公开(公告)号：US20170245976A1

公开(公告)日：2017-08-31

申请号：US15467455

申请日：2017-03-23

Applicant: THE JOHNS HOPKINS UNIVERSITY

Inventor： Gary Gerstenblith ,  Jason Benkoski ,  Jeffrey Brinker ,  George Coles ,  Chao-Wei Hwang ,  Peter Johnston ,  Gordon Tomaselli ,  Robert G. Weiss ,  Steven P. Schulman

IPC: A61F2/02 ,  A61L27/56 ,  A61K35/545 ,  A61L27/28 ,  A61L27/54 ,  A61L27/16 ,  A61L27/38 ,  A61L29/00

CPC classification number: A61F2/022 ,  A61K35/28 ,  A61K35/545 ,  A61L27/16 ,  A61L27/28 ,  A61L27/3834 ,  A61L27/54 ,  A61L27/56 ,  A61L29/00 ,  A61L29/005 ,  A61L29/16 ,  A61L2300/42 ,  A61L2300/64 ,  A61L2430/20 ,  C12N5/0663 ,  C12N2533/30

Abstract: An implantable bioreactor containing a barrier which is designed to allow the release of cell-derived biomolecules, but restricts the entry of immunologic and other cells, or the egress of the cells contained within the bioreactor. Two broad classes of implantable bioreactors are envisioned, encompassing devices for both systemic delivery of the bio-products and local delivery at the target tissue. Bioreactors of both classes can be implanted via surgery, through percutaneous techniques, or other techniques which effect implantation.

公开(公告)号：US10772716B2

公开(公告)日：2020-09-15

申请号：US16281620

申请日：2019-02-21

Applicant: THE JOHNS HOPKINS UNIVERSITY

Inventor： Gary Gerstenblith ,  Jason Benkoski ,  George Coles ,  Chao-Wei Hwang ,  Peter Johnston ,  Gordon Tomaselli ,  Robert G. Weiss ,  Steven P. Schulman ,  Jeffrey A. Brinker

IPC: A61F2/02 ,  A61L27/38 ,  A61L27/54 ,  A61K35/545 ,  A61L29/00 ,  A61L29/16 ,  C12N5/0775 ,  A61K35/28 ,  A61K9/00 ,  A61L29/14 ,  A61L31/10 ,  A61L31/14 ,  A61L31/16 ,  A61L27/16 ,  A61L27/28 ,  A61L27/56

Abstract: A method for promoting healing of tissue by delivering a bioreactor into a subject is provided. The bioreactor is an enclosed housing with paracrine factor producing cells enclosed within the housing. The housing is impermeable to the paracrine factor producing cells, impermeable to immunological cells outside of the housing, and permeable to paracrine factors produced by the paracrine factor producing cells. The paracrine factors produced by the paracrine factor producing cells are released out of the housing to promote healing of the tissue.

公开(公告)号：US20190314416A1

公开(公告)日：2019-10-17

申请号：US16281620

申请日：2019-02-21

Applicant: THE JOHNS HOPKINS UNIVERSITY

Inventor： Gary Gerstenblith ,  Jason Benkoski ,  George Coles ,  Chao-Wei Hwang ,  Peter Johnston ,  Gordon Tomaselli ,  Robert G. Weiss ,  Steven P. Schulman

IPC: A61K35/28 ,  A61L31/14 ,  A61L31/10 ,  A61K9/00 ,  A61L29/14 ,  A61L29/16 ,  A61L31/16

Abstract: A method for promoting healing of tissue by delivering a bioreactor into a subject is provided. The bioreactor is an enclosed housing with paracrine factor producing cells enclosed within the housing. The housing is impermeable to the paracrine factor producing cells, impermeable to immunological cells outside of the housing, and permeable to paracrine factors produced by the paracrine factor producing cells. The paracrine factors produced by the paracrine factor producing cells are released out of the housing to promote healing of the tissue.