公开(公告)号：US20080306607A1

公开(公告)日：2008-12-11

申请号：US12191541

申请日：2008-08-14

Applicant: Yasuharu Hakamatsuka ,  Yuji Takamiya ,  Katsuya Sadamori

Inventor： Yasuharu Hakamatsuka ,  Yuji Takamiya ,  Katsuya Sadamori

IPC: A61F2/28

CPC classification number: A61L27/12 ,  A61F2/28 ,  A61F2/30771 ,  A61F2/32 ,  A61F2002/2817 ,  A61F2002/30062 ,  A61F2002/30118 ,  A61F2002/30144 ,  A61F2002/30146 ,  A61F2002/30154 ,  A61F2002/3024 ,  A61F2002/3028 ,  A61F2002/30677 ,  A61F2002/30785 ,  A61F2002/30828 ,  A61F2002/30879 ,  A61F2002/30892 ,  A61F2002/30957 ,  A61F2002/3412 ,  A61F2002/3611 ,  A61F2210/0004 ,  A61F2230/0006 ,  A61F2230/0017 ,  A61F2230/0021 ,  A61F2230/0063 ,  A61F2230/0069 ,  A61F2310/00293

Abstract: A bone substitute (a material for repairing biological tissues) made from β-TCP as the raw material comprises a plate-type base member on the surface of which a plurality of grooves extending in a single direction are formed and separated from each other by partition wall members having an almost uniform thickness. This material sustains a sufficient binding force after application to a biological tissue and exhibits an excellent effect of forming a biological tissue. This bone substitute (material for repairing biological tissues) having a main body provided with a plurality of grooves extending in a single direction which are separated from each other by partition wall members having an almost uniform thickness, and a biodegradable viscous member which is filled into at least one of the penetrating holes of the main body, and contains an agonistic factor capable of increasing the cell activity, can provide agonistic factors of sufficient types and amounts to a biological tissue, and can control the sustained-release dose thereof.

Abstract translation: 由β-TCP制成的骨替代物（用于修复生物组织的材料）作为原料，包括板状基材，其表面上形成有沿单个方向延伸的多个槽，并通过分隔彼此分离 壁构件具有几乎均匀的厚度。 这种材料在施用到生物组织后维持足够的结合力，并且表现出优异的形成生物组织的效果。 这种骨替代物（用于修复生物组织的材料）具有主体，该主体设置有沿单个方向延伸的多个槽，所述多个槽通过具有几乎均匀厚度的分隔壁构件彼此分离，以及可生物降解的粘性构件，其被填充 主体的穿透孔中的至少一个，并且含有能够增加细胞活性的激动因子，可以向生物组织提供足够类型和量的激动因子，并且可以控制其持续释放剂量。

公开(公告)号：US20070112434A1

公开(公告)日：2007-05-17

申请号：US10555243

申请日：2004-03-31

Applicant: Yasuharu Hakamatsuka ,  Yuji Takamiya ,  Katsuya Sadamori

Inventor： Yasuharu Hakamatsuka ,  Yuji Takamiya ,  Katsuya Sadamori

IPC: A61F2/28

CPC classification number: A61L27/12 ,  A61F2/28 ,  A61F2/30771 ,  A61F2/32 ,  A61F2002/2817 ,  A61F2002/30062 ,  A61F2002/30118 ,  A61F2002/30144 ,  A61F2002/30146 ,  A61F2002/30154 ,  A61F2002/3024 ,  A61F2002/3028 ,  A61F2002/30677 ,  A61F2002/30785 ,  A61F2002/30828 ,  A61F2002/30879 ,  A61F2002/30892 ,  A61F2002/30957 ,  A61F2002/3412 ,  A61F2002/3611 ,  A61F2210/0004 ,  A61F2230/0006 ,  A61F2230/0017 ,  A61F2230/0021 ,  A61F2230/0063 ,  A61F2230/0069 ,  A61F2310/00293

Abstract: A bone substitute (a material for repairing biological tissues) made from β-TCP as the raw material comprises a plate-type base member on the surface of which a plurality of grooves extending in a single direction are formed and separated from each other by partition wall members having an almost uniform thickness. This material sustains a sufficient binding force after application to a biological tissue and exhibits an excellent effect of forming a biological tissue. This bone substitute (material for repairing biological tissues) having a main body provided with a plurality of grooves extending in a single direction which are separated from each other by partition wall members having an almost uniform thickness, and a biodegradable viscous member which is filled into at least one of the penetrating holes of the main body, and contains an agonistic factor capable of increasing the cell activity, can provide agonistic factors of sufficient types and amounts to a biological tissue, and can control the sustained-release dose thereof.

Abstract translation: 由β-TCP制成的骨替代物（用于修复生物组织的材料）作为原料，包括板状基材，其表面上形成有沿单个方向延伸的多个槽，并通过分隔彼此分离 壁构件具有几乎均匀的厚度。 这种材料在施用到生物组织后维持足够的结合力，并且表现出优异的形成生物组织的效果。 这种骨替代物（用于修复生物组织的材料）具有主体，该主体设置有沿单个方向延伸的多个槽，所述多个槽通过具有几乎均匀厚度的分隔壁构件彼此分离，以及可生物降解的粘性构件，其被填充 主体的穿透孔中的至少一个，并且含有能够增加细胞活性的激动因子，可以向生物组织提供足够类型和量的激动因子，并且可以控制其持续释放剂量。

公开(公告)号：US20080099948A1

公开(公告)日：2008-05-01

申请号：US10555140

申请日：2004-03-30

Applicant: Yasuharu Hakamatsuka ,  Yuji Takamiya ,  Katsuya Sadamori

Inventor： Yasuharu Hakamatsuka ,  Yuji Takamiya ,  Katsuya Sadamori

IPC: B27N3/02

CPC classification number: A61L27/12 ,  A61F2/28 ,  A61F2/3094 ,  A61F2002/30154 ,  A61F2002/30224 ,  A61F2002/30785 ,  A61F2230/0021 ,  A61F2230/0069 ,  A61F2310/00293

Abstract: An object is to promote the growth of adhered cells and improve adhesiveness of stem cells. A cylindrical scaffold made of a porous calcium phosphate (for example, beta-TCP) material has a form in which a plurality of through-holes extending in a single direction are separated from each other by partition wall members having an almost uniform thickness. The material for repairing biological tissues wherein each through-hole has a quadrangular shape, and each partition wall member has a plurality of concavities and a plurality of pores in the surface, and a process for producing the same are provided.

Abstract translation: 目的是促进粘附细胞的生长，提高干细胞的粘附性。 由多孔磷酸钙（例如β-TCP）材料制成的圆柱形支架具有这样的形式，其中通过具有几乎均匀厚度的分隔壁构件将单个方向上延伸的多个通孔彼此分离。 用于修复生物组织的材料，其中每个通孔具有四边形形状，并且每个分隔壁构件在表面中具有多个凹部和多个孔，并且提供其制造方法。

公开(公告)号：US5013363A

公开(公告)日：1991-05-07

申请号：US471840

申请日：1990-01-29

Applicant: Yasuharu Hakamatsuka ,  Kazuhiro Watanabe

Inventor： Yasuharu Hakamatsuka ,  Kazuhiro Watanabe

IPC: B22C1/08 ,  C03B19/02 ,  C04B35/14 ,  C04B35/63

CPC classification number: C03B19/02 ,  C04B35/14 ,  C04B35/6313

Abstract: The phosphate mold material of this invention comprises refractory materials and binders as principal components, the refractory materials containing cristobalite and quartz, and the binders containing metal oxides which includes magnesia clinker and a phosphate salt. The proportion of said refractory materials to said binders is 80:20-90:10, and the proportion of cristobalite to quartz is in the range 6:1-7:1.

Abstract translation: 本发明的磷酸盐模具材料包括作为主要成分的耐火材料和粘合剂，含有方英石和石英的耐火材料以及包含氧化镁熟料和磷酸盐的金属氧化物的粘合剂。 所述耐火材料对所述粘合剂的比例为80:20-90:10，方石英与石英的比例为6：1-7：1。

公开(公告)号：USD336336S

公开(公告)日：1993-06-08

申请号：US645010

申请日：1991-01-23

Applicant: Yasuharu Hakamatsuka ,  Kazuhiro Watanabe ,  Mamoru Aihara ,  Manabu Takahashi ,  Toshio Shimizu

Designer： Yasuharu Hakamatsuka ,  Kazuhiro Watanabe ,  Mamoru Aihara ,  Manabu Takahashi ,  Toshio Shimizu

公开(公告)号：US4747876A

公开(公告)日：1988-05-31

申请号：US907587

申请日：1986-09-15

Applicant: Yasuharu Hakamatsuka ,  Kazuhiro Watanabe

Inventor： Yasuharu Hakamatsuka ,  Kazuhiro Watanabe

IPC: C03C3/112 ,  A61K6/00 ,  A61K6/02 ,  A61K6/06 ,  C03C10/16 ,  C09K3/00

CPC classification number: C03C10/16 ,  A61K6/0094 ,  A61K6/0215 ,  A61K6/0235 ,  A61K6/024 ,  A61K6/025 ,  A61K6/0276

Abstract: A dental crown formed of a dental crown material comprising crystallized glass containing 40 to 45% by weight of SiO.sub.2, 11 to 15% by weight of Al.sub.2 O.sub.3, 16 to 23% by weight of MgO, 6.5 to 8% by weight of F, 4.0 to 7.0% by weight of Na.sub.2 O, 5 to 9% by weight of Li.sub.2 O, not more than 1% by weight of TiO.sub.2, 2 to 4% by weight of ZrO.sub.2, and at least one oxide selected from the group consisting of Fe.sub.2 O.sub.3, MnO, CeO.sub.2 and NiO, and having a bending strength of at least 2000 Kg/cm.sup.2.

Abstract translation: 由牙冠材料形成的牙冠，其包含含有40〜45重量％的SiO 2，11〜15重量％的Al 2 O 3，16〜23重量％的MgO，6.5〜8重量％的F，4.0 至7.0重量％的Na 2 O，5至9重量％的Li 2 O，不超过1重量％的TiO 2，2至4重量％的ZrO 2和至少一种选自Fe 2 O 3，MnO ，CeO 2和NiO，并且具有至少2000Kg / cm 2的弯曲强度。

公开(公告)号：US20060115458A1

公开(公告)日：2006-06-01

申请号：US11270081

申请日：2005-11-09

Applicant: Tomoaki Tamura ,  Toshie Tsuchiya ,  Kazuo Isama ,  Masato Tamai ,  Yasuharu Hakamatsuka

Inventor： Tomoaki Tamura ,  Toshie Tsuchiya ,  Kazuo Isama ,  Masato Tamai ,  Yasuharu Hakamatsuka

IPC: A61K35/12 ,  A61F2/02 ,  A61K33/42

CPC classification number: A61L27/3821 ,  A61L27/047 ,  A61L27/306 ,  A61L27/32

Abstract: Osteoblast activity is promoted and a large amount of extracellular substrates are produced so as to promote cell proliferation and/or differentiation. A material for repairing biological tissues, the material comprising a biocompatible material containing at least one of niobium and tantalum, is provided. These metal salts are not toxic even at high concentrations, and can activate osteoblasts to increase the production quantity of extracellular substrates. The material for repairing biological tissues is manufactured by mixing a metal salt solution, a calcium compound, and a phosphate compound (S4), then coprecipitating the metal-containing calcium phosphate.

Abstract translation: 促进成骨细胞活性，产生大量的细胞外基质以促进细胞增殖和/或分化。 提供了用于修复生物组织的材料，该材料包含含有铌和钽中的至少一种的生物相容性材料。 这些金属盐即使在高浓度下也不具有毒性，并且可以活化成骨细胞以增加细胞外底物的产生量。 通过混合金属盐溶液，钙化合物和磷酸盐化合物（S4）来制造用于修复生物组织的材料，然后使含金属的磷酸钙共沉淀。

公开(公告)号：US20050158846A1

公开(公告)日：2005-07-21

申请号：US10509447

申请日：2003-04-09

Applicant: Hiroki Hibino ,  Shin Katayama ,  Hiroyuki Irie ,  Hikaru Inoue ,  Hitoshi Mizuno ,  Yasuharu Hakamatsuka ,  Yoshiharu Saito ,  Hideki Koyanagi

Inventor： Hiroki Hibino ,  Shin Katayama ,  Hiroyuki Irie ,  Hikaru Inoue ,  Hitoshi Mizuno ,  Yasuharu Hakamatsuka ,  Yoshiharu Saito ,  Hideki Koyanagi

IPC: C12M1/34 ,  C12M3/00 ,  C12N5/00 ,  C12N5/07 ,  G01N33/48 ,  G01N33/50 ,  G06F19/00

CPC classification number: G06Q10/08 ,  G06Q10/06

Abstract: The present invention discloses a cell culturing system that cultures predetermined cells collected from a patient and supplies cultured cells to the original patient, which together with enabling correlations between the cultured cells and the supplier of the cells to be managed accurately and easily at all times, allows cultured cells and patients to be collated rapidly. In a cell culturing system 20 that carries in cells containing stem cells and contains them in an incoming transport container to which is attached unique identification information, transfers the transported cells to and cultures them in a culture container to which is attached unique identification information, and carries out the cultured cells by transferring them to an outgoing transport container to which is attached unique identification information, ID numbers attached to the containers before and after transfer are input from a barcode reader 31 whenever the cells are transferred to a different container. The input ID numbers are then stored in a database provided in a managing server 40 in mutual correlation.

Abstract translation: 本发明公开了一种细胞培养系统，其对从患者收集的预定细胞进行培养，并向原始患者提供培养的细胞，同时能够随时准确，容易地管理培养细胞和细胞供应者之间的相关性， 允许培养细胞和患者快速整理。 在携带含有干细胞的细胞的细胞培养系统20中，将其包含在附有唯一识别信息的输入运输容器中，将所运送的细胞转移到培养容器中并将其培养至附有唯一识别信息的培养容器中，以及 通过将培养的细胞转移到附着的唯一识别信息的输送输送容器，每当将细胞转移到不同的容器时，从条形码读取器31输入附着到转移前后的容器的ID号码。 然后将输入的ID号码相互相关地存储在管理服务器40中提供的数据库中。

公开(公告)号：US4770943A

公开(公告)日：1988-09-13

申请号：US123221

申请日：1987-11-20

Applicant: Yasuharu Hakamatsuka ,  Sukezo Kawamura ,  Motohiro Toriyama

Inventor： Yasuharu Hakamatsuka ,  Sukezo Kawamura ,  Motohiro Toriyama

IPC: C04B41/87 ,  A61F2/00 ,  A61L27/00 ,  A61L27/32 ,  C04B41/52 ,  C04B41/89 ,  C23C22/03 ,  B05D1/36 ,  B05D3/02 ,  B05D7/00 ,  B32B9/00

CPC classification number: A61L27/32 ,  C04B41/009 ,  C04B41/52 ,  C04B41/89 ,  A61F2310/00796 ,  C04B2103/008 ,  C04B2111/00836

Abstract: A method of forming a rigid film of calcium phosphate compound having good bio-conformance on a surface of a ceramic or metal substrate is disclosed. According to this method, a slurry of a fine powder of phosphate-series glass of CaO-Na.sub.2 O-P.sub.2 O.sub.5 -Al.sub.2 O.sub.3 is applied to the surface of the substrate and is dried and heat-treated to form a binder layer which covers the surface of the substrate. A peptisation agent such as ammonium polyacrylate and water are mixed with a fine powder of a calcium phosphate compound having a particle size of 1 .mu.m or less to prepare a slurry, and this slurry is applied to the surface of the binder layer. The slurry on the binder layer is dried and heat-treated to form a film of the calcium phosphate compound. The film of the calcium phosphate compound formed by this method is uniform and has high adhesion strength with the substrate.

Abstract translation: 公开了一种在陶瓷或金属基材的表面上形成具有良好生物一致性的磷酸钙化合物刚性膜的方法。 根据该方法，将CaO-Na 2 O-P 2 O 5·Al 2 O 3的磷酸盐系玻璃微粉的浆料涂布在基材的表面上，进行干燥，热处理，形成覆盖表面的粘合剂层 基质。 将聚丙烯酸铵和水等胶溶剂与粒径为1μm以下的磷酸钙化合物的细粉末混合，制成浆料，将该浆料涂布在粘合剂层的表面。 将粘合剂层上的浆料干燥并热处理以形成磷酸钙化合物的膜。 通过该方法形成的磷酸钙化合物的膜是均匀的并且与基材具有高粘附强度。

公开(公告)号：US4713006A

公开(公告)日：1987-12-15

申请号：US844210

申请日：1986-03-26

Applicant: Yasuharu Hakamatsuka ,  Nobuyuki Yokoyama

Inventor： Yasuharu Hakamatsuka ,  Nobuyuki Yokoyama

IPC: A61C8/00 ,  A61K6/02 ,  A61K6/027 ,  C04B35/111 ,  C04B35/486 ,  A61F1/24

CPC classification number: C04B35/111 ,  A61C8/0012 ,  A61C8/005 ,  A61C8/0057 ,  A61C8/0065 ,  A61C8/0069 ,  A61C8/0086 ,  C04B35/486 ,  A61C8/0013 ,  A61C8/0054 ,  C04B2111/00836

Abstract: An artificial tooth root is divided into a tooth root body and a root holder. The material for the artificial tooth root body is selected in consideration of its strength. The outer surface of the root holder that is in contact with the alveolar bone is formed of a biologically activated material for providing strong adhesion between the root holder and the alveolar bone. An impact reducing material is provided between the artificial tooth root body and the root holder to reduce the impact force placed on the tooth root body so that the force applied to the alveolar bone portion is reduced.

Abstract translation: 人造牙根分为牙根体和根部固定器。 考虑到其强度来选择人造牙根体的材料。 与牙槽骨接触的根部保持器的外表面由用于在根部保持器和牙槽骨之间提供强粘附的生物活化材料形成。 在人造牙根体和根部保持器之间设有减震材料，以减少施加在牙根体上的冲击力，使得施加到牙槽骨部分的力减小。