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公开(公告)号：US09546938B2
公开(公告)日：2017-01-17
申请号：US13857087
申请日：2013-04-04
Applicant: Samsung Electronics Co., Ltd.
Inventor： Ga-hee Kim , Chang-eun Yoo , Ye-ryoung Yong , Myo-yong Lee
IPC: C12Q1/68 , G01N1/40 , G01N33/574 , G01N33/50
CPC classification number: G01N1/405 , C12Q1/6886 , G01N33/5076 , G01N33/57492
Abstract: A composition, a kit, and a method of isolating a vesicle from a sample using a compound comprising zwitterion moieties, which may be used to analyze vesicles, and proteins, glycoprotein, lipids, or nucleic acids thereof.
Abstract translation: 使用可用于分析囊泡的包含两性离子部分的化合物和蛋白质，糖蛋白，脂质或其核酸的组合物，试剂盒和从样品中分离囊泡的方法。
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2.发明授权公开(公告)号：US09518125B2
公开(公告)日：2016-12-13
申请号：US14322570
申请日：2014-07-02
Applicant: Samsung Electronics Co., Ltd.
Inventor： Ye-ryoung Yong , Hyun-ju Kang , Ga-hee Kim , Kyung-hee Park , Jong-myeon Park
CPC classification number: C07K16/303 , C07K16/2896
Abstract: Provided is method of diagnosing liver cancer in a subject, the method comprising contacting a sample from a subject with a substance that specifically binds to transmembrane emp24 domain trafficking protein 2 (TMED2), cluster of differentiation 43 (CD43), or any combination thereof on the surface of a microvesicle; and measuring the level of the substance bound to microvesicles in the sample; and related methods and compositions.
Abstract translation: 提供了一种在受试者中诊断肝癌的方法，所述方法包括使来自受试者的样品与特异性结合跨膜emp24结构域运输蛋白2（TMED2），分化簇43（CD43）或其任何组合的物质接触 微泡的表面; 并测量与样品中微泡结合的物质的含量; 以及相关方法和组成。
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公开(公告)号：US09828645B2
公开(公告)日：2017-11-28
申请号：US15425120
申请日：2017-02-06
Applicant: Samsung Electronics Co., Ltd.
Inventor： Kyung-hee Park , Ye-ryoung Yong , Hyun-ju Kang , Ga-hee Kim , Dong-hyun Park , Myo-yong Lee
CPC classification number: C12Q1/6886 , C12Q2600/158 , C12Q2600/178
Abstract: A breast cancer diagnostic composition and kit, and methods of diagnosing breast cancer or acquiring information for breast cancer diagnosis by using the composition or kit are provided. The composition or kit includes a polynucleotide that is the same as or complementary to at least one microRNA (miRNA) selected from the group consisting of hsa-miR-126, hsa-miR-23a, hsa-miR-24, hsa-miR-19b, hsa-miR-103, hsa-miR-142-3p, hsa-miR-144, hsa-miR-15a, hsa-miR-185, hsa-miR-93, and hsa-miR-30c in a vesicle, or a fragment of the microRNA.
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4.发明授权Method for diagnosing breast cancer by detection of polymeric immunoglobulin receptor in vesicles isolated from patients 有权通过检测从患者分离的囊泡中的聚合免疫球蛋白受体来诊断乳腺癌的方法公开(公告)号：US09213029B2
公开(公告)日：2015-12-15
申请号：US14215743
申请日：2014-03-17
Applicant: Samsung Electronics Co., Ltd.
Inventor： Ye-ryoung Yong , Ga-hee Kim , Hyun-ju Kang
IPC: G01N33/574 , C07K16/30 , C07K16/28 , C12N5/07
CPC classification number: G01N33/57415 , C07K16/283 , G01N2333/70535
Abstract: A composition for breast cancer diagnosis using a material specifically binding to a polymeric immunoglobulin receptor (PIGR) or a fragment thereof, and a method for detecting breast cancer or acquiring information for breast cancer diagnosis using the composition.
Abstract translation: 使用特异性结合聚合免疫球蛋白受体（PIGR）或其片段的材料进行乳腺癌诊断的组合物，以及使用该组合物检测乳腺癌或获取乳腺癌诊断信息的方法。
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5.发明授权Composition and kit for diagnosing breast cancer including polynucleotide within vesicle, and method of diagnosing breast cancer using the same 有权用于诊断乳腺癌的组合物和试剂盒，包括囊泡内的多核苷酸，以及使用该乳腺癌诊断乳腺癌的方法公开(公告)号：US09593379B2
公开(公告)日：2017-03-14
申请号：US14132964
申请日：2013-12-18
Applicant: Samsung Electronics Co., Ltd.
Inventor： Kyung-hee Park , Ye-ryoung Yong , Hyun-ju Kang , Ga-hee Kim , Dong-hyun Park , Myo-yong Lee
IPC: C12Q1/68
CPC classification number: C12Q1/6886 , C12Q2600/158 , C12Q2600/178
Abstract: A breast cancer diagnostic composition and kit, and methods of diagnosing breast cancer or acquiring information for breast cancer diagnosis by using the composition or kit are provided. The composition or kit includes a polynucleotide that is the same as or complementary to at least one microRNA (miRNA) selected from the group consisting of hsa-miR-126, hsa-miR-23a, hsa-miR-24, hsa-miR-19b, hsa-miR-103, hsa-miR-142-3p, hsa-miR-144, hsa-miR-15a, hsa-miR-185, hsa-miR-93, and hsa-miR-30c in a vesicle, or a fragment of the microRNA.
Abstract translation: 提供乳腺癌诊断组合物和试剂盒，以及通过使用该组合物或试剂盒诊断乳腺癌或获取乳腺癌诊断信息的方法。 该组合物或试剂盒包括与选自hsa-miR-126，hsa-miR-23a，hsa-miR-24，hsa-miR- 19b，hsa-miR-103，hsa-miR-142-3p，hsa-miR-144，hsa-miR-15a，hsa-miR-185，hsa-miR-93和hsa-miR-30c， 或微小RNA的片段。
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Patent Agency Ranking
公开(公告)号：US20150125864A1
公开(公告)日：2015-05-07
申请号：US14324950
申请日：2014-07-07
Applicant: Samsung Electronics Co., Ltd.
Inventor： Hyun Ju KANG , Ga-hee Kim , Ye-ryoung Yong , Kyung-hee Park , Jong-myeon Park
CPC classification number: G01N1/405 , G01N2015/0065 , Y10T436/25375
Abstract: Provided is a method of stabilizing vesicles in a sample by combining a sample comprising a vesicle with a chelating agent and a composition used in the stabilizing the vesicle in the sample.
Abstract translation: 提供了一种通过将包含囊泡的样品与螯合剂组合的样品和用于稳定样品中囊泡的组合物来稳定样品中的囊泡的方法。
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公开(公告)号：US10048207B2
公开(公告)日：2018-08-14
申请号：US13857089
申请日：2013-04-04
Applicant: Samsung Electronics Co., Ltd.
Inventor： Hyun-ju Kang , Ye-ryoung Yong , Myo-yong Lee
Abstract: Provided are compositions, kits, and methods for detecting a vesicle comprising a membrane permeable marker that is converted into a detectable marker inside the vesicle.
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8.发明申请公开(公告)号：US20150140684A1
公开(公告)日：2015-05-21
申请号：US14334342
申请日：2014-07-17
Applicant: Samsung Electronics Co., Ltd.
Inventor： Ga-hee KIM , Hyun-ju Kang , Ye-ryoung Yong , Jong-myeon Park
IPC: G01N33/548 , C08B37/08
CPC classification number: C08B37/0072 , G01N33/544
Abstract: A target affinity material comprising a biodegradable polymer, wherein the biodegradable polymer comprises one or more solid particles and one or more materials that specifically binds to a target, as well as related methods and kits.
Abstract translation: 包含可生物降解聚合物的靶亲和材料，其中所述生物可降解聚合物包含一种或多种固体颗粒和特异性结合靶的一种或多种材料，以及相关方法和试剂盒。
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公开(公告)号：US10024795B2
公开(公告)日：2018-07-17
申请号：US13785945
申请日：2013-03-05
Applicant: Samsung Electronics Co., Ltd.
Inventor： Hyun-ju Kang , Ye-ryoung Yong , Myo-yong Lee
Abstract: Provided is a method of monitoring a vesicle in a sample, including contacting a vesicle in a sample with a membrane permeable marker that is converted into a detectable marker in the vesicle, measuring a signal of the detectable marker, and monitoring the vesicle based on the measured signal.
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公开(公告)号：US20170145519A1
公开(公告)日：2017-05-25
申请号：US15425120
申请日：2017-02-06
Applicant: Samsung Electronics Co., Ltd.
Inventor： Kyung-hee Park , Ye-ryoung Yong , Hyun-ju Kang , Ga-hee Kim , Dong-hyun Park , Myo-yong Lee
IPC: C12Q1/68
CPC classification number: C12Q1/6886 , C12Q2600/158 , C12Q2600/178
Abstract: A breast cancer diagnostic composition and kit, and methods of diagnosing breast cancer or acquiring information for breast cancer diagnosis by using the composition or kit are provided. The composition or kit includes a polynucleotide that is the same as or complementary to at least one microRNA (miRNA) selected from the group consisting of hsa-miR-126, hsa-miR-23a, hsa-miR-24, hsa-miR-19b, hsa-miR-103, hsa-miR-142-3p, hsa-miR-144, hsa-miR-15a, hsa-miR-185, hsa-miR-93, and hsa-miR-30c in a vesicle, or a fragment of the microRNA.
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