公开(公告)号：US12115499B2

公开(公告)日：2024-10-15

申请号：US16933230

申请日：2020-07-20

申请人： TERUMO KABUSHIKI KAISHA

发明人： Ryuji Hiraguchi

IPC分类号： B01D63/02 ,  A61M1/16 ,  A61M1/36 ,  B01D65/00 ,  B01D69/08

CPC分类号： B01D63/02 ,  A61M1/1625 ,  A61M1/1629 ,  A61M1/1698 ,  A61M1/3623 ,  B01D65/003 ,  B01D69/08 ,  A61M2207/10 ,  B01D2313/20

摘要： In manufacturing an oxygenator (10), an intermediate spacer (18) is arranged between an inner cylinder unit (13) configured by winding a first hollow fiber membrane (14a) and an outer cylinder unit (15) configured by winding a second hollow fiber membrane (16a) so that a first gap (100a) is formed between one end portions of the inner cylinder unit (13) and the outer cylinder unit (15), and a first partition section (62a) is inserted into the first gap (100a). A first end portion (18a) of the intermediate spacer (18) is located at a region which does not overlap the first partition section (62a) in a radial direction. The intermediate spacer (18) independently supports the outer cylinder unit (15) in a state in which a gap (Sa) is formed between an inner peripheral surface of the intermediate spacer (18) and an outer peripheral surface of the inner cylinder unit (13).

公开(公告)号：US11918717B2

公开(公告)日：2024-03-05

申请号：US17269856

申请日：2019-08-27

申请人： NIKKISO CO., LTD.

发明人： Takayoshi Yokoyama ,  Masato Fujiwara ,  Hiroshi Nimura

IPC分类号： A61M1/16 ,  A61M1/14 ,  A61M1/36

CPC分类号： A61M1/1629 ,  A61M1/152 ,  A61M1/153 ,  A61M1/155 ,  A61M1/1562 ,  A61M1/15632 ,  A61M1/36222 ,  A61M1/36223 ,  A61M1/36225 ,  A61M1/362262

摘要： A blood purification device includes a device body and a cassette. The cassette includes: a casing that accommodates a removal water receptacle; and pump tube. The device body includes fingers, a driving unit, and a housing. The cassette can be attached to and removed from the housing of the device body so that the pump tubes are positioned between the plurality of fingers and the outer surfaces of the casing.

公开(公告)号：US20180117235A1

公开(公告)日：2018-05-03

申请号：US15853836

申请日：2017-12-24

申请人： WUHAN TOGO MEDITECH CO., LTD

发明人： Ping ZHOU ,  Lu LIU

IPC分类号： A61M1/34 ,  A61M1/16

CPC分类号： A61M1/3489 ,  A61F2/00 ,  A61M1/1629 ,  A61M1/1662 ,  A61M1/1664 ,  A61M1/1698 ,  A61M2202/0413 ,  A61M2205/3368 ,  A61M2205/36 ,  A61M2210/1071 ,  C12M3/00 ,  C12M21/08 ,  C12M23/34 ,  C12M29/04 ,  C12M29/10

摘要： An integrated on-line monitoring and thermostatic heating apparatus for a bioartificial liver device, the apparatus including a blood inlet, a blood pump, an arterial drip chamber, a bioreactor module, a venous drip chamber, and a blood reinfusion port which are connected in sequence. The bioreactor module includes a thermostatic water tank and a bioreactor disposed in the thermostatic water tank. The bioreactor includes a container, and a first partition and a second partition which are disposed in the container. The first partition and the second partition separate the container into three independent parts, that is, a plasma separator, an oxygenator, and a reactor. The plasma separator and the oxygenator are connected through an external connection pipe. The external connection pipe is equipped with a separation pump. The second partition includes a communication hole, and the reactor and the oxygenator are connected through the communication hole.

公开(公告)号：US09919091B2

公开(公告)日：2018-03-20

申请号：US15248688

申请日：2016-08-26

申请人： Fresenius Medical Care Holdings, Inc.

发明人： Michael James Beiriger ,  Robert Dale Parks ,  Ryan Christopher Kaintz

IPC分类号： A61M1/16 ,  A61M1/14 ,  A61M1/28

CPC分类号： A61M1/1694 ,  A61M1/16 ,  A61M1/1605 ,  A61M1/1629 ,  A61M1/1696 ,  A61M1/28 ,  A61M2205/12 ,  A61M2205/3317 ,  A61M2205/3324 ,  A61M2205/3331 ,  A61M2205/3334 ,  A61M2205/3365 ,  A61M2205/3375 ,  A61M2205/3379 ,  A61M2205/3393 ,  A61M2205/50

摘要： A dialysis system including a housing, a dialysate pump disposed in the housing, and a dialysate line configured to be operatively connected to the dialysate pump such that the dialysate pump can pump dialysate through the dialysate line when the dialysate line is in fluid communication with a dialysate source.

公开(公告)号：US20170216509A1

公开(公告)日：2017-08-03

申请号：US15490070

申请日：2017-04-18

申请人： RAND S.r.l.

发明人： Corrado Bellini

IPC分类号： A61M1/16 ,  A61M1/36 ,  A61M1/26

CPC分类号： A61M1/1698 ,  A61M1/1629 ,  A61M1/3626 ,  A61M1/3666 ,  A61M2205/3673 ,  A61M2205/502 ,  A61M2209/08 ,  A61M2230/207 ,  A61M2230/30 ,  A61M2230/50

摘要： A portable medical apparatus for cardiopulmonary aid to patients includes a transportable machine body that integrates an heater/cooler unit and an extracorporeal circuit for circulating the blood of a patient. The extracorporeal circuit includes a line for drawing venous blood from the patient, a line for returning arterial blood to the patient, a pumping unit for pumping blood along the extracorporeal circuit, a heat exchanger for thermoregulating blood in the extracorporeal circuit, and an oxygenator unit for blood oxygenation.

公开(公告)号：US20160339163A1

公开(公告)日：2016-11-24

申请号：US15112769

申请日：2015-01-16

申请人： EUROSETS S.R.L.

发明人： Antonio PETRALIA ,  Nicola GHELLI ,  Edgardo COSTA ,  Roberto BALANZONI

IPC分类号： A61M1/16 ,  A61M1/36

CPC分类号： A61M1/1698 ,  A61M1/1629 ,  A61M1/1631 ,  A61M1/3627 ,  A61M2207/00

摘要： A device (1) for the extracorporeal oxygenation of the blood of a patient, comprising a containment casing (2) which has at least an inlet port (4) of the venous blood and at least an outlet port (5) of the arterial blood, at least an inlet channel (6) and at least an outlet channel (7) of a work gas intended to provide oxygen to blood and/or to remove CO2 from the same, at least a bundle of hollow fibres (8) arranged within the casing (2) and placed between the inlet channel (6) and the outlet channel (7), the hollow fibres being in communication with the inlet and outlet channels (6, 7) and being intended to be crossed by the relative work gas, at least a first and at least a second filtering elements (12, 13) arranged inside the bundle of hollow fibres (8) and spaced apart the one from the other, the filtering elements (12, 13) being able to trap any air bubbles present in the treated blood, where the first and second filtering elements (12, 13) define a relative open profile and where the hollow fibres (8) cross the first and second filtering elements (12, 13) uninterruptedly.

摘要翻译： 一种用于患者血液的体外氧合的装置（1），包括至少具有静脉血的入口（4）和至少一个动脉血的出口（5）的容纳壳体（2） 至少一个工作气体的入口通道（6）和至少一个用于向血液提供氧气和/或从其中除去CO 2的出口通道（7），至少一束中空纤维（8）布置在 所述壳体（2）并且放置在所述入口通道（6）和所述出口通道（7）之间，所述中空纤维与所述入口通道（6）和所述出口通道（6,7）连通并且被所述相对工作气体 ，至少第一和第二过滤元件（12,13），其布置在所述中空纤维束（8）的内部并且彼此间隔开，所述过滤元件（12,13）能够捕获任何空气 存在于处理过的血液中的气泡，其中第一和第二过滤元件（12,13）限定相对开放的轮廓和wh 使中空纤维（8）不间断地与第一和第二过滤元件（12,13）交叉。

公开(公告)号：US20160331882A1

公开(公告)日：2016-11-17

申请号：US15221732

申请日：2016-07-28

申请人： TERUMO KABUSHIKI KAISHA

发明人： TAKASHI SAITO

IPC分类号： A61M1/16 ,  F28D21/00

CPC分类号： A61M1/1698 ,  A61M1/1629 ,  A61M2207/00 ,  B01D63/02 ,  B01D2313/22 ,  B01D2313/90 ,  B29C53/665 ,  B29C53/8083 ,  B29L2031/18 ,  B29L2031/753 ,  F28D21/0015 ,  F28D2021/005

摘要： A heat exchanger has a hollow fiber membrane layer comprised of a plurality of hollow fiber membrane conduits each of which has a hollow portion allowing a heat medium to pass therethrough. The conduits are derived by winding a base cord of the hollow fiber membrane onto a cylindrical body. The winding follows a generally helical trajectory around the longitudinal axis of the cylindrical body with a plurality of continuous round trips from the first end to the second end and turning back at each respective end, wherein each round trip completes a number of circumferential revolutions N, wherein N is greater than or equal to one, and wherein N is less than two.

摘要翻译： 热交换器具有由多个中空纤维膜管道组成的中空纤维膜层，每个中空纤维膜管道具有允许热介质通过的中空部分。 导管是通过将中空纤维膜的基绳卷绕到圆柱体上得到的。 绕组沿着圆柱体的纵向轴线的大致螺旋状的轨迹，具有从第一端到第二端的多个连续的往返，并且在每个相应的端部处回转，其中每次往返完成多个圆周转数N， 其中N大于或等于1，并且其中N小于2。

公开(公告)号：US20160106901A1

公开(公告)日：2016-04-21

申请号：US14976773

申请日：2015-12-21

申请人： Baxter International Inc. ,  Baxter Healthcare S.A.

发明人： Thomas Kelly ,  Robert W. Childers ,  Don Busby ,  Rodolfo Roger ,  Waleed Musalem El Sayyid ,  Shahid Din

IPC分类号： A61M1/16 ,  A61M1/34

CPC分类号： A61M1/3621 ,  A61M1/1006 ,  A61M1/101 ,  A61M1/1012 ,  A61M1/1037 ,  A61M1/1039 ,  A61M1/1062 ,  A61M1/1081 ,  A61M1/1086 ,  A61M1/16 ,  A61M1/1601 ,  A61M1/1607 ,  A61M1/1613 ,  A61M1/1621 ,  A61M1/1629 ,  A61M1/1633 ,  A61M1/1635 ,  A61M1/1656 ,  A61M1/166 ,  A61M1/1668 ,  A61M1/167 ,  A61M1/1672 ,  A61M1/1696 ,  A61M1/267 ,  A61M1/288 ,  A61M1/341 ,  A61M1/3417 ,  A61M1/342 ,  A61M1/3427 ,  A61M1/3431 ,  A61M1/3434 ,  A61M1/3437 ,  A61M1/3444 ,  A61M1/3451 ,  A61M1/3458 ,  A61M1/3465 ,  A61M1/3468 ,  A61M1/3472 ,  A61M1/3486 ,  A61M1/3624 ,  A61M1/3626 ,  A61M1/3627 ,  A61M1/3643 ,  A61M1/3644 ,  A61M1/3646 ,  A61M1/3647 ,  A61M1/3649 ,  A61M1/365 ,  A61M1/3652 ,  A61M1/3656 ,  A61M2202/0413 ,  A61M2205/12 ,  A61M2205/13 ,  A61M2205/15 ,  A61M2205/18 ,  A61M2205/276 ,  A61M2205/3317 ,  A61M2205/3324 ,  A61M2205/3327 ,  A61M2205/3331 ,  A61M2205/3334 ,  A61M2205/3337 ,  A61M2205/3344 ,  A61M2205/3368 ,  A61M2205/3379 ,  A61M2205/3393 ,  A61M2205/3553 ,  A61M2205/3561 ,  A61M2205/3584 ,  A61M2205/502 ,  A61M2205/505 ,  A61M2205/52 ,  A61M2205/75

摘要： A renal failure therapy machine includes a blood cleaning filter, a sorbent device configured to regenerate used therapy fluid from the blood cleaning filter, a therapy fluid pump configured to pump regenerated therapy fluid from the sorbent device back to the blood cleaning filter, and a flow restrictor in fluid communication with the blood cleaning filter, the therapy fluid pump and the sorbent device, the flow restrictor configured to cause regenerated therapy fluid pumped by the therapy fluid pump from the sorbent device to the blood cleaning filter to be pressurized so that a first amount of the regenerated therapy fluid performs convective clearance and a second amount of the regenerated therapy fluid performs diffusive clearance.

摘要翻译： 肾衰竭治疗机包括血液清洁过滤器，被配置为从血液清洁过滤器再生使用的治疗流体的吸附剂装置，被配置为将再生的治疗流体从吸附装置泵回到血液净化过滤器的治疗液泵， 与血液净化过滤器，治疗流体泵和吸附剂装置流体连通的限流器，流量限制器构造成使由治疗流体泵从吸附装置泵送到血液净化过滤器的再生治疗液被加压，使得第一 再生治疗液的量进行对流清除，第二量的再生治疗液进行扩散间隙。

公开(公告)号：US09302039B2

公开(公告)日：2016-04-05

申请号：US14549818

申请日：2014-11-21

申请人： Baxter International Inc. ,  Baxter Healthcare S.A.

发明人： Thomas Kelly ,  Robert W. Childers ,  Don Busby ,  Rodolfo Roger ,  Waleed Mutasem El Sayyid ,  Shahid Din

IPC分类号： A61M37/00 ,  A61M1/16 ,  A61M1/34 ,  A61M1/36 ,  A61M1/28

CPC分类号： A61M1/3621 ,  A61M1/1006 ,  A61M1/101 ,  A61M1/1012 ,  A61M1/1037 ,  A61M1/1039 ,  A61M1/1062 ,  A61M1/1081 ,  A61M1/1086 ,  A61M1/16 ,  A61M1/1601 ,  A61M1/1607 ,  A61M1/1613 ,  A61M1/1621 ,  A61M1/1629 ,  A61M1/1633 ,  A61M1/1635 ,  A61M1/1656 ,  A61M1/166 ,  A61M1/1668 ,  A61M1/167 ,  A61M1/1672 ,  A61M1/1696 ,  A61M1/267 ,  A61M1/288 ,  A61M1/341 ,  A61M1/3417 ,  A61M1/342 ,  A61M1/3427 ,  A61M1/3431 ,  A61M1/3434 ,  A61M1/3437 ,  A61M1/3444 ,  A61M1/3451 ,  A61M1/3458 ,  A61M1/3465 ,  A61M1/3468 ,  A61M1/3472 ,  A61M1/3486 ,  A61M1/3624 ,  A61M1/3626 ,  A61M1/3627 ,  A61M1/3643 ,  A61M1/3644 ,  A61M1/3646 ,  A61M1/3647 ,  A61M1/3649 ,  A61M1/365 ,  A61M1/3652 ,  A61M1/3656 ,  A61M2202/0413 ,  A61M2205/12 ,  A61M2205/13 ,  A61M2205/15 ,  A61M2205/18 ,  A61M2205/276 ,  A61M2205/3317 ,  A61M2205/3324 ,  A61M2205/3327 ,  A61M2205/3331 ,  A61M2205/3334 ,  A61M2205/3337 ,  A61M2205/3344 ,  A61M2205/3368 ,  A61M2205/3379 ,  A61M2205/3393 ,  A61M2205/3553 ,  A61M2205/3561 ,  A61M2205/3584 ,  A61M2205/502 ,  A61M2205/505 ,  A61M2205/52 ,  A61M2205/75

摘要： A dialysis system includes a dialyzer, a sorbent cartridge configured to clean used dialysate from the dialyzer, a dialysate pump actuator configured to pump dialysate to the dialyzer, and a conductivity sensor located adjacent to a temperature sensor. The dialysis system also includes a disposable cassette configured to carry dialysate pumped by the dialysate pump actuator. The disposable cassette includes a combined conductivity and temperature sensor fluid chamber separate from the conductivity sensor and the temperature sensor and located so as to operate with the conductivity sensor and the temperature sensor, respectively, when mounted for operation.

摘要翻译： 透析系统包括透析器，配置成从透析器清洁用过的透析液的吸附剂盒，配置成将透析液泵送到透析器的透析泵致动器，以及位于温度传感器附近的电导率传感器。 透析系统还包括被配置为承载由透析泵致动器泵送的透析液的一次性盒。 一次性盒包括与电导率传感器和温度传感器分离的组合的电导率和温度传感器流体室，并分别安装在操作时，与电导率传感器和温度传感器一起工作。

公开(公告)号：US09168333B2

公开(公告)日：2015-10-27

申请号：US14511908

申请日：2014-10-10

申请人： Baxter International Inc. ,  Baxter Healthcare S.A.

发明人： Thomas Kelly ,  Robert W. Childers ,  Don Busby ,  Rodolfo Roger ,  Waleed Mutasem El Sayyid ,  Shahid Din

IPC分类号： A61M37/00 ,  A61M1/16 ,  A61M1/34 ,  A61M1/36 ,  A61M1/28

CPC分类号： A61M1/3621 ,  A61M1/1006 ,  A61M1/101 ,  A61M1/1012 ,  A61M1/1037 ,  A61M1/1039 ,  A61M1/1062 ,  A61M1/1081 ,  A61M1/1086 ,  A61M1/16 ,  A61M1/1601 ,  A61M1/1607 ,  A61M1/1613 ,  A61M1/1621 ,  A61M1/1629 ,  A61M1/1633 ,  A61M1/1635 ,  A61M1/1656 ,  A61M1/166 ,  A61M1/1668 ,  A61M1/167 ,  A61M1/1672 ,  A61M1/1696 ,  A61M1/267 ,  A61M1/288 ,  A61M1/341 ,  A61M1/3417 ,  A61M1/342 ,  A61M1/3427 ,  A61M1/3431 ,  A61M1/3434 ,  A61M1/3437 ,  A61M1/3444 ,  A61M1/3451 ,  A61M1/3458 ,  A61M1/3465 ,  A61M1/3468 ,  A61M1/3472 ,  A61M1/3486 ,  A61M1/3624 ,  A61M1/3626 ,  A61M1/3627 ,  A61M1/3643 ,  A61M1/3644 ,  A61M1/3646 ,  A61M1/3647 ,  A61M1/3649 ,  A61M1/365 ,  A61M1/3652 ,  A61M1/3656 ,  A61M2202/0413 ,  A61M2205/12 ,  A61M2205/13 ,  A61M2205/15 ,  A61M2205/18 ,  A61M2205/276 ,  A61M2205/3317 ,  A61M2205/3324 ,  A61M2205/3327 ,  A61M2205/3331 ,  A61M2205/3334 ,  A61M2205/3337 ,  A61M2205/3344 ,  A61M2205/3368 ,  A61M2205/3379 ,  A61M2205/3393 ,  A61M2205/3553 ,  A61M2205/3561 ,  A61M2205/3584 ,  A61M2205/502 ,  A61M2205/505 ,  A61M2205/52 ,  A61M2205/75

摘要： A dialysis system includes a dialysis machine having a pump actuator, a valve actuator and a sorbent device, and a disposable cassette including (i) a housing having a dialyzer inlet port, a dialyzer outlet port, a pump portion configured to operate with the pump actuator, a valve portion configured to operate with the valve actuator, a venous port, and an arterial port, (ii) at least one dialyzer in fluid communication with the housing, the at least one dialyzer including a dialysate inlet, and a dialysate outlet; (iii) an arterial line for connecting to a patient, the arterial line connected to and extending externally from the arterial port of the housing; (iv) a venous line for connecting to a patient, the venous line connected to and extending externally from the venous port of the housing; and (v) first and second dialysate fluid connections in fluid communication with the sorbent device.

摘要翻译： 透析系统包括具有泵致动器，阀致动器和吸附器装置的透析机以及一次性盒，其包括（i）具有透析器入口端口，透析器出口端口的壳体，配置成与泵 致动器，构造成与阀致动器一起操作的阀部分，静脉端口和动脉端口，（ii）与壳体流体连通的至少一个透析器，所述至少一个透析器包括透析液入口和透析液出口 ; （iii）用于连接到患者的动脉线，连接到壳体的动脉端口并从外部延伸的动脉线; （iv）用于连接到患者的静脉线，所述静脉线与所述壳体的静脉端口连接并从所述静脉端口向外延伸; 和（v）与吸附装置流体连通的第一和第二透析液流体连接。