公开(公告)号：US20060115458A1

公开(公告)日：2006-06-01

申请号：US11270081

申请日：2005-11-09

Applicant: Tomoaki Tamura ,  Toshie Tsuchiya ,  Kazuo Isama ,  Masato Tamai ,  Yasuharu Hakamatsuka

Inventor： Tomoaki Tamura ,  Toshie Tsuchiya ,  Kazuo Isama ,  Masato Tamai ,  Yasuharu Hakamatsuka

IPC: A61K35/12 ,  A61F2/02 ,  A61K33/42

CPC classification number: A61L27/3821 ,  A61L27/047 ,  A61L27/306 ,  A61L27/32

Abstract: Osteoblast activity is promoted and a large amount of extracellular substrates are produced so as to promote cell proliferation and/or differentiation. A material for repairing biological tissues, the material comprising a biocompatible material containing at least one of niobium and tantalum, is provided. These metal salts are not toxic even at high concentrations, and can activate osteoblasts to increase the production quantity of extracellular substrates. The material for repairing biological tissues is manufactured by mixing a metal salt solution, a calcium compound, and a phosphate compound (S4), then coprecipitating the metal-containing calcium phosphate.

Abstract translation: 促进成骨细胞活性，产生大量的细胞外基质以促进细胞增殖和/或分化。 提供了用于修复生物组织的材料，该材料包含含有铌和钽中的至少一种的生物相容性材料。 这些金属盐即使在高浓度下也不具有毒性，并且可以活化成骨细胞以增加细胞外底物的产生量。 通过混合金属盐溶液，钙化合物和磷酸盐化合物（S4）来制造用于修复生物组织的材料，然后使含金属的磷酸钙共沉淀。