发明授权
- 专利标题： HLA-A24 agonist epitopes of MUC1-C oncoprotein and compositions and methods of use
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申请号： US17240260申请日： 2021-04-26
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公开(公告)号： US11732017B2公开(公告)日： 2023-08-22
- 发明人: Jeffrey Schlom , Kwong-Yok Tsang
- 申请人： The USA, as represented by the Secretary, Dept. of Health and Human Services
- 申请人地址： US MD Bethesda
- 专利权人： The USA, as represented by the Secretary, Dept. of Health and Human Services
- 当前专利权人： The USA, as represented by the Secretary, Dept. of Health and Human Services
- 当前专利权人地址： US MD Bethesda
- 代理机构： Sheridan Ross P.C.
- 分案原申请号： US16715038 2019.12.16
- 主分类号： C07K14/47
- IPC分类号： C07K14/47 ; C07K14/82 ; A61K38/19 ; A61K38/20 ; A61K38/21 ; A61K38/22 ; A61K31/00 ; A61K45/06 ; A61K39/00 ; A61K39/39 ; C12N7/00 ; A61K38/00
摘要：
The invention provides a human cytotoxic T lymphocyte (CTL) agonist epitope from the C-terminal subunit of mucin 1 (MUC1-C), which can be used as a peptide, polypeptide (protein), and/or in vaccine or other composition for the prevention or therapy of cancer. The invention further provides a nucleic acid encoding the peptide, protein, or polypeptide, a vector comprising the nucleic acid, a cell comprising the peptide, polypeptide, nucleic acid, or vector, and compositions thereof.
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