公开(公告)号：US20230392140A1

公开(公告)日：2023-12-07

申请号：US18304993

申请日：2023-04-21

申请人： Synthorx, Inc. ,  The Scripps Research Institute

发明人： Floyd E. ROMESBERG ,  Xiyu Dong ,  Anne Xiaozhou Zhou

IPC分类号： C12N15/10 ,  C12N9/12

CPC分类号： C12N15/1048 ,  C12N9/1276 ,  C12Y207/07049 ,  C12N15/1096

摘要： Disclosed herein are methods of reverse transcribing a polynucleotide comprising an unnatural ribonucleotide comprising reverse transcribing the polynucleotide with a reverse transcriptase in the presence of an unnatural dNTP comprising an unnatural nucleobase, wherein the reverse transcriptase polymerizes cDNA into which the unnatural NTP is incorporated. In some embodiments, the polynucleotide is present at a concentration less than or equal to about 500 nM and/or the polynucleotide is a tRNA, mRNA, RNA aptamer, or a member of a plurality of RNA aptamer candidates.

公开(公告)号：US20220273767A1

公开(公告)日：2022-09-01

申请号：US17735564

申请日：2022-05-03

申请人： Synthorx, Inc.

发明人： Carolina E. CAFFARO ,  Jerod PTACIN ,  Marcos MILLA

IPC分类号： A61K38/20 ,  A61K47/54 ,  C07K1/107 ,  A61P35/00

摘要： Disclosed herein are interleukin 10 (IL-10) conjugates and uses in the treatment of one or more indications. Also described herein are pharmaceutical compositions and kits comprising one or more of the IL-10 conjugates.

公开(公告)号：US20210338829A1

公开(公告)日：2021-11-04

申请号：US17313579

申请日：2021-05-06

申请人： Synthorx, Inc.

发明人： Carolina E. CAFFARO ,  Jerod PTACIN ,  Marcos MILLA

IPC分类号： A61K47/64 ,  C07K14/54 ,  A61K47/60

摘要： Disclosed herein are interleukin 10 conjugates and uses in the treatment of one or more indications. Also described herein are pharmaceutical compositions and kits comprising one or more of the IL-10 conjugates.

公开(公告)号：US20240287151A1

公开(公告)日：2024-08-29

申请号：US18415445

申请日：2024-01-17

申请人： Synthorx, Inc.

发明人： Carolina E. CAFFARO ,  Jerod PTACIN ,  Marcos MILLA

IPC分类号： C07K14/54 ,  C07K1/107

CPC分类号： C07K14/5443 ,  C07K1/1075 ,  C07K1/1077 ,  C07K2317/52 ,  C07K2319/31 ,  C12N2310/3513 ,  C12N2310/3515

摘要： Disclosed herein are interleukin (IL) 15 conjugates and use in the treatment of one or more indications. Also described herein include pharmaceutical compositions and kits comprising one or more of IL-15 conjugates.

公开(公告)号：US20210046160A1

公开(公告)日：2021-02-18

申请号：US16993967

申请日：2020-08-14

申请人： Synthorx, Inc.

发明人： Jerod PTACIN ,  Carolina E. CAFFARO ,  Marcos MILLA

IPC分类号： A61K38/20 ,  A61K47/68

摘要： Disclosed herein are compositions, kits, and methods comprising interleukin (IL) conjugates (e.g., IL-2 conjugates) in combination with other agents or methods useful for the treatment of one or more indications, such as the treatment of proliferative diseases. Also described herein are pharmaceutical compositions and kits comprising one or more of the interleukin conjugates (e.g., IL-2 conjugates).

公开(公告)号：US20200231644A1

公开(公告)日：2020-07-23

申请号：US16634487

申请日：2018-08-03

申请人： SYNTHORX, INC.

发明人： Jerod PTACIN ,  Carolina E. CAFFARO ,  Marcos MILLA

IPC分类号： C07K14/55 ,  A61K47/54 ,  A61K47/60 ,  C07K14/715

摘要： Disclosed herein are interleukin (IL) conjugates (e.g., IL-2 conjugates) and use in the treatment of one or more indications. Also described herein are pharmaceutical compositions and kits comprising one or more of the interleukin conjugates (e.g., IL-2 conjugates).

公开(公告)号：US20240082359A1

公开(公告)日：2024-03-14

申请号：US18327535

申请日：2023-06-01

申请人： Synthorx, Inc.

发明人： Jerod PTACIN ,  Carolina E. CAFFARO ,  Marcos MILLA

IPC分类号： A61K38/20 ,  A61K47/54 ,  A61K47/60 ,  A61K47/61 ,  A61K47/64 ,  A61K47/65 ,  A61K47/68 ,  C07K14/55 ,  C07K14/715

CPC分类号： A61K38/2013 ,  A61K47/542 ,  A61K47/60 ,  A61K47/61 ,  A61K47/643 ,  A61K47/644 ,  A61K47/65 ,  A61K47/68 ,  C07K14/55 ,  C07K14/7155 ,  A61K38/00

摘要： Disclosed herein are interleukin (IL) conjugates (e.g., IL-2 conjugates) and use in the treatment of one or more indications. Also described herein are pharmaceutical compositions and kits comprising one or more of the interleukin conjugates (e.g., IL-2 conjugates).

公开(公告)号：US11919934B2

公开(公告)日：2024-03-05

申请号：US17001965

申请日：2020-08-25

申请人： Synthorx, Inc.

发明人： Carolina E. Caffaro ,  Jerod Ptacin ,  Marcos Milla

IPC分类号： C07K14/54 ,  C07K1/107

CPC分类号： C07K14/5443 ,  C07K1/1075 ,  C07K1/1077 ,  C07K2317/52 ,  C07K2319/31 ,  C12N2310/3513 ,  C12N2310/3515

摘要： Disclosed herein are interleukin (IL) 15 conjugates and use in the treatment of one or more indications. Also described herein include pharmaceutical compositions and kits comprising one or more of IL-15 conjugates.

公开(公告)号：US11834689B2

公开(公告)日：2023-12-05

申请号：US17196151

申请日：2021-03-09

申请人： SYNTHORX, INC. ,  THE SCRIPPS RESEARCH INSTITUTE

发明人： Jerod Ptacin ,  Carolina Caffaro ,  Hans Aerni ,  Yorke Zhang ,  Emil C. Fischer ,  Aaron W. Feldman ,  Vivian T. Dien ,  Floyd E. Romesberg

IPC分类号： C12N9/00 ,  C12P21/02 ,  C12N15/113 ,  C12N15/90

CPC分类号： C12N9/93 ,  C12N15/113 ,  C12N15/90 ,  C12P21/02 ,  C12Y601/01026

摘要： Disclosed herein are methods, compositions and kits for the synthesis of proteins which comprises unnatural amino acids that utilize a mutant tRNA.

公开(公告)号：US20220324792A1

公开(公告)日：2022-10-13

申请号：US17845495

申请日：2022-06-21

申请人： Synthorx, Inc.

发明人： Hans AERNI ,  Randall SCHEUERMAN ,  Nikolai F. SEPETOV ,  Alexander V. SHIROKOV

IPC分类号： C07C247/22 ,  C07D207/404

摘要： Disclosed herein are methods of preparing N6-((2-azidoethoxy)carbonyl)lysine, N6-((2-azidoethoxy)carbonyl)-L-lysine, and N6-((2-azidoethoxy)carbonyl)-D-lysine. Also disclosed herein are the compounds tert-butyl N2-(tert-butoxycarbonyl)-N6-((2-chloroethoxy)carbonyl)-L-lysinate and tert-butyl N6-((2-azidoethoxy)carbonyl)-N2-(tert-butoxycarbonyl)-L-lysinate, and uses thereof.