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公开(公告)号：US20240117363A1
公开(公告)日：2024-04-11
申请号：US18228251
申请日：2023-07-31
发明人： Floyd E. ROMESBERG , Brian LAMB , Yorke ZHANG
CPC分类号： C12N15/63 , C12N5/10 , C12N9/22 , C12N15/11 , C12N15/70 , C12N2310/20 , C12N2310/3519
摘要： Disclosed herein are methods, cells, engineered microorganisms, and kits for increased production of a nucleic acid molecule that comprises an unnatural nucleotide.
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公开(公告)号：US20200377877A1
公开(公告)日：2020-12-03
申请号：US16063107
申请日：2016-12-16
发明人： Floyd E. ROMESBERG , Brian LAMB , Yorke ZHANG
摘要： Disclosed herein are methods, cells, engineered microorganisms, and kits for increased production of a nucleic acid molecule that comprises an unnatural nucleotide.
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公开(公告)号：US20240218027A1
公开(公告)日：2024-07-04
申请号：US18503341
申请日：2023-11-07
发明人： Floyd E. ROMESBERG , Yorke ZHANG
IPC分类号： C07K14/405 , C12N9/22 , C12N15/10 , C12N15/11 , C12N15/90
CPC分类号： C07K14/405 , C12N9/22 , C12N15/10 , C12N15/11 , C12N15/90 , C12N2310/20 , C12N2800/80
摘要： Disclosed herein are proteins, methods, cells, engineered microorganisms, and kits for generating a modified nucleoside triphosphate transporter from Phaeodactylum tricornutum. Also disclosed herein proteins, methods, cells, engineered microorganisms, and kits for production of a nucleic acid molecule that comprises an unnatural nucleotide utilizing a modified nucleoside triphosphate transporter from Phaeodactylum tricornutum.
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公开(公告)号：US20220243244A1
公开(公告)日：2022-08-04
申请号：US17716848
申请日：2022-04-08
发明人： Floyd E. ROMESBERG , Emil C. FISCHER , Koji HASHIMOTO , Aaron W. FELDMAN , Vivian T. DIEN , Yorke ZHANG
IPC分类号： C12P21/02
摘要： Disclosed herein are compositions, methods, and kits for a cell incorporating unnatural amino acids into an unnatural polypeptide. Also disclosed herein are compositions, methods, and kits for increasing activity and yield of the unnatural polypeptide synthesized by the cell.
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公开(公告)号：US20240043823A1
公开(公告)日：2024-02-08
申请号：US18481086
申请日：2023-10-04
发明人： Jerod PTACIN , Carolina CAFFARO , Hans AERNI , Yorke ZHANG , Emil C. FISCHER , Aaron W. FELDMAN , Vivian T. DIEN , Floyd E. ROMESBERG
IPC分类号： C12N9/00 , C12P21/02 , C12N15/113 , C12N15/90
CPC分类号： C12N9/93 , C12P21/02 , C12Y601/01026 , C12N15/113 , C12N15/90
摘要： Disclosed herein are methods, compositions and kits for the synthesis of proteins which comprises unnatural amino acids that utilize a mutant tRNA.
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公开(公告)号：US20200224234A1
公开(公告)日：2020-07-16
申请号：US16629211
申请日：2018-07-10
摘要： Disclosed herein are in vivo methods, compositions, and kits for producing nucleic acids which comprises at least one unnatural base. Disclosed herein are in vivo methods of producing a nucleic acid with an expanded genetic alphabet, the method comprising incorporatin at least one unnatural base in the nucleic acid. Disclosed herein are semi-synthetic organisms comprising an expanded genetic alphabet, wherein the genetic alphabet comprises at least one unnatural base. Disclosed herein are compositions that include a heterologous or recombinant polymerase and methods of use thereof. Further, disclosed herein are kits that are useful for stably incorporating an unnatural nucleic acid into a nucleic acid molecule, e.g., using the methods provided by the present invention in in vitro condition or under a cell free condition.
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公开(公告)号：US20210222147A1
公开(公告)日：2021-07-22
申请号：US17196151
申请日：2021-03-09
发明人： Jerod PTACIN , Carolina CAFFARO , Hans AERNI , Yorke ZHANG , Emil C. FISCHER , Aaron W. FELDMAN , Vivian T. DIEN , Floyd E. ROMESBERG
IPC分类号： C12N9/00 , C12P21/02 , C12N15/113 , C12N15/90
摘要： Disclosed herein are methods, compositions and kits for the synthesis of proteins which comprises unnatural amino acids that utilize a mutant tRNA.
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公开(公告)号：US20190375802A1
公开(公告)日：2019-12-12
申请号：US16546097
申请日：2019-08-20
发明人： Floyd E. ROMESBERG , Yorke ZHANG
IPC分类号： C07K14/405 , C12N15/11 , C12N9/22 , C12N15/90
摘要： Disclosed herein are proteins, methods, cells, engineered microorganisms, and kits for generating a modified nucleoside triphosphate transporter from Phaeodactylum tricornutum. Also disclosed herein proteins, methods, cells, engineered microorganisms, and kits for production of a nucleic acid molecule that comprises an unnatural nucleotide utilizing a modified nucleoside triphosphate transporter from Phaeodactylum tricornutum.
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公开(公告)号：US20200277342A1
公开(公告)日：2020-09-03
申请号：US16839741
申请日：2020-04-03
发明人： Floyd E. ROMESBERG , Yorke ZHANG
IPC分类号： C07K14/405 , C12N15/90 , C12N15/10 , C12N9/22 , C12N15/11
摘要： Disclosed herein are proteins, methods, cells, engineered microorganisms, and kits for generating a modified nucleoside triphosphate transporter from Phaeodactylum tricornutum. Also disclosed herein proteins, methods, cells, engineered microorganisms, and kits for production of a nucleic acid molecule that comprises an unnatural nucleotide utilizing a modified nucleoside triphosphate transporter from Phaeodactylum tricornutum.
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公开(公告)号：US20190375803A1
公开(公告)日：2019-12-12
申请号：US16546100
申请日：2019-08-20
发明人： Floyd E. ROMESBERG , Yorke ZHANG
IPC分类号： C07K14/405 , C12N15/11 , C12N9/22 , C12N15/90
摘要： Disclosed herein are proteins, methods, cells, engineered microorganisms, and kits for generating a modified nucleoside triphosphate transporter from Phaeodactylum tricornutum. Also disclosed herein proteins, methods, cells, engineered microorganisms, and kits for production of a nucleic acid molecule that comprises an unnatural nucleotide utilizing a modified nucleoside triphosphate transporter from Phaeodactylum tricornutum.
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