公开(公告)号：US12145139B2

公开(公告)日：2024-11-19

申请号：US18351557

申请日：2023-07-13

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD. ,  Arkadi Nerush

Inventor： David Milstein ,  Alex Nerush ,  Matthias Vogt ,  Arup Mukherjee ,  Noel Angel Espinosa-Jalapa ,  Subrata Chakraborty

IPC: B01J31/00 ,  B01J31/18 ,  B01J31/24 ,  C07C249/02 ,  C07B43/06 ,  C07B43/08

Abstract: The present invention relates to novel manganese complexes and their use, inter alia, for homogeneous catalysis in (1) the preparation of imine by dehydrogenative coupling of an alcohol and amine; (2) C—C coupling in Michael addition reaction using nitriles as Michael donors; (3) dehydrogenative coupling of alcohols to give esters and hydrogen gas (4) hydrogenation of esters to form alcohols (including hydrogenation of cyclic esters (lactones) or cyclic di-esters (di-lactones), or polyesters); (5) hydrogenation of amides (including cyclic dipeptides, lactams, diamide, polypeptides and polyamides) to alcohols and amines (or diamine); (6) hydrogenation of organic carbonates (including polycarbonates) to alcohols or hydrogenation of carbamates (including polycarbamates) or urea derivatives to alcohols and amines; (7) dehydrogenation of secondary alcohols to ketones; (8) amidation of esters (i.e., synthesis of amides from esters and amines); (9) acylation of alcohols using esters; (10) coupling of alcohols with water and a base to form carboxylic acids; and (11) preparation of amino acids or their salts by coupling of amino alcohols with water and a base. (12) preparation of amides (including formamides, cyclic dipeptides, diamide, lactams, polypeptides and polyamides) by dehydrogenative coupling of alcohols and amines; (13) preparation of imides from diols.

公开(公告)号：US11731116B2

公开(公告)日：2023-08-22

申请号：US16076697

申请日：2017-02-08

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD. ,  Arkadi Nerush

Inventor： David Milstein ,  Alex Nerush ,  Matthias Vogt ,  Arup Mukherjee ,  Noel Angel Espinosa-Jalapa ,  Subrata Chakraborty

IPC: B01J31/00 ,  B01J31/18 ,  B01J31/24 ,  C07C249/02 ,  C07B43/06 ,  C07B43/08

CPC classification number: B01J31/181 ,  B01J31/2428 ,  C07C249/02 ,  B01J2231/348 ,  B01J2531/72 ,  C07B43/06 ,  C07B43/08

Abstract: The present invention relates to novel manganese complexes and their use, inter alia, for homogeneous catalysis in (1) the preparation of imine by dehydrogenative coupling of an alcohol and amine; (2) C—C coupling in Michael addition reaction using nitriles as Michael donors; (3) dehydrogenative coupling of alcohols to give esters and hydrogen gas (4) hydrogenation of esters to form alcohols (including hydrogenation of cyclic esters (lactones) or cyclic di-esters (di-lactones), or polyesters); (5) hydrogenation of amides (including cyclic dipeptides, lactams, diamide, polypeptides and polyamides) to alcohols and amines (or diamine); (6) hydrogenation of organic carbonates (including polycarbonates) to alcohols or hydrogenation of carbamates (including polycarbamates) or urea derivatives to alcohols and amines; (7) dehydrogenation of secondary alcohols to ketones; (8) amidation of esters (i.e., synthesis of amides from esters and amines); (9) acylation of alcohols using esters; (10) coupling of alcohols with water and a base to form carboxylic acids; and (11) preparation of amino acids or their salts by coupling of amino alcohols with water and a hydrogenative coupling of alcohols and amines; (13) preparation of imides from diols.