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公开(公告)号：US20140134322A1
公开(公告)日：2014-05-15
申请号：US14078167
申请日：2013-11-12
申请人： Steven R. Larsen , Eric Petersen , Scott R. Schewe
发明人： Steven R. Larsen , Eric Petersen , Scott R. Schewe
CPC分类号： A61L31/14 , A61F2/06 , A61L27/303 , A61L27/306 , A61L27/50 , A61L29/103 , A61L29/106 , A61L29/14 , A61L31/084 , A61L31/088 , A61L2400/12 , A61L2400/18 , A61L2420/02 , B23K26/00 , C23C24/04
摘要： Nanoparticles can be embedded into a medical device by accelerating them to a speed of between 100 m/s and 1,000 m/s and embedding the particles into a polymer surface of a medical device or a precursor thereof. In some cases, the nanoparticles can be embedded until the nanoparticles accumulate in sufficient number to adhere together to form a coating over the polymer surface. The nanoparticles can provide a conductive pathway, an abrasion resistant surface, a pro-healing surface, and/or an anti-bacterial surface.
摘要翻译： 通过将纳米颗粒加速至100m / s至1,000m / s的速度并将颗粒包埋在医疗装置或其前体的聚合物表面中，可以将纳米颗粒嵌入医疗装置中。 在一些情况下，纳米颗粒可以被嵌入，直到纳米颗粒累积足够数量以粘附在一起以在聚合物表面上形成涂层。 纳米颗粒可以提供导电通路，耐磨表面，预愈合表面和/或抗细菌表面。
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公开(公告)号：US08920490B2
公开(公告)日：2014-12-30
申请号：US13106449
申请日：2011-05-12
CPC分类号： A61F2/91 , A61F2250/0068
摘要： A medical device is provided with a porous region including a reservoir zone including a polymer and a protective zone between adjacent tissue and the reservoir zone that restricts the tissue from direct contact with the polymer.
摘要翻译： 医疗装置设置有多孔区域，该多孔区域包括储存器区域，该储存器区域包括聚合物和相邻组织与储存区域之间的保护区域，其限制组织与聚合物的直接接触。
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公开(公告)号：US07985063B2
公开(公告)日：2011-07-26
申请号：US11832878
申请日：2007-08-02
IPC分类号： B29C33/38
CPC分类号： A61M25/1029 , B29B2911/14653 , B29B2911/14713 , B29C33/306 , B29C33/42 , B29C33/56 , B29C49/00 , B29C49/0005 , B29C49/14 , B29C49/22 , B29C2049/0089 , B29C2049/4655 , B29K2067/00 , B29K2077/00 , B29K2105/258 , B29L2022/022 , B29L2023/22 , B29L2031/7542
摘要： Molds and related methods and articles are disclosed. In certain embodiments, an exposed surface of the mold has regions with different coefficients of friction.
摘要翻译： 公开了模具及相关方法和制品。 在某些实施例中，模具的暴露表面具有不同摩擦系数的区域。
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4.发明授权Nanoparticle structures and composite materials comprising a silicon-containing compound having a chemical linker that forms a non-covalent bond with a polymer 有权纳米颗粒结构和复合材料，其包含具有与聚合物形成非共价键的化学接头的含硅化合物公开(公告)号：US07470466B2
公开(公告)日：2008-12-30
申请号：US11317963
申请日：2005-12-23
IPC分类号： B32B5/16
CPC分类号： C08J5/005 , B82Y30/00 , C08K9/04 , Y10S977/773 , Y10S977/778 , Y10S977/783 , Y10T428/2982 , Y10T428/2991 , Y10T428/2993 , Y10T428/2998 , Y10T428/31663
摘要： Nanoparticle precursor structures, nanoparticle structures, and composite materials that include the nanoparticle structures in a polymer to form a composite material. The nanoparticle structures have chemical linkage moieties capable of forming non-covalent bonds with portions of a polymer for the composite material. Such composite materials are useful as biomaterials in medical devices.
摘要翻译： 纳米颗粒前体结构，纳米颗粒结构和复合材料，其包括聚合物中的纳米颗粒结构以形成复合材料。 纳米颗粒结构具有能与复合材料的聚合物部分形成非共价键的化学连接部分。 这种复合材料可用作医疗器械中的生物材料。
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公开(公告)号：US08894906B2
公开(公告)日：2014-11-25
申请号：US12787292
申请日：2010-05-25
申请人： Michael S. Arney , Scott R. Schewe
发明人： Michael S. Arney , Scott R. Schewe
IPC分类号： B29C67/00 , B29C47/06 , A61M25/00 , B29C47/10 , B29K75/00 , B29C47/00 , B29K23/00 , B29K67/00 , B29K77/00 , B29K105/06 , B29C65/48 , B29L22/02 , B29C65/00 , B29L31/00 , B29C65/16 , B29K105/12 , B29C65/04
CPC分类号： B29C47/0004 , A61M25/0009 , A61M25/0127 , B29C47/0023 , B29C47/0033 , B29C47/06 , B29C47/065 , B29C47/067 , B29C47/1045 , B29C47/1063 , B29C65/04 , B29C65/16 , B29C65/48 , B29C66/534 , B29K2023/065 , B29K2023/16 , B29K2067/00 , B29K2067/006 , B29K2075/00 , B29K2077/00 , B29K2105/06 , B29K2105/12 , B29L2022/022 , B29L2031/7542 , Y10T428/13
摘要： Medical devices and related methods are disclosed.
摘要翻译： 公开了医疗器械及相关方法。
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公开(公告)号：US07985252B2
公开(公告)日：2011-07-26
申请号：US12182768
申请日：2008-07-30
IPC分类号： A61F2/24
CPC分类号： A61L31/08
摘要： An endoprosthesis includes a plurality of struts defining a flow passage. At least one strut includes (a) a body comprising a bioerodible material and having a thickness and (b) a coating overlying the body. The coating includes a plurality of regions that allow physiological fluids to contact a plurality of corresponding areas of the underlying body when the endoprosthesis is implanted in a physiological environment. The plurality of regions are sized and arranged so that the contacted areas of the body erode substantially through the body in the thickness direction while the coating remains on the body when the endoprosthesis is implanted in the physiological environment.
摘要翻译： 内假体包括限定流动通道的多个支柱。 至少一个支柱包括（a）包含生物腐蚀性材料并且具有厚度的主体和（b）覆盖在身体上的涂层。 涂层包括多个区域，当内生假体植入生理环境时，允许生理流体接触下面身体的多个对应区域。 多个区域的尺寸和布置使得当内部假体植入生理环境中时，身体的接触区域在厚度方向上基本上穿过身体侵蚀，同时涂层保留在身体上。
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公开(公告)号：US20090118814A1
公开(公告)日：2009-05-07
申请号：US11934435
申请日：2007-11-02
CPC分类号： A61L33/00 , A61L31/082 , A61L31/088 , A61L31/14 , C23C14/025 , C23C14/046 , C23C14/08 , C23C14/3464 , C23C14/352
摘要： A method includes: providing a tubular substrate in a chamber, the tubular substrate having a lumen, an a luminal surface and a luminal surface; providing a target in the lumen; depositing a first coating onto the abluminal surface and a second coating onto the luminal surface while keeping the tubular substrate in the chamber. An endoprosthesis, such as a stent, including a first coating on at least one portion of its abluminal surface and a second coating on at least one portion of its luminal surface is also disclosed.
摘要翻译： 一种方法包括：在腔室中提供管状基底，所述管状基底具有内腔，腔内表面和腔表面; 在管腔中提供目标; 将第一涂层沉积到腔内表面上，并将第二涂层沉积到腔表面上，同时将管状基底保持在腔室中。 还公开了内置假体，例如支架，其包括其外侧表面的至少一部分上的第一涂层和其管腔表面的至少一部分上的第二涂层。
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公开(公告)号：US08455088B2
公开(公告)日：2013-06-04
申请号：US11318027
申请日：2005-12-23
IPC分类号： C07F7/02
CPC分类号： D04H1/42 , A61L27/306 , A61L27/446 , A61L29/126 , A61L31/088 , A61L31/128 , A61L2400/12 , B82Y30/00 , C03B37/011 , D01D5/003 , D01F9/00 , D04H3/02 , D04H3/16 , Y10T428/249924 , Y10T428/24994 , Y10T428/249941
摘要： The present disclosure relates to compounds from which nanofibers can be produced, the resulting nanofibers produced from the compounds, and nanofiber reinforced polymers prepared using the nanofibers and a polymer. The compounds used in forming the nanofibers include chemical linkage moieties that are capable of forming non-covalent bonds with portions of the polymer so as to form the nanofiber reinforced polymers. The nanofiber reinforced polymers are useful as biomaterials in medical devices.
摘要翻译： 本公开涉及可以从其制备纳米纤维的化合物，由化合物制备的所得纳米纤维，以及使用纳米纤维和聚合物制备的纳米纤维增强聚合物。 用于形成纳米纤维的化合物包括能与聚合物部分形成非共价键以形成纳米纤维增强聚合物的化学连接部分。 纳米纤维增强聚合物可用作医疗器械中的生物材料。
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公开(公告)号：US08216632B2
公开(公告)日：2012-07-10
申请号：US11934435
申请日：2007-11-02
IPC分类号： A61L33/00
CPC分类号： A61L33/00 , A61L31/082 , A61L31/088 , A61L31/14 , C23C14/025 , C23C14/046 , C23C14/08 , C23C14/3464 , C23C14/352
摘要： A method includes: providing a tubular substrate in a chamber, the tubular substrate having a lumen, an a luminal surface and a luminal surface; providing a target in the lumen; depositing a first coating onto the abluminal surface and a second coating onto the luminal surface while keeping the tubular substrate in the chamber. An endoprosthesis, such as a stent, including a first coating on at least one portion of its abluminal surface and a second coating on at least one portion of its luminal surface is also disclosed.
摘要翻译： 一种方法包括：在腔室中提供管状基底，所述管状基底具有内腔，腔内表面和腔表面; 在管腔中提供目标; 将第一涂层沉积到腔内表面上，并将第二涂层沉积到腔表面上，同时将管状基底保持在腔室中。 还公开了内置假体，例如支架，其包括其外侧表面的至少一部分上的第一涂层和其管腔表面的至少一部分上的第二涂层。
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公开(公告)号：US20110282437A1
公开(公告)日：2011-11-17
申请号：US13105488
申请日：2011-05-11
申请人： Robert W. Warner , Steve Kangas , Liliana Atanasoska , Joseph Thomas Ippoliti , Scott R. Schewe
发明人： Robert W. Warner , Steve Kangas , Liliana Atanasoska , Joseph Thomas Ippoliti , Scott R. Schewe
IPC分类号： A61F2/82
CPC分类号： A61F2/915 , A61F2002/91575 , A61F2210/0076 , A61F2230/0054 , A61F2250/0067
摘要： In embodiments, a stent comprises a biodegradable polymer functionalized with an adhesion-enhancing amino acid.
摘要翻译： 在实施方案中，支架包括用粘附增强的氨基酸官能化的可生物降解的聚合物。
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