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    Drug eluting radially expandable tubular stented grafts
    2.
    发明申请
    Drug eluting radially expandable tubular stented grafts 审中-公开
    药物洗脱可径向扩张的管状支架移植物

    公开(公告)号：US20020042645A1

    公开(公告)日：2002-04-11

    申请号：US09997829

    申请日：2001-11-29

    Inventor： Donald T. Shannon

    IPC: A61F002/06

    CPC classification number: A61F2/07 ,  A61F2/90 ,  A61F2/915 ,  A61F2002/072 ,  A61F2240/001 ,  A61F2250/0067 ,  A61L31/10 ,  B29C53/58 ,  B29K2027/18 ,  B29K2227/18 ,  B29L2031/7534 ,  C08L59/00

    Abstract: Drug eluting stented tubular grafts wherein the stent is coated with a coat comprising a composite of at least one biocompatible, pharmaceutically acceptable, bioerodible polymer and at least one therapeutic substance. The polymer may be a polyester. The therapeutic agent may include selective gene delivery vectors, sirolimus, actinomycin-D and paclitaxel. The stented grafts include an integrally stented embodiment and an internally stented embodiment. In each embodiment, the stent may be either self-expanding or pressure-expandable. Further, the stent may comprise a plurality of elements, wherein each said element comprises an undulating linear shape formed into a generally cylindrical configuration, and wherein each said element is connected to an adjacent neighbor element by at least one linear connector. A method for the treatment of cardiovascular disease by implantation of the stented graft, and an article of manufacture, comprising packaging material and the stented graft are also taught.

    Abstract translation: 药物洗脱固定管状移植物，其中所述支架涂覆有包含至少一种生物相容性，药学上可接受的，可生物侵蚀的聚合物和至少一种治疗物质的复合材料的涂层。 聚合物可以是聚酯。 治疗剂可以包括选择性基因递送载体，西罗莫司，放线菌素D和紫杉醇。 支架移植物包括整体支架的实施例和内部固定的实施例。 在每个实施例中，支架可以是自膨胀的或压力可膨胀的。 此外，支架可以包括多个元件，其中每个所述元件包括形成为大致圆柱形构造的波浪形线状，并且其中每个所述元件通过至少一个线性连接器连接到相邻的邻近元件。 还教导了通过植入支架移植物治疗心血管疾病的方法，以及包括包装材料和支架移植物的制品。

    Stented, radially expandable, tubular PTFE grafts
    3.
    发明授权
    Stented, radially expandable, tubular PTFE grafts 失效
    狭窄的，可径向扩张的管状PTFE移植物

    公开(公告)号：US5928279A

    公开(公告)日：1999-07-27

    申请号：US675644

    申请日：1996-07-03

    Applicant: Donald T. Shannon ,  Chris Kuo ,  John McIntyre ,  Ronald L. Clinkenbeard ,  Yizi Chu ,  Benny Tu

    Inventor： Donald T. Shannon ,  Chris Kuo ,  John McIntyre ,  Ronald L. Clinkenbeard ,  Yizi Chu ,  Benny Tu

    IPC: A61F2/00 ,  A61F2/90 ,  A61L31/10 ,  B29C53/58 ,  A61F2/04 ,  A61F2/06

    CPC classification number: A61F2/07 ,  A61L31/10 ,  A61F2/90 ,  A61F2002/072 ,  A61F2002/075 ,  A61F2240/001 ,  A61F2250/0067 ,  B29C53/58 ,  B29K2027/18 ,  B29K2227/18 ,  B29L2031/7534 ,  Y10S623/901

    Abstract: Stented tubular grafts of expanded, sintered polytetrafluoroethylene (PTFE). The stented PTFE grafts of the present invention include an integrally stented embodiment, an externally stented embodiment, and an internally stented embodiment. In each embodiment, the stent may be either self-expanding or pressure-expandable. Also, in each embodiment, the stent may be coated or covered with a plastic material capable of being affixed (e.g., heat fused) to PTFE. Manufacturing methods are also disclosed by the individual components of the stented grafts are preassembled on a mandrel and are subsequently heated to facilitate attachment of the PTFE layer(s) to one another and/or to the stent. Optionally, the stented graft may be post-flexed and post-expanded following it's removal from the mandrel to ensure that the stented graft will be freely radially expandable and/or radially contractible over it's full intended range of diameters.

    Abstract translation: 膨胀型烧结聚四氟乙烯（PTFE）的支撑管状移植物。 本发明的带支架的PTFE移植物包括整体支架的实施例，外部固定的实施例和内部支架的实施例。 在每个实施例中，支架可以是自膨胀的或压力可膨胀的。 此外，在每个实施例中，支架可以用能够被固定（例如热熔合）到PTFE的塑料材料涂覆或覆盖。 制造方法也被公开由支架移植物的各个部件预先组装在心轴上并随后被加热以便于PTFE层彼此和/或支架的附接。 可选地，支架移植物可以在从心轴移除之后进行后弯曲和后扩展，以确保支架移植物将在其全部直径范围内自由地径向扩张和/或径向收缩。

    POLYMER COMPOSITE COATINGS USING FIBRILLATED PTFE PREFORMS
    4.
    发明申请
    POLYMER COMPOSITE COATINGS USING FIBRILLATED PTFE PREFORMS 审中-公开
    聚四氟乙烯前体聚合物复合涂料

    公开(公告)号：US20160159067A1

    公开(公告)日：2016-06-09

    申请号：US14961286

    申请日：2015-12-07

    Applicant: Michael A. Speckert

    Inventor： Michael A. Speckert

    IPC: B32B38/08 ,  B32B5/02 ,  B32B7/12 ,  B29C65/00 ,  B32B15/08 ,  B32B37/06 ,  B32B38/18 ,  B29C65/48 ,  B05D7/02 ,  B32B37/12

    CPC classification number: B32B38/08 ,  B29C70/025 ,  B29C70/30 ,  B29K2227/18 ,  B32B37/06 ,  B32B37/1284 ,  B32B38/1866

    Abstract: A method for deploying an epoxy-based coating on a surface of an article, the method comprising the steps of: (a) providing an article including a metallic surface to be coated, the metallic surface presenting itself as a substrate; (b) preparing a self-sustaining, cloth-like, flexible, non-woven fibrillated PTFE preform with voids therein; (c) conforming the preform to the metallic surface; (d) infiltrating at least some of the voids with an epoxy in an uncured state; and (e) curing the epoxy; whereby an epoxy-based coating is formed on the metallic surface. In some embodiments, the PTFE preform in step (b) is a composite fibrillated PTFE preform comprising PTFE mixed with hard particles. Articles of manufacture are also disclosed having an epoxy-based coating deployed according to the embodiments of the disclosed coating methods.

    Abstract translation: 一种在制品的表面上展开环氧基涂层的方法，所述方法包括以下步骤：（a）提供包括要涂覆的金属表面的物品，呈现为基材的金属表面; （b）在其中制备具有空隙的自维持的布状，柔性的，无纺布的原纤化PTFE预制件; （c）使预成型件与金属表面一致; （d）在未固化状态下用环氧树脂渗透至少一些空隙; 和（e）固化环氧树脂; 由此在金属表面上形成环氧基涂层。 在一些实施方案中，步骤（b）中的PTFE预制件是包含与硬颗粒混合的PTFE的复合原纤化PTFE预制件。 还公开了根据所公开的涂覆方法的实施方案部署环氧基涂层的制造方法。

    UNIVERSAL JOINT BEARING WITH PLASTIC OUTER RING AND PROCEDURE FOR ITS PORDUCTION
    6.
    发明申请
    UNIVERSAL JOINT BEARING WITH PLASTIC OUTER RING AND PROCEDURE FOR ITS PORDUCTION 有权
    通用联轴器与塑料外圈及其程序

    公开(公告)号：US20080161117A1

    公开(公告)日：2008-07-03

    申请号：US11855512

    申请日：2007-09-14

    Applicant: Kamran Laal Riahi ,  August Stadlmayr

    Inventor： Kamran Laal Riahi ,  August Stadlmayr

    IPC: F16C33/62

    CPC classification number: F16C33/201 ,  B29C53/58 ,  B29C69/003 ,  B29C70/08 ,  B29C70/32 ,  B29C2793/009 ,  B29K2033/00 ,  B29K2227/18 ,  B29K2427/18 ,  B29L2009/00 ,  B29L2031/04 ,  B29L2031/7096 ,  F16C23/046 ,  F16C33/046 ,  Y10S384/908

    Abstract: An outer race for a rocker bearing includes an internal sliding layer and an external support layer, wherein the sliding layer and the bearing layer are formed from a wound composite fiber material. The outer race is identified by exactly one parting line. A rocker bearing with such an outer race and a method for its production is also provided, in which a sliding layer and a support layer of synthetic resin impregnated fibers are wound in succession onto a winding mandrel, and outer races are formed after setting on the winding body thus produced. The sliding layer and the support layer are wound onto a cylindrical winding mandrel, and the outer race is provided with exactly one parting line opening it, and sliding layer material on its inside is removed to such an extent that a partially spherical contour is obtained for receiving a complementary inner race.

    Abstract translation: 用于摇摆轴承的外圈包括内部滑动层和外部支撑层，其中滑动层和承载层由缠绕的复合纤维材料形成。 外圈由一个分型线确定。 还提供了具有这种外圈的摇臂轴承及其制造方法，其中将合成树脂浸渍纤维的滑动层和支撑层相继卷绕到卷绕心轴上，并且在设置在 这样生产的卷绕体。 将滑动层和支撑层卷绕到圆柱形卷绕心轴上，并且外圈设置有正好一个打开它的分型线，并且其内部的滑动层材料被去除到获得部分球形轮廓的程度， 获得补充内线。

    Radially expandable stented tubular PTFE grafts
    7.
    发明授权
    Radially expandable stented tubular PTFE grafts 失效
    径向扩张支架管状PTFE移植物

    公开(公告)号：US06786920B2

    公开(公告)日：2004-09-07

    申请号：US09981337

    申请日：2001-10-16

    Applicant: Donald T. Shannon ,  Chris Kuo ,  John McIntyre ,  Ronald L. Clinkenbeard ,  Yizi Chu ,  Benny Tu

    Inventor： Donald T. Shannon ,  Chris Kuo ,  John McIntyre ,  Ronald L. Clinkenbeard ,  Yizi Chu ,  Benny Tu

    IPC: A61F206

    CPC classification number: A61F2/07 ,  A61F2/90 ,  A61F2002/072 ,  A61F2002/075 ,  A61F2240/001 ,  A61F2250/0067 ,  A61L31/10 ,  B29C53/58 ,  B29K2027/18 ,  B29K2227/18 ,  B29L2031/7534 ,  Y10S623/901 ,  C08L59/00

    Abstract: Stented tubular grafts of expanded, sintered polytetrafluoroethylene (PTFE). The stented PTFE grafts of the present invention include an integrally stented embodiment, an externally stented embodiment, and an internally stented embodiment. In each embodiment, the stent may be either self-expanding or pressure-expandable. Also, in each embodiment, the stent may be coated or covered with a plastic material capable of being affixed (e.g., heat fused) to PTFE. Manufacturing methods are also disclosed by the individual components of the stented grafts are preassembled on a mandrel and are subsequently heated to facilitate attachment of the PTFE layer(s) to one another and/or to the stent Optionally, the stented graft may be post-flexed and post-expanded following it's removal from the mandrel to ensure that the stented graft will be freely radially expandable and/or radially contractible over it's full intended range of diameters.

    Abstract translation: 膨胀型烧结聚四氟乙烯（PTFE）的支撑管状移植物。 本发明的带支架的PTFE移植物包括整体支架的实施例，外部固定的实施例和内部支架的实施例。 在每个实施例中，支架可以是自膨胀的或压力可膨胀的。 此外，在每个实施例中，支架可以用能够被固定（例如热熔合）到PTFE的塑料材料涂覆或覆盖。 制造方法也由所述支架移植物的单个部件预先组装在心轴上并随后被加热以便于使PTFE层彼此和/或支架连接。单独的组件可以是后置固定的移植物， 在从心轴移除之后进行弯曲和后扩展，以确保支架移植物将在其全部直径范围内自由地径向扩张和/或径向收缩。

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