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    Electrode array for neural stimulation
    1.
    发明授权
    Electrode array for neural stimulation 有权
    电极阵列用于神经刺激

    公开(公告)号：US08180453B2

    公开(公告)日：2012-05-15

    申请号：US10033576

    申请日：2001-11-09

    申请人： Robert J. Greenberg ,  Joseph H. Schulman ,  Brian V. Mech

    发明人： Robert J. Greenberg ,  Joseph H. Schulman ,  Brian V. Mech

    IPC分类号： A61N1/04

    CPC分类号： A61N1/36046 ,  A61N1/0543

    摘要： The present invention is an implantable visual prosthesis where the neural stimulator includes an electrode array body suitable to be placed in an epiretinal location with insulation covering the electrode array body and forming voids. Electrodes are recessed within those voids.

    摘要翻译： 本发明是一种可植入视觉假体，其中神经刺激器包括适于放置在外视位置的电极阵列体，其绝缘覆盖电极阵列主体并形成空隙。 电极凹陷在这些空隙内。

    Flexible circuit electrode array with at least one tack opening
    4.
    发明授权
    Flexible circuit electrode array with at least one tack opening 有权
    具有至少一个定位开口的柔性电路电极阵列

    公开(公告)号：US07991478B2

    公开(公告)日：2011-08-02

    申请号：US11821328

    申请日：2007-06-21

    申请人： Robert J. Greenberg ,  Neil Hamilton Talbot ,  Jordan Matthew Neysmith ,  James Singleton Little ,  Brian V. Mech

    发明人： Robert J. Greenberg ,  Neil Hamilton Talbot ,  Jordan Matthew Neysmith ,  James Singleton Little ,  Brian V. Mech

    IPC分类号： A61N1/05

    CPC分类号： A61N1/0543 ,  A61N1/36046 ,  H05K1/036 ,  H05K1/0393 ,  H05K1/118 ,  H05K3/0014 ,  H05K2201/05 ,  H05K2201/053 ,  H05K2201/09063 ,  H05K2201/09409 ,  Y10T29/49002 ,  Y10T29/49117 ,  Y10T29/49155 ,  Y10T29/49156 ,  Y10T29/49158 ,  Y10T29/49174 ,  Y10T29/49176

    摘要： The present invention provides a flexible circuit electrode array adapted for neural stimulation, comprising: a polymer base layer; metal traces deposited on said polymer base layer, including electrodes suitable to stimulate neural tissue; a polymer top layer deposited on said polymer base layer and said metal traces at least one tack opening; wherein said polymer base layer, said metal traces and said polymer top layer are thermoformed in a three dimensional shape.The present invention provides further a method of making a flexible circuit electrode array comprising depositing a polymer base layer; depositing metal on said polymer base layer; patterning said metal to form metal traces; depositing a polymer top layer on said polymer base layer and said metal traces; preparing at least one tack opening; and heating said flexible circuit electrode array in a mold to form a three dimensional shape in said flexible circuit electrode array.

    摘要翻译： 本发明提供一种适用于神经刺激的柔性电路电极阵列，包括：聚合物基层; 沉积在所述聚合物基层上的金属痕迹，包括适于刺激神经组织的电极; 沉积在所述聚合物基层上的聚合物顶层和所述金属迹线至少一个粘性开口; 其中所述聚合物基层，所述金属迹线和所述聚合物顶层被热成型为三维形状。 本发明还提供一种制造柔性电路电极阵列的方法，包括沉积聚合物基层; 在所述聚合物基层上沉积金属; 图案化所述金属以形成金属痕迹; 在所述聚合物基底层和所述金属迹线上沉积聚合物顶层; 准备至少一个开口; 并将所述柔性电路电极阵列加热到模具中，以在所述柔性电路电极阵列中形成三维形状。

    ELECTRODE WITH INCREASED STABILITY AND METHOD OF MANUFACTURING THE SAME
    6.
    发明申请
    ELECTRODE WITH INCREASED STABILITY AND METHOD OF MANUFACTURING THE SAME 审中-公开
    具有增加的稳定性的电极及其制造方法

    公开(公告)号：US20080268134A1

    公开(公告)日：2008-10-30

    申请号：US11924763

    申请日：2007-10-26

    申请人： Dao Min Zhou ,  Jerry Ok ,  Neil Hamilton Talbot ,  Brian V. Mech ,  James Singleton Little ,  Robert J. Greenberg

    发明人： Dao Min Zhou ,  Jerry Ok ,  Neil Hamilton Talbot ,  Brian V. Mech ,  James Singleton Little ,  Robert J. Greenberg

    IPC分类号： H01M4/04

    CPC分类号： A61N1/0543 ,  A61N1/36046

    摘要： The present invention provides an implantable electrode with increased stability having a clustered structure wherein the surface of the electrode is covered with a material comprising openings which are filled with sticks or posts.The present invention provides an implantable electrode with increased stability wherein the surface is of the electrode comprises mesh grids which are filled with sticks which are filed with a conducting or insulating material.The present invention provides a method of manufacturing an electrode with increased stability, comprising: depositing a metal layer on an base layer; applying photoresist layer on the metal layer; patterning the photoresist layer providing openings; electroplating the openings with metal; removing the photoresist layer leaving spaces; and filling the spaces with polymer.The present invention provides A method of manufacturing an electrode with increased stability, comprising: depositing a metal layer on an base layer; applying a polymer layer on the metal layer; applying photoresist layer on the polymer layer; patterning the photoresist layer providing openings; electroplating the openings with metal; and removing the photoresist layer.

    摘要翻译： 本发明提供具有增加的稳定性的可植入电极，其具有聚集结构，其中电极的表面被包括填充有棒或柱的开口的材料覆盖。 本发明提供了具有增加的稳定性的可植入电极，其中电极的表面包括填充有用导电或绝缘材料填充的棒的网状网格。 本发明提供一种具有增加的稳定性的电极的制造方法，包括：在基底层上沉积金属层; 在金属层上施加光致抗蚀剂层; 图案化提供开口的光致抗蚀剂层; 用金属电镀开口; 去除留下空间的光致抗蚀剂层; 并用聚合物填充空间。 本发明提供了一种制造具有增加的稳定性的电极的方法，包括：在基底层上沉积金属层; 在金属层上施加聚合物层; 在聚合物层上施加光致抗蚀剂层; 图案化提供开口的光致抗蚀剂层; 用金属电镀开口; 并除去光致抗蚀剂层。

    Method of fabricating a microfluidic delivery system
    7.
    发明授权
    Method of fabricating a microfluidic delivery system 有权
    制造微流体传递系统的方法

    公开(公告)号：US06949253B2

    公开(公告)日：2005-09-27

    申请号：US10635633

    申请日：2003-08-05

    申请人： Robert J. Greenberg ,  Brian V. Mech

    发明人： Robert J. Greenberg ,  Brian V. Mech

    IPC分类号： A61K9/00 ,  C23C16/27 ,  A61F2/02

    CPC分类号： C23C16/274 ,  A61K9/0009 ,  A61K9/0097 ,  B82Y30/00 ,  C23C16/277 ,  C23C16/278 ,  C23C16/279

    摘要： An implantable biocompatible microchip drug delivery substrate is coated with a thin film of ultra-nanocrystalline diamond; assuring that the device is biocompatible and impermeably sealed, to prevent the substrate from being dissolved by the living tissue and to protect the drugs from premature release or undesired reaction with the body fluids. The coating is selectively patterned by doping to create electrically conductive areas that can be used as an electrically activated release mechanism for drug delivery. The conformal ultra-nanocrystalline diamond coating uniformly covers the device, providing relief from sharp edges and producing a strong, uniformly thick impermeable coating around sharp edges and on high aspect-ratio parts. The ultra-nanocrystalline diamond coating provides a conformal coating on the biocompatible device, which is of approximately uniform thickness around sharp corners and on high aspect-ratio parts. The conformal nature of the coating assures impermeability and strength despite the presence of difficult to coat shapes.

    摘要翻译： 可植入生物相容性微芯片药物输送基底用超微晶金刚石薄膜涂覆; 确保该装置是生物相容的且不可渗透的密封，以防止基质被活组织溶解并保护药物免于与体液的过早释放或不期望的反应。 通过掺杂选择性地图案化涂层以产生可用作用于药物递送的电活化释放机制的导电区域。 保形的超级纳米晶金刚石涂层均匀地覆盖了该设备，从锐利边缘提供浮雕，并在尖锐边缘和高纵横比部件上产生强而均匀的不透水涂层。 超微晶金刚石涂层在生物相容性装置上提供保形涂层，其在锐角附近和高纵横比部件上具有大致均匀的厚度。 涂层的保形性质确保了不渗透性和强度，尽管存在难以涂布的形状。

    Retinal prosthesis with a new configuration
    10.
    发明授权
    Retinal prosthesis with a new configuration 有权
    视网膜假体具有新配置

    公开(公告)号：US08078284B2

    公开(公告)日：2011-12-13

    申请号：US11523965

    申请日：2006-09-19

    申请人： Robert J. Greenberg ,  Matthew J. McMahon ,  James Singleton Little ,  Kelly H. McClure ,  Brian V. Mech ,  Neil Hamilton Talbot ,  Jordan M. Neysmith

    发明人： Robert J. Greenberg ,  Matthew J. McMahon ,  James Singleton Little ,  Kelly H. McClure ,  Brian V. Mech ,  Neil Hamilton Talbot ,  Jordan M. Neysmith

    IPC分类号： A61N1/00

    CPC分类号： A61N1/36046 ,  A61N1/0543 ,  A61N1/37223 ,  H05K1/028 ,  H05K1/0281 ,  H05K1/118 ,  H05K3/0014 ,  H05K3/28 ,  H05K2201/0133 ,  H05K2201/09018 ,  H05K2201/09145 ,  H05K2201/09909 ,  H05K2201/2009 ,  H05K2203/1105 ,  H05K2203/1476 ,  H05K2203/302 ,  Y10T29/49158

    摘要： Polymer materials are useful as electrode array bodies for neural stimulation. They are particularly useful for retinal stimulation to create artificial vision, cochlear stimulation to create artificial hearing, and cortical stimulation, and many related purposes. The pressure applied against the retina, or other neural tissue, by an electrode array is critical. Too little pressure causes increased electrical resistance, along with electric field dispersion. Too much pressure may block blood flow. Common flexible circuit fabrication techniques generally require that a flexible circuit electrode array be made flat. Since neural tissue is almost never flat, a flat array will necessarily apply uneven pressure. Further, the edges of a flexible circuit polymer array may be sharp and cut the delicate neural tissue. By applying the right amount of heat to a completed array, a curve can be induced. With a thermoplastic polymer it may be further advantageous to repeatedly heat the flexible circuit in multiple molds, each with a decreasing radius. Further, it is advantageous to add material along the edges. It is further advantageous to provide a fold or twist in the flexible circuit array. Additional material may be added inside and outside the fold to promote a good seal with tissue.

    摘要翻译： 聚合物材料可用作神经刺激的电极阵列体。 它们特别有用于视网膜刺激以产生人造视觉，耳蜗刺激以产生人造听觉和皮质刺激以及许多相关目的。 通过电极阵列对视网膜或其他神经组织施加的压力是至关重要的。 太小的压力会导致电阻增加以及电场分散。 太大的压力可能会阻止血液流动。 通常的柔性电路制造技术通常需要使柔性电路电极阵列平坦。 由于神经组织几乎从不平坦，平面阵列必然会施加不均匀的压力。 此外，柔性电路聚合物阵列的边缘可以是尖锐的并切割精细的神经组织。 通过将适量的热应用于完整的阵列，可以引起曲线。 对于热塑性聚合物，可以进一步有利的是在多个模具中反复加热柔性电路，每个模具具有减小的半径。 此外，沿着边缘添加材料是有利的。 在柔性电路阵列中提供折叠或扭曲是更有利的。 可以在折叠内部和外部添加附加材料以促进与组织的良好密封。