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公开(公告)号：US10772716B2
公开(公告)日：2020-09-15
申请号：US16281620
申请日：2019-02-21
Applicant: THE JOHNS HOPKINS UNIVERSITY
Inventor： Gary Gerstenblith , Jason Benkoski , George Coles , Chao-Wei Hwang , Peter Johnston , Gordon Tomaselli , Robert G. Weiss , Steven P. Schulman , Jeffrey A. Brinker
IPC: A61F2/02 , A61L27/38 , A61L27/54 , A61K35/545 , A61L29/00 , A61L29/16 , C12N5/0775 , A61K35/28 , A61K9/00 , A61L29/14 , A61L31/10 , A61L31/14 , A61L31/16 , A61L27/16 , A61L27/28 , A61L27/56
Abstract: A method for promoting healing of tissue by delivering a bioreactor into a subject is provided. The bioreactor is an enclosed housing with paracrine factor producing cells enclosed within the housing. The housing is impermeable to the paracrine factor producing cells, impermeable to immunological cells outside of the housing, and permeable to paracrine factors produced by the paracrine factor producing cells. The paracrine factors produced by the paracrine factor producing cells are released out of the housing to promote healing of the tissue.
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公开(公告)号：US10987501B2
公开(公告)日：2021-04-27
申请号：US16728079
申请日：2019-12-27
Applicant: The Johns Hopkins University
Inventor： Chao-Wei Hwang , Zhiyong Xia , Virginia E. Bogdan , Jeffrey A. Brinker , Gary Gerstenblith , Peter V. Johnston , Steven P. Schulman , Gordon Tomaselli , Robert G. Weiss
IPC: A61M37/00 , A61M25/10 , A61L33/00 , A61L27/18 , A61L27/38 , A61L27/54 , A61L27/56 , A61L31/00 , A61L31/14 , A61L31/16 , A61L31/06 , A61F2/04 , A61L31/10 , A61L33/08 , A61F2/07
Abstract: Certain embodiments according to the present invention provide sleeve devices suitable for a wide range of therapeutic uses. In accordance with certain embodiments, the therapeutic sleeve device includes a nanofiber fabric assembly, which defines a plurality of pores, and at least one layer of cells embedded in the nanofiber fabric assembly.
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3.发明授权公开(公告)号：US10729337B2
公开(公告)日：2020-08-04
申请号：US15571771
申请日：2016-05-05
Inventor： Qian Liu , Nichaluk Leartprapun , Jackline Wanjala , Soumyadipta Acharya , Andrew Bicek , Viachaslau Barodka , Umang Anand , Majd Alghatrif , David Kass , B. Westbrook Bernier , Chao-Wei Hwang , Peter Johnston , Trent Langston
IPC: A61B5/021 , A61B5/00 , A61B5/053 , A61B5/0452
Abstract: The present application relates to systems and methods for non-invasively determining at least one of left ventricular end diastolic pressure (LVEDP) or pulmonary capillary wedge pressure (PCWP) in a subject's heart, comprising: receiving, by a computer, a plurality of signals from a plurality of non-invasive sensors that measure a plurality of physiological effects that are correlated with functioning of said subject's heart, said plurality of physiological effects including at least one signal correlated with left ventricular blood pressure and at least one signal correlated with timing of heartbeat cycles of said subject's heart; training a machine learning model on said computer using said plurality of signals for periods of time in which said plurality of signals were being generated during a heart failure event of said subject's heart; determining said LVEDP or PCWP using said machine learning model at a time subsequent to said training and subsequent to said heart failure event.
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公开(公告)号：US20150217030A1
公开(公告)日：2015-08-06
申请号：US14614432
申请日：2015-02-05
Applicant: The Johns Hopkins University
Inventor： Jason J. Benkoski , Peter V. Johnston , Chao-Wei Hwang , Gary Gerstenblith , Robert G. Weiss , Gordon Tomaselli , Steven P. Schulman , Jeffrey A. Brinker
CPC classification number: A61L31/10 , A61L27/34 , A61L27/52 , A61L27/54 , A61L31/145 , A61L31/16 , A61L2300/606 , A61L2300/64 , A61L2420/02 , A61L2420/06 , B05D1/18 , B05D7/53
Abstract: Certain embodiments according to the present invention provide a method for forming medical devices conformally coated with a hydrogel having a wide variety of therapeutic uses. In one aspect, certain embodiments of the invention provide a method for forming a hydrogel-coated medical device comprising immersing a medical device in a polymer solution to form an adhesive layer on an outer surface of the medical device and contacting the medical device with a hydrogel precursor solution having a pH of less than 7 to react the adhesive layer with the hydrogel precursor solution and form a conformal hydrogel coating.
Abstract translation: 根据本发明的某些实施方案提供了一种用于形成医疗器械的方法，所述医疗器件保形地涂覆有具有多种治疗用途的水凝胶。 在一个方面，本发明的某些实施方案提供了形成水凝胶涂覆的医疗装置的方法，包括将医疗装置浸入聚合物溶液中以在医疗装置的外表面上形成粘合剂层，并使医疗装置与水凝胶接触 具有小于7的pH的前体溶液使粘合剂层与水凝胶前体溶液反应并形成共形水凝胶涂层。
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公开(公告)号：US20190314416A1
公开(公告)日：2019-10-17
申请号：US16281620
申请日：2019-02-21
Applicant: THE JOHNS HOPKINS UNIVERSITY
Inventor： Gary Gerstenblith , Jason Benkoski , George Coles , Chao-Wei Hwang , Peter Johnston , Gordon Tomaselli , Robert G. Weiss , Steven P. Schulman
Abstract: A method for promoting healing of tissue by delivering a bioreactor into a subject is provided. The bioreactor is an enclosed housing with paracrine factor producing cells enclosed within the housing. The housing is impermeable to the paracrine factor producing cells, impermeable to immunological cells outside of the housing, and permeable to paracrine factors produced by the paracrine factor producing cells. The paracrine factors produced by the paracrine factor producing cells are released out of the housing to promote healing of the tissue.
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Patent Agency Ranking
公开(公告)号：US10376682B2
公开(公告)日：2019-08-13
申请号：US15290129
申请日：2016-10-11
Applicant: The Johns Hopkins University
Inventor： Chao-Wei Hwang , Hala J. Tomey , Jon R. Resar , Robert C. Matteson, III , George L. Coles, Jr. , Jason J. Benkoski , Morgana M. Trexler
Abstract: Implantable pressure-actuated systems to deliver a drug and/or other substance in response to a pressure difference between a system cavity and an exterior environment, and methods of fabrication and use. A pressure-rupturable membrane diaphragm may be tuned to rupture at a desired rupture threshold, rupture site, with a desired rupture pattern, and/or within a desired rupture time. Tuning may include material selection, thickness control, surface patterning, substrate support patterning. The cavity may be pressurized above or evacuated below the rupture threshold, and a diaphragm-protective layer may be provided to prevent premature rupture in an ambient environment and to dissipate within an implant environment. A drug delivery system may be implemented within a stent to release a substance upon a decrease in blood pressure. The cavity may include a thrombolytic drug to or other substance to treat a blood clot.
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7.发明申请公开(公告)号：US20180160917A1
公开(公告)日：2018-06-14
申请号：US15571771
申请日：2016-05-05
Inventor： Qian Liu , Nichaluk Leartprapun , Jackline Wanjala , Soumyadipta Acharya , Andrew Bicek , Viachaslau Barodka , Umang Anand , Majd Alghatrif , David Kass , B. Westbrook Bernier , Chao-Wei Hwang , Peter Johnston , Trent Langston
Abstract: The present application relates to systems and methods for non-invasively determining at least one of left ventricular end diastolic pressure (LVEDP) or pulmonary capillary wedge pressure (PCWP) in a subject's heart, comprising: receiving, by a computer, a plurality of signals from a plurality of non-invasive sensors that measure a plurality of physiological effects that are correlated with functioning of said subject's heart, said plurality of physiological effects including at least one signal correlated with left ventricular blood pressure and at least one signal correlated with timing of heartbeat cycles of said subject's heart; training a machine learning model on said computer using said plurality of signals for periods of time in which said plurality of signals were being generated during a heart failure event of said subject's heart; determining said LVEDP or PCWP using said machine learning model at a time subsequent to said training and subsequent to said heart failure event.
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公开(公告)号：US20150335788A1
公开(公告)日：2015-11-26
申请号：US14639162
申请日：2015-03-05
Applicant: The Johns Hopkins University
Inventor： Zhiyong Xia , Chao-Wei Hwang , Xiomara Calderon-Colon , Virginia E. Bogdan , Peter V. Johnston
CPC classification number: A61L27/3834 , A61K9/0024 , A61K9/7007 , A61L27/18 , A61L27/54 , A61L27/56 , A61L27/58 , A61L2300/412 , A61L2400/12 , A61L2430/34
Abstract: A therapeutic patch includes at least one layer of a nanofiber fabric and at least one of a plurality of stem cells or a plurality of stem cell-derived paracrine factors embedded in the nanofiber fabric. The therapeutic patch is produced such that the nanofiber fabric is formed of a nanofiber web.
Abstract translation: 治疗性补片包括至少一层纳米纤维织物和多个干细胞中的至少一种或嵌入在纳米纤维织物中的多种干细胞来源的旁分泌因子。 制备治疗贴片，使得纳米纤维织物由纳米纤维网形成。
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9.发明授权Methods of manufacture and use of implantable pressure-actuated drug delivery systems 有权可植入压力致动药物输送系统的制造和使用方法公开(公告)号：US09504586B2
公开(公告)日：2016-11-29
申请号：US14179835
申请日：2014-02-13
Applicant: The Johns Hopkins University
Inventor： Chao-Wei Hwang , Hala J. Tomey , Jon R. Resar , Robert C. Matteson, III , George L. Coles, Jr. , Jason J. Benkoski , Morgana M. Trexler
CPC classification number: A61M31/002 , A61F2/82 , A61F2240/001 , A61F2250/0068 , A61F2250/0071 , A61K9/0012 , A61K9/0024 , A61K9/0097 , A61L31/145 , A61L31/16 , A61L33/0017 , A61L2300/42 , A61L2300/602 , A61L2300/606 , A61L2420/02 , B05D1/005 , C23C14/22 , Y10T29/49826
Abstract: Implantable pressure-actuated systems to deliver a drug and/or other substance in response to a pressure difference between a system cavity and an exterior environment, and methods of fabrication and use. A pressure-rupturable membrane diaphragm may be tuned to rupture at a desired rupture threshold, rupture site, with a desired rupture pattern, and/or within a desired rupture time. Tuning may include material selection, thickness control, surface patterning, substrate support patterning. The cavity may be pressurized above or evacuated below the rupture threshold, and a diaphragm-protective layer may be provided to prevent premature rupture in an ambient environment and to dissipate within an implant environment. A drug delivery system may be implemented within a stent to release a substance upon a decrease in blood pressure. The cavity may include a thrombolytic drug to or other substance to treat a blood clot.
Abstract translation: 可植入的压力致动系统，以响应于系统空腔和外部环境之间的压力差而递送药物和/或其它物质，以及制造和使用方法。 可以调节压力破裂膜隔膜，以在期望的破裂阈值，破裂位置，所需的破裂模式和/或期望的破裂时间内破裂。 调谐可以包括材料选择，厚度控制，表面图案化，衬底支撑图案化。 空腔可以在破裂阈值以下加压或抽真空，并且可以提供隔膜保护层以防止在周围环境中过早破裂并在植入环境内消散。 药物递送系统可以在支架内实施以在血压降低时释放物质。 空腔可以包括用于治疗血块的血栓溶解药物或其他物质。
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公开(公告)号：US20160235956A1
公开(公告)日：2016-08-18
申请号：US15025902
申请日：2014-10-07
Applicant: Chao-Wei HWANG , Zhiyong XIA , Virginia E. BOGDAN , Jeffrey A. BRINKER , Gary GERSTENBLITH , Peter V. JOHNSTON , Steven SCHULMAN , Gorden TOMASELLI , Robert WEISS , THE JOHNS HOPKINS UNIVERSITY
Inventor： Chao-Wei Hwang , Zhiyong Xia , Virginia E. Bogdan , Jeffrey A. Brinker , Gary Gerstenblith , Peter V. Johnston , Steven P. Schulman , Gordon Tomaselli , Robert G. Weiss
IPC: A61M37/00 , A61L33/08 , A61L33/00 , A61L31/00 , A61F2/04 , A61L31/14 , A61L27/56 , A61L27/54 , A61L27/38 , A61L27/18 , A61L31/10 , A61L31/16
CPC classification number: A61M37/00 , A61F2/04 , A61F2002/072 , A61L27/18 , A61L27/3834 , A61L27/54 , A61L27/56 , A61L31/005 , A61L31/06 , A61L31/10 , A61L31/14 , A61L31/146 , A61L31/16 , A61L33/0011 , A61L33/08 , A61L2300/252 , A61L2300/256 , A61L2300/42 , A61L2300/64 , A61L2400/12 , A61L2400/18 , A61L2420/02 , A61M2202/09 , A61M2205/04 , C08L67/04
Abstract: Certain embodiments according to the present invention provide sleeve devices suitable for a wide range of therapeutic uses. In accordance with certain embodiments, the therapeutic sleeve device includes a nanofiber fabric assembly, which defines a plurality of pores, and at least one layer of cells embedded in the nanofiber fabric assembly.
Abstract translation: 根据本发明的某些实施例提供了适用于广泛治疗用途的套筒装置。 根据某些实施例，治疗套管装置包括限定多个孔的纳米纤维织物组件和嵌入在纳米纤维织物组件中的至少一层细胞。
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