公开(公告)号：US08936708B2

公开(公告)日：2015-01-20

申请号：US13784168

申请日：2013-03-04

Applicant: Tecan Trading AG

Inventor： Marc N. Feiglin ,  Michael Benjamin Franklin ,  Timothy Francis Lee ,  Joseph Mamone

IPC: G01N27/447 ,  G01N27/453 ,  B01L3/00 ,  B01L7/00 ,  B01F13/00 ,  C12Q1/68 ,  B01L3/02

CPC classification number: B01L3/502792 ,  B01F13/0071 ,  B01F13/0076 ,  B01F2215/0037 ,  B01L3/0268 ,  B01L3/502715 ,  B01L3/527 ,  B01L7/525 ,  B01L2200/027 ,  B01L2200/0605 ,  B01L2200/10 ,  B01L2200/16 ,  B01L2300/0636 ,  B01L2300/0819 ,  B01L2300/1822 ,  B01L2300/1883 ,  B01L2400/0409 ,  B01L2400/0415 ,  B01L2400/0427 ,  B01L2400/0475 ,  C12Q1/686 ,  G01N27/447 ,  G01N27/44756 ,  G01N27/453 ,  C12Q2563/143 ,  C12Q2563/149 ,  C12Q2563/159

Abstract: Liquid droplet manipulation instrument has electrode array for inducing movement of a droplet by electrowetting, substrate supporting the array and control with electrode selector connected to a voltage control. The selector selects each electrode and provides each with a controlled voltage. The control includes central processing unit for providing the selected electrode with an individual voltage pulse which is a drive voltage or a ground voltage or a stop voltage. The control defines a path for movement of a liquid portion of a larger volume that covers more than one electrode by the simultaneous selection of a group of two or more subsequent drive electrodes and to provide each selected drive electrode with a drive voltage pulse along the path. The control simultaneously provides a group of two or more electrodes adjacent to or identical with the pulsed drive electrodes, with a ground or stop voltage pulse.

Abstract translation: 液滴操作仪具有电极阵列，用于通过电润湿引起液滴的移动，支撑阵列的基板和用电压控制器连接的电极选择器进行控制。 选择器选择每个电极，并为每个电极提供受控电压。 该控制器包括用于向所选择的电极提供作为驱动电压或接地电压或停止电压的单独电压脉冲的中央处理单元。 控制器通过同时选择一组两个或更多个后续驱动电极来定义用于移动覆盖多于一个电极的较大体积的液体部分的路径，并且为每个选定的驱动电极提供沿路径的驱动电压脉冲 。 控制器同时提供与脉冲驱动电极相邻或相同的一组两个或更多个电极，具有接地或停止电压脉冲。

公开(公告)号：US20180074013A1

公开(公告)日：2018-03-15

申请号：US15818428

申请日：2017-11-20

Applicant: TECAN TRADING AG

Inventor： TRAVIS LEE ,  Michael Benjamin Franklin ,  Kailiang Wang ,  Anne R. Kopf-Sill

IPC: G01N27/447

CPC classification number: G01N27/44791 ,  B01L3/502715 ,  B01L3/502738 ,  B01L3/502792 ,  B01L3/5029 ,  B01L3/523 ,  B01L3/527 ,  B01L7/52 ,  B01L2200/025 ,  B01L2200/027 ,  B01L2200/04 ,  B01L2200/0647 ,  B01L2200/141 ,  B01L2300/044 ,  B01L2300/0672 ,  B01L2300/0681 ,  B01L2300/0829 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2300/0887 ,  B01L2300/089 ,  B01L2300/161 ,  B01L2400/0427 ,  B01L2400/043 ,  B01L2400/0478 ,  B01L2400/0683

Abstract: A liquid droplet manipulation system has a substrate with at least one electrode array and a central control unit for controlling selection of individual electrodes of the electrode array and for providing the electrodes with individual voltage pulses for manipulating liquid droplets by electrowetting. A working film is placed on top of the electrodes for manipulating samples in liquid droplets with the electrode array. At least one selected individual electrode of the electrode array is configured to be penetrated by light of an optical detection system for the optical inspection or analysis of samples in liquid droplets that are located on the working film. Also disclosed is working film that is to be placed on the electrode array and a cartridge that includes such a working film for manipulating samples in liquid droplets.

公开(公告)号：US09857332B2

公开(公告)日：2018-01-02

申请号：US13737360

申请日：2013-01-09

Applicant: Tecan Trading AG

Inventor： Travis Lee ,  Michael Benjamin Franklin ,  Kailiang Wang ,  Anne R. Kopf-Sill

IPC: G01N27/447 ,  B01L3/00 ,  B01L7/00

CPC classification number: G01N27/44791 ,  B01L3/502715 ,  B01L3/502738 ,  B01L3/502792 ,  B01L3/5029 ,  B01L3/523 ,  B01L3/527 ,  B01L7/52 ,  B01L2200/025 ,  B01L2200/027 ,  B01L2200/04 ,  B01L2200/0647 ,  B01L2200/141 ,  B01L2300/044 ,  B01L2300/0672 ,  B01L2300/0681 ,  B01L2300/0829 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2300/0887 ,  B01L2300/089 ,  B01L2300/161 ,  B01L2400/0427 ,  B01L2400/043 ,  B01L2400/0478 ,  B01L2400/0683

Abstract: A liquid droplet manipulation system has a substrate with at least one electrode array and a central control unit for controlling selection of individual electrodes of the electrode array and for providing the electrodes with individual voltage pulses for manipulating liquid droplets by electrowetting. A working film is placed on top of the electrodes for manipulating samples in liquid droplets with the electrode array. At least one selected individual electrode of the electrode array is configured to be penetrated by light of an optical detection system for the optical inspection or analysis of samples in liquid droplets that are located on the working film. Also disclosed is working film that is to be placed on the electrode array and a cartridge that includes such a working film for manipulating samples in liquid droplets.

公开(公告)号：US09630176B2

公开(公告)日：2017-04-25

申请号：US13902384

申请日：2013-05-24

Applicant: Tecan Trading AG

Inventor： Tiffany Lay ,  Thomas D. Perroud ,  Michael Benjamin Franklin ,  Anne R. Kopf-Sill

IPC: B01L3/00 ,  B01L9/00

CPC classification number: B01L3/502715 ,  B01L3/502792 ,  B01L3/505 ,  B01L9/527 ,  B01L2200/025 ,  B01L2200/027 ,  B01L2200/0673 ,  B01L2300/043 ,  B01L2300/044 ,  B01L2300/089 ,  B01L2300/123 ,  B01L2400/0427

Abstract: Digital microfluidics system manipulates samples in liquid droplets within a gap of at least one disposable cartridge. It is also provides additional space for collecting and/or storing waste fluids in this digital microfluidics system. It includes at least one waste hollow which is fluidly connected with a gap of a disposable cartridge that includes a bottom layer with a first hydrophobic surface and a top layer with a second hydrophobic surface. The waste hollow is located next to at least one individual waste electrode that is positioned next to at least one individual electrode of an electrode array. Each individual waste electrode is operatively connected to a central control unit and covers in each case a waste electrode area.

公开(公告)号：US20130175169A1

公开(公告)日：2013-07-11

申请号：US13784168

申请日：2013-03-04

Applicant: TECAN TRADING AG

Inventor： Marc N. Feiglin ,  Michael Benjamin Franklin ,  Timothy Francis Lee ,  Joseph Mamone

IPC: G01N27/447

CPC classification number: B01L3/502792 ,  B01F13/0071 ,  B01F13/0076 ,  B01F2215/0037 ,  B01L3/0268 ,  B01L3/502715 ,  B01L3/527 ,  B01L7/525 ,  B01L2200/027 ,  B01L2200/0605 ,  B01L2200/10 ,  B01L2200/16 ,  B01L2300/0636 ,  B01L2300/0819 ,  B01L2300/1822 ,  B01L2300/1883 ,  B01L2400/0409 ,  B01L2400/0415 ,  B01L2400/0427 ,  B01L2400/0475 ,  C12Q1/686 ,  G01N27/447 ,  G01N27/44756 ,  G01N27/453 ,  C12Q2563/143 ,  C12Q2563/149 ,  C12Q2563/159

Abstract: Liquid droplet manipulation instrument has electrode array for inducing movement of a droplet by electrowetting, substrate supporting the array and control with electrode selector connected to a voltage control. The selector selects each electrode and provides each with a controlled voltage. The control includes central processing unit for providing the selected electrode with an individual voltage pulse which is a drive voltage or a ground voltage or a stop voltage. The control defines a path for movement of a liquid portion of a larger volume that covers more than one electrode by the simultaneous selection of a group of two or more subsequent drive electrodes and to provide each selected drive electrode with a drive voltage pulse along the path. The control simultaneously provides a group of two or more electrodes adjacent to or identical with the pulsed drive electrodes, with a ground or stop voltage pulse.

Abstract translation: 液滴操作仪具有电极阵列，用于通过电润湿引起液滴的移动，支撑阵列的基板和用电压控制器连接的电极选择器进行控制。 选择器选择每个电极，并为每个电极提供受控电压。 该控制器包括用于向选定电极提供作为驱动电压或接地电压或停止电压的单独电压脉冲的中央处理单元。 控制器通过同时选择一组两个或更多个后续驱动电极来定义用于移动覆盖多于一个电极的较大体积的液体部分的路径，并且为每个选定的驱动电极提供沿路径的驱动电压脉冲 。 控制器同时提供与脉冲驱动电极相邻或相同的一组两个或更多个电极，具有接地或停止电压脉冲。

公开(公告)号：US11543383B2

公开(公告)日：2023-01-03

申请号：US15818428

申请日：2017-11-20

Applicant: TECAN TRADING AG

Inventor： Travis Lee ,  Michael Benjamin Franklin ,  Kailiang Wang ,  Anne R. Kopf-Sill

IPC: B01L3/00 ,  G01N27/447 ,  B01L7/00

Abstract: A liquid droplet manipulation system has a substrate with at least one electrode array and a central control unit for controlling selection of individual electrodes of the electrode array and for providing the electrodes with individual voltage pulses for manipulating liquid droplets by electrowetting. A working film is placed on top of the electrodes for manipulating samples in liquid droplets with the electrode array. At least one selected individual electrode of the electrode array is configured to be penetrated by light of an optical detection system for the optical inspection or analysis of samples in liquid droplets that are located on the working film. Also disclosed is working film that is to be placed on the electrode array and a cartridge that includes such a working film for manipulating samples in liquid droplets.

公开(公告)号：US20140190832A1

公开(公告)日：2014-07-10

申请号：US13902384

申请日：2013-05-24

Applicant: Tecan Trading AG

Inventor： Tiffany Lay ,  Thomas D. Perroud ,  Michael Benjamin Franklin ,  Anne R. Kopf-Sill

IPC: B01L3/00

CPC classification number: B01L3/502715 ,  B01L3/502792 ,  B01L3/505 ,  B01L9/527 ,  B01L2200/025 ,  B01L2200/027 ,  B01L2200/0673 ,  B01L2300/043 ,  B01L2300/044 ,  B01L2300/089 ,  B01L2300/123 ,  B01L2400/0427

Abstract: Digital microfluidics system manipulates samples in liquid droplets within a gap of at least one disposable cartridge. It is also provides additional space for collecting and/or storing waste fluids in this digital microfluidics system. It includes at least one waste hollow which is fluidly connected with a gap of a disposable cartridge that includes a bottom layer with a first hydrophobic surface and a top layer with a second hydrophobic surface. The waste hollow is located next to at least one individual waste electrode that is positioned next to at least one individual electrode of an electrode array. Each individual waste electrode is operatively connected to a central control unit and covers in each case a waste electrode area.

Abstract translation: 数字微流体系统在至少一个一次性盒的间隙内操作液滴中的样品。 它还提供了用于在该数字微流体系统中收集和/或存储废流体的额外空间。 它包括至少一个与一次性盒的间隙流体连接的废物中空层，其包括具有第一疏水表面的底层和具有第二疏水表面的顶层。 废物中空部位于靠近电极阵列的至少一个单独电极的至少一个单独的废电极旁边。 每个单独的废电极可操作地连接到中央控制单元，并且在每种情况下覆盖废电极区域。

公开(公告)号：US20130126358A1

公开(公告)日：2013-05-23

申请号：US13737360

申请日：2013-01-09

Applicant: TECAN TRADING AG

Inventor： Travis Lee ,  Michael Benjamin Franklin ,  Kailiang Wang

IPC: G01N27/447

CPC classification number: G01N27/44791 ,  B01L3/502715 ,  B01L3/502738 ,  B01L3/502792 ,  B01L3/5029 ,  B01L3/523 ,  B01L3/527 ,  B01L7/52 ,  B01L2200/025 ,  B01L2200/027 ,  B01L2200/04 ,  B01L2200/0647 ,  B01L2200/141 ,  B01L2300/044 ,  B01L2300/0672 ,  B01L2300/0681 ,  B01L2300/0829 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2300/0887 ,  B01L2300/089 ,  B01L2300/161 ,  B01L2400/0427 ,  B01L2400/043 ,  B01L2400/0478 ,  B01L2400/0683

Abstract: A liquid droplet manipulation system has a substrate with at least one electrode array and a central control unit for controlling selection of individual electrodes of the electrode array and for providing the electrodes with individual voltage pulses for manipulating liquid droplets by electrowetting. A working film is placed on top of the electrodes for manipulating samples in liquid droplets with the electrode array. At least one selected individual electrode of the electrode array is configured to be penetrated by light of an optical detection system for the optical inspection or analysis of samples in liquid droplets that are located on the working film. Also disclosed is working film that is to be placed on the electrode array and a cartridge that includes such a working film for manipulating samples in liquid droplets.

Abstract translation: 液滴操作系统具有具有至少一个电极阵列的基板和用于控制电极阵列的各个电极的选择的中央控制单元，并且用于通过电润湿来为电极提供用于操纵液滴的各个电压脉冲。 将工作薄膜放置在电极顶部，用电极阵列操纵液滴中的样品。 电极阵列的至少一个所选择的单独电极被配置为被光学检测系统的光穿透，用于光学检查或分析位于工作膜上的液滴中的样品。 还公开了将放置在电极阵列上的工作膜和包括用于操纵液滴中的样品的这种工作膜的盒。