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    DISPOSABLE CARTRIDGE FOR MICROFLUIDICS SYSTEMS
    3.
    发明申请
    DISPOSABLE CARTRIDGE FOR MICROFLUIDICS SYSTEMS 有权
    用于微流控系统的可替代墨盒

    公开(公告)号：US20150144489A1

    公开(公告)日：2015-05-28

    申请号：US14402717

    申请日：2014-01-06

    Applicant: TECAN TRADING AG

    Inventor： Daniel Hoffmeyer ,  Tiffany Lay ,  Travis Lee ,  Marc N. Feiglin ,  Werner Halg ,  Anne R. Kopf-Sill

    IPC: G01N27/447

    CPC classification number: G01N27/44791 ,  B01L3/502715 ,  B01L3/502792 ,  B01L3/505 ,  B01L2200/027 ,  B01L2200/04 ,  B01L2300/044 ,  B01L2300/123 ,  B01L2400/0427 ,  B81B1/00 ,  G01N27/44756

    Abstract: A disposable cartridge used in a digital microfluidics system has a bottom layer with first hydrophobic surface, a rigid cover plate with second hydrophobic surface, and a gap there-between. The bottom layer is a flexible film on an uppermost surface of a cartridge accommodation site of a system, attracted to and spread over the uppermost surface by an underpressure. A lower surface of the plate and the flexible bottom layer are sealed to each other. The assembled cartridge is removed from the cartridge accommodation site in one piece and potentially includes samples and processing fluids. The system has a base unit and a cartridge accommodation site with an electrode array of individual electrodes and a central control unit for controlling selection of individual electrodes and for providing these electrodes with individual voltage pulses for manipulating liquid droplets within the gap by electrowetting.

    Abstract translation: 在数字微流体系统中使用的一次性盒具有具有第一疏水表面的底层，具有第二疏水表面的刚性盖板及其间的间隙。 底层是在系统的盒容纳位置的最上表面上的柔性膜，通过负压吸引并分布在最上表面上。 板的下表面和柔性底层彼此密封。 将组装的墨盒从墨盒容纳部位一体地取出，并且可能包括样品和处理流体。 该系统具有基本单元和具有单独电极的电极阵列的中心控制单元和用于控制各个电极的选择的中心控制单元和用于通过电润湿来操纵间隙内的液滴的单独电压脉冲的中心控制单元。

    System for manipulating samples in liquid droplets
    7.
    发明授权
    System for manipulating samples in liquid droplets 有权

    公开(公告)号：US11543383B2

    公开(公告)日：2023-01-03

    申请号：US15818428

    申请日：2017-11-20

    Applicant: TECAN TRADING AG

    Inventor： Travis Lee ,  Michael Benjamin Franklin ,  Kailiang Wang ,  Anne R. Kopf-Sill

    IPC: B01L3/00 ,  G01N27/447 ,  B01L7/00

    Abstract: A liquid droplet manipulation system has a substrate with at least one electrode array and a central control unit for controlling selection of individual electrodes of the electrode array and for providing the electrodes with individual voltage pulses for manipulating liquid droplets by electrowetting. A working film is placed on top of the electrodes for manipulating samples in liquid droplets with the electrode array. At least one selected individual electrode of the electrode array is configured to be penetrated by light of an optical detection system for the optical inspection or analysis of samples in liquid droplets that are located on the working film. Also disclosed is working film that is to be placed on the electrode array and a cartridge that includes such a working film for manipulating samples in liquid droplets.

    Microfluidics cartridge with pipetting guide
    8.
    发明授权
    Microfluidics cartridge with pipetting guide 有权

    公开(公告)号：US10137450B2

    公开(公告)日：2018-11-27

    申请号：US14335027

    申请日：2014-07-18

    Applicant: Tecan Trading AG

    Inventor： Tiffany Lay ,  Daniel Hoffmeyer ,  Anne R. Kopf-Sill

    IPC: B01L3/00 ,  B01L3/02

    Abstract: A disposable cartridge configured as a digital microfluidics system for manipulating samples in liquid portions having a cartridge accommodation site and a central control unit for controlling selection of individual electrodes of an electrode array located at the site and for providing plural electrodes with individual voltage pulses for manipulating liquid portions by electrowetting. The cartridge has a hydrophobic working surface and a rigid cover with a second hydrophobic surface, the hydrophobic surfaces facing each other and being separated in parallel planes by a gap. The cartridge has plural pipetting guides for safe entering/withdrawing liquids into/from the gap with a pipette tip. At least one of the pipetting guides provides an abutting surface sealingly admittable by a counter surface of a pipette tip, located at a pipetting orifice that reaches through the rigid cover, and configured to prevent a pipette tip from touching the hydrophobic working surface.

    Microfluidics Systems with Waste Hollow
    10.
    发明申请
    Microfluidics Systems with Waste Hollow 有权
    具有废气空心微流体系统

    公开(公告)号：US20140190832A1

    公开(公告)日：2014-07-10

    申请号：US13902384

    申请日：2013-05-24

    Applicant: Tecan Trading AG

    Inventor： Tiffany Lay ,  Thomas D. Perroud ,  Michael Benjamin Franklin ,  Anne R. Kopf-Sill

    IPC: B01L3/00

    CPC classification number: B01L3/502715 ,  B01L3/502792 ,  B01L3/505 ,  B01L9/527 ,  B01L2200/025 ,  B01L2200/027 ,  B01L2200/0673 ,  B01L2300/043 ,  B01L2300/044 ,  B01L2300/089 ,  B01L2300/123 ,  B01L2400/0427

    Abstract: Digital microfluidics system manipulates samples in liquid droplets within a gap of at least one disposable cartridge. It is also provides additional space for collecting and/or storing waste fluids in this digital microfluidics system. It includes at least one waste hollow which is fluidly connected with a gap of a disposable cartridge that includes a bottom layer with a first hydrophobic surface and a top layer with a second hydrophobic surface. The waste hollow is located next to at least one individual waste electrode that is positioned next to at least one individual electrode of an electrode array. Each individual waste electrode is operatively connected to a central control unit and covers in each case a waste electrode area.

    Abstract translation: 数字微流体系统在至少一个一次性盒的间隙内操作液滴中的样品。 它还提供了用于在该数字微流体系统中收集和/或存储废流体的额外空间。 它包括至少一个与一次性盒的间隙流体连接的废物中空层，其包括具有第一疏水表面的底层和具有第二疏水表面的顶层。 废物中空部位于靠近电极阵列的至少一个单独电极的至少一个单独的废电极旁边。 每个单独的废电极可操作地连接到中央控制单元，并且在每种情况下覆盖废电极区域。

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