公开(公告)号：US08546589B2

公开(公告)日：2013-10-01

申请号：US13497016

申请日：2010-08-31

Applicant: Sergio Mastroianni ,  Paul Pringle ,  Ana Maldonado ,  Gad Rothenberg ,  Igor Mikhel

Inventor： Sergio Mastroianni ,  Paul Pringle ,  Ana Maldonado ,  Gad Rothenberg ,  Igor Mikhel

IPC: C07F19/00 ,  C07F9/6574 ,  C07C253/10

CPC classification number: C07F9/6571 ,  C07B43/08 ,  C07F9/65746

Abstract: Organophosphorus compounds are described that belong to the phosphinite-phosphite family. Catalytic systems comprising a metallic element forming a complex with said phosphinite-phosphite compounds and methods of hydrocyanation employed in the presence of said catalytic systems are also described.

Abstract translation: 描述属于亚磷酸亚磷酸酯族的有机磷化合物。 还描述了包含与所述亚磷酸亚膦酸盐化合物形成络合物的金属元素的催化体系和在所述催化体系存在下使用的氢化氰化方法。

公开(公告)号：US20110319629A1

公开(公告)日：2011-12-29

申请号：US13201053

申请日：2010-02-11

Applicant: Abdul Majeed Seayad ,  Balamurugam Ramalingam ,  Christina Chai ,  Takushi Nagata ,  Kazuhiko Yoshinaga ,  Manabu Wadamoto

Inventor： Abdul Majeed Seayad ,  Balamurugam Ramalingam ,  Christina Chai ,  Takushi Nagata ,  Kazuhiko Yoshinaga ,  Manabu Wadamoto

IPC: C07D213/57 ,  C07D333/50 ,  C07D307/02 ,  C07F7/28 ,  C07C253/00

CPC classification number: B01J31/1805 ,  B01J31/2265 ,  B01J2231/341 ,  B01J2531/46 ,  C07B43/08

Abstract: The present invention relates to titanium catalysts for synthesis reactions produced by bringing a reaction mixture comprising a titanium alkoxide and a ligand in contact with water, wherein the ligand is represented by the general formula (e): wherein R1, R2, R3, and R4 are independently a hydrogen atom, an alkyl group, or the like, and (A) represents a group with two or more carbon atoms. The titanium catalysts may be isolated in solid form and may be stored. The invention further relates to a process for cyanation of imines, wherein the process comprises reacting an imine with a cyanating agent in the presence of the titanium catalyst.

Abstract translation: 本发明涉及通过使包含钛醇盐和配体与水接触的反应混合物而制备的合成反应的钛催化剂，其中配体由通式（e）表示：其中R1，R2，R3和R4 独立地为氢原子，烷基等，（A）表示具有2个以上碳原子的基团。 钛催化剂可以以固体形式分离并且可以被储存。 本发明还涉及一种氰化氰胺的方法，其中该方法包括在钛催化剂存在下使亚胺与氰化剂反应。

公开(公告)号：US11731116B2

公开(公告)日：2023-08-22

申请号：US16076697

申请日：2017-02-08

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD. ,  Arkadi Nerush

Inventor： David Milstein ,  Alex Nerush ,  Matthias Vogt ,  Arup Mukherjee ,  Noel Angel Espinosa-Jalapa ,  Subrata Chakraborty

IPC: B01J31/00 ,  B01J31/18 ,  B01J31/24 ,  C07C249/02 ,  C07B43/06 ,  C07B43/08

CPC classification number: B01J31/181 ,  B01J31/2428 ,  C07C249/02 ,  B01J2231/348 ,  B01J2531/72 ,  C07B43/06 ,  C07B43/08

Abstract: The present invention relates to novel manganese complexes and their use, inter alia, for homogeneous catalysis in (1) the preparation of imine by dehydrogenative coupling of an alcohol and amine; (2) C—C coupling in Michael addition reaction using nitriles as Michael donors; (3) dehydrogenative coupling of alcohols to give esters and hydrogen gas (4) hydrogenation of esters to form alcohols (including hydrogenation of cyclic esters (lactones) or cyclic di-esters (di-lactones), or polyesters); (5) hydrogenation of amides (including cyclic dipeptides, lactams, diamide, polypeptides and polyamides) to alcohols and amines (or diamine); (6) hydrogenation of organic carbonates (including polycarbonates) to alcohols or hydrogenation of carbamates (including polycarbamates) or urea derivatives to alcohols and amines; (7) dehydrogenation of secondary alcohols to ketones; (8) amidation of esters (i.e., synthesis of amides from esters and amines); (9) acylation of alcohols using esters; (10) coupling of alcohols with water and a base to form carboxylic acids; and (11) preparation of amino acids or their salts by coupling of amino alcohols with water and a hydrogenative coupling of alcohols and amines; (13) preparation of imides from diols.

公开(公告)号：US20100179343A1

公开(公告)日：2010-07-15

申请号：US12593873

申请日：2007-03-29

Applicant: Wee Chuan Yeo ,  L. L. Christina Chai ,  Selvasothi Selvaratnam ,  Takushi Nagata ,  Kasuhiko Yoshinaga

Inventor： Wee Chuan Yeo ,  L. L. Christina Chai ,  Selvasothi Selvaratnam ,  Takushi Nagata ,  Kasuhiko Yoshinaga

IPC: C07C253/30

CPC classification number: C07C253/30 ,  C07B41/02 ,  C07B43/08 ,  C07B53/00 ,  C07C255/19

Abstract: The present invention relates to a method of producing an optically active cyanohydrin derivative, which comprises reacting an aldehyde or an asymmetrical ketone with a cyanating agent in the presence of a Lewis base and a titanium compound produced from a partial hydrolysate of titanium tetraalkoxide and an optically active ligand represented by formula (II) or a titanium oxoalkoxide compound represented by formula (I) [TixOy](OR1)4x-2y, and an optically active ligand represented by formula (II), wherein R1 is an optionally substituted alkyl group or an optionally substituted aryl group; x is an integer of not less than 2; y is an integer of not less than 1; and y/x satisfies 0.1

Abstract translation: 本发明涉及一种制备光学活性羟腈衍生物的方法，其包括在路易斯碱和由四烷氧基钛的部分水解产物和光学上产生的钛化合物存在下使醛或不对称酮与氰化剂反应 由式（II）表示的活性配体或由式（I）[TixOy]（OR1）4x-2y表示的氧代烷氧基钛化合物和由式（II）表示的光学活性配体，其中R 1是任选取代的烷基或 任选取代的芳基; x是不小于2的整数; y是不小于1的整数; y / x满足0.1

公开(公告)号：US5750761A

公开(公告)日：1998-05-12

申请号：US608455

申请日：1996-02-28

Applicant: Rainer Hamprecht ,  Claudia Muller

Inventor： Rainer Hamprecht ,  Claudia Muller

IPC: C07D239/88 ,  C07B43/08 ,  C07C253/00 ,  C07C253/08 ,  C07C255/32 ,  C07C255/34 ,  C07C255/41 ,  C07C317/44 ,  C07D213/74 ,  C07D215/12 ,  C07D231/36 ,  C07D231/52 ,  C07D277/20 ,  C07D277/42 ,  C07D333/60 ,  C07D405/04 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04 ,  C07D471/04 ,  C07D491/052 ,  C07D498/04 ,  C09B23/01 ,  C09B23/10 ,  C09B23/14 ,  C09B57/00 ,  C09B57/02 ,  D06P1/16 ,  D06P3/26 ,  C07C255/03

CPC classification number: C07C315/04 ,  C07B43/08 ,  C07C253/00 ,  C07C253/08 ,  C09B23/0091 ,  C09B23/102 ,  C09B23/143 ,  C09B57/00 ,  C09B57/02

Abstract: A process for the preparation of compounds of the formula ##STR1## wherein the substituents X, Y and Z have the meaning given in the description, by reaction of compounds of the formula ##STR2## with a cyanide and an oxidizing agent other than Br.sub.2 in the presence of halides which offers industrial hygiene advantages and renders possible large-scale industrial access to dyestuff syntheses has been found.

Abstract translation: 制备式“IMAGE”化合物的方法，其中取代基X，Y和Z具有本说明书中给出的含义，通过式（ⅩⅧ）化合物与氰化物和除Br2之外的氧化剂的反应 已经发现存在提供工业卫生优点并使大规模工业进入染料合成的卤化物。

公开(公告)号：US11905296B2

公开(公告)日：2024-02-20

申请号：US17790042

申请日：2021-01-27

Applicant: AZAD PHARMA AG

Inventor： Hartmut Zinser ,  Tamar Danielyan ,  Meri Grigoryan ,  Mariam Gharibyan ,  Mikayel Movsisyan ,  Kristine Nerkararyan

IPC: C07D489/12 ,  C07B49/00 ,  C07B43/08 ,  C07B43/04 ,  C07B31/00 ,  C07B37/12 ,  C07D498/12 ,  A61P25/36 ,  A61P25/04

CPC classification number: C07D489/12 ,  A61P25/04 ,  A61P25/36 ,  C07B31/00 ,  C07B37/12 ,  C07B43/04 ,  C07B43/08 ,  C07B49/00 ,  C07D498/12 ,  C07D489/12 ,  C07B49/00 ,  C07D489/12 ,  C07B43/08 ,  C07D489/12 ,  C07B43/04 ,  C07D489/12 ,  C07B31/00 ,  C07D489/12 ,  C07B37/12

Abstract: The present invention relates to a novel route of synthesis for the opioid receptor antagonist Buprenorphine or a pharmaceutically acceptable salt thereof, starting from thebaine, wherein the route comprises the reaction of thebaine with a dienophile; forming an alkylated reaction product by reaction with a Grignard-reagent; formation of an cyanamide; deprotection of the cyanamide- and the phenolic-oxygen-moiety, wherein the cleavage of one or both groups is performed in the presence of an alkali or alkaline earth sulfide; followed by derivatization with a cyclopropyl-halogen and hydrogenation to yield Buprenorphine.

公开(公告)号：US20180311631A1

公开(公告)日：2018-11-01

申请号：US15967078

申请日：2018-04-30

Applicant: IntraMicron, Inc. ,  Auburn University

Inventor： Bruce Tatarchuk ,  David Scarborough ,  Paul Dimick ,  Hongyun Yang

IPC: B01J8/34 ,  B01J8/00 ,  B01J4/00 ,  B01J8/02

CPC classification number: B01J8/34 ,  B01J4/001 ,  B01J8/008 ,  B01J8/0242 ,  B01J8/0278 ,  B01J8/0285 ,  B01J8/0446 ,  B01J8/0453 ,  B01J8/0469 ,  B01J8/0492 ,  B01J8/0496 ,  B01J19/002 ,  B01J2208/00017 ,  B01J2208/00327 ,  B01J2219/0018 ,  B01J2219/00263 ,  B01J2219/00265 ,  C07B41/04 ,  C07B41/06 ,  C07B43/08 ,  C07D301/08

Abstract: Described herein are improved chemical reactors for carrying out partial oxidation reactions. The chemical reactor permits the use of levels of oxygen above the lower explosion limit (LEL) typically used in partial oxidation reactions, which increases both volumetric reactivity and conversion per pass, resulting in reduced separation and reactant recycle costs. Also described are methods of using the reactors.

公开(公告)号：US20170291881A1

公开(公告)日：2017-10-12

申请号：US15509722

申请日：2015-09-10

Applicant: AhR Pharmaceuticals, Inc.

Inventor： Jiasheng Song ,  Suoming Zhang ,  Guodong Li ,  Luqing Yang

IPC: C07D277/20 ,  C07D417/06 ,  C07D209/12

CPC classification number: C07D277/20 ,  C07B43/08 ,  C07C67/47 ,  C07D209/12 ,  C07D417/06

Abstract: Methods of synthesizing 2-(1′H-indole-3′-carbonyl)-thiazole-4-carboxylic acid methyl ester (ITE) and structural analogs thereof. The methods include condensation reactions or condensation and oxidation reactions to form the thiazoline or thiazole moiety of ITE or its structural analogs.

公开(公告)号：US20120209007A9

公开(公告)日：2012-08-16

申请号：US13201053

申请日：2010-02-11

Applicant: Abdul Majeed Seayad ,  Balamurugam Ramalingam ,  Christina Chai ,  Takushi Nagata ,  Kazuhiko Yoshinaga ,  Manabu Wadamoto

Inventor： Abdul Majeed Seayad ,  Balamurugam Ramalingam ,  Christina Chai ,  Takushi Nagata ,  Kazuhiko Yoshinaga ,  Manabu Wadamoto

IPC: C07D213/57 ,  C07D333/50 ,  C07D307/02 ,  C07F7/28 ,  C07C253/00

CPC classification number: B01J31/1805 ,  B01J31/2265 ,  B01J2231/341 ,  B01J2531/46 ,  C07B43/08

Abstract: The present invention relates to titanium catalysts for synthesis reactions produced by bringing a reaction mixture comprising a titanium alkoxide and a ligand in contact with water, wherein the ligand is represented by the general formula (e): wherein R1, R2, R3, and R4 are independently a hydrogen atom, an alkyl group, or the like, and (A) represents a group with two or more carbon atoms. The titanium catalysts may be isolated in solid form and may be stored. The invention further relates to a process for cyanation of imines, wherein the process comprises reacting an imine with a cyanating agent in the presence of the titanium catalyst.

Abstract translation: 本发明涉及通过使包含钛醇盐和配体与水接触的反应混合物而制备的合成反应的钛催化剂，其中配体由通式（e）表示：其中R1，R2，R3和R4 独立地为氢原子，烷基等，（A）表示具有2个以上碳原子的基团。 钛催化剂可以以固体形式分离并且可以被储存。 本发明还涉及一种氰化氰胺的方法，其中该方法包括在钛催化剂存在下使亚胺与氰化剂反应。

公开(公告)号：US20080031788A1

公开(公告)日：2008-02-07

申请号：US11836811

申请日：2007-08-10

Applicant: John Brophy ,  Frederick Pesa ,  Anna Tonkovich ,  Jeffrey McDaniel ,  Kai Jarosch

Inventor： John Brophy ,  Frederick Pesa ,  Anna Tonkovich ,  Jeffrey McDaniel ,  Kai Jarosch

IPC: B01J10/00 ,  C07D301/04

CPC classification number: C07C253/26 ,  B01J19/0093 ,  B01J2219/00783 ,  B01J2219/00804 ,  B01J2219/00835 ,  B01J2219/0086 ,  B01J2219/00873 ,  C07B41/00 ,  C07B43/08 ,  C07C45/33 ,  C07C45/34 ,  C07C45/35 ,  C07C45/36 ,  C07C51/252 ,  C07C51/265 ,  C07C67/05 ,  C07C253/24 ,  C07C47/22 ,  C07C57/04 ,  C07C63/16 ,  C07C69/01 ,  C07C255/08 ,  C07C69/15 ,  C07C69/155

Abstract: This invention relates to a process for converting a hydrocarbon reactant to a product comprising an oxygenate or a nitrile, the process comprising: (A) flowing a reactant composition comprising the hydrocarbon reactant, and oxygen or a source of oxygen, and optionally ammonia, through a microchannel reactor in contact with a catalyst to convert the hydrocarbon reactant to the product, the hydrocarbon reactant undergoing an exothermic reaction in the microchannel reactor; (B) transferring heat from the microchannel reactor to a heat exchanger during step (A); and (C) quenching the product from step (A).

Abstract translation: 本发明涉及一种将烃反应物转化为含有氧化合物或腈的产物的方法，该方法包括：（A）使包含烃反应物的反应物组合物和氧气或氧源和任选的氨通过 与催化剂接触以将烃反应物转化成产物的微通道反应器，在微通道反应器中经历放热反应的烃反应物; （B）在步骤（A）期间将热量从微通道反应器传递到热交换器; 和（C）淬灭步骤（A）的产物。