专利检索 ap:("Synthorx, Inc." OR "The Scripps Research Institute") AND inv:"Hans AERNI" 第 1 页

1.

发明公开
INCORPORATION OF UNNATURAL NUCLEOTIDES AND METHODS THEREOF 审中-公开

公开(公告)号：US20240043823A1

公开(公告)日：2024-02-08

申请号：US18481086

申请日：2023-10-04

申请人： Synthorx, Inc. , The Scripps Research Institute

发明人： Jerod PTACIN , Carolina CAFFARO , Hans AERNI , Yorke ZHANG , Emil C. FISCHER , Aaron W. FELDMAN , Vivian T. DIEN , Floyd E. ROMESBERG

IPC分类号： C12N9/00 , C12P21/02 , C12N15/113 , C12N15/90

CPC分类号： C12N9/93 , C12P21/02 , C12Y601/01026 , C12N15/113 , C12N15/90

摘要： Disclosed herein are methods, compositions and kits for the synthesis of proteins which comprises unnatural amino acids that utilize a mutant tRNA.

2.

发明申请
INCORPORATION OF UNNATURAL NUCLEOTIDES AND METHODS THEREOF 有权

公开(公告)号：US20210222147A1

公开(公告)日：2021-07-22

申请号：US17196151

申请日：2021-03-09

申请人： SYNTHORX, INC. , THE SCRIPPS RESEARCH INSTITUTE

发明人： Jerod PTACIN , Carolina CAFFARO , Hans AERNI , Yorke ZHANG , Emil C. FISCHER , Aaron W. FELDMAN , Vivian T. DIEN , Floyd E. ROMESBERG

IPC分类号： C12N9/00 , C12P21/02 , C12N15/113 , C12N15/90

摘要： Disclosed herein are methods, compositions and kits for the synthesis of proteins which comprises unnatural amino acids that utilize a mutant tRNA.

3.

发明申请
METHODS OF PREPARING N6-((2-AZIDOETHOXY)CARBONYL)LYSINE 有权

公开(公告)号：US20220324792A1

公开(公告)日：2022-10-13

申请号：US17845495

申请日：2022-06-21

申请人： Synthorx, Inc.

发明人： Hans AERNI , Randall SCHEUERMAN , Nikolai F. SEPETOV , Alexander V. SHIROKOV

IPC分类号： C07C247/22 , C07D207/404

摘要： Disclosed herein are methods of preparing N6-((2-azidoethoxy)carbonyl)lysine, N6-((2-azidoethoxy)carbonyl)-L-lysine, and N6-((2-azidoethoxy)carbonyl)-D-lysine. Also disclosed herein are the compounds tert-butyl N2-(tert-butoxycarbonyl)-N6-((2-chloroethoxy)carbonyl)-L-lysinate and tert-butyl N6-((2-azidoethoxy)carbonyl)-N2-(tert-butoxycarbonyl)-L-lysinate, and uses thereof.