公开(公告)号：US20080306607A1

公开(公告)日：2008-12-11

申请号：US12191541

申请日：2008-08-14

Applicant: Yasuharu Hakamatsuka ,  Yuji Takamiya ,  Katsuya Sadamori

Inventor： Yasuharu Hakamatsuka ,  Yuji Takamiya ,  Katsuya Sadamori

IPC: A61F2/28

CPC classification number: A61L27/12 ,  A61F2/28 ,  A61F2/30771 ,  A61F2/32 ,  A61F2002/2817 ,  A61F2002/30062 ,  A61F2002/30118 ,  A61F2002/30144 ,  A61F2002/30146 ,  A61F2002/30154 ,  A61F2002/3024 ,  A61F2002/3028 ,  A61F2002/30677 ,  A61F2002/30785 ,  A61F2002/30828 ,  A61F2002/30879 ,  A61F2002/30892 ,  A61F2002/30957 ,  A61F2002/3412 ,  A61F2002/3611 ,  A61F2210/0004 ,  A61F2230/0006 ,  A61F2230/0017 ,  A61F2230/0021 ,  A61F2230/0063 ,  A61F2230/0069 ,  A61F2310/00293

Abstract: A bone substitute (a material for repairing biological tissues) made from β-TCP as the raw material comprises a plate-type base member on the surface of which a plurality of grooves extending in a single direction are formed and separated from each other by partition wall members having an almost uniform thickness. This material sustains a sufficient binding force after application to a biological tissue and exhibits an excellent effect of forming a biological tissue. This bone substitute (material for repairing biological tissues) having a main body provided with a plurality of grooves extending in a single direction which are separated from each other by partition wall members having an almost uniform thickness, and a biodegradable viscous member which is filled into at least one of the penetrating holes of the main body, and contains an agonistic factor capable of increasing the cell activity, can provide agonistic factors of sufficient types and amounts to a biological tissue, and can control the sustained-release dose thereof.

Abstract translation: 由β-TCP制成的骨替代物（用于修复生物组织的材料）作为原料，包括板状基材，其表面上形成有沿单个方向延伸的多个槽，并通过分隔彼此分离 壁构件具有几乎均匀的厚度。 这种材料在施用到生物组织后维持足够的结合力，并且表现出优异的形成生物组织的效果。 这种骨替代物（用于修复生物组织的材料）具有主体，该主体设置有沿单个方向延伸的多个槽，所述多个槽通过具有几乎均匀厚度的分隔壁构件彼此分离，以及可生物降解的粘性构件，其被填充 主体的穿透孔中的至少一个，并且含有能够增加细胞活性的激动因子，可以向生物组织提供足够类型和量的激动因子，并且可以控制其持续释放剂量。

公开(公告)号：US20070112434A1

公开(公告)日：2007-05-17

申请号：US10555243

申请日：2004-03-31

Applicant: Yasuharu Hakamatsuka ,  Yuji Takamiya ,  Katsuya Sadamori

Inventor： Yasuharu Hakamatsuka ,  Yuji Takamiya ,  Katsuya Sadamori

IPC: A61F2/28

CPC classification number: A61L27/12 ,  A61F2/28 ,  A61F2/30771 ,  A61F2/32 ,  A61F2002/2817 ,  A61F2002/30062 ,  A61F2002/30118 ,  A61F2002/30144 ,  A61F2002/30146 ,  A61F2002/30154 ,  A61F2002/3024 ,  A61F2002/3028 ,  A61F2002/30677 ,  A61F2002/30785 ,  A61F2002/30828 ,  A61F2002/30879 ,  A61F2002/30892 ,  A61F2002/30957 ,  A61F2002/3412 ,  A61F2002/3611 ,  A61F2210/0004 ,  A61F2230/0006 ,  A61F2230/0017 ,  A61F2230/0021 ,  A61F2230/0063 ,  A61F2230/0069 ,  A61F2310/00293

Abstract: A bone substitute (a material for repairing biological tissues) made from β-TCP as the raw material comprises a plate-type base member on the surface of which a plurality of grooves extending in a single direction are formed and separated from each other by partition wall members having an almost uniform thickness. This material sustains a sufficient binding force after application to a biological tissue and exhibits an excellent effect of forming a biological tissue. This bone substitute (material for repairing biological tissues) having a main body provided with a plurality of grooves extending in a single direction which are separated from each other by partition wall members having an almost uniform thickness, and a biodegradable viscous member which is filled into at least one of the penetrating holes of the main body, and contains an agonistic factor capable of increasing the cell activity, can provide agonistic factors of sufficient types and amounts to a biological tissue, and can control the sustained-release dose thereof.

Abstract translation: 由β-TCP制成的骨替代物（用于修复生物组织的材料）作为原料，包括板状基材，其表面上形成有沿单个方向延伸的多个槽，并通过分隔彼此分离 壁构件具有几乎均匀的厚度。 这种材料在施用到生物组织后维持足够的结合力，并且表现出优异的形成生物组织的效果。 这种骨替代物（用于修复生物组织的材料）具有主体，该主体设置有沿单个方向延伸的多个槽，所述多个槽通过具有几乎均匀厚度的分隔壁构件彼此分离，以及可生物降解的粘性构件，其被填充 主体的穿透孔中的至少一个，并且含有能够增加细胞活性的激动因子，可以向生物组织提供足够类型和量的激动因子，并且可以控制其持续释放剂量。

公开(公告)号：US20080099948A1

公开(公告)日：2008-05-01

申请号：US10555140

申请日：2004-03-30

Applicant: Yasuharu Hakamatsuka ,  Yuji Takamiya ,  Katsuya Sadamori

Inventor： Yasuharu Hakamatsuka ,  Yuji Takamiya ,  Katsuya Sadamori

IPC: B27N3/02

CPC classification number: A61L27/12 ,  A61F2/28 ,  A61F2/3094 ,  A61F2002/30154 ,  A61F2002/30224 ,  A61F2002/30785 ,  A61F2230/0021 ,  A61F2230/0069 ,  A61F2310/00293

Abstract: An object is to promote the growth of adhered cells and improve adhesiveness of stem cells. A cylindrical scaffold made of a porous calcium phosphate (for example, beta-TCP) material has a form in which a plurality of through-holes extending in a single direction are separated from each other by partition wall members having an almost uniform thickness. The material for repairing biological tissues wherein each through-hole has a quadrangular shape, and each partition wall member has a plurality of concavities and a plurality of pores in the surface, and a process for producing the same are provided.

Abstract translation: 目的是促进粘附细胞的生长，提高干细胞的粘附性。 由多孔磷酸钙（例如β-TCP）材料制成的圆柱形支架具有这样的形式，其中通过具有几乎均匀厚度的分隔壁构件将单个方向上延伸的多个通孔彼此分离。 用于修复生物组织的材料，其中每个通孔具有四边形形状，并且每个分隔壁构件在表面中具有多个凹部和多个孔，并且提供其制造方法。

公开(公告)号：US07491526B2

公开(公告)日：2009-02-17

申请号：US10513616

申请日：2003-08-15

Applicant: Tsuyoshi Yanai ,  Yuji Takamiya ,  Hiroki Hibino

Inventor： Tsuyoshi Yanai ,  Yuji Takamiya ,  Hiroki Hibino

IPC: C12M1/00

CPC classification number: C12M23/58 ,  B29C65/2046 ,  B29C65/2076 ,  B29C66/1142 ,  B29C66/5221 ,  B29C66/857 ,  C12M21/18 ,  C12M23/26

Abstract: Contamination by dust particles, bacteria and so forth in each processing step can be reduced by a simple constitution. A culture vessel is used in which a medium vessel in which a medium is sealed and a waste medium vessel capable of housing the fluid in a main culture vessel are connected to the main culture vessel by connecting lines capable of restricting the flow of fluid between them in a state in which they are sealed from the outside. A culture apparatus is composed in which the inner volume of each vessel is variable, and is provided with a case provided with indentations for housing each vessel, and a pressing means that contracts the vessels housed in the indentations by applying external pressure.

Abstract translation: 通过简单的结构可以减少每个加工步骤中的尘埃颗粒，细菌等的污染。 使用培养容器，其中介质被密封的介质容器和能够容纳主培养容器中的流体的废物容器通过连接能够限制它们之间的流体流动的管线连接到主培养容器 处于从外部密封的状态。 一种培养装置，其中每个容器的内部体积是可变的，并且设置有设置有用于容纳每个容器的凹陷的壳体，以及通过施加外部压力来收缩容纳在压痕中的容器的按压装置。

公开(公告)号：US20080076133A1

公开(公告)日：2008-03-27

申请号：US11900192

申请日：2007-09-10

Applicant: Kunio Hori ,  Sachiko Karaki ,  Tokio Kano ,  Yuji Takamiya

Inventor： Kunio Hori ,  Sachiko Karaki ,  Tokio Kano ,  Yuji Takamiya

IPC: C12Q1/68

CPC classification number: G01N33/6803 ,  C12Q1/6816 ,  C12Q1/6823 ,  C12Q1/6827 ,  C12Q1/6858 ,  C12Q2565/107 ,  C12Q2561/113 ,  C12Q2537/143 ,  C12Q2531/101 ,  C12Q2565/102 ,  C12Q2535/125 ,  C12Q2521/514

Abstract: The present invention discloses a method of detecting a polymorphism site. According to an embodiment of the present invention, there is provided a method comprising (1) reacting a test sample containing a polymorphism site with at least one type of probe which is capable of binding to the polymorphism site of the test sample with a high affinity and labeled with a marker substance, and (2) optically measuring and analyzing a positional change of the marker substance at a plurality of time points in the course of the reaction, thereby detecting the polymorphism site.

Abstract translation: 本发明公开了一种检测多态性位点的方法。 根据本发明的实施方案，提供了一种方法，其包括（1）使含有多态性位点的测试样品与能够以高亲和力结合到测试样品的多态性位点的至少一种类型的探针 并用标记物质标记，（2）在反应过程中在多个时间点光学测量和分析标记物质的位置变化，从而检测多态位点。

公开(公告)号：US20050239196A1

公开(公告)日：2005-10-27

申请号：US10513616

申请日：2003-08-15

Applicant: Tsuyoshi Yanai ,  Yuji Takamiya ,  Hiroki Hibino

Inventor： Tsuyoshi Yanai ,  Yuji Takamiya ,  Hiroki Hibino

IPC: C12M1/00 ,  C12M3/00

CPC classification number: C12M23/58 ,  B29C65/2046 ,  B29C65/2076 ,  B29C66/1142 ,  B29C66/5221 ,  B29C66/857 ,  C12M21/18 ,  C12M23/26

Abstract: Contamination by dust particles, bacteria and so forth in each processing step can be reduced by a simple constitution. A culture vessel is used in which a medium vessel in which a medium is sealed and a waste medium vessel capable of housing the fluid in a main culture vessel are connected to the main culture vessel by connecting lines capable of restricting the flow of fluid between them in a state in which they are sealed from the outside. A culture apparatus is composed in which the inner volume of each vessel is variable, and is provided with a case provided with indentations for housing each vessel, and a pressing means that contracts the vessels housed in the indentations by applying external pressure.

Abstract translation: 通过简单的结构可以减少每个加工步骤中的尘埃颗粒，细菌等的污染。 使用培养容器，其中介质被密封的介质容器和能够容纳主培养容器中的流体的废物容器通过连接能够限制它们之间的流体流动的管线连接到主培养容器 处于从外部密封的状态。 一种培养装置，其中每个容器的内部体积是可变的，并且设置有设置有用于容纳每个容器的凹陷的壳体，以及通过施加外部压力来收缩容纳在压痕中的容器的按压装置。