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公开(公告)号：US07614135B2
公开(公告)日：2009-11-10
申请号：US11927156
申请日：2007-10-29
IPC分类号： H01R3/00
CPC分类号： B01L3/50853 , A61B5/00 , A61B5/14532 , A61B5/14546 , A61B5/1473 , A61B5/14865 , A61K9/0004 , A61K9/0009 , A61K9/0097 , A61K47/6957 , A61K49/0002 , B01J19/0093 , B01J2219/00317 , B01J2219/00351 , B01J2219/00783 , B01J2219/00819 , B01J2219/00822 , B01J2219/00824 , B01J2219/00828 , B01J2219/00831 , B01J2219/00833 , B01J2219/00835 , B01J2219/00844 , B01J2219/00853 , B01J2219/00873 , B01J2219/00889 , B01J2219/00907 , B01J2219/00925 , B01J2219/00952 , B01J2219/00957 , B01J2219/00966 , B01J2219/0097 , B01J2219/00984 , B01J2219/00986 , B01L2200/12 , B01L2300/023 , B01L2300/049 , B01L2300/0627 , B01L2300/0654 , B01L2300/0819 , B01L2400/0677 , C40B60/14 , G01N2035/00158 , G01N2035/00247 , Y10T29/49007 , Y10T29/49117 , Y10T436/25
摘要： Methods are provided for making a reservoir-based sensor device. The method may include fabricating a first substrate portion which comprises an upper surface, an opposed lower surface, a plurality of through holes defining reservoirs between said upper surface and said lower surface, and a plurality of reservoir caps closing off one end of said through holes at said upper surface; fabricating a plurality of sensors on an upper surface of a second substrate portion; aligning the first and second substrate portions such that each of said plurality of sensors is in alignment with each of said plurality of reservoirs; and bonding together the lower surface of said first substrate portion and the upper surface of said second substrate portion to seal each of said sensors inside the reservoir with which it is aligned.
摘要翻译： 提供了制备基于储液器的传感器装置的方法。 该方法可以包括制造第一衬底部分，其包括上表面，相对的下表面，在所述上表面和所述下表面之间限定储存器的多个通孔，以及封闭所述通孔的一端的多个贮存器盖 在所述上表面; 在第二基板部分的上表面上制造多个传感器; 对准所述第一和第二基板部分，使得所述多个传感器中的每一个与所述多个储存器中的每一个对齐; 以及将所述第一基板部分的下表面和所述第二基板部分的上表面接合在一起，以密封与所述第二基板部分对准的所述储存器内的每个所述传感器。
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2.发明申请Device for release of chemical molecules using pressure-generated rupture of reservoirs 审中-公开使用压力产生的储层破裂释放化学分子的装置公开(公告)号：US20050124979A1
公开(公告)日：2005-06-09
申请号：US11039048
申请日：2005-01-19
申请人： John Santini , Norman Sheppard
发明人： John Santini , Norman Sheppard
IPC分类号： G01N21/64 , A61K9/00 , A61K38/28 , A61P3/10 , B01J19/00 , B01L3/00 , B01L99/00 , B81B1/00 , C40B60/14 , G01N21/27 , G01N21/41 , G01N27/12 , G01N27/28 , G01N27/327 , G01N27/416 , G01N33/66 , G01N35/00 , C12Q1/68 , A61K9/22 , C12M1/34 , G01N33/543
CPC分类号： B01L3/50853 , A61B5/00 , A61B5/14532 , A61B5/14546 , A61B5/1473 , A61B5/14865 , A61K9/0004 , A61K9/0009 , A61K9/0097 , A61K47/6957 , A61K49/0002 , B01J19/0093 , B01J2219/00317 , B01J2219/00351 , B01J2219/00783 , B01J2219/00819 , B01J2219/00822 , B01J2219/00824 , B01J2219/00828 , B01J2219/00831 , B01J2219/00833 , B01J2219/00835 , B01J2219/00844 , B01J2219/00853 , B01J2219/00873 , B01J2219/00889 , B01J2219/00907 , B01J2219/00925 , B01J2219/00952 , B01J2219/00957 , B01J2219/00966 , B01J2219/0097 , B01J2219/00984 , B01J2219/00986 , B01L2200/12 , B01L2300/023 , B01L2300/049 , B01L2300/0627 , B01L2300/0654 , B01L2300/0819 , B01L2400/0677 , C40B60/14 , G01N2035/00158 , G01N2035/00247 , Y10T29/49007 , Y10T29/49117 , Y10T436/25
摘要： Devices are provided for controlled release of chemical molecules, such as drugs or diagnostic agents. The devices comprises a substrate; a plurality of discrete reservoirs located in the substrate, wherein the reservoirs each have at least one opening at a surface of the substrate; chemical molecules, for release, disposed in the reservoirs; a rupturable barrier layer closing the at least one opening; and a pressure generating material disposed in the reservoirs, the pressure generating material being selected from the group consisting of water-swellable materials, osmotic pressure generating materials, and combinations thereof, wherein the chemical molecules can be selectively released from each reservoir by rupturing of the barrier layer, due to pressure generated by the pressure generating material.
摘要翻译： 提供了用于控制释放化学分子的装置，例如药物或诊断剂。 所述装置包括基板; 位于所述基板中的多个分立的储存器，其中所述储存器各自在所述基板的表面具有至少一个开口; 用于释放的化学分子，放置在储存器中; 封闭所述至少一个开口的可破裂阻挡层; 以及设置在所述储存器中的压力产生材料，所述压力产生材料选自水溶胀性材料，渗透压产生材料及其组合，其中所述化学分子可以通过破裂所述化学分子而被选择性地从每个储存器释放 阻挡层，由于压力产生材料产生的压力。
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公开(公告)号：US20040053268A1
公开(公告)日：2004-03-18
申请号：US10363852
申请日：2003-10-06
发明人： Frank Karlsen
IPC分类号： C12M001/34
CPC分类号： B01L7/525 , B01J19/0093 , B01J2219/00867 , B01J2219/00873 , B01J2219/00891 , B01J2219/00925 , B01J2219/00961 , B01J2219/0097 , B01L3/5027 , B01L2300/0654 , B01L2300/0816 , B01L2300/0864 , B01L2300/087 , B01L2300/1827 , B81B1/00 , G01N2035/00158 , G01N2035/00366
摘要： A microfabricated reaction chamber system for carrying out a nucleic acid sequence amplifiation and detection process on a nucleic acid sample, the process comprising at least first and second process steps using first and second reagents, the device cmprising: an inlet port; a first reaction chamber in communication with the inlet port, for carrying out the first process step; a second reaction chamber in communication with the first reaction chamber, for carrying out the second process step; and an outlet port in communication with the second reaction chamber.
摘要翻译： 一种用于对核酸样品进行核酸序列扩增和检测过程的微制造反应室系统，该方法包括使用第一和第二试剂的至少第一和第二工艺步骤，所述装置包括：入口端口; 与入口连通的第一反应室，用于执行第一工艺步骤; 与第一反应室连通的第二反应室，用于进行第二工艺步骤; 以及与第二反应室连通的出口。
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公开(公告)号：US06573491B1
公开(公告)日：2003-06-03
申请号：US09572763
申请日：2000-05-17
IPC分类号： B01D5944
CPC分类号： G21K1/006 , B01J19/0046 , B01J19/0093 , B01J19/121 , B01J19/126 , B01J19/127 , B01J19/129 , B01J2219/00317 , B01J2219/00351 , B01J2219/00585 , B01J2219/00587 , B01J2219/00596 , B01J2219/00605 , B01J2219/00612 , B01J2219/00637 , B01J2219/00641 , B01J2219/00659 , B01J2219/00781 , B01J2219/00891 , B01J2219/00925 , B01J2219/00927 , B01J2219/00934 , B01J2219/00941 , B01J2219/00943 , B01J2219/00948 , B01L3/50273 , B01L3/502753 , B01L3/502761 , B01L2300/089 , B01L2400/0454 , C40B60/14 , H05H3/04
摘要： The present invention provides electromagnetic energy driven separation methods, including methods for separating molecules in a mixture, for increasing diffusion rate of a substance in a medium, and for moving fluids on a substrate. Such methods work with extremely small volumes of target and may be used for medical diagnosis and treatment.
摘要翻译： 本发明提供了电磁能驱动分离方法，包括用于分离混合物中的分子的方法，用于增加介质中物质的扩散速率，以及用于移动衬底上的流体。 这种方法使用极小体积的靶标，可用于医疗诊断和治疗。
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公开(公告)号：US08442611B2
公开(公告)日：2013-05-14
申请号：US12688508
申请日：2010-01-15
CPC分类号： B01L3/50853 , A61B5/00 , A61B5/14532 , A61B5/14546 , A61B5/1473 , A61B5/14865 , A61K9/0004 , A61K9/0009 , A61K9/0097 , A61K47/6957 , A61K49/0002 , B01J19/0093 , B01J2219/00317 , B01J2219/00351 , B01J2219/00783 , B01J2219/00819 , B01J2219/00822 , B01J2219/00824 , B01J2219/00828 , B01J2219/00831 , B01J2219/00833 , B01J2219/00835 , B01J2219/00844 , B01J2219/00853 , B01J2219/00873 , B01J2219/00889 , B01J2219/00907 , B01J2219/00925 , B01J2219/00952 , B01J2219/00957 , B01J2219/00966 , B01J2219/0097 , B01J2219/00984 , B01J2219/00986 , B01L2200/12 , B01L2300/023 , B01L2300/049 , B01L2300/0627 , B01L2300/0654 , B01L2300/0819 , B01L2400/0677 , C40B60/14 , G01N2035/00158 , G01N2035/00247 , Y10T29/49007 , Y10T29/49117 , Y10T436/25
摘要： A medical device is provided which may include a reservoir which has an opening and contains a sensor; a reservoir cap closing off the opening to isolate the sensor from an environmental component outside the reservoirs, the reservoir cap being impermeable to the environmental component and adapted to selectively undergo a phase change to disintegrate the reservoir cap and thereby expose the sensor to the environmental component. A method of use may include (i) selectively disintegrating a reservoir cap to expose a sensor which is disposed inside a reservoir of a device implanted in a patient, the disintegrating comprising inducing a phase change in the reservoir cap; and (ii) using the sensor to generate an output signal, wherein the output signal is recorded and stored in a writeable computer memory chips, directed to a microprocessor for immediate analysis and processing, or sent to a remote location away from the device.
摘要翻译： 提供一种医疗装置，其可以包括具有开口并包含传感器的储存器; 储存器盖封闭开口以将传感器与储存器外部的环境部件隔离，储存器盖不可渗透到环境部件并且适于选择性地进行相变以分解储存器盖，从而将传感器暴露于环境部件 。 使用的方法可以包括（i）选择性地分解储存器盖以暴露设置在植入患者体内的装置的储存器内部的传感器，所述分解包括引起储存器盖中的相变; 以及（ii）使用所述传感器来产生输出信号，其中所述输出信号被记录并存储在可写入计算机存储器芯片中，指向微处理器以进行即时分析和处理，或者发送到远离所述设备的远程位置。
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公开(公告)号：US07985386B2
公开(公告)日：2011-07-26
申请号：US12240728
申请日：2008-09-29
IPC分类号： B01D21/00
CPC分类号： B01L3/50853 , A61B5/00 , A61B5/14532 , A61B5/14546 , A61B5/1473 , A61B5/14865 , A61K9/0004 , A61K9/0009 , A61K9/0097 , A61K47/6957 , A61K49/0002 , B01J19/0093 , B01J2219/00317 , B01J2219/00351 , B01J2219/00783 , B01J2219/00819 , B01J2219/00822 , B01J2219/00824 , B01J2219/00828 , B01J2219/00831 , B01J2219/00833 , B01J2219/00835 , B01J2219/00844 , B01J2219/00853 , B01J2219/00873 , B01J2219/00889 , B01J2219/00907 , B01J2219/00925 , B01J2219/00952 , B01J2219/00957 , B01J2219/00966 , B01J2219/0097 , B01J2219/00984 , B01J2219/00986 , B01L2200/12 , B01L2300/023 , B01L2300/049 , B01L2300/0627 , B01L2300/0654 , B01L2300/0819 , B01L2400/0677 , C40B60/14 , G01N2035/00158 , G01N2035/00247 , Y10T29/49007 , Y10T29/49117 , Y10T436/25
摘要： An implantable medical device is provided for use with an external detector to detect an analyte in vivo. In one embodiment, the device consisting essentially of a substrate; a plurality of discrete reservoirs located in the substrate, each reservoir having at least one opening; a reacting component contained in each reservoir; and at least one non-degradable barrier layer covering each reservoir opening, the barrier layer being permeable to an analyte to be detected, wherein the reacting component remains inside the reservoirs and can react with the analyte to be detected, and wherein the device is adapted for implantation into the body of a patient.
摘要翻译： 提供可植入的医疗装置，用于与外部检测器一起检测体内分析物。 在一个实施例中，该装置基本上由基底组成; 多个分立储存器，位于基板中，每个储存器具有至少一个开口; 每个储存器中包含的反应组分; 以及覆盖每个储存器开口的至少一个不可降解的阻挡层，所述阻挡层对待检测的分析物是可渗透的，其中所述反应成分保留在所述储存器的内部并且可以与待检测的分析物反应，并且其中所述装置适应 用于植入患者的身体。
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公开(公告)号：US07648677B2
公开(公告)日：2010-01-19
申请号：US11927092
申请日：2007-10-29
IPC分类号： C12Q1/68
CPC分类号： B01L3/50853 , A61B5/00 , A61B5/14532 , A61B5/14546 , A61B5/1473 , A61B5/14865 , A61K9/0004 , A61K9/0009 , A61K9/0097 , A61K47/6957 , A61K49/0002 , B01J19/0093 , B01J2219/00317 , B01J2219/00351 , B01J2219/00783 , B01J2219/00819 , B01J2219/00822 , B01J2219/00824 , B01J2219/00828 , B01J2219/00831 , B01J2219/00833 , B01J2219/00835 , B01J2219/00844 , B01J2219/00853 , B01J2219/00873 , B01J2219/00889 , B01J2219/00907 , B01J2219/00925 , B01J2219/00952 , B01J2219/00957 , B01J2219/00966 , B01J2219/0097 , B01J2219/00984 , B01J2219/00986 , B01L2200/12 , B01L2300/023 , B01L2300/049 , B01L2300/0627 , B01L2300/0654 , B01L2300/0819 , B01L2400/0677 , C40B60/14 , G01N2035/00158 , G01N2035/00247 , Y10T29/49007 , Y10T29/49117 , Y10T436/25
摘要： Methods for operating a sensor device are provided, which may include (a) providing at a site (e.g., implanting in a patient) a device which comprises at least first and second reservoirs, a first sensor and corresponding first reference sensor located within the first reservoir, a second sensor and corresponding second reference sensor located within the second reservoir, a first reservoir cap closing an opening in the first reservoir and a second reservoir cap closing an opening in the second reservoir, and a power source, control circuitry, and electrodes for selectively disintegrating each reservoir cap; (b) disintegrating the first reservoir cap and operating the first sensor and reference sensor; and (c) using the first reference sensor to determine whether the first sensor is operating properly. If not operating properly, then the control circuitry initiates disintegration of the second reservoir cap and operation of the second sensor and reference sensor.
摘要翻译： 提供了用于操作传感器装置的方法，其可以包括（a）在现场（例如，植入患者体内）提供包括至少第一和第二储存器的装置，第一传感器和位于第一 储存器，第二传感器和位于第二储存器内的对应的第二参考传感器，封闭第一储存器中的开口的第一储存器盖和封闭第二储存器中的开口的第二储存器盖，以及电源，控制电路和电极 用于选择性地分解每个储存器盖; （b）分解第一储存器盖并操作第一传感器和参考传感器; 和（c）使用第一参考传感器来确定第一传感器是否正常工作。 如果操作不正常，则控制电路启动第二储存器盖的分解和第二传感器和参考传感器的操作。
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公开(公告)号：US06551838B2
公开(公告)日：2003-04-22
申请号：US09798562
申请日：2001-03-02
IPC分类号： G01N100
CPC分类号： B01L3/50853 , A61B5/00 , A61B5/14532 , A61B5/14546 , A61B5/1473 , A61B5/14865 , A61K9/0004 , A61K9/0009 , A61K9/0097 , A61K47/6957 , A61K49/0002 , B01J19/0093 , B01J2219/00317 , B01J2219/00351 , B01J2219/00783 , B01J2219/00819 , B01J2219/00822 , B01J2219/00824 , B01J2219/00828 , B01J2219/00831 , B01J2219/00833 , B01J2219/00835 , B01J2219/00844 , B01J2219/00853 , B01J2219/00873 , B01J2219/00889 , B01J2219/00907 , B01J2219/00925 , B01J2219/00952 , B01J2219/00957 , B01J2219/00966 , B01J2219/0097 , B01J2219/00984 , B01J2219/00986 , B01L2200/12 , B01L2300/023 , B01L2300/049 , B01L2300/0627 , B01L2300/0654 , B01L2300/0819 , B01L2400/0677 , C40B60/14 , G01N2035/00158 , G01N2035/00247 , Y10T29/49007 , Y10T29/49117 , Y10T436/25
摘要： Microchip devices are provided which include a substrate having a plurality of reservoirs containing a secondary device, a reacting component, or a combination thereof. At least one barrier layer covers each reservoir to isolate the reservoir contents from one or more environmental components outside the reservoirs. The barrier layer can be selectively disintegrated or permeabilized to expose the isolated contents to the one or more environmental components. The secondary device preferably includes a sensor or sensing component, for example, a biosensor, or a light detection or imaging device, such as an optical fiber. Preferred reacting components include catalysts and reagent, which may be immobilized in the reservoirs.
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公开(公告)号：US20100247401A1
公开(公告)日：2010-09-30
申请号：US12744431
申请日：2008-11-25
CPC分类号： B01J19/0093 , B01J2219/00783 , B01J2219/00831 , B01J2219/00835 , B01J2219/00853 , B01J2219/0086 , B01J2219/00925 , B01J2219/00936 , B01J2219/00943 , B01J2219/00945
摘要： Disclosed is a device for performing radiation assisted chemical processing including a fluid path, defined at least in part by a first surface of a wall transparent to radiation useful for performing radiation assisted chemical processing, and a gas discharge or plasma chamber arranged for producing the radiation, wherein the chamber is defined at least in part by a second surface of the transparent wall, opposite the first A related method of forming a photocatalytic reactor comprises among other steps the step of wash-coating the fluid path so as to deposit a photocatalytic material therein, wherein the step of wash-coating includes depositing, and not depositing or removing photocatalytic mateπal, respectively, on a first portion or from a second portion of the of non-circular cross section of the path, the second portion including at least some of the first surface of the wall of transparent material
摘要翻译： 公开了一种用于执行辐射辅助化学处理的装置，其包括流体路径，该流体路径至少部分地由对用于进行辐射辅助化学处理的辐射透明的壁的第一表面以及被布置用于产生辐射的气体放电或等离子体室 ，其中所述室至少部分地由所述透明壁的第二表面限定，与形成光催化反应器的第一A相关方法相反，包括以下步骤：洗涤涂布流体路径以沉积光催化材料的步骤 其中，所述洗涤步骤包括沉积并且不沉积或除去光催化剂配合物分别在所述路径的非圆形横截面的第一部分或第二部分上，所述第二部分包括在 至少一些透明材料墙的第一表面
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公开(公告)号：US20070183933A1
公开(公告)日：2007-08-09
申请号：US10598086
申请日：2005-02-17
申请人： Hiroshi Kawazoe , Kiyoshi Yasue , Kunihiko Akai , Yoshinori Inoue
发明人： Hiroshi Kawazoe , Kiyoshi Yasue , Kunihiko Akai , Yoshinori Inoue
IPC分类号： B01L3/00
CPC分类号： B01J19/0093 , B01J2219/00783 , B01J2219/00788 , B01J2219/00822 , B01J2219/00831 , B01J2219/00833 , B01J2219/0086 , B01J2219/00869 , B01J2219/00873 , B01J2219/00918 , B01J2219/00925 , B01L3/5027 , B01L3/502707 , B01L2300/0627 , B01L2300/0816 , B01L2300/0838 , B01L2300/0861 , B01L2300/0874 , B01L2300/1827
摘要： The present invention provides a supporting unit of microfluid system having a smaller restriction on the number of the steps and capacity of the reaction and analysis that can be produced easily, and a microfluid-system supporting unit allowing mounting of complicated fluid circuits densely. The present invention relates to a microfluid-system supporting unit, comprising a first supporting plate and at least one hollow filament constituting the channel of the microfluid system, wherein the hollow filament is placed on the first supporting plate in any shape and a particular internal region of the hollow filament has a function.
摘要翻译： 本发明提供了一种微流体系统的支撑单元，其对可容易地制造的反应和分析的步骤数量和容量的限制受到较小限制，并且微流体系统支持单元允许密集地安装复杂的流体回路。 本发明涉及一种微流体系统支撑单元，其包括第一支撑板和构成微流体系统的通道的至少一个中空细丝，其中中空丝以任何形状和特定内部区域放置在第一支撑板上 的中空丝具有功能。
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