公开(公告)号：US20170145519A1

公开(公告)日：2017-05-25

申请号：US15425120

申请日：2017-02-06

Applicant: Samsung Electronics Co., Ltd.

Inventor： Kyung-hee Park ,  Ye-ryoung Yong ,  Hyun-ju Kang ,  Ga-hee Kim ,  Dong-hyun Park ,  Myo-yong Lee

IPC: C12Q1/68

CPC classification number: C12Q1/6886 ,  C12Q2600/158 ,  C12Q2600/178

Abstract: A breast cancer diagnostic composition and kit, and methods of diagnosing breast cancer or acquiring information for breast cancer diagnosis by using the composition or kit are provided. The composition or kit includes a polynucleotide that is the same as or complementary to at least one microRNA (miRNA) selected from the group consisting of hsa-miR-126, hsa-miR-23a, hsa-miR-24, hsa-miR-19b, hsa-miR-103, hsa-miR-142-3p, hsa-miR-144, hsa-miR-15a, hsa-miR-185, hsa-miR-93, and hsa-miR-30c in a vesicle, or a fragment of the microRNA.

公开(公告)号：US09657345B2

公开(公告)日：2017-05-23

申请号：US13899223

申请日：2013-05-21

Applicant: Samsung Electronics Co., Ltd.

Inventor： Dong-hyun Park ,  Sung-woo Hong ,  Kyung-hee Park ,  Myo-yong Lee

IPC: C12Q1/68 ,  C07H21/00 ,  C12P19/34

CPC classification number: C12Q1/6876 ,  C12Q1/6844 ,  C12Q2525/207 ,  C12Q2525/307 ,  C12Q2531/119

Abstract: Provided is a dual-hybridization polynucleotide including a first complementary region that is complementary to the 3′-terminus of a target nucleic and a second complementary region that is complementary to the 5′-terminus of the target nucleic acid, a composition and kit including the polynucleotide, and a method of producing a nucleotide sequence complementary to the target nucleic acid. The first complementary region to be bound at the 3′-terminus of the target nucleic acid can be shortened and the target nucleic acid may be amplified with excellent specificity and/or sensitivity.

公开(公告)号：US09518125B2

公开(公告)日：2016-12-13

申请号：US14322570

申请日：2014-07-02

Applicant: Samsung Electronics Co., Ltd.

Inventor： Ye-ryoung Yong ,  Hyun-ju Kang ,  Ga-hee Kim ,  Kyung-hee Park ,  Jong-myeon Park

IPC: G01N31/00 ,  G01N33/53 ,  C07K16/30 ,  C07K16/28

CPC classification number: C07K16/303 ,  C07K16/2896

Abstract: Provided is method of diagnosing liver cancer in a subject, the method comprising contacting a sample from a subject with a substance that specifically binds to transmembrane emp24 domain trafficking protein 2 (TMED2), cluster of differentiation 43 (CD43), or any combination thereof on the surface of a microvesicle; and measuring the level of the substance bound to microvesicles in the sample; and related methods and compositions.

Abstract translation: 提供了一种在受试者中诊断肝癌的方法，所述方法包括使来自受试者的样品与特异性结合跨膜emp24结构域运输蛋白2（TMED2），分化簇43（CD43）或其任何组合的物质接触 微泡的表面; 并测量与样品中微泡结合的物质的含量; 以及相关方法和组成。

公开(公告)号：US09828645B2

公开(公告)日：2017-11-28

申请号：US15425120

申请日：2017-02-06

Applicant: Samsung Electronics Co., Ltd.

Inventor： Kyung-hee Park ,  Ye-ryoung Yong ,  Hyun-ju Kang ,  Ga-hee Kim ,  Dong-hyun Park ,  Myo-yong Lee

IPC: C07H21/04 ,  C12Q1/68

CPC classification number: C12Q1/6886 ,  C12Q2600/158 ,  C12Q2600/178

Abstract: A breast cancer diagnostic composition and kit, and methods of diagnosing breast cancer or acquiring information for breast cancer diagnosis by using the composition or kit are provided. The composition or kit includes a polynucleotide that is the same as or complementary to at least one microRNA (miRNA) selected from the group consisting of hsa-miR-126, hsa-miR-23a, hsa-miR-24, hsa-miR-19b, hsa-miR-103, hsa-miR-142-3p, hsa-miR-144, hsa-miR-15a, hsa-miR-185, hsa-miR-93, and hsa-miR-30c in a vesicle, or a fragment of the microRNA.

公开(公告)号：US20150104879A1

公开(公告)日：2015-04-16

申请号：US14322570

申请日：2014-07-02

Applicant: Samsung Electronics Co., Ltd.

Inventor： Ye-ryoung YONG ,  Hyun-ju Kang ,  Ga-hee Kim ,  Kyung-hee Park ,  Jong-myeon Park

IPC: G01N33/574 ,  C07K16/30

CPC classification number: C07K16/303 ,  C07K16/2896

Abstract: Provided is method of diagnosing liver cancer in a subject, the method comprising contacting a sample from a subject with a substance that specifically binds to transmembrane emp24 domain trafficking protein 2 (TMED2), cluster of differentiation 43 (CD43), or any combination thereof on the surface of a microvesicle; and measuring the level of the substance bound to microvesicles in the sample; and related methods and compositions.

Abstract translation: 提供了一种在受试者中诊断肝癌的方法，所述方法包括使来自受试者的样品与特异性结合跨膜emp24结构域运输蛋白2（TMED2），分化簇43（CD43）或其任何组合的物质接触 微泡的表面; 并测量与样品中微泡结合的物质的含量; 以及相关方法和组成。

公开(公告)号：US09593379B2

公开(公告)日：2017-03-14

申请号：US14132964

申请日：2013-12-18

Applicant: Samsung Electronics Co., Ltd.

Inventor： Kyung-hee Park ,  Ye-ryoung Yong ,  Hyun-ju Kang ,  Ga-hee Kim ,  Dong-hyun Park ,  Myo-yong Lee

IPC: C12Q1/68

CPC classification number: C12Q1/6886 ,  C12Q2600/158 ,  C12Q2600/178

Abstract: A breast cancer diagnostic composition and kit, and methods of diagnosing breast cancer or acquiring information for breast cancer diagnosis by using the composition or kit are provided. The composition or kit includes a polynucleotide that is the same as or complementary to at least one microRNA (miRNA) selected from the group consisting of hsa-miR-126, hsa-miR-23a, hsa-miR-24, hsa-miR-19b, hsa-miR-103, hsa-miR-142-3p, hsa-miR-144, hsa-miR-15a, hsa-miR-185, hsa-miR-93, and hsa-miR-30c in a vesicle, or a fragment of the microRNA.

Abstract translation: 提供乳腺癌诊断组合物和试剂盒，以及通过使用该组合物或试剂盒诊断乳腺癌或获取乳腺癌诊断信息的方法。 该组合物或试剂盒包括与选自hsa-miR-126，hsa-miR-23a，hsa-miR-24，hsa-miR- 19b，hsa-miR-103，hsa-miR-142-3p，hsa-miR-144，hsa-miR-15a，hsa-miR-185，hsa-miR-93和hsa-miR-30c， 或微小RNA的片段。

公开(公告)号：US20150125864A1

公开(公告)日：2015-05-07

申请号：US14324950

申请日：2014-07-07

Applicant: Samsung Electronics Co., Ltd.

Inventor： Hyun Ju KANG ,  Ga-hee Kim ,  Ye-ryoung Yong ,  Kyung-hee Park ,  Jong-myeon Park

IPC: G01N1/40 ,  C12Q1/68

CPC classification number: G01N1/405 ,  G01N2015/0065 ,  Y10T436/25375

Abstract: Provided is a method of stabilizing vesicles in a sample by combining a sample comprising a vesicle with a chelating agent and a composition used in the stabilizing the vesicle in the sample.

Abstract translation: 提供了一种通过将包含囊泡的样品与螯合剂组合的样品和用于稳定样品中囊泡的组合物来稳定样品中的囊泡的方法。