38/22 ,  A61K39/00117 ,  A61K39/39 ,  A61K45/06 ,  C07K14/82 ,  C12N7/00 ,  A61K38/00 ,  A61K2039/5154 ,  A61K2039/53 ,  A61K2039/55588 ,  C07K2319/00 ,  C12N2710/24143 ,  C12N2710/24171 ,  A61K38/20 ,  A61K2300/00 ,  A61K38/217 ,  A61K2300/00 ,  A61K38/191 ,  A61K2300/00 ,  A61K38/195 ,  A61K2300/00 ,  A61K38/193 ,  A61K2300/00 ,  A61K38/22 ,  A61K2300/00 ,  A61K31/00 ,  A61K2300/00

摘要： The invention provides a human cytotoxic T lymphocyte (CTL) agonist epitope from the C-terminal subunit of mucin 1 (MUC1-C), which can be used as a peptide, polypeptide (protein), and/or in vaccine or other composition for the prevention or therapy of cancer. The invention further provides a nucleic acid encoding the peptide, protein, or polypeptide, a vector comprising the nucleic acid, a cell comprising the peptide, polypeptide, nucleic acid, or vector, and compositions thereof.

公开(公告)号：US20230241107A1

公开(公告)日：2023-08-03

申请号：US18047236

申请日：2022-10-17

申请人： Immatics Biotechnologies GmbH

发明人： Heiko SCHUSTER ,  Janet PEPER ,  Philipp WAGNER ,  Hans-Georg RAMMENSEE

IPC分类号： A61K35/17 ,  C07K14/47 ,  A61K39/00 ,  C07K7/06 ,  C07K7/08 ,  C07K14/725 ,  C07K16/30 ,  C12N15/115 ,  C12P21/02 ,  C12Q1/6881 ,  C12Q1/6886 ,  G01N33/574

CPC分类号： A61K35/17 ,  C07K14/4748 ,  A61K39/0011 ,  C07K7/06 ,  C07K7/08 ,  C07K14/4727 ,  C07K14/7051 ,  C07K16/30 ,  C12N15/115 ,  C12P21/02 ,  C12Q1/6881 ,  C12Q1/6886 ,  G01N33/57484 ,  A61K2039/5158 ,  C12N2310/16 ,  C12Q2600/136 ,  C12Q2600/156 ,  C12Q2600/158 ,  G01N2333/70539 ,  G01N2500/04

摘要： The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.

公开(公告)号：US20230190813A1

公开(公告)日：2023-06-22

申请号：US18047195

申请日：2022-10-17

申请人： Immatics Biotechnologies GmbH

发明人： Heiko SCHUSTER ,  Janet PEPER ,  Philipp WAGNER ,  Hans-Georg RAMMENSEE

IPC分类号： A61K35/17 ,  C07K14/47 ,  A61K39/00 ,  C07K7/06 ,  C07K7/08 ,  C07K14/725 ,  C07K16/30 ,  C12N15/115 ,  C12P21/02 ,  C12Q1/6881 ,  C12Q1/6886 ,  G01N33/574

CPC分类号： A61K35/17 ,  C07K14/4748 ,  A61K39/0011 ,  C07K7/06 ,  C07K7/08 ,  C07K14/4727 ,  C07K14/7051 ,  C07K16/30 ,  C12N15/115 ,  C12P21/02 ,  C12Q1/6881 ,  C12Q1/6886 ,  G01N33/57484 ,  A61K2039/5158 ,  C12N2310/16 ,  C12Q2600/136 ,  C12Q2600/156 ,  C12Q2600/158 ,  G01N2333/70539 ,  G01N2500/04

摘要： The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.

公开(公告)号：US20190002513A1

公开(公告)日：2019-01-03

申请号：US16034654

申请日：2018-07-13

申请人： The USA, as represented by the Secretary, Dept. of Health and Human Services

发明人： Jeffrey Schlom ,  Kwong-Yok Tsang

IPC分类号： C07K14/47 ,  C12N7/00 ,  A61K38/19 ,  A61K38/20 ,  A61K38/22 ,  A61K31/00 ,  C07K14/82 ,  A61K45/06 ,  A61K39/39 ,  A61K39/00 ,  A61K38/21 ,  A61K38/00

CPC分类号： C07K14/4727 ,  A61K31/00 ,  A61K38/00 ,  A61K38/191 ,  A61K38/193 ,  A61K38/195 ,  A61K38/20 ,  A61K38/217 ,  A61K38/22 ,  A61K39/0011 ,  A61K39/39 ,  A61K45/06 ,  A61K2039/5154 ,  A61K2039/53 ,  A61K2039/55588 ,  C07K14/82 ,  C07K2319/00 ,  C12N7/00 ,  C12N2710/24143 ,  C12N2710/24171 ,  A61K2300/00

摘要： The invention provides a human cytotoxic T lymphocyte (CTL) agonist epitope from the C-terminal subunit of mucin 1 (MUC1-C), which can be used as a peptide, polypeptide (protein), and/or in vaccine or other composition for the prevention or therapy of cancer. The invention further provides a nucleic acid encoding the peptide, protein, or polypeptide, a vector comprising the nucleic acid, a cell comprising the peptide, polypeptide, nucleic acid, or vector, and compositions thereof.

公开(公告)号：US20170362288A1

公开(公告)日：2017-12-21

申请号：US15633184

申请日：2017-06-26

申请人： PRECISION BIOLOGICS, INC.

发明人： Xue-Ping WANG

IPC分类号： C07K14/47 ,  A61K47/64 ,  A61K45/06 ,  G01N33/574 ,  C07K16/30 ,  A61K39/00 ,  A61K38/00

CPC分类号： C07K14/4727 ,  A61K38/00 ,  A61K39/0011 ,  A61K45/06 ,  A61K47/64 ,  A61K47/643 ,  A61K47/645 ,  A61K47/646 ,  A61K2039/505 ,  C07K14/4748 ,  C07K16/3092 ,  C07K2317/34 ,  C07K2317/732 ,  C07K2319/00 ,  G01N33/57419 ,  G01N33/57438 ,  G01N2333/4725

摘要： The invention relates to a peptidomimetic of an NPC-1 epitope on the MUC5AC protein which is differentially expressed in pancreatic and colorectal cancer, and diagnostic and therapeutic usages. Further, antibodies that selectively bind the NPC-1 epitope peptidomimetics and may be used in diagnostic and therapeutic methods.

公开(公告)号：US20170355777A1

公开(公告)日：2017-12-14

申请号：US15615588

申请日：2017-06-06

申请人： University of Leicester ,  Omeros Corporation

发明人： Hans-Wilhelm Schwaeble ,  Gregory A. Demopulos

IPC分类号： C07K16/30 ,  G01N33/574 ,  A61K47/68

CPC分类号： C07K16/3092 ,  A61K47/6859 ,  A61K47/6869 ,  C07K14/4727 ,  C07K16/3015 ,  C07K2317/34 ,  C07K2317/56 ,  C07K2317/565 ,  G01N33/57438 ,  G01N33/57449 ,  G01N33/57492 ,  G01N2333/4725

摘要： In various embodiments the invention provides anti-mucin-like protein (MLP) monoclonal antibodies, compositions and methods for detecting MLP as a biomarker for mucin-secreting type of cancer such as ovarian or pancreatic cancer.

公开(公告)号：US20170290889A1

公开(公告)日：2017-10-12

申请号：US15484555

申请日：2017-04-11

申请人： New York University

发明人： P'ng Loke ,  Kenneth Cadwell ,  Deepshika Ramanan ,  Rowann Bowcutt

IPC分类号： A61K38/20 ,  A61K35/62 ,  A61K35/74 ,  A61K38/17

CPC分类号： A61K38/20 ,  A61K35/62 ,  A61K35/74 ,  A61K38/1735 ,  A61K38/2026 ,  A61K38/2086 ,  C07K14/4727 ,  C07K14/54 ,  C07K14/5406 ,  C07K14/5437 ,  C07K2319/30 ,  A61K2300/00

摘要： The present invention relates to the use of type 2 cytokines and mucins for increasing the amount or activity of bacterial species of the Clostridia class in the gastrointestinal tract, for treating dysbiosis in the gastrointestinal tract, for treating gastrointestinal and inflammatory disorders, and for promoting wound healing in the gastrointestinal tract.

公开(公告)号：US20170072037A1

公开(公告)日：2017-03-16

申请号：US15362233

申请日：2016-11-28

申请人： The University of Toledo

发明人： Steven J. Sucheck ,  Katherine A. Wall ,  Sourav Sarkar

IPC分类号： A61K39/00 ,  A61K9/00 ,  A61K39/39 ,  A61K9/127

CPC分类号： A61K39/0011 ,  A61K9/0019 ,  A61K9/127 ,  A61K39/0012 ,  A61K39/39 ,  A61K47/543 ,  A61K47/6925 ,  A61K2039/55516 ,  A61K2039/55555 ,  A61K2039/55572 ,  A61K2039/6018 ,  A61K2039/627 ,  C07C323/60 ,  C07K7/06 ,  C07K7/08 ,  C07K14/4727 ,  C07K14/705 ,  C07K16/1275 ,  C07K16/3092 ,  C07K2317/34

摘要： Compositions, methods of making, and methods of using, xenoantigen-displaying anti-cancer vaccines are described.

摘要翻译： 描述了组合物，制备方法和使用异种野生型显示抗癌疫苗的方法。