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78 条记录 (耗时 0.084 秒)

    RNAi modulation of RSV and therapeutic uses thereof
    2.
    发明授权
    RNAi modulation of RSV and therapeutic uses thereof 有权
    RSV的RNAi调节及其治疗用途

    公开(公告)号：US08263572B2

    公开(公告)日：2012-09-11

    申请号：US13160268

    申请日：2011-06-14

    申请人： Rachel Meyers

    发明人： Rachel Meyers

    IPC分类号： A61K31/70 ,  C07H21/02 ,  C07H21/04

    CPC分类号： C12N15/1131 ,  A61K9/0078 ,  A61K31/713 ,  A61M11/06 ,  A61M15/00 ,  A61M16/14 ,  A61M2202/04 ,  A61M2202/064 ,  C12N2310/14 ,  C12N2320/31 ,  C12N2320/32

    摘要： The present invention is based on the in vivo demonstration that RSV can be inhibited through intranasal administration of iRNA agents as well as by parenteral administration of such agents. Further, it is shown that effective viral reduction can be achieved with more than one virus being treated concurrently. Based on these findings, the present invention provides general and specific compositions and methods that are useful in reducing RSV mRNA levels, RSV protein levels and viral titers in a subject, e.g., a mammal, such as a human. These findings can be applied to other respiratory viruses.

    摘要翻译： 本发明基于体内证据，可以通过鼻内施用iRNA试剂以及通过肠胃外给药这种试剂来抑制RSV。 此外，显示可以同时治疗多于一种的病毒来实现有效的病毒降低。 基于这些发现，本发明提供了可用于减少受试者例如哺乳动物（例如人）中的RSV mRNA水平，RSV蛋白水平和病毒滴度的一般和特定组合物和方法。 这些发现可以应用于其他呼吸道病毒。

    3714, 16742, 23546, and 13887 novel protein kinase molecules and uses therefor
    4.
    发明申请
    3714, 16742, 23546, and 13887 novel protein kinase molecules and uses therefor 审中-公开
    3714,16742,23546和13887新型蛋白激酶分子及其用途

    公开(公告)号：US20070178515A1

    公开(公告)日：2007-08-02

    申请号：US11726163

    申请日：2007-03-21

    申请人： Rachel Meyers ,  John Hunter

    发明人： Rachel Meyers ,  John Hunter

    IPC分类号： C12Q1/68 ,  C07H21/04 ,  C12P21/06 ,  C12N9/12

    CPC分类号： C12N9/1205 ,  C12Q1/48 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/136 ,  C12Q2600/156

    摘要： The invention provides isolated nucleic acids molecules, designated 3714, 16742, 23546, or 13887 nucleic acid molecules, which encode novel protein kinases. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 3714, 16742, 23546, or 13887 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 3714, 16742, 23546, or 13887 gene has been introduced or disrupted. The invention still further provides isolated 3714, 16742, 23546, or 13887 proteins, fusion proteins, antigenic peptides and anti-3714, -16742, -23546, or -13887 antibodies. Diagnostic, screening, and therapeutic methods utilizing compositions of the invention are also provided.

    摘要翻译： 本发明提供编码新的蛋白激酶的分离的核酸分子，命名为3714,16742,23546或13887核酸分子。 本发明还提供反义核酸分子，含有3714,16742,23546或13887核酸分子的重组表达载体，已经引入表达载体的宿主细胞，以及非人类转基因动物，其中3714,16742,23546或 13887基因已被引入或破坏。 本发明还进一步提供分离的3714,16742,23546或13887蛋白，融合蛋白，抗原肽和抗-3714，-16742，-23546或-13887抗体。 还提供了利用本发明组合物的诊断，筛选和治疗方法。

    3714, 16742, 23546, and 13887 novel protein kinase molecules and uses therefor
    5.
    发明授权
    3714, 16742, 23546, and 13887 novel protein kinase molecules and uses therefor 有权
    3714,16742,23546和13887新型蛋白激酶分子及其用途

    公开(公告)号：US07214502B2

    公开(公告)日：2007-05-08

    申请号：US10393316

    申请日：2003-03-20

    申请人： Rachel Meyers ,  John Joseph Hunter

    发明人： Rachel Meyers ,  John Joseph Hunter

    IPC分类号： C12Q1/48 ,  C12N9/12

    CPC分类号： C12N9/1205 ,  C12Q1/48 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/136 ,  C12Q2600/156

    摘要： The invention provides isolated nucleic acids molecules, designated 3714, 16742, 23546, or 13887 nucleic acid molecules, which encode novel protein kinases. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 3714, 16742, 23546, or 13887 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 3714, 16742, 23546, or 13887 gene has been introduced or disrupted. The invention sill further provides isolated 3714, 16742, 23546, or 13887 proteins, fusion proteins, antigenic peptides and anti-3714, -16742, -23546, or -13887 antibodies. Diagnostic, screening, and therapeutic methods utilizing compositions of the invention are also provided.

    摘要翻译： 本发明提供编码新的蛋白激酶的分离的核酸分子，命名为3714,16742,23546或13887核酸分子。 本发明还提供反义核酸分子，含有3714,16742,23546或13887核酸分子的重组表达载体，已经引入表达载体的宿主细胞，以及非人类转基因动物，其中3714,16742,23546或 13887基因已被引入或破坏。 本发明进一步提供分离的3714,16742,23546或13887蛋白，融合蛋白，抗原肽和抗-3714，-16742，-23546或-13887抗体。 还提供了利用本发明组合物的诊断，筛选和治疗方法。

    62112, a novel human dehydrogenase and uses thereof
    8.
    发明授权
    62112, a novel human dehydrogenase and uses thereof 失效
    62112，一种新的人脱氢酶及其用途

    公开(公告)号：US07166428B2

    公开(公告)日：2007-01-23

    申请号：US09945326

    申请日：2001-08-31

    申请人： Rachel Meyers ,  John Joseph Hunter

    发明人： Rachel Meyers ,  John Joseph Hunter

    IPC分类号： C12Q1/68

    CPC分类号： C12N9/001 ,  A61K38/00 ,  C07K2319/00

    摘要： The invention provides isolated nucleic acids molecules, designated DHDR-7 nucleic acid molecules, which encode novel human dehydrogenase molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing DHDR-7 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a DHDR-7 gene has been introduced or disrupted. The invention still further provides isolated DHDR-7 polypeptides, fusion polypeptides, antigenic peptides and anti-DHDR-7 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

    摘要翻译： 本发明提供编码新的人脱氢酶分子的分离的核酸分子，命名为DHDR-7核酸分子。 本发明还提供了反义核酸分子，含有DHDR-7核酸分子的重组表达载体，其中引入了表达载体的宿主细胞，以及DHDR-7基因导入或破坏的非人类转基因动物。 本发明还进一步提供了分离的DHDR-7多肽，融合多肽，抗原肽和抗DHDR-7抗体。 还提供利用本发明组合物的诊断方法。

    14094, a novel human trypsin family member and uses thereof
    9.
    发明申请
    14094, a novel human trypsin family member and uses thereof 审中-公开
    14094，一种新型人胰蛋白酶家族成员及其用途

    公开(公告)号：US20070009433A1

    公开(公告)日：2007-01-11

    申请号：US11403988

    申请日：2006-04-13

    申请人： Rachel Meyers ,  Kyle MacBeth

    发明人： Rachel Meyers ,  Kyle MacBeth

    IPC分类号： A61K51/00 ,  G01N33/574 ,  A61K39/395 ,  A61K38/17 ,  C40B30/06

    CPC分类号： A61K38/17 ,  A61K47/6871 ,  A61K51/1075 ,  A61K2039/505 ,  C07K16/40 ,  C12N9/6427 ,  G01N33/573 ,  G01N33/57415 ,  G01N33/57419 ,  G01N33/57423 ,  G01N33/57449 ,  G01N2333/96433 ,  G01N2500/00

    摘要： The invention provides isolated nucleic acids molecules, designated 14094 nucleic acid molecules, which encode a novel trypsin family member. Elevated expression of 14094 mRNA was detected in breast, ovarian, lung, and liver cancers compared to normal cells derived from these tissues. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 14094 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 14094 gene has been introduced or disrupted. The invention still further provides isolated 14094 proteins, fusion proteins, antigenic peptides and anti-14094 antibodies. Therapeutic and diagnostic methods utilizing compositions of the invention to, for example, treat, prevent, and/or diagnose neoplastic conditions, are also provided.

    摘要翻译： 本发明提供编码新型胰蛋白酶家族成员的分离的核酸分子，命名为14094个核酸分子。 与来自这些组织的正常细胞相比，在乳腺癌，卵巢癌，肺癌和肝癌中检测到14094个mRNA的表达升高。 本发明还提供了反义核酸分子，含有14094个核酸分子的重组表达载体，其中引入了表达载体的宿主细胞，以及14094基因导入或破坏的非人类转基因动物。 本发明还进一步提供了分离的14094蛋白，融合蛋白，抗原肽和抗-144094抗体。 还提供了利用本发明组合例如治疗，预防和/或诊断肿瘤病症的治疗和诊断方法。