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公开(公告)号：US12005115B2
公开(公告)日：2024-06-11
申请号：US16922322
申请日：2020-07-07
发明人： Masaru Kanekiyo , Gary J. Nabel , Jeffrey Cohen , Wei Bu
IPC分类号： A61K39/245 , A61K39/12 , C07K14/00 , C07K14/005 , C07K14/195 , C07K16/08 , C12N7/00 , A61K39/00
CPC分类号： A61K39/245 , A61K39/12 , C07K14/00 , C07K14/005 , C07K14/195 , C07K16/085 , C12N7/00 , A61K2039/55505 , A61K2039/575 , A61K2039/64 , C07K2317/33 , C07K2317/76 , C07K2319/00 , C07K2319/40 , C07K2319/735 , C12N2710/16222 , C12N2710/16234 , C12N2710/16271
摘要： Vaccines are provided that elicit neutralizing antibodies to Epstein-Barr virus (EBV). Some vaccines comprise nanoparticles that display envelope proteins from EBV on their surface. The nanoparticles comprise fusion proteins comprising a monomeric subunit of a self-assembly protein, such as ferritin, joined to at least a portion of an EBV envelope protein. The fusion proteins self-assemble to form the envelope protein-displaying nanoparticles. Such vaccines can be used to vaccinate an individual against infection by different types of Epstein-Barr viruses as well as Epstein-Barr viruses that are antigenically divergent from the virus from which the EBV envelope protein was obtained. Also provided are fusion proteins and nucleic acid molecules encoding such proteins.
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公开(公告)号：US11827669B2
公开(公告)日：2023-11-28
申请号：US16631290
申请日：2018-07-19
IPC分类号： C07K16/08 , A61K47/68 , A61K45/06 , A61K39/00 , G01N33/569
CPC分类号： C07K16/082 , A61K45/06 , A61K47/6839 , G01N33/56994 , A61K2039/585 , C07K2317/24 , C07K2317/31 , C07K2317/33 , C07K2317/55 , C07K2317/565 , C07K2317/92 , G01N2333/02 , G01N2469/10 , G01N2800/26
摘要： Antibodies and compositions of matter useful for the detection, diagnosis and treatment of Hepatitis B Virus infection in mammals, and to methods of using those compositions of matter for the same.
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公开(公告)号：US11590216B2
公开(公告)日：2023-02-28
申请号：US17130551
申请日：2020-12-22
申请人： GLOBEIMMUNE, INC. , The USA, as represented by the Secretary, Dept. of Health and Human Services
发明人： James Hodge , Jeffrey Schlom , Alex Franzusoff
摘要： Disclosed are immunotherapeutic compositions and the concurrent use of combinations of such compositions for the improved induction of therapeutic immune responses and/or for the prevention, amelioration and/or treatment of disease, including, but not limited to, cancer and infectious disease.
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公开(公告)号：US11549125B2
公开(公告)日：2023-01-10
申请号：US16637152
申请日：2017-08-09
发明人： Lina Li , Robert Kotin
摘要： Closed-ended, linear, duplex (CELID) DNA molecules, recombinant AAV (rAAV), particles comprising CELID DNA, methods of making such molecules and particles, and therapeutic applications of such particles.
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公开(公告)号：US11065318B2
公开(公告)日：2021-07-20
申请号：US16211492
申请日：2018-12-06
申请人： GlobeImmune, Inc. , The USA, as represented by the Secretary, Dept. of Health and Human Services
发明人： Alex Franzusoff , Zhimin Guo , Jeffrey Schlom , Kwong-Yok Tsang
IPC分类号： A61K39/00 , C07K14/47 , A61K35/13 , A61K35/17 , A61K35/28 , A61K31/65 , A61K31/704 , A61K31/7068
摘要： Disclosed are yeast-based immunotherapeutic compositions comprising mucin-1 (MUC1), as well as methods for the prevention and/or treatment of cancers characterized by the expression or overexpression of mucin-1 (MUC1).
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公开(公告)号：US20210106666A1
公开(公告)日：2021-04-15
申请号：US17129633
申请日：2020-12-21
申请人： GlobeImmune, Inc. , The USA, as represented by the Secretary, Dept. of Health and Human Services
发明人： Claudia Palena , Zhimin Guo , David Apelian , Jeffrey Schlom
IPC分类号： A61K39/00 , A61K38/17 , A61K36/064 , A61K45/06 , A61N5/10 , C07K14/435
摘要： Disclosed are yeast-based immunotherapeutic compositions comprising Brachyury antigens, and methods for the prevention and/or treatment of cancers characterized by the expression or overexpression of Brachyury.
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7.发明申请公开(公告)号：US20210101872A1
公开(公告)日：2021-04-08
申请号：US16976012
申请日：2019-03-08
申请人： The USA, as represented by the Secretary, Dept. of Health and Human Services , Pontificia Universidad Católica de Chile
发明人： Juan J. Marugan , Marc Ferrer , Noel T. Southall , Andres E. Dulcey , Xin Hu , Christopher R. Dextras , Daniel C. Talley , Alejandra Alvarez , Silvana Zanlungo , Rommy M. Von Bernhardi
IPC分类号： C07D243/38 , C07D267/20 , C07F7/08 , C07D281/16 , C07D267/18 , C07C227/22 , C07C201/12 , C07C319/14 , C07D401/04 , C07D403/04 , C07D413/10 , C07F5/02 , C07D413/04 , C07D471/04 , C07D487/04 , C07D413/14 , C07D417/04 , A61P33/06 , A61P25/28 , A61P25/08 , A61P35/02 , A61K31/554 , A61K31/5513 , A61K31/553
摘要： Disclosed herein are embodiments of a compound that inhibits c-Abl tyrosine kinase (also referred to herein as “c-Abl”). The compound embodiments described herein are novel c-Abl inhibitors that can bind to c-Abl at an allosteric site and inhibit its activity in various pathways. The compound embodiments also are capable of crossing the blood brain barrier and therefore are useful in inhibiting c-Abl activity as it affects pathways and/or proteins in the brain. The compound embodiments described herein are effective therapeutic agents for treating diseases involving c-Abl, such as cancers, motor neuron diseases, and neurodegenerative diseases. Also disclosed herein are embodiments of methods for making and using the c-Abl inhibitory compound embodiments.
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8.发明授权公开(公告)号：US10925938B2
公开(公告)日：2021-02-23
申请号：US16250514
申请日：2019-01-17
申请人： THE USA, AS REPRESENTED BY THE SECRETARY, DEPT. OF HEALTH AND HUMAN SERVICES , UNM Rainforest Innovations
发明人： Alan Remaley , John T. Schiller , Marcelo Amar , Bryce Chackerian
IPC分类号： A61K39/005 , A61P9/10 , C07K9/00 , C07K11/00 , A61K39/00 , A61K38/10 , C12N9/64 , A61K47/69 , A61K45/06 , C07K14/47
摘要： A vaccine construct comprising an antigenic PCSK9 peptide and an immunogenic carrier, and methods of using the same that are effective to lower blood cholesterol levels in a mammal and treat dyslipidemias and related disease states in a mammal without the frequency of administration required by passive immunity strategies.
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公开(公告)号：US10724007B2
公开(公告)日：2020-07-28
申请号：US16173217
申请日：2018-10-29
IPC分类号： C12N7/04 , C12N7/00 , C07K14/005 , C07K14/18 , A61K39/00
摘要： The invention is related to a dengue virus or chimeric dengue virus that contains a mutation in the 3′ untranslated region (3′-UTR) comprising a Δ30 mutation that removes the TL-2 homologous structure in each of the dengue virus serotypes 1, 2, 3, and 4, and nucleotides additional to the Δ30 mutation deleted from the 3′-UTR that removes sequence in the 5′ direction as far as the 5′ boundary of the TL-3 homologous structure in each of the dengue serotypes 1, 2, 3, and 4, or a replacement of the 3′-UTR of a dengue virus of a first serotype with the 3′-UTR of a dengue virus of a second serotype, optionally containing the Δ30 mutation and nucleotides additional to the Δ30 mutation deleted from the 3′-UTR; and immunogenic compositions, methods of inducing an immune response, and methods of producing a dengue virus or chimeric dengue virus.
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公开(公告)号：US20200046818A1
公开(公告)日：2020-02-13
申请号：US16664543
申请日：2019-10-25
申请人： Globeimmune, Inc. , The USA, as represented by the Secretary, Dept. of Health and Human Services
IPC分类号： A61K39/00
摘要： Disclosed are methods of the treatment or prevention of chordoma which include the step of administering a yeast-based immunotherapeutic composition. The yeast-based immunotherapeutic composition preferably comprises a Brachyury antigen.
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