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    Radially expandable stented tubular PTFE grafts
    1.
    发明授权
    Radially expandable stented tubular PTFE grafts 失效
    径向扩张支架管状PTFE移植物

    公开(公告)号：US06786920B2

    公开(公告)日：2004-09-07

    申请号：US09981337

    申请日：2001-10-16

    Applicant: Donald T. Shannon ,  Chris Kuo ,  John McIntyre ,  Ronald L. Clinkenbeard ,  Yizi Chu ,  Benny Tu

    Inventor： Donald T. Shannon ,  Chris Kuo ,  John McIntyre ,  Ronald L. Clinkenbeard ,  Yizi Chu ,  Benny Tu

    IPC: A61F206

    CPC classification number: A61F2/07 ,  A61F2/90 ,  A61F2002/072 ,  A61F2002/075 ,  A61F2240/001 ,  A61F2250/0067 ,  A61L31/10 ,  B29C53/58 ,  B29K2027/18 ,  B29K2227/18 ,  B29L2031/7534 ,  Y10S623/901 ,  C08L59/00

    Abstract: Stented tubular grafts of expanded, sintered polytetrafluoroethylene (PTFE). The stented PTFE grafts of the present invention include an integrally stented embodiment, an externally stented embodiment, and an internally stented embodiment. In each embodiment, the stent may be either self-expanding or pressure-expandable. Also, in each embodiment, the stent may be coated or covered with a plastic material capable of being affixed (e.g., heat fused) to PTFE. Manufacturing methods are also disclosed by the individual components of the stented grafts are preassembled on a mandrel and are subsequently heated to facilitate attachment of the PTFE layer(s) to one another and/or to the stent Optionally, the stented graft may be post-flexed and post-expanded following it's removal from the mandrel to ensure that the stented graft will be freely radially expandable and/or radially contractible over it's full intended range of diameters.

    Abstract translation: 膨胀型烧结聚四氟乙烯（PTFE）的支撑管状移植物。 本发明的带支架的PTFE移植物包括整体支架的实施例，外部固定的实施例和内部支架的实施例。 在每个实施例中，支架可以是自膨胀的或压力可膨胀的。 此外，在每个实施例中，支架可以用能够被固定（例如热熔合）到PTFE的塑料材料涂覆或覆盖。 制造方法也由所述支架移植物的单个部件预先组装在心轴上并随后被加热以便于使PTFE层彼此和/或支架连接。单独的组件可以是后置固定的移植物， 在从心轴移除之后进行弯曲和后扩展，以确保支架移植物将在其全部直径范围内自由地径向扩张和/或径向收缩。

    Laminated self-sealing vascular access graft
    2.
    发明授权
    Laminated self-sealing vascular access graft 失效
    层压自密封血管通路移植物

    公开(公告)号：US06319279B1

    公开(公告)日：2001-11-20

    申请号：US09419315

    申请日：1999-10-15

    Applicant: Don Shannon ,  Chris Kuo ,  Benny Tu

    Inventor： Don Shannon ,  Chris Kuo ,  Benny Tu

    IPC: A61F206

    CPC classification number: A61F2/06

    Abstract: A vascular access graft that is radially supported and self-sealing upon puncture with, for example, a dialysis needle. The graft has at least one access segment that is formed by an inner layer, an intermediate layer, and outer layer. The intermediate layer has, in longitudinal cross-section, regions of different densities. Radial support members within the intermediate layer prevent collapse of vascular access graft and may be formed of a material that has a lower melting temperature than the other components of the graft. A porous or low-density material is provided between the radial support members to permit blood seepage therein, and the graft is formed by heating to cause the radial support members to melt slightly into the interstitial spaces of the low-density material. The radial support members may be individual turns of a helical coil of FEP, and the low-density material may be compressed PTFE “cotton”. The inner and outer layers may also be formed of PTFE. An adhesive layer of FEP may be provided closely surrounding the inner layer to further anchor the various components of the graft during the step of heating. The inner layer extends on either side of the access segment to provide junction segments that can be cleanly trimmed to size, and which can be used for graft cannulation in lieu of the access segment after suitable tissue ingrowth. A method of manufacture of the vascular access graft is also provided.

    Abstract translation: 一种血管通路移植物，在例如透析针穿刺时径向支撑并自我密封。 移植物具有由内层，中间层和外层形成的至少一个进入段。 中间层在纵向截面中具有不同密度的区域。 中间层内的径向支撑构件防止血管进入移植物的塌陷，并且可以由具有比移植物的其它成分更低的熔化温度的材料形成。 在径向支撑构件之间设置多孔或低密度材料以允许血液渗透，并且通过加热形成移植物以使径向支撑构件稍微熔化到低密度材料的间隙空间中。 径向支撑构件可以是FEP的螺旋线圈的单圈，并且低密度材料可以压缩PTFE“棉”。 内层和外层也可以由PTFE形成。 FEP的粘合剂层可以紧密地围绕内层提供，以在加热步骤中进一步锚固移植物的各种组分。 内层在进入段的任一侧延伸，以提供能够被干净地修剪成尺寸的接合部分，并且其可以用于在合适的组织向内生长之后代替接近段的移植物插管。 还提供了血管通路移植物的制造方法。

    Stented, radially expandable, tubular PTFE grafts
    4.
    发明授权
    Stented, radially expandable, tubular PTFE grafts 失效
    狭窄的，可径向扩张的管状PTFE移植物

    公开(公告)号：US06790225B1

    公开(公告)日：2004-09-14

    申请号：US09358350

    申请日：1999-07-21

    Applicant: Donald T. Shannon ,  Chris Kuo ,  John McIntyre ,  Ronald L. Clinkenbeard ,  Yizi Chu ,  Benny Tu

    Inventor： Donald T. Shannon ,  Chris Kuo ,  John McIntyre ,  Ronald L. Clinkenbeard ,  Yizi Chu ,  Benny Tu

    IPC: A61F206

    CPC classification number: A61F2/07 ,  A61F2/90 ,  A61F2002/072 ,  A61F2002/075 ,  A61F2240/001 ,  A61F2250/0067 ,  A61L31/10 ,  B29C53/58 ,  B29K2027/18 ,  B29K2227/18 ,  B29L2031/7534 ,  Y10S623/901 ,  C08L59/00

    Abstract: Stented tubular grafts of expanded, sintered polytetrafluoroethylene (PTFE). The stented PTFE grafts of the present invention include an integrally stented embodiment, an externally stented embodiment, and an internally stented embodiment. In each embodiment, the stent may be either self-expanding or pressure-expandable. Also, in each embodiment, the stent may be coated or covered with a plastic material capable of being affixed (e.g., heat fused) to PTFE. Manufacturing methods are also disclosed by the individual components of the stented grafts are preassembled on a mandrel and are subsequently heated to facilitate attachment of the PTFE layer(s) to one another and/or to the stent. Optionally, the stented graft may be post-flexed and post-expanded following it's removal from the mandrel to ensure that the stented graft will be freely radially expandable and/or radially contractible over it's full intended range of diameters.

    Abstract translation: 膨胀型烧结聚四氟乙烯（PTFE）的支撑管状移植物。 本发明的带支架的PTFE移植物包括整体支架的实施例，外部固定的实施例和内部支架的实施例。 在每个实施例中，支架可以是自膨胀的或压力可膨胀的。 此外，在每个实施例中，支架可以用能够被固定（例如热熔合）到PTFE的塑料材料涂覆或覆盖。 制造方法也被公开由支架移植物的各个部件预先组装在心轴上并随后被加热以便于PTFE层彼此和/或支架的附接。 可选地，支架移植物可以在从心轴移除之后进行后弯曲和后扩展，以确保支架移植物将在其全部直径范围内自由地径向扩张和/或径向收缩。

    Method for substantially non-delaminable smooth ventricular assist device conduit and product from same
    5.
    发明授权
    Method for substantially non-delaminable smooth ventricular assist device conduit and product from same 有权
    基本上不可分层平滑心室辅助装置导管及其产品的方法

    公开(公告)号：US08162900B2

    公开(公告)日：2012-04-24

    申请号：US12653100

    申请日：2009-12-07

    Applicant: Donald T. Shannon ,  Chris Kuo ,  Benny Tu ,  Mike Randall

    Inventor： Donald T. Shannon ,  Chris Kuo ,  Benny Tu ,  Mike Randall

    IPC: A61M25/00

    CPC classification number: B32B37/04 ,  A61L29/041 ,  A61L29/085 ,  A61L31/048 ,  A61L31/10 ,  A61M1/10 ,  A61M1/1008 ,  A61M1/12 ,  A61M1/122 ,  B32B1/08 ,  B32B2327/18 ,  C08L27/18

    Abstract: A method of non-delaminably bonding a non-porous thermoplastic elastomer to a substrate by heating a bilayer of the elastomer and the substrate for a predetermined time and a product obtained by the method. Methods for producing non-delaminable conduits and non-delaminable kink-resistant conduits constructed of biocompatible elastomers and substrates, and products produced by these methods are taught. Methods, products, and articles of manufacture relating to non-delaminable monofilament supported kink-resistive conduits that may be used as inflow conduits in left ventricular assist devices for treatment of heart failure are also provided.

    Abstract translation: 通过将弹性体和基板的双层加热预定时间并通过该方法获得的产品，将非多孔热塑性弹性体非基材层合到基材上的方法。 制备由生物相容性弹性体和基材构成的非分层管道和非分层耐扭结管道的方法以及由这些方法生产的产品。 还提供了可用作用于治疗心力衰竭的左心室辅助装置中的流出管道的与非分层单丝支撑的扭结线路相关的方法，产品和制品。

    Stented, radially expandable, tubular PTFE grafts
    7.
    发明授权
    Stented, radially expandable, tubular PTFE grafts 失效
    狭窄的，可径向扩张的管状PTFE移植物

    公开(公告)号：US5928279A

    公开(公告)日：1999-07-27

    申请号：US675644

    申请日：1996-07-03

    Applicant: Donald T. Shannon ,  Chris Kuo ,  John McIntyre ,  Ronald L. Clinkenbeard ,  Yizi Chu ,  Benny Tu

    Inventor： Donald T. Shannon ,  Chris Kuo ,  John McIntyre ,  Ronald L. Clinkenbeard ,  Yizi Chu ,  Benny Tu

    IPC: A61F2/00 ,  A61F2/90 ,  A61L31/10 ,  B29C53/58 ,  A61F2/04 ,  A61F2/06

    CPC classification number: A61F2/07 ,  A61L31/10 ,  A61F2/90 ,  A61F2002/072 ,  A61F2002/075 ,  A61F2240/001 ,  A61F2250/0067 ,  B29C53/58 ,  B29K2027/18 ,  B29K2227/18 ,  B29L2031/7534 ,  Y10S623/901

    Abstract: Stented tubular grafts of expanded, sintered polytetrafluoroethylene (PTFE). The stented PTFE grafts of the present invention include an integrally stented embodiment, an externally stented embodiment, and an internally stented embodiment. In each embodiment, the stent may be either self-expanding or pressure-expandable. Also, in each embodiment, the stent may be coated or covered with a plastic material capable of being affixed (e.g., heat fused) to PTFE. Manufacturing methods are also disclosed by the individual components of the stented grafts are preassembled on a mandrel and are subsequently heated to facilitate attachment of the PTFE layer(s) to one another and/or to the stent. Optionally, the stented graft may be post-flexed and post-expanded following it's removal from the mandrel to ensure that the stented graft will be freely radially expandable and/or radially contractible over it's full intended range of diameters.

    Abstract translation: 膨胀型烧结聚四氟乙烯（PTFE）的支撑管状移植物。 本发明的带支架的PTFE移植物包括整体支架的实施例，外部固定的实施例和内部支架的实施例。 在每个实施例中，支架可以是自膨胀的或压力可膨胀的。 此外，在每个实施例中，支架可以用能够被固定（例如热熔合）到PTFE的塑料材料涂覆或覆盖。 制造方法也被公开由支架移植物的各个部件预先组装在心轴上并随后被加热以便于PTFE层彼此和/或支架的附接。 可选地，支架移植物可以在从心轴移除之后进行后弯曲和后扩展，以确保支架移植物将在其全部直径范围内自由地径向扩张和/或径向收缩。

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