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    Catheter systems and packaged kits for dual layer guide tubes
    1.
    发明授权
    Catheter systems and packaged kits for dual layer guide tubes 有权

    公开(公告)号：US11752303B2

    公开(公告)日：2023-09-12

    申请号：US16689604

    申请日：2019-11-20

    Applicant: Ablative Solutions, Inc.

    Inventor： David R. Fischell ,  Tim A. Fischell

    IPC: A61M25/00 ,  A61M25/06 ,  A61M25/01 ,  A61B5/00

    CPC classification number: A61M25/0084 ,  A61M25/0074 ,  A61M25/0108 ,  A61M25/0662 ,  A61B5/6848 ,  A61M25/0097 ,  A61M2025/0039 ,  A61M2025/0086 ,  A61M2025/0087 ,  A61M2025/0681 ,  A61M2202/0468 ,  A61M2210/12

    Abstract: A catheter-based/intravascular ablation (denervation) system includes a multiplicity of needles which expand open around a central axis to engage the wall of a blood vessel, or the wall of the left atrium, allowing the injection of a cytotoxic and/or neurotoxic solution for ablating conducting tissue, or nerve fibers around the ostium of the pulmonary vein, or circumferentially in or just beyond the outer layer of the renal artery. The expandable needle delivery system is formed with self-expanding materials and include structures, near the end portion of the needles, or using separate guide tubes. The system also includes means to limit and/or adjust the depth of penetration of the ablative fluid into the tissue of the wall of the targeted blood vessel. The preferred embodiment of the catheter delivered through the vascular system of a patient includes a multiplicity of expandable guide tubes that engage the wall of a blood vessel. Injection needles having injection egress at or near their sharpened distal end are then advanced through the guide tubes to penetrate the wall of the blood vessel to a prescribed depth. The ability to provide PeriVascular injection so as to only affect the outer layer(s) of a blood vessel without affecting the media has particular application for PeriVascular Renal Denervation (PVRD) of the sympathetic nerves which lie in the adventitia or outside the adventitia of the renal artery.

    INJECTION DEVICES AND METHODS OF USE THEREOF
    3.
    发明申请
    INJECTION DEVICES AND METHODS OF USE THEREOF 审中-公开
    注射装置及其使用方法

    公开(公告)号：US20160287811A1

    公开(公告)日：2016-10-06

    申请号：US15082147

    申请日：2016-03-28

    Applicant: Boston Scientific Scimed, Inc.

    Inventor： Elisabeth GABIN ,  Sharon HUNTER ,  Thomas JONES ,  Gary LEANNA ,  Eric SCHNEIDER ,  Manoj MADHAVAN ,  Benedicta CHUMO

    IPC: A61M5/32

    CPC classification number: A61M25/0097 ,  A61M25/0084 ,  A61M2025/0086

    Abstract: Medical devices for injecting tissue and methods of use thereof are described. The medical device may comprise a handle, a shaft, and a plurality of needles extending through the shaft, each needle defining a lumen therethrough and being independently moveable along a longitudinal axis of the device to transition from a retracted configuration to an extended configuration. In the extended configuration, a distal portion of each needle may deflect radially outward with respect to the longitudinal axis of the device. The medical device may comprise an end cap coupled to the distal end of the shaft and/or a locking mechanism to selectively lock the needles in the retracted configuration and/or extended configuration.

    Abstract translation: 描述了用于注射组织的医疗装置及其使用方法。 医疗装置可以包括手柄，轴和延伸穿过轴的多个针，每个针限定穿过其中的腔，并且可以沿着装置的纵向轴线独立地移动以从缩回构型转变到延伸构型。 在延伸构造中，每个针的远侧部分可以相对于装置的纵向轴线径向向外偏转。 医疗装置可以包括联接到轴的远端的端盖和/或锁定机构，以选择性地将针锁定在缩回构型和/或延伸构型中。

    Multi-needle injection device
    5.
    发明授权
    Multi-needle injection device 有权
    多针注射装置

    公开(公告)号：US09149585B2

    公开(公告)日：2015-10-06

    申请号：US13866439

    申请日：2013-04-19

    Applicant: Cook Medical Technologies LLC

    Inventor： Jennifer Rodenberg ,  William Bourdeau ,  Charles Baxter ,  Steven Charlebois ,  Zach Wagner ,  Sara Sherman

    IPC: A61M5/00 ,  A61M5/32 ,  A61M25/00

    CPC classification number: A61M5/3295 ,  A61M25/0084 ,  A61M25/0097 ,  A61M2025/0008 ,  A61M2025/0086 ,  A61M2025/0087

    Abstract: A medical device and a method of treating stress urinary incontinence are provided. The device includes a cannula with a plurality of apertures. A plurality of needles is disposed within a lumen of the cannula. A handle includes a housing and a shifter mechanism to translate the plurality of needles from a first position in which the needles are disposed within the lumen of the cannula, to a second position in which a distal portion of each needle extends out of the lumen through respective apertures. The handle also includes a slot including a transversal track defining a potential range of rotational motion of the shifter mechanism with respect to the housing, and a plurality of longitudinal tracks defining a potential range of translational motion of the shifter mechanism with respect to the housing. The shifter mechanism may also rotate the cannula with respect to the handle.

    Abstract translation: 提供了一种医疗装置和治疗压力性尿失禁的方法。 该装置包括具有多个孔的套管。 多个针布置在套管的内腔内。 手柄包括壳体和换档器机构，用于将多个针从其中布置在套管内腔中的第一位置平移到第二位置，在第二位置，每个针的远端部分延伸出管腔通过 各孔。 手柄还包括一个槽，该槽包括限定换挡机构相对于壳体的旋转运动的潜在范围的横向轨道，以及多个纵向轨道，其限定换挡器机构相对于壳体的平移运动的潜在范围。 换档机构还可以相对于把手旋转套管。

    Expandable catheter system for fluid injection into and deep to the wall of a blood vessel
    7.
    发明授权
    Expandable catheter system for fluid injection into and deep to the wall of a blood vessel 有权
    可扩张导管系统，用于注入血管壁并深入血管壁

    公开(公告)号：US09056185B2

    公开(公告)日：2015-06-16

    申请号：US13342521

    申请日：2012-01-03

    Applicant: David R. Fischell ,  Tim A. Fischell

    Inventor： David R. Fischell ,  Tim A. Fischell

    IPC: A61M31/00 ,  A61M25/00 ,  A61M5/46 ,  A61M25/06 ,  A61B5/00

    CPC classification number: A61M5/46 ,  A61B5/6848 ,  A61M25/0026 ,  A61M25/0084 ,  A61M25/0097 ,  A61M25/0662 ,  A61M2025/0039 ,  A61M2025/0085 ,  A61M2025/0086 ,  A61M2025/0681 ,  A61M2202/0007 ,  A61M2205/0266 ,  A61M2210/12

    Abstract: A catheter-based/intravascular fluid injection system with application to renal denervation includes a multiplicity of needles which expand open around a central axis to engage the wall of a blood vessel, or the wall of the left atrium, allowing the injection of a cytotoxic and/or neurotoxic solution for ablating conducting tissue, or nerve fibers around the ostium of the pulmonary vein, or circumferentially in or just beyond the outer layer of the renal artery. The expandable delivery system includes expandable components that facilitate positioning of a multiplicity of injection needles against the inside wall of a blood vessel from where they can be advanced. The system also includes means to limit and/or adjust the depth of penetration of the ablative fluid into the tissue of the wall of the targeted blood vessel.

    Abstract translation: 应用于肾去神经支配的基于导管的/血管内流体注射系统包括多个针，其围绕中心轴线敞开，以与血管的壁或左心房的壁接合，允许注射细胞毒性和 或用于烧蚀导管组织的神经毒性溶液，或肺静脉口周围的神经纤维，或在肾动脉的外层周围或周边。 可扩展递送系统包括可扩展部件，其有助于将多个注射针定位在血管的内壁上，从而可以将其推进。 该系统还包括限制和/或调节烧蚀液体渗透到目标血管壁的组织中的深度的装置。

    Catheter for introduction of medications to the tissues of a heart or other organ
    9.
    发明授权
    Catheter for introduction of medications to the tissues of a heart or other organ 有权
    导管用于将药物引入心脏或其他器官的组织

    公开(公告)号：US09011380B2

    公开(公告)日：2015-04-21

    申请号：US12722931

    申请日：2010-03-12

    Applicant: Tengiz Tkebuchava

    Inventor： Tengiz Tkebuchava

    IPC: A61M25/00 ,  A61B5/00 ,  A61B17/00 ,  A61B18/00

    CPC classification number: A61M25/0084 ,  A61B5/0215 ,  A61B5/4839 ,  A61B2017/00247 ,  A61B2018/00392 ,  A61M5/329 ,  A61M25/003 ,  A61M25/0071 ,  A61M2025/0002 ,  A61M2025/0037 ,  A61M2025/0085 ,  A61M2025/0086 ,  A61M2025/0096

    Abstract: A positionable, direct-injection catheter that can access a specific region of the heart or other organ. The catheter is provided with one or two needle shafts, which may be located within respective sheaths that extend axially along the interior of the lumen of a main catheter shaft. Each needle shaft carries, at a distal end thereof a penetrable element or “needle” that is normally retracted within the distal tip of the main shaft during travel to the target organ, but is subsequently deployed by action of a handle-mounted trigger mechanism to extend the needles into the organ's wall. Each extended needle is curved to relative to the shaft's axis to enter the organ wall in a flattened trajectory that both reduces the chance of puncture through the wall and anchors the needles into the wall during injection (for reduced chance of pullout under pressure). A plurality of apertures which provide for more complete agent delivery rapidly, while maintaining a low delivery velocity to effect treatment delivery in as short a period of time as possible without the problems caused by high velocity delivery. The needles are typically arranged to exit the tip at contralateral orientations relative to each other.

    Abstract translation: 可定位的直接注射导管，可以进入心脏或其他器官的特定区域。 导管设置有一个或两个针轴，其可以位于沿着主导管轴的内腔的内部轴向延伸的相应护套内。 每个针轴在其远端处具有可穿透元件或“针”，该可穿透元件或“针”在行进到目标器官期间通常缩回到主轴的远侧末端内，但随后通过手柄安装的触发机构的动作来展开 将针伸入器官的墙壁。 每个延伸的针相对于轴的轴线弯曲，以平坦的轨迹进入器官壁，两者都减少了刺穿穿过壁的机会，并且在注射期间将针固定到壁中（为了减少在压力下拔出的可能性）。 多个孔可快速地提供更完整的药剂递送，同时保持较低的输送速度，以尽可能短的时间段内实现治疗输送，而不会由高速输送引起的问题。 针通常布置成相对于彼此以对侧取向离开尖端。

    DEVICES, SYSTEMS AND METHODS FOR ACUTE OR CHRONIC DELIVERY OF SUBSTANCES OR APPARATUS TO EXTRAVASCULAR TREATMENT SITES
    10.
    发明申请
    DEVICES, SYSTEMS AND METHODS FOR ACUTE OR CHRONIC DELIVERY OF SUBSTANCES OR APPARATUS TO EXTRAVASCULAR TREATMENT SITES 有权
    用于急性或慢性输送物质或设备到体外治疗站点的设备，系统和方法

    公开(公告)号：US20140288414A1

    公开(公告)日：2014-09-25

    申请号：US14216091

    申请日：2014-03-17

    Applicant: Medtronic Vascular, Inc.

    Inventor： Joshua Makower ,  Theodore Lamson ,  Christopher J. Flaherty ,  John Reggie ,  John Chang ,  Joseph Catanese ,  David Tholfsen

    IPC: A61M25/01 ,  A61B6/12

    CPC classification number: A61M25/0108 ,  A61B6/12 ,  A61M5/007 ,  A61M25/0084 ,  A61M2025/0086 ,  A61M2025/0087 ,  A61M2025/009 ,  A61M2210/12

    Abstract: Methods and apparatus for delivery of substances or apparatus to target sites located outside blood vessels within the body of a human or animal patient. A vessel wall penetrating catheter is inserted into the vasculature, positioned and oriented within a blood vessel near the target extravascular site and a penetrator is advanced from the catheter so as to penetrate outwardly through the wall of the blood vessel in the direction of the target site. Thereafter, a delivery catheter is passed through a lumen of the penetrator to the target site. A desired substance or apparatus is then delivered to or obtained from the target site. In some applications, the penetrator may be retracted into the vessel wall penetrating catheter and the vessel wall penetrating catheter may be removed, leaving the delivery catheter in place for chronic or continuous delivery of substance(s) to and/or obtaining of information or samples from the target site. Alternatively, a delivery catheter having an occlusion member or balloon may be advanced into a vein or venule and the occlusion member or balloon may be used to occlude the lumen of the vein or venule during and after injection of a substance through the catheter, such that the substance will not be carried away by normal venous blood flow and will remain in the vein or venule for a sufficient period of time to have its intended effect (e.g. to enter adjacent tissues through capillary beds drained by that vein or venule).

    Abstract translation: 用于将物质或装置输送到位于人或动物患者体内的血管外的位置的方法和装置。 将血管壁穿透导管插入脉管系统中，定位并定向在目标血管外部位附近的血管内，并且穿透器从导管前进，以便沿目标部位的方向向外穿过血管壁 。 此后，输送导管穿过穿透器的内腔到目标部位。 然后将所需的物质或装置输送到目标部位或从目标部位获得。 在一些应用中，穿透器可以缩回到穿过导管的血管壁中，并且可以移除穿透导管的血管壁，使输送导管留在适当位置，以便将物质慢慢地或连续地递送到和/或获得信息或样品 从目标网站。 或者，具有闭塞构件或气囊的输送导管可以推入静脉或小静脉中，并且阻塞构件或气囊可以在通过导管注射物质期间和之后用于闭塞静脉或小静脉的内腔，使得 该物质不会被正常的静脉血流带走，并将在静脉或小静脉中保持足够的时间以达到其预期效果（例如，通过由该静脉或小静脉排出的毛细血管床进入相邻组织）。

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