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    Ferrocenyl ligands for homogeneous, enantioselective hydrogenation catalysts
    3.
    发明授权
    Ferrocenyl ligands for homogeneous, enantioselective hydrogenation catalysts 有权
    用于均相，对映选择性加氢催化剂的二茂铁基配体

    公开(公告)号：US07671225B2

    公开(公告)日：2010-03-02

    申请号：US11579692

    申请日：2005-05-03

    申请人： Matthias Lotz ,  Felix Spindler

    发明人： Matthias Lotz ,  Felix Spindler

    IPC分类号： C07F19/00 ,  C07F17/02

    CPC分类号： C07C231/18 ,  B01J31/2295 ,  B01J31/2409 ,  B01J31/2433 ,  B01J31/2438 ,  B01J2231/643 ,  B01J2231/645 ,  B01J2531/0286 ,  B01J2531/821 ,  B01J2531/822 ,  B01J2531/827 ,  C07B2200/07 ,  C07C51/36 ,  C07C67/303 ,  C07C67/31 ,  C07C213/02 ,  C07F17/02 ,  C07C57/30 ,  C07C69/34 ,  C07C69/732 ,  C07C69/675 ,  C07C217/08 ,  C07C233/47

    摘要： Compounds of the formula (I) or (I′), where R1 is a hydrogen atom or C1-C4-alkyl and R′1 is C1-C4-alkyl; X1 and X2 are each, independently of one another, a secondary phosphine group; R2 is hydrogen, R01R02R03Si—, C1-C18.acyl substituted by halogen, hydroxy, C1-C8-alkoxy or R04R05N—, -or R06—X01—C(O)—; R01, R02 and R03 are each, independently of one another, C1-C12-alkyl, unsubstituted or C1-C4-alkyl or C1-C4-alkoxy-substituted C6-C10-aryl or C7-C12-aralkyl; R04 and R05 are each, independently of one another, hydrogen, C1-C12-alkyl, C3-C8-cycloalkyl, C6-C10-aryl or C7-C12-aralkyl, or R04 and R05 together are trimethylene, tetramethylene, pentamethylene or 3-oxapcntylene; R06 is C1-C18-alkyl, unsubstituted or C1-C4-alkyl- or C1-C4-alkoxy-substituted C3-C8-cycloalkyl, C6-C10-aryl or C7-C12-aralkyl; X01 is —O— or —NH—; T is C6-C20-arylene; v is 0 or an integer from 1 to 4; and * denotes a mixture of racemic or enantiomerically pure diastereomers or pure racemic or enantiomerically diastereomers, are excellent chiral ligands for metal complexes as enantioselective catalysts for the hydrogenation of prochiral organic compounds.

    摘要翻译： 式（I）或（I'）的化合物，其中R 1是氢原子或C 1 -C 4 - 烷基，R'1是C 1 -C 4烷基; X1和X2各自独立地为次膦基; R2是氢，被卤素，羟基，C1-C8-烷氧基或R04R05N-取代的C1-C18烷基酰基，或 - R06-X01-C（O） - ; R01，R02和R03各自独立地为C1-C12烷基，未取代的或C1-C4-烷基或C1-C4-烷氧基取代的C6-C10-芳基或C7-C12-芳烷基; R 04和R 05彼此独立地为氢，C 1 -C 12 - 烷基，C 3 -C 8 - 环烷基，C 6 -C 10 - 芳基或C 7 -C 12 - 芳烷基，或R 04和R 05一起是三亚甲基，四亚甲基，五亚甲基或3 氧亚麻 R06是C1-C18-烷基，未取代的或C1-C4-烷基 - 或C1-C4-烷氧基取代的C3-C8-环烷基，C6-C10-芳基或C7-C12-芳烷基; X01为-O-或-NH-; T是C 6 -C 20亚芳基; v为0或1至4的整数; 和*表示外消旋或对映体纯的非对映异构体或纯外消旋或对映异构体非对映体的混合物，作为用于前手性有机化合物氢化的对映选择性催化剂的金属络合物的优异手性配体。

    Ferrocenyl diphosphines as ligands for homogeneous catalysts
    4.
    再颁专利
    Ferrocenyl diphosphines as ligands for homogeneous catalysts 有权
    二茂铁基二膦作为均相催化剂的配体

    公开(公告)号：USRE37344E1

    公开(公告)日：2001-08-28

    申请号：US09572931

    申请日：2000-05-18

    申请人： Antonio Togni ,  Felix Spindler ,  Nadia Zanetti ,  Amina Tijani

    发明人： Antonio Togni ,  Felix Spindler ,  Nadia Zanetti ,  Amina Tijani

    IPC分类号： C07F1702

    CPC分类号： C07F17/02 ,  B01J31/2291 ,  B01J31/2295 ,  B01J31/2409 ,  B01J31/2471 ,  B01J2231/643 ,  B01J2231/645 ,  B01J2531/0205 ,  B01J2531/0286 ,  B01J2531/822 ,  B01J2531/827 ,  B01J2531/842 ,  C07C67/303 ,  C07C67/31 ,  C07C209/52 ,  C07C231/18 ,  Y10S526/943 ,  C07C69/34 ,  C07C69/732

    摘要： Compounds of formula I wherein R1 is C1-C8alkyl, phenyl or phenyl which is substituted by 1 to 3 C1-C4alkyl or C1-C4alkoxy groups; R2 and R3 are identical and are C1-C12alkyl, C5-C12cycloalkyl or C1-C4alkyl- or C1-C4alkoxy-substituted C5-C12cycloalkyl, or phenyl which is substituted by one to three identical or different members selected from the group consisting of C1-C4alkyl, C1-C4alkoxy, —SiR4R5R6, halogen, —SO3M, —CO2M, —PO3M, —NR7R8 and —[⊕NR7R8R9]X⊖; or R2 and R3 are different and are C1-C12alkyl, C5-C12cycloalkyl, C1-C4alkyl- or C1-C4-alkoxy-substituted C5-C12cycloalkyl, phenyl or phenyl which is substituted by one to three identical or different members selected from the group consisting of C1-C4alkyl, C1-C4alkoxy, —SiR4R5R6, halogen, —SO3M, —CO2M, —PO3M2, —NR7R8 and —[⊕NR7R8R9]X⊖; or the group —PR2R3 is a radical of formula II and R4, R5 and R6 are each independently of one another C1-C12alkyl or phenyl, R7 and R8 are H, C1-C2alkyl, phenyl or R7 and R8, taken together, are tetramethylene, pentamethylene or 3-oxa-1,5-pentylene, R9 is H or C1-C4alkyl, M is H or an alkali metal, X⊖ is the anion of a monobasic acid, and * is a stereogenic carbon atom, in the form of their racemates and diastereomers or mixtures of diastereoisomers. Rhodium and iridium complexes with these ligands are suitable for use as homogeneous enantioselective catalysts for the hydrogenation of prochiral compounds, containing carbon double bonds or carbon/hetero atom double bonds.

    摘要翻译： 其中R 1为C 1 -C 8烷基，苯基或被1至3个C 1 -C 4烷基或C 1 -C 4烷氧基取代的苯基的式I化合物; R 2和R 3相同，为C 1 -C 12烷基，C 5 -C 12环烷基或C 1 -C 4烷基 - 或C 1 -C 4烷氧基取代的C 5 -C 12环烷基或被一至三个相同或不同的选自C1- C4烷基，C1-C4烷氧基，-SiR4R5R6，卤素，-SO3M，-CO2M，-PO3M，-NR7R8和 - [⊕R7R8R9]X⊖; 或R 2和R 3不同，为C 1 -C 12烷基，C 5 -C 12环烷基，C 1 -C 4烷基 - 或C 1 -C 4 - 烷氧基取代的C 5 -C 12环烷基，苯基或被一至三个相同或不同的基团取代的苯基， 由C1-C4烷基，C1-C4烷氧基，-SiR4R5R6，卤素，-SO3M，-CO2M，-PO3M2，-NR7R8和 - [⊕R7R8R9]X⊖组成; 或基团-PR 2 R 3是式II的基团，R 4，R 5和R 6各自独立地为C 1 -C 12烷基或苯基，R 7和R 8为H，C 1 -C 2烷基，苯基或R 7和R 8一起为四亚甲基， 五亚甲基或3-氧杂-1,5-亚戊基，R9为H或C1-C4烷基，M为H或碱金属，X为一元酸的阴离子，*为立体碳原子，为 它们的外消旋体和非对映异构体或非对映异构体的混合物。 与这些配体的铑和铱络合物适合用作含有碳双键或碳/杂原子双键的前手性化合物氢化的均匀对映选择性催化剂。

    Catalyst complex and process for producing multimodal molecular weight polyolefins
    6.
    发明授权
    Catalyst complex and process for producing multimodal molecular weight polyolefins 有权
    用于生产多峰分子量聚烯烃的催化剂复合物和方法

    公开(公告)号：US08420563B2

    公开(公告)日：2013-04-16

    申请号：US12450382

    申请日：2008-03-05

    申请人： Syriac Palackal ,  Atieh Aburaqabah ,  Helmut G. Alt ,  Christian Goerl

    发明人： Syriac Palackal ,  Atieh Aburaqabah ,  Helmut G. Alt ,  Christian Goerl

    IPC分类号： C08F4/642 ,  C08F4/6592 ,  C08F4/70 ,  B01J31/22 ,  C07F17/00

    CPC分类号： B01J31/1805 ,  B01J31/143 ,  B01J31/146 ,  B01J31/2243 ,  B01J31/2295 ,  B01J2231/122 ,  B01J2231/20 ,  B01J2531/0205 ,  B01J2531/0286 ,  B01J2531/46 ,  B01J2531/48 ,  B01J2531/49 ,  C07F17/00 ,  C08F4/65912 ,  C08F10/00 ,  C08F110/02 ,  C08F2410/03 ,  C08F4/65927 ,  C08F2500/05 ,  C08F2500/04 ,  C08F4/64048

    摘要： Multinuclear catalyst complex comprising two or more active metal centers and at least one phenoxyimine derivative and at least one substituted cyclopentadienyl, indenyl or fluorenyl derivative, each phenoxyimine derivative being bonded to a cyclopentadienyl, indenyl or fluorenyl derivative forming a ligand framework, the cyclopentadienyl, indenyl or fluorenyl derivative being coordinated with one of the metal centers and the phenoxyimine derivative being coordinated with an active metal center other than the metal center the cyclopentadienyl, indenyl or fluorenyl derivative is coordinated with, and wherein the phenoxyimine derivative is derived from a phenoxyimine compound of the formula wherein R1 is hydrogen, alkyl, cycloalkyl, aryl or aralkyl; R2 is hydrogen, halogen, alkyl, cycloalkyl, aryl, O-alkyl or aralkyl; and R3 is alkyl, cycloalkyl, aryl or aralkyl, process for preparing a multinuclear catalyst composition comprising the steps of bonding the substituted phenoxyimine compound to a substituted cyclopentadienyl, indenyl or fluorenyl derivative to obtain a ligand framework and reacting at least one ligand framework with an active metal component and process for the polymerization of olefins, in particular of ethylene and optionally one or more other a-olefins, wherein said multinuclear catalyst is applied.

    摘要翻译： 包含两个或多个活性金属中心和至少一个苯亚胺亚胺衍生物和至少一个取代的环戊二烯基，茚基或芴基衍生物的多核催化剂络合物，每个苯亚胺亚胺衍生物与形成配体骨架的环戊二烯基，茚基或芴基衍生物结合，环戊二烯基，茚基 或芴基衍生物与金属中心之一配位，苯氧基亚胺衍生物与金属中心以外的活性金属中心配位，环戊二烯基，茚基或芴基衍生物与其配位，其中苯氧基亚胺衍生物衍生自 其中R 1是氢，烷基，环烷基，芳基或芳烷基; R2是氢，卤素，烷基，环烷基，芳基，O-烷基或芳烷基; 并且R3是烷基，环烷基，芳基或芳烷基，制备多核催化剂组合物的方法包括以下步骤：将取代的苯氧亚胺化合物与取代的环戊二烯基，茚基或芴基衍生物结合，得到配体框架并使至少一个配体框架与 活性金属组分和用于烯烃聚合的方法，特别是乙烯和任选的一种或多种其它α-烯烃的聚合方法，其中应用所述多核催化剂。

    Ferrocenyl diphosphines as ligands for homogeneous catalysts
    8.
    发明授权
    Ferrocenyl diphosphines as ligands for homogeneous catalysts 失效
    二茂铁基二膦作为均相催化剂的配体

    公开(公告)号：US5563309A

    公开(公告)日：1996-10-08

    申请号：US459435

    申请日：1995-06-02

    申请人： Antonio Togni ,  Felix Spindler ,  Nadia Zanetti ,  Amina Tijani

    发明人： Antonio Togni ,  Felix Spindler ,  Nadia Zanetti ,  Amina Tijani

    IPC分类号： B01J31/22 ,  B01J31/24 ,  C07B35/02 ,  C07B41/02 ,  C07B43/04 ,  C07B53/00 ,  C07B61/00 ,  C07C45/41 ,  C07C45/64 ,  C07C49/245 ,  C07C67/303 ,  C07C67/31 ,  C07C209/52 ,  C07C217/08 ,  C07C231/18 ,  C07C235/16 ,  C07F17/02 ,  C07F19/00 ,  C07C5/02 ,  C07F17/00

    CPC分类号： C07F17/02 ,  B01J31/2291 ,  B01J31/2295 ,  B01J31/2409 ,  B01J31/2471 ,  C07C209/52 ,  C07C231/18 ,  C07C67/303 ,  C07C67/31 ,  B01J2231/643 ,  B01J2231/645 ,  B01J2531/0205 ,  B01J2531/0286 ,  B01J2531/822 ,  B01J2531/827 ,  B01J2531/842 ,  Y10S526/943

    摘要： Compounds of formula I ##STR1## wherein R.sub.1 is C.sub.1 -C.sub.8 alkyl, phenyl or phenyl which is substituted by 1 to 3 C.sub.1 -C.sub.4 alkyl or C.sub.1 -C.sub.4 alkoxy groups; R.sub.2 and R.sub.3 are identical and are C.sub.1 -C.sub.12 alkyl, C.sub.5 -C.sub.12 cycloalkyl or C.sub.1 -C.sub.4 alkyl- or C.sub.1 -C.sub.4 alkoxy-substituted C.sub.5 -C.sub.12 cycloalkyl, or phenyl which is substituted by one to three identical or different members selected from the group consisting of C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy,--SiR.sub.4 R.sub.5 R.sub.6, halogen, --SO.sub.3 M,--CO.sub.2 M,--PO.sub.3 M,--NR.sub.7 R.sub.8 and --[.sup..sym. NR.sub.7 R.sub.8 R.sub.9 ]X.sup..crclbar. ; or R.sub.1 and R.sub.3 are different and are C.sub.1 -C.sub.12 alkyl, C.sub.5 -C.sub.12 cycloalkyl, C.sub.1 -C.sub.4 alkyl- or C.sub.1 -C.sub.4 alkoxy-substituted C.sub.5 -C.sub.12 cycloalkyl, phenyl or phenyl which is substituted by one to three identical or different members selected from the group consisting of C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy,--SiR.sub.4 R.sub.5 R.sub.6, halogen, --SO.sub.3 M,--CO.sub.2 M,--PO.sub.3 M.sub.2, --NR.sub.7 R.sub.8 and --[.sup..sym. NR.sub.7 R.sub.8 R.sub.9 ]X.sup..crclbar. ; or the group --PR.sub.2 R.sub.3 is a radical of formula II ##STR2## and R.sub.4, R.sub.5 and R.sub.6 are each independently of one another C.sub.1 -C.sub.12 alkyl or phenyl, R.sub.7 and R.sub.8 are H, C.sub.1 -C.sub.12 alkyl, phenyl or R.sub.7 and R.sub.8, taken together, are tetramethylene, pentamethylene or 3-oxa-1,5-pentylene, R.sub.9 is H or C.sub.1 -C.sub.4 alkyl, M is H or an alkali metal, X.sup..crclbar. is the anion of a monobasic acid, and * is a stereogenic carbon atom, in the form of their racemates and diastereoisomers or mixtures of diastereoisomers. Rhodium and iridium complexes with these ligands are suitable for use as homogeneous enantioselective catalysts for the hydrogenation of prochiral compounds containing carbon double bonds or carbon/hereto atom double bonds.

    摘要翻译： 式I的化合物其中R 1是C 1 -C 8烷基，苯基或被1至3个C 1 -C 4烷基或C 1 -C 4烷氧基取代的苯基; R 2和R 3相同，为C 1 -C 12烷基，C 5 -C 12环烷基或C 1 -C 4烷基 - 或C 1 -C 4烷氧基取代的C 5 -C 12环烷基或被一至三个相同或不同的选自C1- C 1-4烷基，C 1 -C 4烷氧基，-SiR 4 R 5 R 6，卤素，-SO 3 M，-CO 2 M，-PO 3 M，-NR 7 R 8和 - [（+）NR 7 R 8 R 9] X（ - ）。 或R 1和R 3不同，为C 1 -C 12烷基，C 5 -C 12环烷基，C 1 -C 4烷基 - 或C 1 -C 4烷氧基取代的C 5 -C 12环烷基，苯基或被一至三个相同或不同的成员取代的苯基， C 1 -C 4烷基，C 1 -C 4烷氧基，-SiR 4 R 5 R 6，卤素，-SO 3 M，-CO 2 M，-PO 3 M 2，-NR 7 R 8和 - [（+）NR 7 R 8 R 9] X（ - ）。 或基团-PR 2 R 3是式II的基团（II），且R 4，R 5和R 6彼此独立地为C 1 -C 12烷基或苯基，R 7和R 8为H，C 1 -C 12烷基，苯基或R 7和R 8 一起是四亚甲基，五亚甲基或3-氧杂-1,5-亚戊基，R9是H或C1-C4烷基，M是H或碱金属，X（ - ）是一元酸的阴离子，*是 其外消旋体和非对映异构体形式的立体碳原子或非对映异构体的混合物。 与这些配位体的铑和铱络合物适合用作含碳双键或碳/原子双键的前手性化合物氢化的均匀对映选择性催化剂。

    Ferrocenyl diphosphines as ligands for homogeneous catalysts
    9.
    发明授权
    Ferrocenyl diphosphines as ligands for homogeneous catalysts 失效
    二茂铁基二膦作为均相催化剂的配体

    公开(公告)号：US5463097A

    公开(公告)日：1995-10-31

    申请号：US292150

    申请日：1994-08-17

    申请人： Antonio Togni ,  Felix Spindler ,  Nadia Zanetti ,  Amina Tijani

    发明人： Antonio Togni ,  Felix Spindler ,  Nadia Zanetti ,  Amina Tijani

    IPC分类号： B01J31/22 ,  B01J31/24 ,  C07B35/02 ,  C07B41/02 ,  C07B43/04 ,  C07B53/00 ,  C07B61/00 ,  C07C45/41 ,  C07C45/64 ,  C07C49/245 ,  C07C67/303 ,  C07C67/31 ,  C07C209/52 ,  C07C217/08 ,  C07C231/18 ,  C07C235/16 ,  C07F17/02 ,  C07F19/00 ,  C07F15/00

    CPC分类号： C07F17/02 ,  B01J31/2291 ,  B01J31/2295 ,  B01J31/2409 ,  B01J31/2471 ,  C07C209/52 ,  C07C231/18 ,  C07C67/303 ,  C07C67/31 ,  B01J2231/643 ,  B01J2231/645 ,  B01J2531/0205 ,  B01J2531/0286 ,  B01J2531/822 ,  B01J2531/827 ,  B01J2531/842 ,  Y10S526/943

    摘要： A complex of the formula V or VI,[X.sub.1 M.sub.1 YZ]X.sub.1 M.sub.1 Y].sup..sym. A.sub.1.sup..crclbar.wherein X.sub.1 is two C.sub.2 -C.sub.12 olefins or one C.sub.5 -C.sub.12 diene, Z is Cl, Br or I, A.sub.1.sup..crclbar. is the anion of an oxyacid or complex acid, M.sub.1 is Rh or Ir, and Y is a compound of the formula I ##STR1## wherein R.sub.1 is C.sub.1 -C.sub.8 alkyl, phenyl or phenyl which is substituted by 1 to 3 C.sub.1 -C.sub.4 alkyl or C.sub.1 -C.sub.4 alkoxy groups; R.sub.2 and R.sub.3 are identical and are C.sub.1 -C.sub.12 alkyl, C.sub.5 -C.sub.12 cycloalkyl or C.sub.1 -C.sub.4 alkyl- or C.sub.1 -C.sub.4 alkoxy-substituted C.sub.5 -C.sub.12 cycloalkyl, or phenyl which is substituted by one to three identical or different members selected from the group consisting of C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, --SiR.sub.4 R.sub.5 R.sub.6, halogen, --SO.sub.3 M, --CO.sub.2 M, --PO.sub.3 M, --NR.sub.7 R.sub.8 and --[.sup..sym. NR.sub.7 R.sub.8 R.sub.9 ]X.sup..crclbar. ; or R.sub.2 and R.sub.3 are different and are C.sub.1 -C.sub.12 alkyl, C.sub.5 -C.sub.12 cycloalkyl, C.sub.1 -C.sub.4 alkyl- or C.sub.1 -C.sub.4 alkoxy-substituted C.sub.5 -C.sub.12 cycloalkyl, phenyl or phenyl which is substituted by one to three identical or different members selected from the group consisting of C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, --SiR.sub.4 R.sub.5 R.sub.6, halogen, --SO.sub.3 M, --CO.sub.2 M, --PO.sub.3 M.sub.2, --NR.sub.7 R.sub.8 and --[.sup..sym. NR.sub.7 R.sub.8 R.sub.9 ]X.sup..crclbar. ; or the group --PR.sub.2 R.sub.3 is a radical of formula II ##STR2## and R.sub.4, R.sub.5 and R.sub.6 are each independently of one another C.sub.1 -C.sub.12 alkyl or phenyl, R.sub.7 and R.sub.8 are H, C.sub.1 -C.sub.12 alkyl, phenyl or R.sub.7 and R.sub.8, taken together, are tetramethylene, pentamethylene or 3-oxa-1,5-pentylene, R.sub.9 is H or C.sub.1 -C.sub.4 alkyl, M is H or an alkali metal, X.sup..crclbar. is the anion of a monobasic acid, and * is a stereogenic carbon atom, in the form of their racemates and diastereoisomers or mixtures of diastereoisomers.

    摘要翻译： 式Ⅴ或Ⅵ的络合物[X1M1YZ] X1M1Y]（+）A1（ - ）其中X1是两个C2-C12烯烃或一个C5-C12二烯，Z是Cl，Br或I，A1（ - ）是 含氧酸或络合酸，M1为Rh或Ir，Y为式Ⅰ化合物其中R 1为C 1 -C 8烷基，苯基或被1至3个C 1 -C 4烷基或C 1 -C 4烷基取代的苯基， C4烷氧基; R 2和R 3相同，为C 1 -C 12烷基，C 5 -C 12环烷基或C 1 -C 4烷基 - 或C 1 -C 4烷氧基取代的C 5 -C 12环烷基或被一至三个相同或不同的选自C1- C 1-4烷基，C 1 -C 4烷氧基，-SiR 4 R 5 R 6，卤素，-SO 3 M，-CO 2 M，-PO 3 M，-NR 7 R 8和 - [（+）NR 7 R 8 R 9] X（ - ）。 或R 2和R 3不同，为C 1 -C 12烷基，C 5 -C 12环烷基，C 1 -C 4烷基 - 或C 1 -C 4烷氧基取代的C 5 -C 12环烷基，被一至三个相同或不同的成员所取代的苯基或苯基，所述相同或不同的成员选自 C 1 -C 4烷基，C 1 -C 4烷氧基，-SiR 4 R 5 R 6，卤素，-SO 3 M，-CO 2 M，-PO 3 M 2，-NR 7 R 8和 - [（+）NR 7 R 8 R 9] X（ - ）。 或基团-PR 2 R 3是式II的基团（II），且R 4，R 5和R 6彼此独立地为C 1 -C 12烷基或苯基，R 7和R 8为H，C 1 -C 12烷基，苯基或R 7和R 8 一起是四亚甲基，五亚甲基或3-氧杂-1,5-亚戊基，R9是H或C1-C4烷基，M是H或碱金属，X（ - ）是一元酸的阴离子，*是 其外消旋体和非对映异构体形式的立体碳原子或非对映异构体的混合物。

    Ferrocenyl diphosphines as ligands for homogeneous catalysts
    10.
    发明授权
    Ferrocenyl diphosphines as ligands for homogeneous catalysts 失效
    二茂铁基二膦作为均相催化剂的配体

    公开(公告)号：US5371256A

    公开(公告)日：1994-12-06

    申请号：US037783

    申请日：1993-03-26

    申请人： Antonio Togni ,  Felix Spindler ,  Nadia Zanetti ,  Amina Tijani

    发明人： Antonio Togni ,  Felix Spindler ,  Nadia Zanetti ,  Amina Tijani

    IPC分类号： B01J31/22 ,  B01J31/24 ,  C07B35/02 ,  C07B41/02 ,  C07B43/04 ,  C07B53/00 ,  C07B61/00 ,  C07C45/41 ,  C07C45/64 ,  C07C49/245 ,  C07C67/303 ,  C07C67/31 ,  C07C209/52 ,  C07C217/08 ,  C07C231/18 ,  C07C235/16 ,  C07F17/02 ,  C07F19/00

    CPC分类号： C07F17/02 ,  B01J31/2291 ,  B01J31/2295 ,  B01J31/2409 ,  B01J31/2471 ,  C07C209/52 ,  C07C231/18 ,  C07C67/303 ,  C07C67/31 ,  B01J2231/643 ,  B01J2231/645 ,  B01J2531/0205 ,  B01J2531/0286 ,  B01J2531/822 ,  B01J2531/827 ,  B01J2531/842 ,  Y10S526/943

    摘要： Compounds of formula I ##STR1## wherein R.sub.1 is C.sub.1 -C.sub.8 alkyl, phenyl or phenyl which is substituted by 1 to 3 C.sub.1 -C.sub.4 alkyl or C.sub.1 -C.sub.4 alkoxy groups; R.sub.2 and R.sub.3 are identical and are C.sub.1 -C.sub.12 alkyl, C.sub.5 -C.sub.12 cycloalkyl or C.sub.1 -C.sub.4 alkyl- or C.sub.1 -C.sub.4 alkoxy-substituted C.sub.5 -C.sub.12 cycloalkyl, or phenyl which is substituted by one to three identical or different members selected from the group consisting of C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, --SiR.sub.4 R.sub.5 R.sub.6, halogen, --SO.sub.3 M, --CO.sub.2 M, --PO.sub.3 M,--NR.sub.7 R.sub.8 and --[.sup..sym. NR.sub.7 R.sub.8 R.sub.9 ]X.sup..crclbar. ; or R.sub.2 and R.sub.3 are different and are C.sub.1 -C.sub.12 alkyl, C.sub.5 -C.sub.12 cycloalkyl, C.sub.1 -C.sub.4 alkyl- or C.sub.1 -C.sub.4 alkoxy-substituted C.sub.5 -C.sub.12 cycloalkyl, phenyl or phenyl which is substituted by one to three identical or different members selected from the group consisting of C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, --SiR.sub.4 R.sub.5 R.sub.6, halogen, --SO.sub.3 M, --CO.sub.2 M, --PO.sub.3 M.sub.2, --NR.sub.7 R.sub.8 and --[.sup..sym.NR.sub.7 R.sub.8 R.sub.9 ]X.sup..crclbar. ; or the group --PR.sub.2 R.sub.3 is a radical of formula II ##STR2## and R.sub.4, R.sub.5 and R.sub.6 are each independently of one another C.sub.1 -C.sub.12 alkyl or phenyl, R.sub.7 and R.sub.8 are H, C.sub.1 -C.sub.2 alkyl, phenyl or R.sub.7 and R.sub.8, taken together, are tetramethylene, pentamethylene or 3-oxa-1,5-pentylene, R.sub.9 is H or C.sub.1 -C.sub.4 alkyl, M is H or an alkali metal, X.sup..crclbar. is the anion of a monobasic acid, and * is a stereogenic carbon atom, in the form of their racemates and diastereoisomers or mixtures of diastereoisomers. Rhodium and iridium complexes with these ligands are suitable for use as homogeneous enantioselective catalysts for the hydrogenation of prochiral compounds containing carbon double bonds or carbon/hetero atom double bonds.

    摘要翻译： 式I的化合物其中R 1是C 1 -C 8烷基，苯基或被1至3个C 1 -C 4烷基或C 1 -C 4烷氧基取代的苯基; R 2和R 3相同，为C 1 -C 12烷基，C 5 -C 12环烷基或C 1 -C 4烷基 - 或C 1 -C 4烷氧基取代的C 5 -C 12环烷基或被一至三个相同或不同的选自C1- C 1-4烷基，C 1 -C 4烷氧基，-SiR 4 R 5 R 6，卤素，-SO 3 M，-CO 2 M，-PO 3 M，-NR 7 R 8和 - [（+）NR 7 R 8 R 9] X（ - ）。 或R 2和R 3不同，为C 1 -C 12烷基，C 5 -C 12环烷基，C 1 -C 4烷基 - 或C 1 -C 4烷氧基取代的C 5 -C 12环烷基，被一至三个相同或不同的成员所取代的苯基或苯基，所述相同或不同的成员选自 C 1 -C 4烷基，C 1 -C 4烷氧基，-SiR 4 R 5 R 6，卤素，-SO 3 M，-CO 2 M，-PO 3 M 2，-NR 7 R 8和 - [（+）NR 7 R 8 R 9] X（ - ）。 或基团-PR 2 R 3是式II的基团（II），且R 4，R 5和R 6彼此独立地为C 1 -C 12烷基或苯基，R 7和R 8为H，C 1 -C 2烷基，苯基或R 7和R 8 一起是四亚甲基，五亚甲基或3-氧杂-1,5-亚戊基，R9是H或C1-C4烷基，M是H或碱金属，X（ - ）是一元酸的阴离子，*是 其外消旋体和非对映异构体形式的立体碳原子或非对映异构体的混合物。 与这些配体的铑和铱配合物适合用作含碳双键或碳/杂原子双键的前手性化合物氢化的均匀对映选择性催化剂。