公开(公告)号：US12122821B2

公开(公告)日：2024-10-22

申请号：US16510220

申请日：2019-07-12

申请人： H. LUNDBECK A/S

发明人： Brian Baker ,  Jeffrey T.L. Smith ,  John Latham

IPC分类号： C07K16/18 ,  A61K39/00 ,  C07K16/26 ,  G01N33/50 ,  G01N33/66

CPC分类号： C07K16/18 ,  G01N33/5038 ,  G01N33/5088 ,  G01N33/66 ,  A61K2039/505 ,  C07K16/26 ,  C07K2317/76 ,  G01N2333/5753

摘要： The present disclosure provides methods for the prevention or treatment of metabolic disorders. In exemplary embodiments, methods of administering an anti-CGRP antibody are provided, optionally in combination with a second agent, wherein peripheral and/or hepatic glucose utilization is increased, thereby preventing or treating diseases and disorders associated with insulin resistance. Compositions comprising an anti-CGRP antibody are also provided, optionally in combination with a second agent, which are suitable for administration to increase peripheral and/or hepatic glucose utilization and thereby prevent or treat diseases and disorders associated with insulin resistance.

公开(公告)号：US20240319203A1

公开(公告)日：2024-09-26

申请号：US18579620

申请日：2022-08-04

申请人： H. LUNDBECK A/S

发明人： Anne-Marie JACOBSEN ,  Line Rorbaek OLSEN ,  Frank SCHALK ,  Nico van de MERBEL

IPC分类号： G01N33/68

CPC分类号： G01N33/6848 ,  G01N33/6842 ,  G01N33/6896 ,  G01N2800/2821 ,  G01N2800/52

摘要： The present invention relates to a method of measuring pS396 Tau in a sample comprising the steps of i-iv, i) Treating a CSF sample from a subject suffering or suspected to be suffering from a Tau pathology with trypsin, ii) Subjecting the sample in step i) to a desphosphorylation agent and subsequently take part of the sample aside for step iv) before proceeding to step iii) with the remaining sample, iii) Subjecting the dephosphorylated sample from step ii) to a second trypsin treatment, iv) Measuring the amount of the Tau peptides (SPVVSGDTSPR) corresponding to Tau residues 396-406 in the samples from step ii) and step iii) using LC-MS.

公开(公告)号：US20240293397A1

公开(公告)日：2024-09-05

申请号：US18483780

申请日：2023-10-10

申请人： H. Lundbeck A/S

发明人： Marianne DRAGHEIM ,  Ioana Florea

IPC分类号： A61K31/495

CPC分类号： A61K31/495

摘要： The invention provides new therapeutic uses of 1-[2-(2,4-dimethyl-phenylsulfanyl)phenyl]-piperazine and pharmaceutically acceptable salts thereof.

公开(公告)号：US12077794B2

公开(公告)日：2024-09-03

申请号：US16272079

申请日：2019-02-11

申请人： H. LUNDBECK A/S

发明人： Gary Lesnicki ,  Mark Young

IPC分类号： C12P21/00 ,  C12N1/16 ,  C12N15/67 ,  C12N15/90

CPC分类号： C12P21/00 ,  C12N1/16 ,  C12N15/67 ,  C12N15/905 ,  C07K2317/14 ,  C12N2523/00

摘要： Methods for producing heterologous proteins are disclosed. In particular, the present disclosure provides improved methods of producing desired proteins, including multi-subunit proteins such as antibodies, with a higher yield and improved purity. In exemplary embodiments, the transformed cells are a yeast, e.g., methylotrophic yeast such as Pichia pastoris.

公开(公告)号：US20240270832A1

公开(公告)日：2024-08-15

申请号：US18609223

申请日：2024-03-19

申请人： H. LUNDBECK A/S

发明人： Roger K. Cady ,  Jeffrey T.L. Smith ,  Joseph Hirman ,  Barbara Schaeffler ,  Lahar Mehta

IPC分类号： C07K16/18 ,  A61K9/00 ,  A61K31/4172 ,  A61K38/00 ,  A61K39/00 ,  A61K39/395 ,  A61K45/06 ,  A61K47/26 ,  A61P25/06

CPC分类号： C07K16/18 ,  A61K9/0019 ,  A61K31/4172 ,  A61K39/3955 ,  A61K45/06 ,  A61K47/26 ,  A61P25/06 ,  A61K38/00 ,  A61K2039/505 ,  A61K2039/545 ,  C07K2317/24

摘要： Methods for rapid treatment of chronic migraine are provided. Exemplary methods provide relief from migraine within 24 hours of administration. Also provided are methods for acute treatment of migraine. Exemplary methods comprise administration of an anti-CGRP antagonist antibody to a patient in need thereof.

公开(公告)号：US20240239880A1

公开(公告)日：2024-07-18

申请号：US18609247

申请日：2024-03-19

申请人： H. LUNDBECK A/S

发明人： Roger K. Cady ,  Jeffrey T.L. Smith ,  Joseph Hirman ,  Barbara Schaeffler ,  Lahar Mehta

IPC分类号： C07K16/18 ,  A61K9/00 ,  A61K31/4172 ,  A61K39/395 ,  A61K45/06 ,  A61K47/26 ,  A61P25/06 ,  A61K38/00 ,  A61K39/00

CPC分类号： C07K16/18 ,  A61K9/0019 ,  A61K31/4172 ,  A61K39/3955 ,  A61K45/06 ,  A61K47/26 ,  A61P25/06 ,  A61K38/00 ,  A61K2039/505 ,  A61K2039/545 ,  C07K2317/24

摘要： Methods for immediate relief of migraine or headache are provided comprising the administration of an anti-CGRP antagonist antibody to a patient in need thereof.

公开(公告)号：US12018004B2

公开(公告)日：2024-06-25

申请号：US18053582

申请日：2022-11-08

申请人： H. Lundbeck A/S ,  THE SCRIPPS RESEARCH INSTITUTE

发明人： Justin S. Cisar ,  Cheryl A. Grice ,  Todd K. Jones ,  Micah J. Niphakis ,  Jae Won Chang ,  Kenneth M. Lum ,  Benjamin F. Cravatt

IPC分类号： C07D295/205 ,  A61P25/22 ,  C07C271/10 ,  C07C271/12 ,  C07D205/04 ,  C07D207/09 ,  C07D207/14 ,  C07D213/38 ,  C07D213/40 ,  C07D213/55 ,  C07D215/42 ,  C07D215/46 ,  C07D231/12 ,  C07D231/16 ,  C07D231/56 ,  C07D241/04 ,  C07D261/08 ,  C07D263/32 ,  C07D271/06 ,  C07D295/26 ,  C07D307/79 ,  C07D317/46 ,  C07D317/58 ,  C07D401/04 ,  C07D401/10 ,  C07D403/10 ,  C07D405/14 ,  C07D407/06 ,  C07D413/06 ,  C07D413/10 ,  C07D471/04 ,  C07D471/10 ,  C07D487/04 ,  C07D491/107

CPC分类号： C07D295/205 ,  A61P25/22 ,  C07C271/10 ,  C07C271/12 ,  C07D205/04 ,  C07D207/09 ,  C07D207/14 ,  C07D213/38 ,  C07D213/40 ,  C07D213/55 ,  C07D215/42 ,  C07D215/46 ,  C07D231/12 ,  C07D231/16 ,  C07D231/56 ,  C07D241/04 ,  C07D261/08 ,  C07D263/32 ,  C07D271/06 ,  C07D295/26 ,  C07D307/79 ,  C07D317/46 ,  C07D317/58 ,  C07D401/04 ,  C07D401/10 ,  C07D403/10 ,  C07D405/14 ,  C07D407/06 ,  C07D413/06 ,  C07D413/10 ,  C07D471/04 ,  C07D471/10 ,  C07D487/04 ,  C07D491/107

摘要： This disclosure provides compounds and compositions which may be modulators of MAGL and/or ABHD6 and their use as medicinal agents, processes for their preparation, and pharmaceutical compositions that include disclosed compounds as at least one active agent. The disclosure also provides for method of treating a patient in need thereof, where the patient is suffering from post-traumatic stress disorder comprising administering a disclosed compound or composition.

公开(公告)号：US20240190909A1

公开(公告)日：2024-06-13

申请号：US18511231

申请日：2023-11-16

申请人： H. Lundbeck A/S

发明人： Klaus Gjervig Jensen ,  Lisbet Kværnø ,  Morten Jørgensen ,  Martin Juhl ,  Heidi Lopez De Diego ,  Karin Fredholt ,  Frans Dennis Therkelsen ,  Tobias Gylling Frihed ,  Mikkel Fog Jacobsen

IPC分类号： C07H15/26

CPC分类号： C07H15/26 ,  C07B2200/13

摘要： The present invention relates to new solid forms of the compound (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(((4aR,10aR)-7-hydroxy-1-propyl-1,2,3,4,4a,5,10,10a-octahydrobenzo[g]quinolin-6-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid with the formula (Id) below.




The compound of formula (Id) is a prodrug of a catecholamine for use in treatment of neurodegenerative diseases and disorders such as Parkinson's Disease.

公开(公告)号：US11993612B2

公开(公告)日：2024-05-28

申请号：US18331289

申请日：2023-06-08

申请人： H. Lundbeck A/S

发明人： Thomas Jensen ,  Mikkel Jessing ,  Wanwan Yu ,  David Rodriguez Diaz ,  Jacob Nielsen ,  Christopher Richard Jones ,  Thomas Andersen ,  Mikkel Fog Jacobsen

IPC分类号： C07D498/22

CPC分类号： C07D498/22 ,  C07B2200/05

摘要： The present invention is directed to compounds of formula I




The compounds are considered useful for the treatment of diseases associated with LRRK2 such as Parkinson's disease.

公开(公告)号：US11938185B2

公开(公告)日：2024-03-26

申请号：US17122243

申请日：2020-12-15

申请人： H. LUNDBECK A/S

发明人： Maria-Cristina Loomis ,  Leon F. Garcia-Martinez ,  Benjamin H. Dutzar ,  Daniel S. Allison ,  Katherine Lee Hendrix ,  Ethan W. Ojala ,  Pei Fan ,  Jeffrey T. L. Smith ,  John A. Latham ,  Charlie Karasek ,  Jenny Mulligan ,  Michelle Scalley-Kim ,  Erica Stewart ,  Vanessa Lisbeth Rubin ,  Jens J. Billgren

IPC分类号： A61K39/395 ,  A61P9/08 ,  A61P25/06 ,  C07K14/705 ,  C07K14/72 ,  C07K16/18 ,  C07K16/26 ,  C07K16/28 ,  C07K16/42 ,  C12N5/07 ,  C12N15/09 ,  C12N15/63 ,  G01N33/68 ,  A61K38/00 ,  A61K38/17 ,  A61K38/22 ,  A61K39/00 ,  A61K48/00 ,  C07K14/47 ,  C07K14/575

CPC分类号： A61K39/3955 ,  A61P9/08 ,  A61P25/06 ,  C07K14/70503 ,  C07K14/72 ,  C07K16/18 ,  C07K16/26 ,  C07K16/28 ,  C07K16/2869 ,  C07K16/4241 ,  C12N5/06 ,  C12N15/09 ,  C12N15/63 ,  G01N33/6854 ,  A61K38/00 ,  A61K38/17 ,  A61K38/22 ,  A61K2039/505 ,  A61K48/00 ,  C07K14/47 ,  C07K14/575 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92 ,  G01N2333/575 ,  Y02A50/30

摘要： The present invention is directed to antibodies and antigen binding fragments thereof having binding specificity for PACAP. The antibodies and antigen binding fragments thereof comprise the sequences of the VH, VL, and CDR polypeptides described herein, and the polynucleotides encoding them. Antibodies and antigen binding fragments described herein bind to and/or compete for binding to the same linear or conformational epitope(s) on human PACAP as an anti-PACAP antibody. The invention contemplates conjugates of anti-PACAP antibodies and binding fragments thereof conjugated to one or more functional or detectable moieties. Methods of making said anti-PACAP antibodies and antigen binding fragments thereof are also contemplated. Other embodiments of the invention contemplate using anti-PACAP antibodies, and binding fragments thereof, for the diagnosis, assessment, and treatment of diseases and disorders associated with PACAP and conditions where antagonism of PACAP-related activities, such as vasodilation, photophobia, mast cell degranulation, and/or neuronal activation, would be therapeutically beneficial.