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公开(公告)号：US20130066370A1
公开(公告)日：2013-03-14
申请号：US13604450
申请日：2012-09-05
IPC分类号： A61L17/08
CPC分类号： A61L17/08 , A61B2017/00938 , A61B2017/00942 , A61F2013/00319 , A61F2013/00323 , A61L2300/64
摘要： Provided in one embodiment is a suture, comprising: a porous interior component comprising a volume of pores or interstices, the volume comprising a binding surface; and a first number of biological cells dispersed in the volume; wherein the first number of biological cells in the volume is greater than a threshold number representing a second number of the biological cells at 100% confluence on the binding surface.
摘要翻译： 在一个实施方案中提供了一种缝合线，其包括：包含一定体积的孔或间隙的多孔内部部件，所述体积包括结合表面; 和分散在体积中的第一数量的生物细胞; 其中体积中的第一数量的生物细胞大于表示在结合表面上100％汇合的第二数量的生物细胞的阈值数。
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2.发明授权公开(公告)号：US08876864B2
公开(公告)日：2014-11-04
申请号：US12489557
申请日：2009-06-23
CPC分类号： A61L17/005 , A61B17/06114 , A61B17/06166 , A61B2017/00884 , A61B2017/00893 , A61B2017/06185 , A61L17/06 , A61L2300/404 , A61L2300/414 , A61L2300/42 , A61L2300/45 , A61L2300/604 , A61L2300/64 , D06B1/10
摘要： Materials and methods for immobilizing bioactive molecules, stem and other precursor cells, and other agents of therapeutic value in surgical sutures and other tissue scaffold devices are described herein. Broadly drawn to the integration and incorporation of bioactive materials into suture constructs, tissue scaffolds and medical devices, the present invention has particular utility in the development of novel systems that enable medical personnel performing surgical and other medical procedures to utilize and subsequently reintroduce bioactive materials extracted from a patient (or their allogenic equivalents) to a wound or target surgical site.
摘要翻译： 本文描述了用于固定生物活性分子，茎和其它前体细胞的材料和方法以及在外科缝线和其它组织支架装置中具有治疗价值的其它试剂。 广泛地将生物活性材料整合并结合到缝合结构，组织支架和医疗装置中，本发明在开发新颖的系统方面具有特别的用途，这些系统使得医疗人员能够执行手术和其他医疗程序来利用和随后重新引入提取的生物活性材料 从患者（或其同种异体等同物）到伤口或靶外科手术部位。
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3.发明授权Therapeutic material delivery system for tissue voids and cannulated implants 有权用于组织空隙和插管植入物的治疗材料输送系统公开(公告)号：US08317799B2
公开(公告)日：2012-11-27
申请号：US12414194
申请日：2009-03-30
CPC分类号： A61B17/3468 , A61B17/0057 , A61B17/3472 , A61B17/3478 , A61B17/864 , A61M31/00
摘要： Described herein is a novel drug delivery assembly having particular applicability to the field of orthopedic and surgical medicine. The devices and assemblies described herein enable the efficient application and retention of potentially expensive therapeutic materials to very specific locations, particularly those associated with voids in bone and tissue. One particularly unique aspect of the present invention involves the introduction of constructs which promote the retention of therapeutic material in the target area of application for beneficial use, for example by forming a proximal barrier that prevents leakage of the therapeutic material out of the target area. Additionally, the present invention provides unique devices and methods for surgical introduction of such constructs. The present invention finds particular application in connection with introduction of stem and progenitor cells, bioactive molecules and bone scaffold materials in conjunction with bone voids and with the use of cannulated implants, such as bone screws (also surgical screws) and pins. The present invention also has beneficial use in the delivery of cancer drugs, antimicrobials, bone cements and other therapeutic materials.
摘要翻译： 本文描述了具有对矫形外科医学领域特别适用的新型药物递送组件。 本文所述的装置和组件能够有效地应用和保留潜在的昂贵的治疗材料到非常特定的位置，特别是那些与骨骼和组织中的空隙有关的部位。 本发明的一个特别独特的方面涉及引入促进治疗材料在用于有益用途的目标应用领域中的保留的构建体，例如通过形成防止治疗材料渗出目标区域的近侧屏障。 另外，本发明提供了用于手术引入这种构建体的独特装置和方法。 本发明特别适用于引入干细胞和祖细胞，生物活性分子和骨骼支架材料以及骨空隙以及使用插管植入物，例如骨螺钉（也是手术螺钉）和引脚。 本发明还可用于递送癌症药物，抗微生物剂，骨水泥和其它治疗材料。
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4.发明申请Therapeutic Material Delivery System for Tissue Voids and Cannulated Implants 审中-公开组织空洞和插管植入物的治疗物质输送系统公开(公告)号：US20130261597A1
公开(公告)日：2013-10-03
申请号：US13588110
申请日：2012-08-17
CPC分类号： A61M5/315 , A61B17/3468 , A61B17/3472 , A61B17/3478 , A61B17/864 , A61F2/28 , A61M5/19 , A61M5/3295
摘要： Described herein is a novel drug delivery assembly having particular applicability to the field of orthopedic and surgical medicine. The devices and assemblies described herein enable the efficient application and retention of potentially expensive therapeutic materials to very specific locations, particularly those associated with voids in bone and tissue. One particularly unique aspect of the present invention involves the introduction of constructs which promote the retention of therapeutic material in the target area of application for beneficial use, for example by forming a proximal barrier that prevents leakage of the therapeutic material out of the target area. Additionally, the present invention provides unique devices and methods for surgical introduction of such constructs. The present invention finds particular application in connection with introduction of stem and progenitor cells, bioactive molecules and bone scaffold materials in conjunction with bone voids and with the use of cannulated implants, such as bone screws (also surgical screws) and pins. The present invention also has beneficial use in the delivery of cancer drugs, antimicrobials, bone cements and other therapeutic materials.
摘要翻译： 本文描述了具有对矫形外科医学领域特别适用的新型药物递送组件。 本文所述的装置和组件能够有效地应用和保留潜在的昂贵的治疗材料到非常特定的位置，特别是那些与骨骼和组织中的空隙有关的部位。 本发明的一个特别独特的方面涉及引入促进治疗材料在用于有益用途的目标应用领域中的保留的构建体，例如通过形成防止治疗材料渗出目标区域的近侧屏障。 另外，本发明提供了用于手术引入这种构建体的独特装置和方法。 本发明特别适用于引入干细胞和祖细胞，生物活性分子和骨骼支架材料以及骨空隙以及使用插管植入物，例如骨螺钉（也是手术螺钉）和引脚。 本发明还可用于递送癌症药物，抗微生物剂，骨水泥和其它治疗材料。
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5.发明授权Method of assigning and deducing the location of articles detected by multiple RFID antennae 有权分配和推导由多个RFID天线检测到的物品的位置的方法公开(公告)号：US08339265B2
公开(公告)日：2012-12-25
申请号：US13093081
申请日：2011-04-25
IPC分类号： G08B13/14
CPC分类号： G08B13/2462 , G06K7/0008 , G06K7/10316 , G06K7/10336 , G06K7/10356 , G06K2017/0045 , G06Q10/087 , G07G1/0045 , G08B13/2474 , H01Q1/22 , H01Q1/2216 , H01Q7/00
摘要： In accordance with preferred embodiments or the invention, a method (and corresponding apparatus) is provided for deducing the location of one or more items or objects to be monitored. In exemplary embodiments, the method (and corresponding apparatus) is implemented in RFID (radio frequency identification) applications (e.g., reading RFID tags at 13.56 MHz and approximately 900 MHz) by deducing the location of an item associated with a unique RFID tag in one or more areas of detection covered by multiple RFID reader antennae.
摘要翻译： 根据优选实施例或本发明，提供了一种用于推导要监视的一个或多个物品或位置的位置的方法（以及相应的装置）。 在示例性实施例中，方法（以及相应的装置）通过将与唯一RFID标签相关联的物品的位置推送到一个RFID（射频识别）应用中（例如，以13.56MHz和约900MHz读取RFID标签）来实现 或多个RFID读取器天线覆盖的更多的检测区域。
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6.发明申请公开(公告)号：US20080305348A1
公开(公告)日：2008-12-11
申请号：US11761045
申请日：2007-06-11
申请人： Richard H. Spedden
发明人： Richard H. Spedden
CPC分类号： G01N33/5432 , A61L27/54 , A61L29/16 , A61L31/16 , A61L2300/232 , C08L1/02 , C08L5/04 , C08L89/00 , C08L91/06 , Y10T428/31504 , Y10T428/31844
摘要： Disclosed herein are glycosylated amphiphilic molecules composed of hydrophobic “tails” and hydrophilic “heads” that self align to form a membrane at the interface of a polar solvent and a non-polar liquid or a solid. The present invention is directed to a solid state membrane, typically a thin film, composed of a non-polar solid material having the hydrophobic “tail” of a glycosylated amphiphilic molecule embedded in or linked to its surface such that the hydrophilic “head” protrudes from the solid surface and presents useful properties to the surrounding environment. A membrane or film in accordance with the present invention is produced when a non-polar liquid, in the presence of a polar solvent and an amphiphilic biological compound, undergoes a transformation from liquid to solid, through thermal, chemical or radiative means, with the resultant effect that the amphiphilic molecule is affixed or “locked” to the surface, more particularly the hydrophobic ends of the amphiphilic compounds are mechanically or chemically linked to or embedded in the non-polar solid. The membrane and micelles produced therefrom remain stable even in the absence of the polar solvent, thereby allowing the hydrophilic components of the amphiphilic compounds to present useful properties at the surface thereof.
摘要翻译： 本文公开了由疏水性“尾”和亲水“头”组成的糖基化两亲分子，其自对准以在极性溶剂和非极性液体或固体的界面处形成膜。 本发明涉及一种固态膜，通常是由非极性固体材料组成的固体膜，该非极性固体材料具有嵌入或连接于其表面的糖基化两亲性分子的疏水“尾”，使得亲水性“头”突出 从固体表面，并向周围环境提供有用的特性。 当非极性液体在极性溶剂和两亲性生物化合物的存在下，通过热，化学或辐射方式从液体转变为固体时，产生根据本发明的膜或膜， 两亲分子被固定或“锁定”在表面上，特别是两亲化合物的疏水末端与非极性固体机械地或化学地连接或嵌入非极性固体中。 由此产生的膜和胶束即使在不存在极性溶剂的情况下也保持稳定，从而使两亲性化合物的亲水组分在其表面具有有用的性质。
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7.发明授权Stem cell capture and immobilization coatings for medical devices and implants 有权用于医疗器械和植入物的干细胞捕获和固定涂层公开(公告)号：US08518431B2
公开(公告)日：2013-08-27
申请号：US13543059
申请日：2012-07-06
申请人： Richard H. Spedden , Judy Qiu , William Borch
发明人： Richard H. Spedden , Judy Qiu , William Borch
CPC分类号： A61L27/38 , A61L27/227 , A61L29/005 , A61L29/048 , A61L31/005 , A61L31/047
摘要： Constructs and methods for immobilizing stem and other precursor cells, as well as other bioactive materials of therapeutic value on the surfaces of medical devices, such as bone, cartilage, spinal and tooth implants, are described herein. The present invention has broad application in the incorporation of bioactive and therapeutic materials in or on a medical implant or other interventional device, having particular value in enabling the real-time, utilization by medical personnel of bioactive materials extracted from the patient and subsequently reintroduced and immobilized in an implant device.
摘要翻译： 本文描述了用于固定茎和其它前体细胞以及治疗价值的其它生物活性材料在医疗装置（例如骨，软骨，脊髓和牙齿植入物）的表面上的构造和方法。 本发明在将生物活性和治疗性材料并入医用植入物或其他介入装置中或在医疗植入物或其他介入装置上具有广泛的应用，其特征在于能够实时地利用医务人员从患者中提取的生物活性物质并随后重新引入和 固定在植入装置中。
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8.发明申请METHOD OF ASSIGNING AND DEDUCING THE LOCATION OF ARTICLES DETECTED BY MULTIPLE RFID ANTENNAE 有权通过多个RFID天线检测的文章的位置的分配和减少方法公开(公告)号：US20110199211A1
公开(公告)日：2011-08-18
申请号：US13093081
申请日：2011-04-25
IPC分类号： G08B13/14
CPC分类号： G08B13/2462 , G06K7/0008 , G06K7/10316 , G06K7/10336 , G06K7/10356 , G06K2017/0045 , G06Q10/087 , G07G1/0045 , G08B13/2474 , H01Q1/22 , H01Q1/2216 , H01Q7/00
摘要： In accordance with preferred embodiments or the invention, a method (and corresponding apparatus) is provided for deducing the location of one or more items or objects to be monitored. In exemplary embodiments, the method (and corresponding apparatus) is implemented in RFID (radio frequency identification) applications (e.g., reading RFID tags at 13.56 MHz and approximately 900 MHz) by deducing the location of an item associated with a unique RFID tag in one or more areas of detection covered by multiple RFID reader antennae.
摘要翻译： 根据优选实施例或本发明，提供了一种用于推导要监视的一个或多个物品或位置的位置的方法（以及相应的装置）。 在示例性实施例中，方法（以及相应的装置）通过将与唯一RFID标签相关联的物品的位置推送到一个RFID（射频识别）应用中（例如，以13.56MHz和约900MHz读取RFID标签）来实现 或多个RFID读取器天线覆盖的更多的检测区域。
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9.发明申请STEM CELL CAPTURE AND IMMOBILIZATION COATINGS FOR MEDICAL DEVICES AND IMPLANTS 有权用于医疗器械和植入物的干细胞捕获和固定涂层公开(公告)号：US20100034864A1
公开(公告)日：2010-02-11
申请号：US12537409
申请日：2009-08-07
申请人： Richard H. Spedden , Judy Qiu , William Borch
发明人： Richard H. Spedden , Judy Qiu , William Borch
CPC分类号： A61L27/38 , A61L27/227 , A61L29/005 , A61L29/048 , A61L31/005 , A61L31/047
摘要： Constructs and methods for immobilizing stem and other precursor cells, as well as other bioactive materials of therapeutic value on the surfaces of medical devices, such as bone, cartilage, spinal and tooth implants, are described herein. The present invention has broad application in the incorporation of bioactive and therapeutic materials in or on a medical implant or other interventional device, having particular value in enabling the real-time, utilization by medical personnel of bioactive materials extracted from the patient and subsequently reintroduced and immobilized in an implant device.
摘要翻译： 本文描述了用于固定茎和其它前体细胞以及治疗价值的其它生物活性材料在医疗装置（例如骨，软骨，脊髓和牙齿植入物）的表面上的构造和方法。 本发明在将生物活性和治疗性材料并入医用植入物或其他介入装置中或在医疗植入物或其他介入装置上具有广泛的应用，其特征在于能够实时地利用医务人员从患者中提取的生物活性物质并随后重新引入和 固定在植入装置中。
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10.发明授权Stem cell capture and immobilization coatings for medical devices and implants 有权用于医疗器械和植入物的干细胞捕获和固定涂层公开(公告)号：US08889168B2
公开(公告)日：2014-11-18
申请号：US12537409
申请日：2009-08-07
申请人： Richard H. Spedden , Judy Qiu , William Borch
发明人： Richard H. Spedden , Judy Qiu , William Borch
IPC分类号： A61L17/06 , A61L29/16 , A61L31/16 , A61L29/00 , A61L27/22 , A61L31/00 , A61L27/38 , A61L29/04 , A61L31/04 , A61K9/107 , A61K35/12
CPC分类号： A61L27/38 , A61L27/227 , A61L29/005 , A61L29/048 , A61L31/005 , A61L31/047
摘要： Constructs and methods for immobilizing stem and other precursor cells, as well as other bioactive materials of therapeutic value on the surfaces of medical devices, such as bone, cartilage, spinal and tooth implants, are described herein. The present invention has broad application in the incorporation of bioactive and therapeutic materials in or on a medical implant or other interventional device, having particular value in enabling the real-time, utilization by medical personnel of bioactive materials extracted from the patient and subsequently reintroduced and immobilized in an implant device.
摘要翻译： 本文描述了用于固定茎和其它前体细胞以及治疗价值的其它生物活性材料在医疗装置（例如骨，软骨，脊髓和牙齿植入物）的表面上的构造和方法。 本发明在将生物活性和治疗性材料并入医用植入物或其他介入装置中或在医疗植入物或其他介入装置上具有广泛的应用，其特征在于能够实时地利用医务人员从患者中提取的生物活性材料并随后重新引入和 固定在植入装置中。
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