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    Inhibiting growth of tumors with certain substituted phenoxy dimethyl alkanoic acids, esters or salts
    2.
    发明授权
    Inhibiting growth of tumors with certain substituted phenoxy dimethyl alkanoic acids, esters or salts 失效
    用某些取代的苯氧基二甲基链烷酸，酯或盐抑制肿瘤的生长

    公开(公告)号：US4758580A

    公开(公告)日：1988-07-19

    申请号：US874547

    申请日：1986-06-16

    Applicant: Yoso Numasaki ,  Koichiro Takahashi ,  Isao Ohata

    Inventor： Yoso Numasaki ,  Koichiro Takahashi ,  Isao Ohata

    IPC: C07D233/60 ,  A61K31/415 ,  A61K31/44 ,  A61K31/4402 ,  A61K31/4406 ,  A61P35/00 ,  C07D213/63 ,  C07D213/64 ,  C07D213/65 ,  C07D521/00 ,  A61K31/435

    CPC classification number: C07D213/64 ,  A61K31/415 ,  A61K31/44 ,  C07D213/65 ,  C07D231/12 ,  C07D233/56 ,  C07D249/08

    Abstract: This disclosure describes compositions of matter useful as growth inhibitors of transplanted tumors in mammals: and this invention discloses a method of inducing the regression and/or palliation of various types of tumors in mammals (mammary cancer, liver cancer, skin cancer, etc.), said method comprising giving to said mammals an effective amount of a compound of the following formula: ##STR1## [wherein A represents an imidazolyl group or a pyridyl group, l represents 0 or 1, m and n each, which may be the same of different, represents an integer of 1 to 6, and, R represents a hydrogen atom or a lower alkyl group], or a salt thereof; the invention also discloses a method of inhibition (or prevention) of metastasis of the various cancers.The above formula compounds have low toxicity, and it is expected to apply various types of administration thereof such as oral administration and parenteral administration. In particular, it is expected that the compounds are useful as new type of medical (anti-cancer) compounds which can be administered orally.

    Abstract translation: 本公开描述了用作哺乳动物移植肿瘤生长抑制剂的物质的组合物：本发明公开了诱导哺乳动物（乳腺癌，肝癌，皮肤癌等）中各种类型肿瘤的消退和/或缓解的方法， 所述方法包括给予所述哺乳动物有效量的下式化合物：其中A代表咪唑基或吡啶基，l代表0或1，m和n各自可以相同 不同，表示1〜6的整数，R表示氢原子或低级烷基]或其​​盐; 本发明还公开了抑制（或预防）各种癌症转移的方法。 上述配方化合物的毒性低，预期可以应用各种类型的给药，例如口服给药和肠胃外给药。 特别地，预期这些化合物可用作可以口服给药的新型医疗（抗癌）化合物。

    Agent inducing increase in bone mass
    6.
    发明申请
    Agent inducing increase in bone mass 审中-公开
    诱导骨量增加的药剂

    公开(公告)号：US20060173009A1

    公开(公告)日：2006-08-03

    申请号：US10563107

    申请日：2004-06-30

    Applicant: Hiroyuki Kanoh ,  Koichiro Takahashi ,  Hiromi Nara ,  Tatsuhiko Yamanoi ,  Shinji Fukushima ,  Ryo Naito ,  Susumu Igarashi

    Inventor： Hiroyuki Kanoh ,  Koichiro Takahashi ,  Hiromi Nara ,  Tatsuhiko Yamanoi ,  Shinji Fukushima ,  Ryo Naito ,  Susumu Igarashi

    IPC: A61K31/503

    CPC classification number: A61K31/5025 ,  A61K31/662 ,  A61K31/663 ,  A61K2300/00

    Abstract: Osteoporosis and the like metabolic bone diseases have a high frequency of causing lumbago and the like pains and bone fracture, due to lowering of the bone strength caused by the reduction of bone mass. Accordingly, great concern has been directed toward the creation of a drug which can increase the bone mass and bone strength by controlling the whole bone metabolism. The pharmaceutical composition or combination product of the invention comprising a non-living body-derived non-peptide osteoblast differentiation promoting compound and a bisphosphonate having a bone resorption inhibitory action is useful as a bone mass increasing inducer which can increase the bone mass and/or bone strength by controlling the bone metabolism.

    Abstract translation: 骨质疏松等代谢性骨疾病由于骨质量下降引起的骨强度降低，频繁地引起腰痛等骨折。 因此，非常关注通过控制整个骨代谢来增加骨量和骨强度的药物的产生。 包含非生物体衍生的非肽成骨细胞分化促进化合物和具有骨吸收抑制作用的二膦酸盐的本发明的药物组合物或组合产品可用作骨质量增加诱导剂，其可以增加骨量和/或 通过控制骨骼代谢的骨骼力量。

    Optical disc apparatus and method for adjusting a servo of same
    7.
    发明授权
    Optical disc apparatus and method for adjusting a servo of same 有权
    光盘装置及其调整方法

    公开(公告)号：US06928034B2

    公开(公告)日：2005-08-09

    申请号：US10024589

    申请日：2001-12-17

    Applicant: Hiroshi Ohtsu ,  Toshisada Takada ,  Koichiro Takahashi

    Inventor： Hiroshi Ohtsu ,  Toshisada Takada ,  Koichiro Takahashi

    IPC: G11B21/10 ,  G11B7/005 ,  G11B7/09 ,  G11B7/095 ,  G11B7/00

    CPC classification number: G11B7/0908 ,  G11B7/0901 ,  G11B7/094 ,  G11B7/0945 ,  G11B7/0956

    Abstract: In an optical disc apparatus, a minimum jitter value is established from each jitter value measured in correspondence to a successively changed servo constant, and multiplied by a prescribed ratio so as to set a jitter threshold value. Servo constants corresponding to at least two jitter values substantially equal to the jitter threshold value is established, and an optimum servo constant is set based on this minimum of two servo constants. By doing this, it is possible to quickly and accurately detect the optimum servo constant, and achieve good servo adjustment.

    Abstract translation: 在光盘装置中，根据与连续变化的伺服常数相对应地测量的每个抖动值建立最小抖动值，并乘以规定的比例，以便设置抖动阈值。 建立对应于基本上等于抖动阈值的至少两个抖动值的伺服常数，并且基于两个伺服常数的最小值来设定最佳伺服常数。 通过这样做，可以快速，准确地检测最佳伺服常数，实现良好的伺服调整。

    Bone-forming graft
    8.
    发明授权
    Bone-forming graft 失效
    骨形成移植物

    公开(公告)号：US5830493A

    公开(公告)日：1998-11-03

    申请号：US817409

    申请日：1997-03-25

    Applicant: Shoji Yokota ,  Seitaro Shimokawa ,  Ritsu Sonohara ,  Akira Okada ,  Koichiro Takahashi

    Inventor： Shoji Yokota ,  Seitaro Shimokawa ,  Ritsu Sonohara ,  Akira Okada ,  Koichiro Takahashi

    IPC: A61L27/18 ,  A61L27/20 ,  A61L27/22 ,  A61L27/44 ,  A61L27/54 ,  A61L27/56 ,  A61F2/00

    CPC classification number: A61L27/44 ,  A61L27/18 ,  A61L27/20 ,  A61L27/22 ,  A61L27/54 ,  A61L27/56 ,  A61L2300/252 ,  A61L2300/414 ,  A61L2300/602 ,  A61L2430/02

    Abstract: A bone-forming graft that includes a bone morphogenetic protein (BMP) carried on a composite porous body. The composite porous body has a porous frame of a bioabsorbable hydrophilic material and a surface layer of a bioabsorbable polymer material. In particular, the present invention relates to a bone-forming graft in which the bioabsorbable hydrophilic material is one or more compounds selected from a group consisting of gelatin, hyaluronic acid, a hyaluronic acid derivative, collagen, a collagen derivative, chitosan, a chitosan derivative, and triethanolamine alginate. The bioabsorbable polymeric material is one or more compounds selected from a group consisting of a polylactic acid, a copolymer of a polylactic acid and a polyglycolic acid, and a copolymer of poly�bis(p-carboxyphenoxy)propane!anhydride and sebacic acid. The graft has excellent formability and workability and has an internal structure suitable for in vivo bone formation. Bone formation occurs not only at the periphery of the graft but also within the graft.

    Abstract translation: PCT No.PCT / JP95 / 01970。 371日期1997年3月25日 102（e）1997年3月25日PCT PCT 1995年9月28日PCT公布。 公开号WO96 / 10426 日期1996年4月11日一种骨形成移植物，其包括承载在复合多孔体上的骨形态发生蛋白（BMP）。 复合多孔体具有生物可吸收亲水材料的多孔框架和生物可吸收聚合物材料的表面层。 特别地，本发明涉及一种成骨移植物，其中生物可吸收亲水材料是一种或多种选自明胶，透明质酸，透明质酸衍生物，胶原，胶原衍生物，壳聚糖，壳聚糖 衍生物和海藻酸三乙醇胺。 生物可吸收聚合物材料是一种或多种选自聚乳酸，聚乳酸和聚乙醇酸的共聚物以及聚[双（对 - 羧基苯氧基）丙烷]酐和癸二酸的共聚物的化合物。 移植物具有优异的成形性和可加工性，并且具有适于体内骨形成的内部结构。 骨形成不仅发生在移植物的周边，而且在移植物内。

    Locking assembly for a metal watchband
    9.
    发明授权
    Locking assembly for a metal watchband 失效
    金属表带锁紧组件

    公开(公告)号：US06308382B1

    公开(公告)日：2001-10-30

    申请号：US09405563

    申请日：1999-09-24

    Applicant: Koichiro Takahashi ,  Kai Cheung Ho

    Inventor： Koichiro Takahashi ,  Kai Cheung Ho

    IPC: A44B1100

    CPC classification number: A44C5/24 ,  Y10T24/2155 ,  Y10T24/2166 ,  Y10T24/4782

    Abstract: The present invention provides a clasp assembly for a metallic watch chain, mainly comprising: an inner bend plate, an outer bend plate, and a clasp cap. Said inner bend plate can fit into the narrow groove of the outer bend plate. A convex clasp is disposed on the inner bend plate and corresponds to a concave clasp disposed on the outer bend plate in shape, position and size, and the two clasps engage with each other. The lock and release of the convex and concave clasps causes the lock and release of the watch chain. The clasp cap pivotably connects with the inner bend plate through screws. The hole of the clasp cap connects with the watch chain, and the outer bend plate connects with the watch chain through the cylindrical bodies at the left end. The structure of the clasp assembly is simple and is easy to use.

    Abstract translation: 本发明提供了一种用于金属手表链的扣件组件，主要包括：内弯板，外弯板和扣帽。 所述内弯板可以装配到外弯板的窄槽中。 凸形扣具设置在内弯板上，对应于形状，位置和尺寸设置在外弯板上的凹扣，并且两扣相互啮合。 凸形和凹形扣的锁定和释放导致手表链的锁定和释放。 扣环通过螺丝与内弯板可枢转地连接。 扣帽的孔与表链连接，外弯板通过左端的圆柱体与表链连接。 扣环组合结构简单，使用方便。

    Epitaxial wafer for GaP pure green light-emitting diode and GaP pure green light-emitting diode
    10.
    发明授权
    Epitaxial wafer for GaP pure green light-emitting diode and GaP pure green light-emitting diode 失效
    GaP纯绿色发光二极管和GaP纯绿色发光二极管的外延晶片

    公开(公告)号：US5886369A

    公开(公告)日：1999-03-23

    申请号：US965192

    申请日：1997-11-06

    Applicant: Koichi Hasegawa ,  Koichiro Takahashi

    Inventor： Koichi Hasegawa ,  Koichiro Takahashi

    IPC: H01L21/208 ,  H01L33/30 ,  H01L33/40 ,  H01L27/15

    CPC classification number: H01L33/30 ,  H01L33/0062 ,  H01L33/025

    Abstract: An epitaxial wafer for a GaP pure green light emitting diode includes an n-type single crystal GaP substrate formed in order thereon with a first n-type GaP epitaxial layer, a second n-type GaP epitaxial layer and a p-type GaP epitaxial layer. The p-type GaP epitaxial layer has a sulfur concentration of not greater than 1.times.10.sup.17 cm.sup.31 3, the second n-type GaP epitaxial layer has a carrier concentration on a side thereof interfacing with the p-type GaP epitaxial layer of 0.5-5.times.10.sup.17 cm.sup.-3, and the p-type GaP epitaxial layer has a carrier concentration on a side thereof interfacing with the second n-type GaP epitaxial layer that is 1-10.times.10.sup.17 cm.sup.-3 and is not less than twice the carrier concentration of the second n-type GaP epitaxial layer on the side thereof interfacing with the p-type GaP epitaxial layer. A GaP pure green light-emitting diode exhibiting high brightness includes the epitaxial wafer, an n-type electrode provided on a back surface of the single crystal substrate and a p-type electrode provided on the upper surface of the p-type GaP epitaxial layer.

    Abstract translation: 用于GaP纯绿色发光二极管的外延晶片包括依次形成有第一n型GaP外延层，第二n型GaP外延层和p型GaP外延层的n型单晶GaP衬底 。 p型GaP外延层的硫浓度不大于1×10 17 cm -3 3 3，第二n型GaP外延层在其与p型GaP外延层接合的一侧上具有0.5-5×10 17 cm -1的GaP外延层， 3，并且p型GaP外延层在其与第二n型GaP外延层接合的一侧上的载流子浓度为1-10×10 17 cm -3，并且不小于第二n-型GaP外延层的载流子浓度的两倍， GaP外延层与p型GaP外延层接合。 显示高亮度的GaP纯绿色发光二极管包括外延晶片，设置在单晶衬底的背面上的n型电极和设置在p型GaP外延层的上表面上的p型电极 。

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