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16 条记录 (耗时 0.016 秒)

    Method of modulating gene expression with reduced immunostimulatory response
    1.
    发明授权
    Method of modulating gene expression with reduced immunostimulatory response 失效
    用免疫刺激反应降低调节基因表达的方法

    公开(公告)号：US5968909A

    公开(公告)日：1999-10-19

    申请号：US511536

    申请日：1995-08-04

    申请人： Sudhir Agrawal ,  Jamal Temsamani ,  Qiuyan Zhao

    发明人： Sudhir Agrawal ,  Jamal Temsamani ,  Qiuyan Zhao

    IPC分类号： C12N15/09 ,  A61K31/00 ,  A61K31/70 ,  A61K31/7088 ,  A61K31/7125 ,  A61K48/00 ,  A61P31/00 ,  A61P35/00 ,  C07H21/00 ,  C07H21/04

    CPC分类号： A61K31/7125 ,  C07H21/00

    摘要： The present invention provides a method of reducing the immunostimulatory effects of certain phosphorothioate oligonucleotides used to treat pathogen-mediated disease states and other medical conditions. Immunostimulatory effects of phosphorothioate oligonucleotides are reduced in accordance with the method of the invention by modifying at least one chemical structure within the phosphorothioate oligonucleotide to produce an immunostimulatory response-reducing phosphorothioate oligonucleotide, which is then administered to a mammal afflicted with the disease or condition being treated. The immune response of the mammal is also monitored in the method of the invention.

    摘要翻译： 本发明提供降低用于治疗病原体介导的疾病状态和其他医学病症的某些硫代磷酸酯寡核苷酸的免疫刺激作用的方法。 通过改变硫代磷酸酯寡核苷酸内的至少一种化学结构以产生免疫刺激性应答还原型硫代磷酸酯寡核苷酸，然后将其施用于患有疾病或病症的哺乳动物，根据本发明的方法减少硫代磷酸酯寡核苷酸的免疫刺激作用 治疗。 还在本发明的方法中监测哺乳动物的免疫应答。

    Use of cyclodextrins to modulate gene expression with reduced immunostimulatory response
    2.
    发明授权
    Use of cyclodextrins to modulate gene expression with reduced immunostimulatory response 失效
    使用环糊精调节基因表达减少的免疫刺激反应

    公开(公告)号：US06667293B1

    公开(公告)日：2003-12-23

    申请号：US08527126

    申请日：1995-09-12

    申请人： Qiuyan Zhao ,  Jamal Temsamani ,  Sudhir Agrawal

    发明人： Qiuyan Zhao ,  Jamal Temsamani ,  Sudhir Agrawal

    IPC分类号： A01N4304

    CPC分类号： B82Y5/00 ,  A61K47/6951

    摘要： The present invention provides a method of reducing the immunostimulatory effects of certain phosphorothioate oligonucleotides used to treat pathogen-mediated disease states and other medical conditions. Immunostimulatory effects of phosphorothioate oligonucleotides are reduced in accordance with the method of the invention by administering the phosphorothioate oligonucleotide in a therapeutic formulation which includes at least one cyclodextrin to a mammal afflicted with the disease or condition being treated. The immune response of the mammal is also monitored in the method of the invention.

    摘要翻译： 本发明提供降低用于治疗病原体介导的疾病状态和其他医学病症的某些硫代磷酸酯寡核苷酸的免疫刺激作用的方法。 根据本发明的方法，通过将硫代磷酸酯寡核苷酸给予包含至少一种环糊精的治疗制剂给予所治疗的疾病或病症的哺乳动物，降低了硫代磷酸酯寡核苷酸的免疫刺激作用。 还在本发明的方法中监测哺乳动物的免疫应答。

    Pharmaceutical composition comprising an anti-cancer and at least a peptide
    5.
    发明授权
    Pharmaceutical composition comprising an anti-cancer and at least a peptide 失效
    包含抗癌和至少一种肽的药物组合物

    公开(公告)号：US07527792B1

    公开(公告)日：2009-05-05

    申请号：US09856940

    申请日：1999-11-26

    申请人： Jamal Temsamani ,  Michel Kaczorek

    发明人： Jamal Temsamani ,  Michel Kaczorek

    IPC分类号： A61K39/38

    CPC分类号： A61K47/62

    摘要： The invention concerns a pharmaceutical composition for treating and/or preventing cancer comprising at least an anti-cancer agent, characterised in that said anticancer agent is associated in the composition with at least a peptide capable of carrying said agent into the cancer cells and prevent the occurrence of chemoresistance to said agent.

    摘要翻译： 本发明涉及用于治疗和/或预防癌症的药物组合物，其包含至少一种抗癌剂，其特征在于所述抗癌剂与该组合物中至少一种能将所述药物携带到癌细胞中的肽相结合并防止 对所述试剂的化学耐药性的发生。

    Transporting of taxoid derivatives through the blood brain barrier
    6.
    发明申请
    Transporting of taxoid derivatives through the blood brain barrier 审中-公开
    通过血脑屏障运输紫杉烷衍生物

    公开(公告)号：US20060293242A1

    公开(公告)日：2006-12-28

    申请号：US10490357

    申请日：2002-09-26

    申请人： Jamal Temsamani ,  Anthony Rees

    发明人： Jamal Temsamani ,  Anthony Rees

    IPC分类号： A61K38/10 ,  A61K38/08 ,  A61K31/704 ,  A61K31/525 ,  C07K7/08 ,  C07K7/06

    CPC分类号： A61K47/62

    摘要： Taxoid derivatives are used in the treatment of cancers, particular cancers of the central nervous system, such as brain cancers. Taxoid derivatives are transported across the blood/brain barrier (BBB). A compound is provided which consists of at least one taxoid derivative bound to at least one vector peptide capable of increasing the solubility of the derivative and advantageously allowing it to be transported across the BBB.

    摘要翻译： 紫杉烷衍生物用于治疗癌症，特别是中枢神经系统癌症，如脑癌。 紫杉烷衍生物通过血液/脑屏障（BBB）运输。 提供了一种化合物，其由至少一种结合至少一种能够增加衍生物的溶解度的载体肽结合的紫杉烷衍生物组成，有利地允许其跨越BBB传输。

    USE OF THE PAT NONAPEPTIDE IN TREATING AND PREVENTING NEURODEGENERATIVE DISEASES
    8.
    发明申请
    USE OF THE PAT NONAPEPTIDE IN TREATING AND PREVENTING NEURODEGENERATIVE DISEASES 有权
    使用非特异性蛋白酶治疗和预防神经损伤性疾病

    公开(公告)号：US20130116193A1

    公开(公告)日：2013-05-09

    申请号：US13809805

    申请日：2011-07-11

    申请人： Jamal Temsamani ,  Claude Laruelle

    发明人： Jamal Temsamani ,  Claude Laruelle

    IPC分类号： A61K38/08

    CPC分类号： A61K38/32 ,  A61K38/08 ,  A61K38/22

    摘要： The invention relates to the use of the PAT nonapeptide in the manufacture of a drug for preventing or treating a neurodegenerative disease such as Alzheimer's disease. The parenteral route of administration is preferable, including the subcutaneous, intraperitoneal, intravenous or intranasal routes. The invention also relates to an injectable formulation containing the PAT nonapeptide which can be administered to patients suffering from a neurodegenerative disease such as Alzheimer's disease.

    摘要翻译： 本发明涉及PAT单肽在制备用于预防或治疗神经变性疾病如阿尔茨海默病的药物中的用途。 肠胃外给药途径是优选的，包括皮下，腹膜内，静脉内或鼻内途径。 本发明还涉及含有PAT九肽的可注射制剂，其可以施用于患有神经变性疾病如阿尔茨海默病的患者。

    Use of the PAT nanopeptide in treating and preventing neurodegenerative diseases
    10.
    发明授权
    Use of the PAT nanopeptide in treating and preventing neurodegenerative diseases 有权
    使用PAT纳米肽治疗和预防神经退行性疾病

    公开(公告)号：US09192654B2

    公开(公告)日：2015-11-24

    申请号：US13809805

    申请日：2011-07-11

    申请人： Jamal Temsamani ,  Claude Laruelle

    发明人： Jamal Temsamani ,  Claude Laruelle

    IPC分类号： A61K38/32 ,  A61K38/08 ,  A61K38/22

    CPC分类号： A61K38/32 ,  A61K38/08 ,  A61K38/22

    摘要： The invention relates to the use of the PAT nonapeptide in the manufacture of a drug for preventing or treating a neurodegenerative disease such as Alzheimer's disease. The parenteral route of administration is preferable, including the subcutaneous, intraperitoneal, intravenous or intranasal routes. The invention also relates to an injectable formulation containing the PAT nonapeptide which can be administered to patients suffering from a neurodegenerative disease such as Alzheimer's disease.

    摘要翻译： 本发明涉及PAT单肽在制备用于预防或治疗神经变性疾病如阿尔茨海默病的药物中的用途。 肠胃外给药途径是优选的，包括皮下，腹膜内，静脉内或鼻内途径。 本发明还涉及含有PAT九肽的可注射制剂，其可以施用于患有神经变性疾病如阿尔茨海默病的患者。