公开(公告)号：US11976024B2

公开(公告)日：2024-05-07

申请号：US17838897

申请日：2022-06-13

Applicant: Henkel AG & Co. KGaA

Inventor： Umar Farid ,  Jessica Ramos ,  Michael Thai Trung King ,  Justine O'Sullivan ,  Isidro Cobo Cardenete ,  Ciara Goff ,  Cormac Duffy ,  Marisa Phelan ,  Barry Burns

IPC: C07C253/30 ,  C07C227/18 ,  C07C253/08 ,  C07C253/14

CPC classification number: C07C253/30 ,  C07C227/18 ,  C07C253/08 ,  C07C253/14

Abstract: This invention relates to a process for producing cyanoacetates involving contacting a salt of an alkyl, alkenyl, alkynyl or aryl formyl acetate with a hydroxyl amine acid under appropriate conditions and for a time sufficient to yield a cyanoacetate.

公开(公告)号：US6100419A

公开(公告)日：2000-08-08

申请号：US213904

申请日：1998-12-17

Applicant: Yasutaka Ishii ,  Tatsuya Nakano

Inventor： Yasutaka Ishii ,  Tatsuya Nakano

IPC: B01J27/135 ,  B01J31/22 ,  C07B61/00 ,  C07C227/18 ,  C07C227/20 ,  C07C229/28 ,  C07C229/48 ,  C07C253/08 ,  C07C255/46 ,  C07C255/64 ,  C07C253/10 ,  C07C249/08

CPC classification number: C07C253/08 ,  C07C227/20

Abstract: In the presence of a metal catalyst such as a samarium compound, an oxime ester compound shown by the formula (1): ##STR1## wherein R.sup.1, R.sup.2, and R.sup.3 are the same or different from each other, and each represents a non-reactive atom or a non-reactive organic group; and R.sup.2 and R.sup.3, together with the adjacent carbon atom, may bond together to form a ringis reacted with a cyanogenation agent such as an .alpha.-cyanohydrin compound (e.g., acetone cyanohydrin)to form an .alpha.-aminonitrile derivative. By hydrolyzing the .alpha.-aminonitrile derivative, the corresponding .alpha.-amino acid or a salt thereof can be obtained. According to the above processes, an .alpha.-aminonitrile derivative and an .alpha.-amino acid can be obtained in high yields.

Abstract translation: 在诸如钐化合物的金属催化剂存在下，由式（1）表示的肟酯化合物：其中R1，R2和R3彼此相同或不同，并且各自表示非反应性原子或 非反应性有机基团; 并且R2和R3与相邻碳原子一起可以键合在一起形成环，与氰化剂如α-氰基醇化合物（例如丙酮氰醇）反应形成α-氨基腈衍生物。 通过水解α-氨基腈衍生物，可以得到相应的α-氨基酸或其盐。 根据上述方法，可以高产率获得α-氨基腈衍生物和α-氨基酸。

公开(公告)号：US09914693B2

公开(公告)日：2018-03-13

申请号：US14771409

申请日：2014-02-12

Applicant: BASF SE

Inventor： Hermann Luyken ,  Stephanie Jaegli ,  Michael Lorenz ,  Gordon Brasche ,  Markus Jegelka ,  Barbara Becker ,  Robert Baumann ,  Johann-Peter Melder ,  Boris Buschhaus ,  Thomas Krug

IPC: C07C209/48 ,  C07C253/00 ,  C07C253/30 ,  C07C209/86 ,  C07C253/08

CPC classification number: C07C209/48 ,  C07C209/86 ,  C07C253/00 ,  C07C253/08 ,  C07C253/30 ,  C07C255/12 ,  C07C255/25 ,  C07C211/10

Abstract: The present invention relates to a process for preparing ethylenediamine (EDA), where the process comprises the steps a) to c). In step a), formaldehyde is reacted with hydrocyanic acid (HCN) to form formaldehyde cyanohydrin (FACH), where the hydrocyanic acid is completely free or largely free of sulfur dioxide (SO2). The FACH prepared in this way is reacted with ammonia (NH3) to form aminoacetonitrile (AAN) in step b), whereupon a hydrogenation of AAN in the presence of a catalyst to form EDA is carried out in step c).

公开(公告)号：US20140031576A1

公开(公告)日：2014-01-30

申请号：US14110940

申请日：2012-03-26

Applicant: Tatsuya Toriumi

Inventor： Tatsuya Toriumi

IPC: C07C253/30

CPC classification number: C07C253/30 ,  C07C253/08 ,  C07C255/37

Abstract: A process for producing a mandelonitrile compound represented by the following formula (2), comprising a step of reacting a benzaldehyde compound represented by the following formula (1) with at least one member selected from the group consisting of metal cyanides and hydrogen cyanide in the presence of a phase transfer catalyst in a solvent.

Abstract translation: 一种制备由下式（2）表示的扁桃腈化合物的方法，包括使下式（1）表示的苯甲醛化合物与选自金属氰化物和氰化氢中的至少一种在 在溶剂中存在相转移催化剂。

公开(公告)号：US20120142964A1

公开(公告)日：2012-06-07

申请号：US13322720

申请日：2010-06-03

Applicant: Hans Lammkers ,  Martin Heus ,  Tjerk Oedse Boonstra ,  Adrianus Maria Reichwein

Inventor： Hans Lammkers ,  Martin Heus ,  Tjerk Oedse Boonstra ,  Adrianus Maria Reichwein

IPC: C07C227/18 ,  C07C253/30

CPC classification number: C07C253/08 ,  C07C229/24 ,  C07C255/25

Abstract: The present invention relates to a process comprising the reaction of a cyanide with an amino acid and an aldehyde, characterized in that the cyanide is a cyanide salt, the amino acid is aspartic acid and/or glutamic acid in the acidic form, and the process is performed under acidic pH by the addition of between 0 and 1 equivalent of an acid based on the amount of aspartic or glutamic acid.

Abstract translation: 本发明涉及氰化物与氨基酸和醛的反应的方法，其特征在于氰化物是氰化物盐，氨基酸是酸性形式的天冬氨酸和/或谷氨酸，该方法 通过加入基于天冬氨酸或谷氨酸的量的0至1当量的酸在酸性pH下进行。

公开(公告)号：US3869501A

公开(公告)日：1975-03-04

申请号：US39200873

申请日：1973-08-27

Applicant: ICI LTD

Inventor： WADDAN DHAFIR YUSUF

IPC: C07B61/00 ,  B01J27/00 ,  B01J31/00 ,  C07C67/00 ,  C07C253/00 ,  C07C253/10 ,  C07C255/02 ,  C07C255/07 ,  C07C121/04

CPC classification number: C07C253/08 ,  C07C253/10 ,  C07C255/07

Abstract: Organic nitriles are obtained by reaction of an olefin and hydrogen cyanide in the presence of a catalytic amount of a Group IB metal salt, especially a cuprous halide and an organic acid. With butadiene as the olefin the nitrile product contains more than 80% by weight of linear 3-pentene nitrile.

Abstract translation: 有机腈通过烯烃和氰化氢在催化量的IB族金属盐，特别是卤化亚铜和有机酸的存在下反应获得。 使用丁二烯作为烯烃，腈产品含有超过80重量％的线性3-戊烯腈。

公开(公告)号：US09828329B2

公开(公告)日：2017-11-28

申请号：US15125850

申请日：2015-03-11

Applicant: BASF SE

Inventor： Hermann Luyken ,  Stephanie Jaegli ,  Michael Lorenz ,  Gordon Brasche ,  Markus Jegelka ,  Barbara Becker ,  Robert Baumann ,  Johann-Peter Melder ,  Boris Buschhaus ,  Thomas Krug

IPC: C07C209/84

CPC classification number: C07C209/84 ,  C07C209/16 ,  C07C209/48 ,  C07C213/04 ,  C07C253/08 ,  C07C253/30 ,  C07C211/10 ,  C07C255/16 ,  C07C255/25 ,  C07C215/08

Abstract: The present invention relates to a process for purifying ethylenediamine (EDA) by distillation, wherein the process comprises the steps a) and b). In step a), a mixture (G1) comprising water, EDA and N-methylethylenediamine (N-MeEDA) is fed into a distillation apparatus (D1), and the major part of the water comprised in the mixture (G1) is separated off overhead at a pressure of greater than 4.8 bara. From the bottom of (D1), the water-enriched mixture (G2) is fed into a distillation apparatus (D2) in step b). At the top of (D2), the major part of the N-MeEDA is distilled off. The stream (S3) obtained from the bottom of (D2) comprises EDA, with the components water and N-MeEDA comprised in the mixture (G1) having been largely or completely removed. Further distillation steps can optionally be carried out in order to obtain pure EDA, for example when diethylenetriamine (DETA) is additionally comprised in the mixture (G1). If ammonia is additionally comprised in the mixture (G1), an ammonia removal is preferably additionally carried out before carrying out the step a) in the process of the invention.

公开(公告)号：US20160009633A1

公开(公告)日：2016-01-14

申请号：US14771409

申请日：2014-02-12

Applicant: BASF SE

Inventor： Hermann LUYKEN ,  Stephanie JAEGLI ,  Michael LORENZ ,  Gordon BRASCHE ,  Markus JEGELKA ,  Barbara BECKER ,  Robert BAUMANN ,  Johann-Peter MELDER ,  Boris BUSCHHAUS ,  Thomas KRUG

IPC: C07C209/48 ,  C07C253/00 ,  C07C253/30

CPC classification number: C07C209/48 ,  C07C209/86 ,  C07C253/00 ,  C07C253/08 ,  C07C253/30 ,  C07C255/12 ,  C07C255/25 ,  C07C211/10

Abstract: The present invention relates to a process for preparing ethylenediamine (EDA), where the process comprises the steps a) to c). In step a), formaldehyde is reacted with hydrocyanic acid (HCN) to form formaldehyde cyanohydrin (FACH), where the hydrocyanic acid is completely free or largely free of sulfur dioxide (SO2). The FACH prepared in this way is reacted with ammonia (NH3) to form aminoacetonitrile (AAN) in step b), whereupon a hydrogenation of AAN in the presence of a catalyst to form EDA is carried out in step c).

Abstract translation: 本发明涉及一种制备乙二胺（EDA）的方法，其中该方法包括步骤a）至c）。 在步骤a）中，甲醛与氢氰酸（HCN）反应形成甲醛氰醇（FACH），其中氢氰酸完全游离或大部分不含二氧化硫（SO2）。 在步骤b）中，以这种方式制备的FACH与氨（NH 3）反应形成氨基乙腈（AAN），于是在催化剂存在下形成EDA的AAN的氢化在步骤c）中进行。

公开(公告)号：US08309753B2

公开(公告)日：2012-11-13

申请号：US12936340

申请日：2009-04-03

Applicant: Koichi Nakazawa

Inventor： Koichi Nakazawa

IPC: C07C253/00 ,  C07F5/06

CPC classification number: C07B53/00 ,  C07C253/00 ,  C07C253/08 ,  C07D413/14 ,  C07C255/37

Abstract: A method of producing an optically active cyanohydrin compound represented by formula (3), which includes reacting an aldehyde compound represented by formula (2) with hydrogen cyanide in the presence of a silyl compound and an asymmetric complex which is obtained by reacting an optically active pyridine compound represented by formula (1) with an aluminum halide, and wherein Q1, Q2, R1 and R2 are defined in the specification.

Abstract translation: 一种制备由式（3）表示的光学活性羟腈化合物的方法，其包括在甲硅烷基化合物和不对称络合物的存在下使式（2）表示的醛化合物与氰化氢反应，所述不对称络合物是通过使光学活性 式（1）表示的吡啶化合物与卤化铝，其中Q1，Q2，R1和R2在本说明书中定义。

公开(公告)号：US06794542B2

公开(公告)日：2004-09-21

申请号：US10148853

申请日：2002-10-09

Applicant: Wilhelmus Hubertus Joseph Boesten ,  Harold Monro Moody ,  Bernardus Kaptein ,  Johannes Paulus Gerardus Seerden ,  Marcelles Van Der Sluis ,  Ben Lange De ,  Quirinus Bernardus Broxterman

Inventor： Wilhelmus Hubertus Joseph Boesten ,  Harold Monro Moody ,  Bernardus Kaptein ,  Johannes Paulus Gerardus Seerden ,  Marcelles Van Der Sluis ,  Ben Lange De ,  Quirinus Bernardus Broxterman

IPC: C07C23305

CPC classification number: C07C253/00 ,  C07B2200/07 ,  C07C209/62 ,  C07C227/32 ,  C07C231/06 ,  C07C231/18 ,  C07C253/08 ,  C07C253/30 ,  C07C229/08 ,  C07C233/06 ,  C07C237/20 ,  C07C255/25 ,  C07C255/43

Abstract: Process for the preparation of a diasteromerically enriched phenylglycine amide derivative in which an enantiomerically enriched phenylglycine amide is converted into the corresponding Schiff base with the aid of compound R2—C(O)—R3, and the Schiff base obtained is subsequently converted into the diastereomerically enriched phenyglycine amide derivative with the aid of a cyanide source, a reducing agent or an allyl organometallic compound. The phenylglycine amide derivatives obtained are interesting starting materials for the preparation of for example enantiomerically enriched &agr;- and or &bgr;-amino acids and derivatives thereof, such as amides and esters, and amines.

Abstract translation: 制备非对映体富集的苯基甘氨酸酰胺衍生物的方法，其中通过化合物R2-C（O）-R3将对映异构体富集的苯基甘氨酸酰胺转化成相应的希夫碱，随后将获得的席夫碱转化为非对映异构体 在氰化物源，还原剂或烯丙基有机金属化合物的帮助下，富集的苯基甘氨酸酰胺衍生物。 获得的苯基甘氨酸酰胺衍生物是用于制备例如对映体富集的α-和/或β-氨基酸及其衍生物如酰胺和酯以及胺的令人感兴趣的起始原料。