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    Cartridge, kit and method for manipulating liquids having biological samples
    7.
    发明授权
    Cartridge, kit and method for manipulating liquids having biological samples 有权

    公开(公告)号：US10357773B2

    公开(公告)日：2019-07-23

    申请号：US15398518

    申请日：2017-01-04

    Applicant: TECAN TRADING AG

    Inventor： Marc N. Feiglin

    IPC: G01N27/453 ,  B01L3/00 ,  B01L3/02 ,  G01N27/447 ,  B01F13/00 ,  B01L7/00 ,  C12Q1/686

    Abstract: A cartridge has a container with at least one well, protrusions distributed on the container base side, and a flat polymer film having a lower surface and a hydrophobic upper surface kept at a distance (d) to the container base side by the protrusions. The container and the film are reversibly attachable to a liquid droplet manipulation instrument so that the lower surface of the film abuts at least one electrode array of the instrument. The container enables displacement of at least one liquid droplet from a well onto the hydrophobic upper surface of the flat polymer film and above the electrode array. The liquid droplet manipulation instrument comprises a control unit with a voltage control and an electrode selector for individually selecting each electrode of the electrode array and for providing the selected electrode with a voltage and thus controlling a guided movement of a liquid droplet on the hydrophobic upper surface of the flat polymer film by electrowetting. Also disclosed are a corresponding kit and method.

    DISPOSABLE CARTRIDGE FOR MICROFLUIDICS SYSTEMS
    9.
    发明申请
    DISPOSABLE CARTRIDGE FOR MICROFLUIDICS SYSTEMS 有权
    用于微流控系统的可替代墨盒

    公开(公告)号：US20150144489A1

    公开(公告)日：2015-05-28

    申请号：US14402717

    申请日：2014-01-06

    Applicant: TECAN TRADING AG

    Inventor： Daniel Hoffmeyer ,  Tiffany Lay ,  Travis Lee ,  Marc N. Feiglin ,  Werner Halg ,  Anne R. Kopf-Sill

    IPC: G01N27/447

    CPC classification number: G01N27/44791 ,  B01L3/502715 ,  B01L3/502792 ,  B01L3/505 ,  B01L2200/027 ,  B01L2200/04 ,  B01L2300/044 ,  B01L2300/123 ,  B01L2400/0427 ,  B81B1/00 ,  G01N27/44756

    Abstract: A disposable cartridge used in a digital microfluidics system has a bottom layer with first hydrophobic surface, a rigid cover plate with second hydrophobic surface, and a gap there-between. The bottom layer is a flexible film on an uppermost surface of a cartridge accommodation site of a system, attracted to and spread over the uppermost surface by an underpressure. A lower surface of the plate and the flexible bottom layer are sealed to each other. The assembled cartridge is removed from the cartridge accommodation site in one piece and potentially includes samples and processing fluids. The system has a base unit and a cartridge accommodation site with an electrode array of individual electrodes and a central control unit for controlling selection of individual electrodes and for providing these electrodes with individual voltage pulses for manipulating liquid droplets within the gap by electrowetting.

    Abstract translation: 在数字微流体系统中使用的一次性盒具有具有第一疏水表面的底层，具有第二疏水表面的刚性盖板及其间的间隙。 底层是在系统的盒容纳位置的最上表面上的柔性膜，通过负压吸引并分布在最上表面上。 板的下表面和柔性底层彼此密封。 将组装的墨盒从墨盒容纳部位一体地取出，并且可能包括样品和处理流体。 该系统具有基本单元和具有单独电极的电极阵列的中心控制单元和用于控制各个电极的选择的中心控制单元和用于通过电润湿来操纵间隙内的液滴的单独电压脉冲的中心控制单元。

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