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23 条记录 (耗时 0.026 秒)

    Tri(lower alkoxy) benzene derivatives
    1.
    发明授权
    Tri(lower alkoxy) benzene derivatives 失效
    三（低级烷氧基）苯衍生物

    公开(公告)号：US5498635A

    公开(公告)日：1996-03-12

    申请号：US314057

    申请日：1994-09-28

    申请人： Hiromu Hara ,  Tatsuya Maruyama ,  Munetoshi Saito ,  Toshiyasu Mase

    发明人： Hiromu Hara ,  Tatsuya Maruyama ,  Munetoshi Saito ,  Toshiyasu Mase

    IPC分类号： A61K31/165 ,  A61K31/17 ,  A61K31/275 ,  A61K31/40 ,  A61K31/445 ,  A61K31/535 ,  A61K31/54 ,  C07C237/06 ,  C07C237/20 ,  C07C255/43 ,  C07C275/34 ,  C07C275/40 ,  C07D295/13 ,  C07D295/14 ,  C07D295/145

    CPC分类号： C07D295/13 ,  C07C237/20 ,  C07C275/34 ,  C07D295/145

    摘要： This invention relates to a tri(lower alkoxy)benzene derivative of the general formula (I), or its salt, optical isomer or solvate, ##STR1## wherein: R.sup.1, R.sup.2 and R.sup.3 : same or different and each represents a lower alkyl group;A: a group of the formula ##STR2## and R.sup.4 and R.sup.5 : same or different and each represents a lower alkyl group, an aralkyl group or an aryl group, provided that R.sup.4 and R.sup.5 may, taken together with the adjacent nitrogen atom, form a pyrrolidinyl group, a piperidino group, a morpholino group, a thiomorpholino group, or a piperazinyl group optionally substituted by a lower alkyl group in 4-position;to pharmaceutical compositions containing the same, and to processes for their production. The compound of the invention is useful as value as a pulmonary-surfactant secretion promoting agent.

    摘要翻译： 本发明涉及通式（I）的三（低级烷氧基）苯衍生物或其盐，旋光异构体或溶剂化物，其中：R1，R2和R3相同或不同，并且各自表示 低级烷基; A：通式“IMAGE”和R 4和R 5的基团相同或不同，各自表示低级烷基，芳烷基或芳基，条件是R 4和R 5可以与相邻的氮原子一起形成 吡咯烷基，哌啶子基，吗啉代基，硫代吗啉代基或任选被4-位的低级烷基取代的哌嗪基; 包含其的药物组合物及其生产方法。 本发明的化合物可用作肺表面活性剂分泌促进剂的价值。

    Benzimidazolinone derivatives
    2.
    发明授权
    Benzimidazolinone derivatives 失效
    苯并咪唑啉酮衍生物

    公开(公告)号：US5162318A

    公开(公告)日：1992-11-10

    申请号：US684866

    申请日：1991-04-15

    申请人： Hiromu Hara ,  Tatsuya Maruyama ,  Munetoshi Saito ,  Makoto Takeuchi ,  Toshiyasu Mase

    发明人： Hiromu Hara ,  Tatsuya Maruyama ,  Munetoshi Saito ,  Makoto Takeuchi ,  Toshiyasu Mase

    IPC分类号： C07D235/26 ,  C07D521/00

    CPC分类号： C07D231/12 ,  C07D233/56 ,  C07D235/26 ,  C07D249/08

    摘要： Benzimidazolinone derivatives of the general formula (I): ##STR1## wherein R.sup.1, R.sup.2 and R.sup.3, which may be the same or different, each is a hydrogen or halogen atom or a lower alkyl, halo-lower alkyl, hydroxy-lower alkyl, hydroxyl, lower alkoxy, aryloxy, acyl, cyano, carboxyl, a lower alkoxycarbonyl, carbamoyl, nitro or nitrogen-containing 5- or 6-membered heterocyclic group; A is an ethylene group which may optionally have at least one branch; R.sup.4 and R.sup.5, which may be the same or different, each is a lower alkyl group or R.sup.4 and R.sup.5, together with the adjacent nitrogen atom, represent a pyrrolidinyl, piperidino or a morpholino group provided that when ##STR2## is a piperidino or diethylamino group, at least one of R.sup.1, R.sup.2 and R.sup.3 is other than a hydrogen atom, or pharmaceutically acceptable salts thereof, methods of producing the same and pharmaceutical compositions containing the same are disclosed. Pharmacologically, the above compounds (I) have pulmonary surfactant secretion promoting activity.