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    Inhibiting growth of tumors with certain substituted phenoxy dimethyl alkanoic acids, esters or salts
    2.
    发明授权
    Inhibiting growth of tumors with certain substituted phenoxy dimethyl alkanoic acids, esters or salts 失效
    用某些取代的苯氧基二甲基链烷酸，酯或盐抑制肿瘤的生长

    公开(公告)号：US4758580A

    公开(公告)日：1988-07-19

    申请号：US874547

    申请日：1986-06-16

    Applicant: Yoso Numasaki ,  Koichiro Takahashi ,  Isao Ohata

    Inventor： Yoso Numasaki ,  Koichiro Takahashi ,  Isao Ohata

    IPC: C07D233/60 ,  A61K31/415 ,  A61K31/44 ,  A61K31/4402 ,  A61K31/4406 ,  A61P35/00 ,  C07D213/63 ,  C07D213/64 ,  C07D213/65 ,  C07D521/00 ,  A61K31/435

    CPC classification number: C07D213/64 ,  A61K31/415 ,  A61K31/44 ,  C07D213/65 ,  C07D231/12 ,  C07D233/56 ,  C07D249/08

    Abstract: This disclosure describes compositions of matter useful as growth inhibitors of transplanted tumors in mammals: and this invention discloses a method of inducing the regression and/or palliation of various types of tumors in mammals (mammary cancer, liver cancer, skin cancer, etc.), said method comprising giving to said mammals an effective amount of a compound of the following formula: ##STR1## [wherein A represents an imidazolyl group or a pyridyl group, l represents 0 or 1, m and n each, which may be the same of different, represents an integer of 1 to 6, and, R represents a hydrogen atom or a lower alkyl group], or a salt thereof; the invention also discloses a method of inhibition (or prevention) of metastasis of the various cancers.The above formula compounds have low toxicity, and it is expected to apply various types of administration thereof such as oral administration and parenteral administration. In particular, it is expected that the compounds are useful as new type of medical (anti-cancer) compounds which can be administered orally.

    Abstract translation: 本公开描述了用作哺乳动物移植肿瘤生长抑制剂的物质的组合物：本发明公开了诱导哺乳动物（乳腺癌，肝癌，皮肤癌等）中各种类型肿瘤的消退和/或缓解的方法， 所述方法包括给予所述哺乳动物有效量的下式化合物：其中A代表咪唑基或吡啶基，l代表0或1，m和n各自可以相同 不同，表示1〜6的整数，R表示氢原子或低级烷基]或其​​盐; 本发明还公开了抑制（或预防）各种癌症转移的方法。 上述配方化合物的毒性低，预期可以应用各种类型的给药，例如口服给药和肠胃外给药。 特别地，预期这些化合物可用作可以口服给药的新型医疗（抗癌）化合物。

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